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Conserved domains on  [gi|21361519|ref|NP_057083|]
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adiponectin receptor protein 1 [Homo sapiens]

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
129-352 1.34e-54

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.


:

Pssm-ID: 251670  Cd Length: 207  Bit Score: 180.53  E-value: 1.34e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   129 FRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFmaPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSE-KVSRTFSKL 207
Cdd:pfam03006   1 FSLHNETANIWTHLLGAILFIVLLIFLLVLASLGG--SPWAVVPFSIYGLSLFLLLLVSTLYHLFSCHSEgRVKYILRKL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   208 DYSGIALLIMGSFVPWLYYSFycSPQPRLIYLSIVCVLGISAIIVAQWDRfatPKHRQTRAGVFLGLGLSGVVPTMHFti 287
Cdd:pfam03006  79 DHSGIYLLIAGSYTPFLLYAL--CGPLGWILLIFIWGLALLGILLKLFPL---KRFRWLRTVLYLLMGWLGIIPIKHL-- 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361519   288 aegfVKATTVGQMGWFFLMAVMYITGAGLYAARiperfFPGKFDIWFQSHQIFHVLVVAAAFVHF 352
Cdd:pfam03006 152 ----ILALGGGGLVLLVLGGVLYTLGAIFYALR-----FPGPFDIWGHSHQIFHLFVVLGALCHY 207
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
129-352 1.34e-54

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.


Pssm-ID: 251670  Cd Length: 207  Bit Score: 180.53  E-value: 1.34e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   129 FRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFmaPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSE-KVSRTFSKL 207
Cdd:pfam03006   1 FSLHNETANIWTHLLGAILFIVLLIFLLVLASLGG--SPWAVVPFSIYGLSLFLLLLVSTLYHLFSCHSEgRVKYILRKL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   208 DYSGIALLIMGSFVPWLYYSFycSPQPRLIYLSIVCVLGISAIIVAQWDRfatPKHRQTRAGVFLGLGLSGVVPTMHFti 287
Cdd:pfam03006  79 DHSGIYLLIAGSYTPFLLYAL--CGPLGWILLIFIWGLALLGILLKLFPL---KRFRWLRTVLYLLMGWLGIIPIKHL-- 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361519   288 aegfVKATTVGQMGWFFLMAVMYITGAGLYAARiperfFPGKFDIWFQSHQIFHVLVVAAAFVHF 352
Cdd:pfam03006 152 ----ILALGGGGLVLLVLGGVLYTLGAIFYALR-----FPGPFDIWGHSHQIFHLFVVLGALCHY 207
COG1272 COG1272
Predicted membrane protein, hemolysin III homolog [General function prediction only]
105-355 5.01e-31

Predicted membrane protein, hemolysin III homolog [General function prediction only]


Pssm-ID: 224191  Cd Length: 226  Bit Score: 118.11  E-value: 5.01e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519 105 KDNDYLLHGHRPPMPSFracfksifriHTETGNIWTHLLGFVLFLFLgiLTMLRPNMYFMAPLQEKVVFGMFFLGAVLCL 184
Cdd:COG1272   2 RDNNYIAEGKRSKSYSW----------HEEIANAITHLIGAILAIVG--LVLLLVYALITGSALAVIVFSIYGLSLFLLF 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519 185 SFSWLFHTVYcHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCspQPRLIYLSIVCVLGISAIIVAQwdrFATPKHR 264
Cdd:COG1272  70 LVSTLYHSIP-NGQKAKAILRKFDHSGIYVLIAGSYTPFLLVGLYG--PLGWILLGLIWGLALAGILFKL---FFKKRFR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519 265 QTRAGVFLGLGLSGVVPTMHFTIAEGFVKATtvgqmgWFFLMAVMYITGAGLYAARIperffpgkfDIWFQSHQIFHVLV 344
Cdd:COG1272 144 KLSLVLYLAMGWLGLIVIKPLIAKLGLIGLV------LLALGGVLYSVGAIFYVLRI---------DRIPYSHAIWHLFV 208
                       250
                ....*....|.
gi 21361519 345 VAAAFVHFYGV 355
Cdd:COG1272 209 VGGAACHFIAI 219
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
134-355 8.91e-12

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 233258  Cd Length: 204  Bit Score: 62.72  E-value: 8.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   134 ETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAplQEKVVFGMFFLGAVLCLSFSWLFHTVyCHSEKVSRTFSKLDYSGIA 213
Cdd:TIGR01065   2 EIANAITHGIGAVLSIIALALLVIYSWDHGGA--VAVLGFSIYGISLILLFLVSTLYHSI-PKGSKAKNWLRKIDHSMIY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   214 LLIMGSFVPWLYYSFYcSPQPRLIyLSIVCVLGISAIIVAQwdrFATPKHRQTRAGVFLGLGLS--GVVPTMhftiaegf 291
Cdd:TIGR01065  79 VLIAGTYTPFLLLALP-GPLGWTV-LWIIWGLAIGGIIYKL---FFHKRPRWLSLFLYLIMGWLvvLVIKPL-------- 145
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21361519   292 VKATTVGQMGWFFLMAVMYITGAGLYAARIPerffpgkfdIWFQSHQIFHVLVVAAAFVHFYGV 355
Cdd:TIGR01065 146 YHNLPGAGFSLLAAGGLLYTVGAIFYALKWP---------IPFTYHAIWHLFVLGASACHFVAI 200
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
129-352 1.34e-54

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.


