NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|194068499|dbj|BAG55070|]
View 

toll-like receptor 9 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-504 5.54e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  113 TIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNcyyknpcrqALEVAP 192
Cdd:COG4886    59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN---------QLTDLP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  193 GALLGLGNLTHLSLKYNNLTVVPRNLPS--SLEYLLLSYNRIVKLaPEDLANLTALRVLDVGGNcrrcdhapnpcmecpr 270
Cdd:COG4886   130 EELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN---------------- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  271 hfpQLH--PDTFSHLSRLEGLVLKDSSLSWLNASwFRGLGNLRVLDLSENflykCITKTKAFQGLTQLRKLNLSFNyqkr 348
Cdd:COG4886   193 ---QITdlPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN---- 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  349 vsfaHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS 428
Cdd:COG4886   261 ----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194068499  429 GASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
Cdd:COG4886   337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-739 9.63e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  495 LSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKldlyhehSFTELPRLEALDLSYNSqpfgmqgVGHNFSFVAHL 574
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ-------LTDLPEELANL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  575 RTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLDLSQNRLHTlLPQTLRNLpKS 654
Cdd:COG4886   136 TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-------LGNLTNLKELDLSNNQITD-LPEPLGNL-TN 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  655 LQVLRLRDNYLAFFKwWSLHFLPKLEVLDLAGNQLKALTngSLPAGTRLRRLDVSCNSISFVAPgfFSKAKELRELNLSA 734
Cdd:COG4886   207 LEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSN 281


                  ....*
gi 194068499  735 NALKT 739
Cdd:COG4886   282 NQLTD 286
SEFIR super family cl23749
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 870-1009 2.11e-08

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


The actual alignment was detected with superfamily member smart00255:

Pssm-ID: 474043 [Multi-domain]  Cd Length: 140  Bit Score: 53.87  E-value: 2.11e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499    870 YDAFVVFdktqsAVADWVYNELRGQLEECRGRwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAH--TDrvSGLL 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRG--YGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPnyAE--SEWC 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194068499    948 RASFLLAQQRLLEDRKDVVVLVILSPDGR--RSRYVRLRQRLcRQSVLLWPHQPSGQrsFWAQL 1009
Cdd:smart00255   73 LDELVAALENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKA 133
LRR_8 pfam13855
Leucine rich repeat;
64-135 1.23e-07

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194068499    64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCppvgLSpmhfpchmTIEPSTFLAVPTLEELNLSYNNI 135
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL----LT--------TLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-504 5.54e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  113 TIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNcyyknpcrqALEVAP 192
Cdd:COG4886    59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN---------QLTDLP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  193 GALLGLGNLTHLSLKYNNLTVVPRNLPS--SLEYLLLSYNRIVKLaPEDLANLTALRVLDVGGNcrrcdhapnpcmecpr 270
Cdd:COG4886   130 EELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN---------------- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  271 hfpQLH--PDTFSHLSRLEGLVLKDSSLSWLNASwFRGLGNLRVLDLSENflykCITKTKAFQGLTQLRKLNLSFNyqkr 348
Cdd:COG4886   193 ---QITdlPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN---- 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  349 vsfaHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS 428
Cdd:COG4886   261 ----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194068499  429 GASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
Cdd:COG4886   337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-739 9.63e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  495 LSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKldlyhehSFTELPRLEALDLSYNSqpfgmqgVGHNFSFVAHL 574
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ-------LTDLPEELANL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  575 RTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLDLSQNRLHTlLPQTLRNLpKS 654
Cdd:COG4886   136 TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-------LGNLTNLKELDLSNNQITD-LPEPLGNL-TN 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  655 LQVLRLRDNYLAFFKwWSLHFLPKLEVLDLAGNQLKALTngSLPAGTRLRRLDVSCNSISFVAPgfFSKAKELRELNLSA 734
Cdd:COG4886   207 LEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSN 281


                  ....*
gi 194068499  735 NALKT 739
Cdd:COG4886   282 NQLTD 286
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 200-737 2.77e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.68  E-value: 2.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  200 NLTHLSLKYNNLT-VVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCrRCDHAPNpcmecprhfpqlhpd 278
Cdd:PLN00113  119 SLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV-LVGKIPN--------------- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  279 TFSHLSRLEGLVL--------------KDSSLSWLNASW----------FRGLGNLRVLDLSENFLYKCITKTkafqgLT 334
Cdd:PLN00113  183 SLTNLTSLEFLTLasnqlvgqiprelgQMKSLKWIYLGYnnlsgeipyeIGGLTSLNHLDLVYNNLTGPIPSS-----LG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  335 QLRKLNLSFNYQKRVSFahlSLAPSFGSLVALKELDMHGiffRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAF 414
Cdd:PLN00113  258 NLKNLQYLFLYQNKLSG---PIPPSIFSLQKLISLDLSD---NSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSL 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  415 PGLRYVDLSDNRISGasELTATMGEADggekvwlqpgdlapapvdtpssedfrpncstlNFT-LDLSRNNLVTVQPEMFA 493
Cdd:PLN00113  332 PRLQVLQLWSNKFSG--EIPKNLGKHN--------------------------------NLTvLDLSTNNLTGEIPEGLC 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  494 QLSHLQCLRLSHNCISQAVNGSqFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQpfgmqgVGHNFSFVAH 573
Cdd:PLN00113  378 SSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL------QGRINSRKWD 450

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  574 LRTLRHLSLAHNNihsqvsqqlcstslraldFSGNalghmwaegdlyLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPK 653
Cdd:PLN00113  451 MPSLQMLSLARNK------------------FFGG------------LPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE 500

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  654 SLQvLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLkaltNGSLPAGTR----LRRLDVSCNSISFVAPGFFSKAKELRE 729
Cdd:PLN00113  501 LMQ-LKLSENKLSGEIPDELSSCKKLVSLDLSHNQL----SGQIPASFSempvLSQLDLSQNQLSGEIPKNLGNVESLVQ 575


                  ....*...
gi 194068499  730 LNLSANAL 737
Cdd:PLN00113  576 VNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 401-737 1.77e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  401 NFINQAQLGIFRaFPGLRYVDLSDNRISGaseltatmgeadggekvwlqpgdlapapvdtPSSEDFRPNCSTLNFtLDLS 480
Cdd:PLN00113   80 NISGKISSAIFR-LPYIQTINLSNNQLSG-------------------------------PIPDDIFTTSSSLRY-LNLS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  481 RNNLVTVQPEMFaqLSHLQCLRLSHNCISQAVNgSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNsqpfg 560
Cdd:PLN00113  127 NNNFTGSIPRGS--IPNLETLDLSNNMLSGEIP-NDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN----- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  561 mQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCS-TSLRALDFSGNAL-GHMWAE-GDL----YLHFFQ-------- 625
Cdd:PLN00113  199 -QLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGlTSLNHLDLVYNNLtGPIPSSlGNLknlqYLFLYQnklsgpip 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  626 ----GLSGLIWLDLSQNRLHTLLPQTLRNLpKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGT 701
Cdd:PLN00113  278 psifSLQKLISLDLSDNSLSGEIPELVIQL-QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHN 356

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 194068499  702 RLRRLDVSCNSISFVAPGFFSKAKELRELNLSANAL 737
Cdd:PLN00113  357 NLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL 392
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 393-422 9.22e-13

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 63.13  E-value: 9.22e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 194068499   393 LQTLRLQMNFINQAQLGIFRAFPGLRYVDL 422
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
LRR_8 pfam13855
Leucine rich repeat;
496-555 8.10e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 8.10e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   496 SHLQCLRLSHNCIsQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYN 555
Cdd:pfam13855    1 PNLRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
TIR smart00255
Toll - interleukin 1 - resistance;
870-1009 2.11e-08

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 53.87  E-value: 2.11e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499    870 YDAFVVFdktqsAVADWVYNELRGQLEECRGRwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAH--TDrvSGLL 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRG--YGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPnyAE--SEWC 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194068499    948 RASFLLAQQRLLEDRKDVVVLVILSPDGR--RSRYVRLRQRLcRQSVLLWPHQPSGQrsFWAQL 1009
Cdd:smart00255   73 LDELVAALENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKA 133
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 143-344 3.10e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  143 KSLISLSLSHTNILMLDSasLAGLHALRFLFMDGNCYYKNPcrqalevapgALLGLGNLTHLSLKYNNLTVVP--RNLPS 220
Cdd:cd21340     2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE----------NLEFLTNLTHLYLQNNQIEKIEnlENLVN 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  221 sLEYLLLSYNRIVKLapEDLANLTALRVLDVGGNCRRCDHapnpcmecprhfpQLHPDTFSHLSRLEglvlkdsSLSWLN 300
Cdd:cd21340    70 -LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPGE-------------KLTFDPRSLAALSN-------SLRVLN 126

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 194068499  301 AS--------WFRGLGNLRVLDLSENFL--YKCITKTkaFQGLTQLRKLNLSFN 344
Cdd:cd21340   127 ISgnnidslePLAPLRNLEQLDASNNQIsdLEELLDL--LSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
64-135 1.23e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194068499    64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCppvgLSpmhfpchmTIEPSTFLAVPTLEELNLSYNNI 135
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL----LT--------TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 476-739 1.65e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  476 TLDLSRNNL------VTVQPEMFAQLSHLQCLRLSHNCISQAvnGSQFLPL----TGLQVLDLSHNKLDLYHEH----SF 541
Cdd:cd00116    55 ELCLSLNETgriprgLQSLLQGLTKGCGLQELDLSDNALGPD--GCGVLESllrsSSLQELKLNNNGLGDRGLRllakGL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  542 TEL-PRLEALDLSYNS-QPFGMQGVGHNFSfvaHLRTLRHLSLAHNNIHSQVSQQLC-----STSLRALDFSGNALGHmw 614
Cdd:cd00116   133 KDLpPALEKLVLGRNRlEGASCEALAKALR---ANRDLKELNLANNGIGDAGIRALAeglkaNCNLEVLDLNNNGLTD-- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  615 aEGDlylhffqglsgliwldlsqnrlhTLLPQTLRNLpKSLQVLRLRDNylaffkwwslhflpkleVLDLAGnqLKALTN 694
Cdd:cd00116   208 -EGA-----------------------SALAETLASL-KSLEVLNLGDN-----------------NLTDAG--AAALAS 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 194068499  695 GSLPAGTRLRRLDVSCNSISFVAPGFFSKA----KELRELNLSANALKT 739
Cdd:cd00116   244 ALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 870-997 6.89e-04