Pssm-ID: 251670  Cd Length: 207  Bit Score: 180.53  E-value: 1.34e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   129 FRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFmaPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSE-KVSRTFSKL 207
Cdd:pfam03006   1 FSLHNETANIWTHLLGAILFIVLLIFLLVLASLGG--SPWAVVPFSIYGLSLFLLLLVSTLYHLFSCHSEgRVKYILRKL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   208 DYSGIALLIMGSFVPWLYYSFycSPQPRLIYLSIVCVLGISAIIVAQWDRfatPKHRQTRAGVFLGLGLSGVVPTMHFti 287
Cdd:pfam03006  79 DHSGIYLLIAGSYTPFLLYAL--CGPLGWILLIFIWGLALLGILLKLFPL---KRFRWLRTVLYLLMGWLGIIPIKHL-- 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361519   288 aegfVKATTVGQMGWFFLMAVMYITGAGLYAARiperfFPGKFDIWFQSHQIFHVLVVAAAFVHF 352
Cdd:pfam03006 152 ----ILALGGGGLVLLVLGGVLYTLGAIFYALR-----FPGPFDIWGHSHQIFHLFVVLGALCHY 207
COG1272 COG1272
Predicted membrane protein, hemolysin III homolog [General function prediction only]
105-355 5.01e-31

Predicted membrane protein, hemolysin III homolog [General function prediction only]


Pssm-ID: 224191  Cd Length: 226  Bit Score: 118.11  E-value: 5.01e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519 105 KDNDYLLHGHRPPMPSFracfksifriHTETGNIWTHLLGFVLFLFLgiLTMLRPNMYFMAPLQEKVVFGMFFLGAVLCL 184
Cdd:COG1272   2 RDNNYIAEGKRSKSYSW----------HEEIANAITHLIGAILAIVG--LVLLLVYALITGSALAVIVFSIYGLSLFLLF 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519 185 SFSWLFHTVYcHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCspQPRLIYLSIVCVLGISAIIVAQwdrFATPKHR 264
Cdd:COG1272  70 LVSTLYHSIP-NGQKAKAILRKFDHSGIYVLIAGSYTPFLLVGLYG--PLGWILLGLIWGLALAGILFKL---FFKKRFR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519 265 QTRAGVFLGLGLSGVVPTMHFTIAEGFVKATtvgqmgWFFLMAVMYITGAGLYAARIperffpgkfDIWFQSHQIFHVLV 344
Cdd:COG1272 144 KLSLVLYLAMGWLGLIVIKPLIAKLGLIGLV------LLALGGVLYSVGAIFYVLRI---------DRIPYSHAIWHLFV 208
                       250
                ....*....|.
gi 21361519 345 VAAAFVHFYGV 355
Cdd:COG1272 209 VGGAACHFIAI 219
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
134-355 8.91e-12

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 233258  Cd Length: 204  Bit Score: 62.72  E-value: 8.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   134 ETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAplQEKVVFGMFFLGAVLCLSFSWLFHTVyCHSEKVSRTFSKLDYSGIA 213
Cdd:TIGR01065   2 EIANAITHGIGAVLSIIALALLVIYSWDHGGA--VAVLGFSIYGISLILLFLVSTLYHSI-PKGSKAKNWLRKIDHSMIY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361519   214 LLIMGSFVPWLYYSFYcSPQPRLIyLSIVCVLGISAIIVAQwdrFATPKHRQTRAGVFLGLGLS--GVVPTMhftiaegf 291
Cdd:TIGR01065  79 VLIAGTYTPFLLLALP-GPLGWTV-LWIIWGLAIGGIIYKL---FFHKRPRWLSLFLYLIMGWLvvLVIKPL-------- 145
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21361519   292 VKATTVGQMGWFFLMAVMYITGAGLYAARIPerffpgkfdIWFQSHQIFHVLVVAAAFVHFYGV 355
Cdd:TIGR01065 146 YHNLPGAGFSLLAAGGLLYTVGAIFYALKWP---------IPFTYHAIWHLFVLGASACHFVAI 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.12
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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