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 41.58  E-value: 6.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   870 YDAFVVFdkTQSAVADWVYNELRGQLEECRgrwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLlra 949
Cdd:pfam01582    1 YDVFLSF--RGSDTREWFVSHLLKELKQKG----IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGW--- 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   950 sFLLAQQRLLEDRKD---VVVLVILSPDGRRSR---------YVRLRQRLCRQSVLLWPH 997
Cdd:pfam01582   72 -CLDELVKILECALDlgqKVIPIFYEVDPSDVRkqtgsfgkaFKKHKKVLTEEKVLKWRG 130
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-504 5.54e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  113 TIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNcyyknpcrqALEVAP 192
Cdd:COG4886    59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN---------QLTDLP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  193 GALLGLGNLTHLSLKYNNLTVVPRNLPS--SLEYLLLSYNRIVKLaPEDLANLTALRVLDVGGNcrrcdhapnpcmecpr 270
Cdd:COG4886   130 EELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN---------------- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  271 hfpQLH--PDTFSHLSRLEGLVLKDSSLSWLNASwFRGLGNLRVLDLSENflykCITKTKAFQGLTQLRKLNLSFNyqkr 348
Cdd:COG4886   193 ---QITdlPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN---- 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  349 vsfaHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS 428
Cdd:COG4886   261 ----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194068499  429 GASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
Cdd:COG4886   337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-739 9.63e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  495 LSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKldlyhehSFTELPRLEALDLSYNSqpfgmqgVGHNFSFVAHL 574
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ-------LTDLPEELANL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  575 RTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLDLSQNRLHTlLPQTLRNLpKS 654
Cdd:COG4886   136 TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-------LGNLTNLKELDLSNNQITD-LPEPLGNL-TN 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  655 LQVLRLRDNYLAFFKwWSLHFLPKLEVLDLAGNQLKALTngSLPAGTRLRRLDVSCNSISFVAPgfFSKAKELRELNLSA 734
Cdd:COG4886   207 LEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSN 281


                  ....*
gi 194068499  735 NALKT 739
Cdd:COG4886   282 NQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-254 2.09e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   23 TLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAprgNVTSLSLSSNRIHHLhDSDFAHLPSLRHLNLKWNcppvg 102
Cdd:COG4886    76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT---NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN----- 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  103 lspmhfpcHMTIEPSTFLAVPTLEELNLSYNNIMTVPA----LPKsLISLSLSHTNILMLdSASLAGLHALRFLFMDGNc 178
Cdd:COG4886   147 --------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITDL-PEPLGNLTNLEELDLSGN- 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194068499  179 yyknpcrqALEVAPGALLGLGNLTHLSLKYNNLTVVPR--NLPsSLEYLLLSYNRIVKLAPedLANLTALRVLDVGGN 254
Cdd:COG4886   216 --------QLTDLPEPLANLTNLETLDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPP--LANLTNLKTLDLSNN 282
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 200-737 2.77e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.68  E-value: 2.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  200 NLTHLSLKYNNLT-VVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCrRCDHAPNpcmecprhfpqlhpd 278
Cdd:PLN00113  119 SLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV-LVGKIPN--------------- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  279 TFSHLSRLEGLVL--------------KDSSLSWLNASW----------FRGLGNLRVLDLSENFLYKCITKTkafqgLT 334
Cdd:PLN00113  183 SLTNLTSLEFLTLasnqlvgqiprelgQMKSLKWIYLGYnnlsgeipyeIGGLTSLNHLDLVYNNLTGPIPSS-----LG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  335 QLRKLNLSFNYQKRVSFahlSLAPSFGSLVALKELDMHGiffRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAF 414
Cdd:PLN00113  258 NLKNLQYLFLYQNKLSG---PIPPSIFSLQKLISLDLSD---NSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSL 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  415 PGLRYVDLSDNRISGasELTATMGEADggekvwlqpgdlapapvdtpssedfrpncstlNFT-LDLSRNNLVTVQPEMFA 493
Cdd:PLN00113  332 PRLQVLQLWSNKFSG--EIPKNLGKHN--------------------------------NLTvLDLSTNNLTGEIPEGLC 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  494 QLSHLQCLRLSHNCISQAVNGSqFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQpfgmqgVGHNFSFVAH 573
Cdd:PLN00113  378 SSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL------QGRINSRKWD 450

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  574 LRTLRHLSLAHNNihsqvsqqlcstslraldFSGNalghmwaegdlyLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPK 653
Cdd:PLN00113  451 MPSLQMLSLARNK------------------FFGG------------LPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE 500

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  654 SLQvLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLkaltNGSLPAGTR----LRRLDVSCNSISFVAPGFFSKAKELRE 729
Cdd:PLN00113  501 LMQ-LKLSENKLSGEIPDELSSCKKLVSLDLSHNQL----SGQIPASFSempvLSQLDLSQNQLSGEIPKNLGNVESLVQ 575


                  ....*...
gi 194068499  730 LNLSANAL 737
Cdd:PLN00113  576 VNISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
476-707 2.63e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  476 TLDLSRNNLVTVqPEMFAQLSHLQCLRLSHNCISQAvnGSQFLPLTGLQVLDLSHNKLdlyhehsfTELPrlealdlsyn 555
Cdd:COG4886   117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQL--------TDLP---------- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  556 sqpfgmqgvghnfSFVAHLRTLRHLSLAHNNIhSQVSQQLCS-TSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLD 634
Cdd:COG4886   176 -------------EELGNLTNLKELDLSNNQI-TDLPEPLGNlTNLEELDLSGNQLTDLPEP-------LANLTNLETLD 234

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194068499  635 LSQNRLHTlLPQtLRNLPKsLQVLRLRDNYLAFFKwwSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLD 707
Cdd:COG4886   235 LSNNQLTD-LPE-LGNLTN-LEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
567-762 2.97e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  567 NFSFVAHLRTLRHLSLAHNNIHSQVsqqlcsTSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLDLSQNRLHTLlPQ 646
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGNEELSNL------TNLESLDLSGNQLTDLPEE-------LANLTNLKELDLSNNQLTDL-PE 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  647 TLRNLPKsLQVLRLRDNYLAFFKWWSLHfLPKLEVLDLAGNQLKALTNgSLPAGTRLRRLDVSCNSISFVaPGFFSKAKE 726
Cdd:COG4886   154 PLGNLTN-LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTN 229

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 194068499  727 LRELNLSANALKTVdhSWFGPLaSALQILDVSANPL 762
Cdd:COG4886   230 LETLDLSNNQLTDL--PELGNL-TNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-588 5.30e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 5.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   65 VTSLSLSSNRIH-HLHDSDFAHLPSLRHLNLKWNcppvglspmHFPCHMtiePSTFLavPTLEELNLSyNNIMT--VPAL 141
Cdd:PLN00113   95 IQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN---------NFTGSI---PRGSI--PNLETLDLS-NNMLSgeIPND 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  142 PKSLISLSLSHT--NILMLD-SASLAGLHALRFLFMDGNCYYKNPCRQALEVA----------------PGALLGLGNLT 202
Cdd:PLN00113  160 IGSFSSLKVLDLggNVLVGKiPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKslkwiylgynnlsgeiPYEIGGLTSLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  203 HLSLKYNNLT-VVPRNLP--SSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNcrrcdhapNPCMECPRHFPQLH--- 276
Cdd:PLN00113  240 HLDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN--------SLSGEIPELVIQLQnle 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  277 -------------PDTFSHLSRLEGLVLKDSSLSwlnASWFRGLG---NLRVLDLSENFLYKCITKTKAFQGltQLRKLN 340
Cdd:PLN00113  312 ilhlfsnnftgkiPVALTSLPRLQVLQLWSNKFS---GEIPKNLGkhnNLTVLDLSTNNLTGEIPEGLCSSG--NLFKLI 386

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  341 LsfnyqkrvsfahlslapsfgslvalkeldmhgiFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
Cdd:PLN00113  387 L---------------------------------FSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFL 433

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  421 DLSDNRISGASEltatmgeadggEKVW----LQPGDLAPAPVDTPSSEDFRpncSTLNFTLDLSRNNLVTVQPEMFAQLS 496
Cdd:PLN00113  434 DISNNNLQGRIN-----------SRKWdmpsLQMLSLARNKFFGGLPDSFG---SKRLENLDLSRNQFSGAVPRKLGSLS 499

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  497 HLQCLRLSHNCISQAVNgSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNsqpfgmQGVGHNFSFVAHLRT 576
Cdd:PLN00113  500 ELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN------QLSGEIPKNLGNVES 572

                         570
                  ....*....|..
gi 194068499  577 LRHLSLAHNNIH 588
Cdd:PLN00113  573 LVQVNISHNHLH 584
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
476-732 3.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  476 TLDLSRNNLVTVqPEMFAQLSHLQCLRLSHNCISQAvnGSQFLPLTGLQVLDLSHNKL-DLyhEHSFTELPRLEALDLSY 554
Cdd:COG4886   140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNNQItDL--PEPLGNLTNLEELDLSG 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  555 NsqpfgmqGVGHNFSFVAHLRTLRHLSLAHNNIhSQVSQQLCSTSLRALDFSGNALGHmwaegdlyLHFFQGLSGLIWLD 634
Cdd:COG4886   215 N-------QLTDLPEPLANLTNLETLDLSNNQL-TDLPELGNLTNLEELDLSNNQLTD--------LPPLANLTNLKTLD 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  635 LSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSIS 714
Cdd:COG4886   279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                         250
                  ....*....|....*...
gi 194068499  715 FVAPGFFSKAKELRELNL 732
Cdd:COG4886   359 LSLLLTLLLTLGLLGLLE 376
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
283-671 1.26e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 1.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  283 LSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENflykcitktKAFQGLTQLRKLNLSFNyqkRVSfahlSLAPSFGS 362
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGN---QLT----DLPEELAN 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  363 LVALKELDMHGIFFRSLDEttlrPLARLPMLQTLRLQMNFINQAQLGIFRaFPGLRYVDLSDNRISgasELTATMGEADG 442
Cdd:COG4886   135 LTNLKELDLSNNQLTDLPE----PLGNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQIT---DLPEPLGNLTN 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  443 GEKVWLQPGDLAPAPVDTPssedfrpNCSTLNfTLDLSRNNLVTVqPEmFAQLSHLQCLRLSHNCISQAvngSQFLPLTG 522
Cdd:COG4886   207 LEELDLSGNQLTDLPEPLA-------NLTNLE-TLDLSNNQLTDL-PE-LGNLTNLEELDLSNNQLTDL---PPLANLTN 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  523 LQVLDLSHNKLdlyhehSFTELPRLEALDLSYNSQPFGMQGVGHNfsFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRA 602
Cdd:COG4886   274 LKTLDLSNNQL------TDLKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194068499  603 LDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWW 671
Cdd:COG4886   346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 401-737 1.77e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  401 NFINQAQLGIFRaFPGLRYVDLSDNRISGaseltatmgeadggekvwlqpgdlapapvdtPSSEDFRPNCSTLNFtLDLS 480
Cdd:PLN00113   80 NISGKISSAIFR-LPYIQTINLSNNQLSG-------------------------------PIPDDIFTTSSSLRY-LNLS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  481 RNNLVTVQPEMFaqLSHLQCLRLSHNCISQAVNgSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNsqpfg 560
Cdd:PLN00113  127 NNNFTGSIPRGS--IPNLETLDLSNNMLSGEIP-NDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN----- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  561 mQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCS-TSLRALDFSGNAL-GHMWAE-GDL----YLHFFQ-------- 625
Cdd:PLN00113  199 -QLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGlTSLNHLDLVYNNLtGPIPSSlGNLknlqYLFLYQnklsgpip 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  626 ----GLSGLIWLDLSQNRLHTLLPQTLRNLpKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGT 701
Cdd:PLN00113  278 psifSLQKLISLDLSDNSLSGEIPELVIQL-QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHN 356

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 194068499  702 RLRRLDVSCNSISFVAPGFFSKAKELRELNLSANAL 737
Cdd:PLN00113  357 NLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-647 2.73e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.50  E-value: 2.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNcppvglsPMHFPchmtIEPSTFLAVPTLEELNLSYNNIMTvpALPKS 144
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN-------QLSGP----IPDDIFTTSSSLRYLNLSNNNFTG--SIPRG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  145 LIS----LSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNpcrqalevAPGALLGLGNLTHLSLKYNNLT-VVPRNLP 219
Cdd:PLN00113  138 SIPnletLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGK--------IPNSLTNLTSLEFLTLASNQLVgQIPRELG 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  220 S--SLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNcrrcdhapnpcmecprHFPQLHPDTFSHLSRLEGLVLKDSSLS 297
Cdd:PLN00113  210 QmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN----------------NLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  298 WLNASWFRGLGNLRVLDLSENFLYKCITKTkafqgltqlrklnlsfnyqkrvsfahlslapsfgsLVALKELDMHGIFFR 377
Cdd:PLN00113  274 GPIPPSIFSLQKLISLDLSDNSLSGEIPEL-----------------------------------VIQLQNLEILHLFSN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  378 SLDETTLRPLARLPMLQTLRLQMNFIN---QAQLGifrAFPGLRYVDLSDNRISGasELTATMGEAdggekvwlqpGDLA 454
Cdd:PLN00113  319 NFTGKIPVALTSLPRLQVLQLWSNKFSgeiPKNLG---KHNNLTVLDLSTNNLTG--EIPEGLCSS----------GNLF 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  455 PAPVDTPSSEDFRP----NCSTLNfTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNgSQFLPLTGLQVLDLSH 530
Cdd:PLN00113  384 KLILFSNSLEGEIPkslgACRSLR-RVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRIN-SRKWDMPSLQMLSLAR 461

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  531 NKLdlyhehsFTELP------RLEALDLSYNsqpfgmQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCS-TSLRAL 603
Cdd:PLN00113  462 NKF-------FGGLPdsfgskRLENLDLSRN------QFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSScKKLVSL 528

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194068499  604 DFSGNAL-GHMWAE-------GDLYLHFFQgLSG-----------LIWLDLSQNRLHTLLPQT 647
Cdd:PLN00113  529 DLSHNQLsGQIPASfsempvlSQLDLSQNQ-LSGeipknlgnvesLVQVNISHNHLHGSLPST 590
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-433 5.02e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 5.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  132 YNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNL 211
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  212 TVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNcrrcdhapnpcmecprhfpQLH--PDTFSHLSRLEGL 289
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN-------------------QLTdlPEELANLTNLKEL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  290 VLKDSSLSWLNASwFRGLGNLRVLDLSENFLYKCitkTKAFQGLTQLRKLNLSFNyqkRVSfahlSLAPSFGSLVALKEL 369
Cdd:COG4886   142 DLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNN---QIT----DLPEPLGNLTNLEEL 210

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194068499  370 DMHGIFFRSLDEttlrPLARLPMLQTLRLQMNFINqaQLGIFRAFPGLRYVDLSDNRISGASEL 433
Cdd:COG4886   211 DLSGNQLTDLPE----PLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLPPL 268
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 393-422 9.22e-13

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 63.13  E-value: 9.22e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 194068499   393 LQTLRLQMNFINQAQLGIFRAFPGLRYVDL 422
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
24-240 2.32e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 2.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   24 LALGTLPAFLPCELQPHGLVNCNwlfLKSVPHfsmaAPRGNVTSLSLSSNRIHHLHDSdfahLP-SLRHLNLKWN----C 98
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNE---LKSLPE----NLQGNIKTLYANSNQLTSIPAT----LPdTIQEMELSINriteL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   99 P---PVGLSPMHFPCH-MTIEPSTflaVPT-LEELNLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSASLAGLhalRFL 172
Cdd:PRK15370  257 PerlPSALQSLDLFHNkISCLPEN---LPEeLRYLSVYDNSIRTLPAhLPSGITHLNVQSNSLTALPETLPPGL---KTL 330

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194068499  173 FMDGN---CYYKN--PCRQALEVAPGALLGLG-----NLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLaPEDL 240
Cdd:PRK15370  331 EAGENaltSLPASlpPELQVLDVSKNQITVLPetlppTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL-PESL 407
LRR_8 pfam13855
Leucine rich repeat;
496-555 8.10e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 8.10e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   496 SHLQCLRLSHNCIsQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYN 555
Cdd:pfam13855    1 PNLRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
476-533 1.09e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.09e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 194068499   476 TLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQaVNGSQFLPLTGLQVLDLSHNKL 533
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPSLRYLDLSGNRL 61
TIR smart00255
Toll - interleukin 1 - resistance;
870-1009 2.11e-08

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 53.87  E-value: 2.11e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499    870 YDAFVVFdktqsAVADWVYNELRGQLEECRGRwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAH--TDrvSGLL 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRG--YGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPnyAE--SEWC 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194068499    948 RASFLLAQQRLLEDRKDVVVLVILSPDGR--RSRYVRLRQRLcRQSVLLWPHQPSGQrsFWAQL 1009
Cdd:smart00255   73 LDELVAALENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKA 133
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
592-762 2.81e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 2.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  592 SQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNylaffkwW 671
Cdd:COG4886    35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------E 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  672 SLHFLPKLEVLDLAGNQLKALTNgSLPAGTRLRRLDVSCNSISFVaPGFFSKAKELRELNLSANALKTVDhSWFGPLaSA 751
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNL-TN 183

                         170
                  ....*....|.
gi 194068499  752 LQILDVSANPL 762
Cdd:COG4886   184 LKELDLSNNQI 194
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 143-344 3.10e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  143 KSLISLSLSHTNILMLDSasLAGLHALRFLFMDGNCYYKNPcrqalevapgALLGLGNLTHLSLKYNNLTVVP--RNLPS 220
Cdd:cd21340     2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE----------NLEFLTNLTHLYLQNNQIEKIEnlENLVN 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  221 sLEYLLLSYNRIVKLapEDLANLTALRVLDVGGNCRRCDHapnpcmecprhfpQLHPDTFSHLSRLEglvlkdsSLSWLN 300
Cdd:cd21340    70 -LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPGE-------------KLTFDPRSLAALSN-------SLRVLN 126

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 194068499  301 AS--------WFRGLGNLRVLDLSENFL--YKCITKTkaFQGLTQLRKLNLSFN 344
Cdd:cd21340   127 ISgnnidslePLAPLRNLEQLDASNNQIsdLEELLDL--LSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
701-762 3.52e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 3.52e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194068499   701 TRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASaLQILDVSANPL 762
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
284-344 1.19e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.19e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194068499   284 SRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLyKCITKtKAFQGLTQLRKLNLSFN 344
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSP-GAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
64-135 1.23e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194068499    64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCppvgLSpmhfpchmTIEPSTFLAVPTLEELNLSYNNI 135
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL----LT--------TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 476-739 1.65e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  476 TLDLSRNNL------VTVQPEMFAQLSHLQCLRLSHNCISQAvnGSQFLPL----TGLQVLDLSHNKLDLYHEH----SF 541
Cdd:cd00116    55 ELCLSLNETgriprgLQSLLQGLTKGCGLQELDLSDNALGPD--GCGVLESllrsSSLQELKLNNNGLGDRGLRllakGL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  542 TEL-PRLEALDLSYNS-QPFGMQGVGHNFSfvaHLRTLRHLSLAHNNIHSQVSQQLC-----STSLRALDFSGNALGHmw 614
Cdd:cd00116   133 KDLpPALEKLVLGRNRlEGASCEALAKALR---ANRDLKELNLANNGIGDAGIRALAeglkaNCNLEVLDLNNNGLTD-- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  615 aEGDlylhffqglsgliwldlsqnrlhTLLPQTLRNLpKSLQVLRLRDNylaffkwwslhflpkleVLDLAGnqLKALTN 694
Cdd:cd00116   208 -EGA-----------------------SALAETLASL-KSLEVLNLGDN-----------------NLTDAG--AAALAS 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 194068499  695 GSLPAGTRLRRLDVSCNSISFVAPGFFSKA----KELRELNLSANALKT 739
Cdd:cd00116   244 ALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
127-318 8.70e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.16  E-value: 8.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  127 ELNLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSaslaGLHalrflfmdgncyyknpcrqalevapgallglGNLTHLS 205
Cdd:PRK15370  182 ELRLKILGLTTIPAcIPEQITTLILDNNELKSLPE----NLQ-------------------------------GNIKTLY 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  206 LKYNNLTVVPRNLPSSLEYLLLSYNRIVKLaPEDLAnlTALRVLDVGGNCRRC--DHAP----------NPCMECPRHFP 273
Cdd:PRK15370  227 ANSNQLTSIPATLPDTIQEMELSINRITEL-PERLP--SALQSLDLFHNKISClpENLPeelrylsvydNSIRTLPAHLP 303

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194068499  274 Q--LHPDTFSHL---------SRLEGLVLKDSSLSWLNASWfrgLGNLRVLDLSEN 318
Cdd:PRK15370  304 SgiTHLNVQSNSltalpetlpPGLKTLEAGENALTSLPASL---PPELQVLDVSKN 356
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 510-737 9.41e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 9.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  510 QAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTEL----PRLEALDLSYNsqPFGMQGVGHNFSFVAHLRTLRHLSLAHN 585
Cdd:COG5238   169 AAISMAKALQNNSVETVYLGCNQIGDEGIEELAEAltqnTTVTTLWLKRN--PIGDEGAEILAEALKGNKSLTTLDLSNN 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  586 NIHSQVSQQL-----CSTSLRALDFSGNALGHmwaEGDLYL-HFFQGLSGLIWLDLSQNRLHTllpQTLRNLPKSLQVLR 659
Cdd:COG5238   247 QIGDEGVIALaealkNNTTVETLYLSGNQIGA---EGAIALaKALQGNTTLTSLDLSVNRIGD---EGAIALAEGLQGNK 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  660 lrdnylaffkwwslhflpKLEVLDLAGNQL-----KALTNgSLPAGTRLRRLDVSCNSISFVAPGFFSKA----KELREL 730
Cdd:COG5238   321 ------------------TLHTLNLAYNGIgaqgaIALAK-ALQENTTLHSLDLSDNQIGDEGAIALAKYlegnTTLREL 381


                  ....*..
gi 194068499  731 NLSANAL 737
Cdd:COG5238   382 NLGKNNI 388
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-373 1.41e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  198 LGNLTHLSLKYNNLTVVP---------------------RNLPS--SLEYLLLSYNRIVKLapEDLANLTALRVLDVGGN 254
Cdd:cd21340     1 LKRITHLYLNDKNITKIDnlslcknlkvlylydnkitkiENLEFltNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  255 CrrcdhapnpcmecprhfpqlhpdtfshLSRLEGL---------------VLKDSSLSWLNASWFRGLGNLRVLDLSENf 319
Cdd:cd21340    79 R---------------------------ISVVEGLenltnleelhienqrLPPGEKLTFDPRSLAALSNSLRVLNISGN- 130

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 194068499  320 lykCITKTKAFQGLTQLRKLNLSFNYQKRVSfahlSLAPSFGSLVALKELDMHG 373
Cdd:cd21340   131 ---NIDSLEPLAPLRNLEQLDASNNQISDLE----ELLDLLSSWPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
677-737 2.60e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.60e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194068499   677 PKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANAL 737
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
200-254 3.13e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.13e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 194068499   200 NLTHLSLKYNNLTVVP----RNLPSsLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGN 254
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 494-638 4.75e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 4.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  494 QLSHLQCLRLSHNCISQAVNgsqFLPLTGLQVLDLSHNKLdlyhehSFTE----LPRLEALDLSYNSQPFGMQGVGHNFS 569
Cdd:cd21340    44 FLTNLTHLYLQNNQIEKIEN---LENLVNLKKLYLGGNRI------SVVEglenLTNLEELHIENQRLPPGEKLTFDPRS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194068499  570 FVAHLRTLRHLSLAHNNIhSQVSQQLCSTSLRALDFSGNALGHMwaeGDLyLHFFQGLSGLIWLDLSQN 638
Cdd:cd21340   115 LAALSNSLRVLNISGNNI-DSLEPLAPLRNLEQLDASNNQISDL---EEL-LDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 650-760 8.66e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 8.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  650 NLPKSLQVLRLRDNYLAFFKwwSLHFLPKLEVLDLAGNQLKALTN-GSLPagtRLRRLDVSCNSISFVApGfFSKAKELR 728
Cdd:cd21340    21 SLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENlENLV---NLKKLYLGGNRISVVE-G-LENLTNLE 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 194068499  729 ELNLSANALKTVDHSWFGP-----LASALQILDVSAN 760
Cdd:cd21340    94 ELHIENQRLPPGEKLTFDPrslaaLSNSLRVLNISGN 130
LRR_8 pfam13855
Leucine rich repeat;
598-665 1.19e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.19e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194068499   598 TSLRALDFSGNALGHmwaegdLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPkSLQVLRLRDNYL 665
Cdd:pfam13855    1 PNLRSLDLSNNRLTS------LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 477-556 1.27e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.04  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  477 LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSqFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNS 556
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPS-LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501
LRR_8 pfam13855
Leucine rich repeat;
628-689 1.51e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.51e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194068499   628 SGLIWLDLSQNRLHTLLPQTLRNLPkSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQL 689
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 133-255 2.79e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  133 NNIMTVPALP--KSLISLSLSHTNILMLDSasLAGLHALRFLFMDGNCyyknpcrqaLEVAPGaLLGLGNLTHLSLKYNN 210
Cdd:cd21340    34 NKITKIENLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR---------ISVVEG-LENLTNLEELHIENQR 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 194068499  211 L------TVVPRNLPS---SLEYLLLSYNRIVKLapEDLANLTALRVLDVGGNC 255
Cdd:cd21340   102 LppgeklTFDPRSLAAlsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQ 153
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 573-714 2.98e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  573 HLRTLRHLSLAHNNIhsQVSQQLCS-TSLRALDFSGNALGHMwaEGdlylhfFQGLSGLIWLDLSQNRL---HTLL--PQ 646
Cdd:cd21340    44 FLTNLTHLYLQNNQI--EKIENLENlVNLKKLYLGGNRISVV--EG------LENLTNLEELHIENQRLppgEKLTfdPR 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  647 TLRNLPKSLQVLRLRDNYLAFFKwwSLHFLPKLEVLDLAGNQLKALTN--GSLPAGTRLRRLDVSCNSIS 714
Cdd:cd21340   114 SLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
521-587 3.98e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.98e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194068499   521 TGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSqpfgMQGVgHNFSFVaHLRTLRHLSLAHNNI 587
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL----LTTL-SPGAFS-GLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
275-318 4.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 4.61e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 194068499   275 LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSEN 318
Cdd:pfam13855   16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
123-177 6.13e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.13e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 194068499   123 PTLEELNLSYNNIMTVPAL----PKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGN 177
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 599-777 4.86e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  599 SLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKS--LQVLRLRDNYLAF----FKWWS 672
Cdd:cd00116    52 SLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSssLQELKLNNNGLGDrglrLLAKG 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  673 L-HFLPKLEVLDLAGNQLkalTNGS-------LPAGTRLRRLDVSCNSISfvAPGF------FSKAKELRELNLSANALK 738
Cdd:cd00116   132 LkDLPPALEKLVLGRNRL---EGAScealakaLRANRDLKELNLANNGIG--DAGIralaegLKANCNLEVLDLNNNGLT 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 194068499  739 TVDHSWFG---PLASALQILDVSANPLHCACGAAFMDFLLEV 777
Cdd:cd00116   207 DEGASALAetlASLKSLEVLNLGDNNLTDAGAAALASALLSP 248
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 469-555 5.20e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  469 NCSTLNfTLDLSRNNL-----VTVQPE-MFAQLSHLQCLRLSHNCISqavNGSQFLPLTGLQVLDLSHNKLDLYHE--HS 540
Cdd:cd21340    88 NLTNLE-ELHIENQRLppgekLTFDPRsLAALSNSLRVLNISGNNID---SLEPLAPLRNLEQLDASNNQISDLEEllDL 163

                          90
                  ....*....|....*
gi 194068499  541 FTELPRLEALDLSYN 555
Cdd:cd21340   164 LSSWPSLRELDLTGN 178
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 870-997 6.89e-04

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 41.58  E-value: 6.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   870 YDAFVVFdkTQSAVADWVYNELRGQLEECRgrwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLlra 949
Cdd:pfam01582    1 YDVFLSF--RGSDTREWFVSHLLKELKQKG----IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGW--- 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   950 sFLLAQQRLLEDRKD---VVVLVILSPDGRRSR---------YVRLRQRLCRQSVLLWPH 997
Cdd:pfam01582   72 -CLDELVKILECALDlgqKVIPIFYEVDPSDVRkqtgsfgkaFKKHKKVLTEEKVLKWRG 130
LRR_8 pfam13855
Leucine rich repeat;
190-232 7.53e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 7.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 194068499   190 VAPGALLGLGNLTHLSLKYNNLTVVPRNL---PSSLEYLLLSYNRI 232
Cdd:pfam13855   16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 64-254 1.50e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   64 NVTSLSLSSNRIHHLhdSDFAHLPSLRHLNLKWNCppvgLSpmhfpchmTIEPstFLAVPTLEELNLSYNNIMTVpalpk 143
Cdd:cd21340    25 NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQ----IE--------KIEN--LENLVNLKKLYLGGNRISVV----- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  144 slislslshtnilmldsASLAGLHALRFLFMDGNcyyKNPCRQALEVAPGALLGLGN-LTHLSLKYNNLTVVpRNLP--S 220
Cdd:cd21340    84 -----------------EGLENLTNLEELHIENQ---RLPPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAplR 142

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 194068499  221 SLEYLLLSYNRIVKLAP--EDLANLTALRVLDVGGN 254
Cdd:cd21340   143 NLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
654-713 2.73e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.73e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499   654 SLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSI 713
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 633-719 2.76e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  633 LDLSQNRLHTLLPQTLRNLpKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLkaltNGSLPAG----TRLRRLDV 708
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKL-RHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF----NGSIPESlgqlTSLRILNL 497

                          90
                  ....*....|.
gi 194068499  709 SCNSISFVAPG 719
Cdd:PLN03150  498 NGNSLSGRVPA 508
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 476-611 2.89e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  476 TLDLSRNNlVTVQ-----PEMFAQLSHLQCLRLSHNCISQ--AVNGSQFLPLT-GLQVLDLSHNKLD-----LYHEHsFT 542
Cdd:COG5238   268 TLYLSGNQ-IGAEgaialAKALQGNTTLTSLDLSVNRIGDegAIALAEGLQGNkTLHTLNLAYNGIGaqgaiALAKA-LQ 345

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194068499  543 ELPRLEALDLSYNsqPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQ----VSQQLCSTSLRALDFSGNALG 611
Cdd:COG5238   346 ENTTLHSLDLSDN--QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQgaeaLIDALQTNRLHTLILDGNLIG 416
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 309-346 4.07e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 4.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 194068499   309 NLRVLDLSENflykCITKTKAFQGLTQLRKLNLSFNYQ 346
Cdd:pfam12799    2 NLEVLDLSNN----QITDIPPLAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 198-254 8.10e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 8.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194068499  198 LGNLTHLSLKYNNLT-VVPRNLPS--SLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGN 254
Cdd:PLN03150  441 LRHLQSINLSGNSIRgNIPPSLGSitSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
309-373 9.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 9.93e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194068499   309 NLRVLDLSENFLYKciTKTKAFQGLTQLRKLNLSFNYQKRVSfahlslAPSFGSLVALKELDMHG 373
Cdd:pfam13855    2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLS------PGAFSGLPSLRYLDLSG 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH