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Conserved domains on  [gi|187735300|ref|YP_001877412|]
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protein serine/threonine phosphatase [Akkermansia muciniphila ATCC BAA-835]

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List of domain hits

Name Accession Description Interval E-value
PP2Cc super family cl00120
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
39-207 5.17e-21

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


The actual alignment was detected with superfamily member COG0631:

Pssm-ID: 260203  Cd Length: 262  Bit Score: 88.57  E-value: 5.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  39 IVCDGMGGHLRGDCASC----VVAQEFAAVFAESGIEDIPERLTAALHAANRALSAIQKEPEES---GTTLLAVFIRDHF 111
Cdd:COG0631   42 AVADGMGGHAAGEVASKlaveALARLFDETNFNSLNESLEELLKEAILKANEAIAEEGQLNEDVrgmGTTLVLLLIRGNK 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300 112 LWWISVGDSPLYLWSGADSFrmdRLNEDHSmrpIADSLYRKGKMSLQGAL--RQRCILRSAVmgGPMELVDISAMPLLLH 189
Cdd:COG0631  122 LYVANVGDSRAYLLRDGELK---QLTEDHS---LVNRLEQRGIITPEEARshPRRNALTRAL--GDFDLLEPDITELELE 193
                        170
                 ....*....|....*...
gi 187735300 190 PGDAVLACSDGLqvWSEL 207
Cdd:COG0631  194 PGDFLLLCSDGL--WDVV 209
 
Name Accession Description Interval E-value
PTC1 COG0631
Serine/threonine protein phosphatase [Signal transduction mechanisms]
39-207 5.17e-21

Serine/threonine protein phosphatase [Signal transduction mechanisms]


Pssm-ID: 223704  Cd Length: 262  Bit Score: 88.57  E-value: 5.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  39 IVCDGMGGHLRGDCASC----VVAQEFAAVFAESGIEDIPERLTAALHAANRALSAIQKEPEES---GTTLLAVFIRDHF 111
Cdd:COG0631   42 AVADGMGGHAAGEVASKlaveALARLFDETNFNSLNESLEELLKEAILKANEAIAEEGQLNEDVrgmGTTLVLLLIRGNK 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300 112 LWWISVGDSPLYLWSGADSFrmdRLNEDHSmrpIADSLYRKGKMSLQGAL--RQRCILRSAVmgGPMELVDISAMPLLLH 189
Cdd:COG0631  122 LYVANVGDSRAYLLRDGELK---QLTEDHS---LVNRLEQRGIITPEEARshPRRNALTRAL--GDFDLLEPDITELELE 193
                        170
                 ....*....|....*...
gi 187735300 190 PGDAVLACSDGLqvWSEL 207
Cdd:COG0631  194 PGDFLLLCSDGL--WDVV 209
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
18-234 1.26e-17

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083  Cd Length: 254  Bit Score: 78.52  E-value: 1.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  18 GKRREQED---VVKSLPAAGGMLGIVCDGMGGHLRGDCASCVVAQEFAAVFAE---SGIEDIPERLTAALHAANRAL-SA 90
Cdd:cd00143   10 GDRKTNEDavvIKPNLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEEtltLSEEDIEEALRKAFLRADEEIlEE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  91 IQKEPEE--SGTTLLAVFIRDHFLWWISVGDSPLYLWSGADSFrmdRLNEDHSmrpIADSLYRKGKMSLQGALRQRCILR 168
Cdd:cd00143   90 AQDEPDDarSGTTAVVALIRGNKLYVANVGDSRAVLCRNGEAV---QLTKDHK---PVNEEERERIEKAGGRVSNGRVPG 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187735300 169 S-AVMG--GPMELVD-ISAMP-----LLLHPGDAVLACSDGLqvWSELlrepsflalqkardcSSRELVGIIMEQ 234
Cdd:cd00143  164 VlAVTRalGDFDLKPgVSAEPdvtvvKLTEDDDFLILASDGL--WDVL---------------SNQEAVDIVRSE 221
PP2C_SIG smart00331
Sigma factor PP2C-like phosphatases;
33-235 7.51e-11

Sigma factor PP2C-like phosphatases;


Pssm-ID: 214624  Cd Length: 193  Bit Score: 58.51  E-value: 7.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300    33 AGGMLGIVCDGMGGHLrgdcASCVVAQEFAAVFAESGIEDIPerLTAALHAANRALSaiQKEPEESGTTLLA--VFIRDH 110
Cdd:smart00331  28 EGRLLIAIADVMGKGL----AAALAMSMARSALRTLLSEGIS--LSQILERLNRAIY--ENGEDGMFATLFLalYDFAGG 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300   111 FLWWISVGDSPLYLWSgadsfrmdrlNEDHSMRPIADSlyrkgkmslqgalrqrcilrSAVMG-GPMELVDISAMPllLH 189
Cdd:smart00331 100 TLSYANAGHSPPYLLR----------ADGGLVEDLDDL--------------------GAPLGlEPDVEVDVRELT--LE 147
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 187735300   190 PGDAVLACSDGLqvWSELLREPSFLALQKARDCSSRELVGIIMEQV 235
Cdd:smart00331 148 PGDLLLLYTDGL--TEARNPERLEELLEELLGSPPAEIAQRILEEL 191
PP2C_2 pfam13672
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
34-202 9.86e-11

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 257978  Cd Length: 210  Bit Score: 58.48  E-value: 9.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300   34 GGMLGIVCDGMGGHLRGDCASCVVAQEFAAVFAES-------GIEDIPERLTAALHAANRALSAIQK-EPEESGTTLLAV 105
Cdd:pfam13672  23 DGWLIAVADGAGSAKYSDVGARLAVEAAVEALRELldsgelpELEALVRQILNDILALVRQEAAAQGlEPRDYATTLLLA 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  106 FIRDHFLWWISVGDSPLYLWSGADSFRmdRLNEDHSmRPIADSLYRkgkMSLQGALRQRCILRsavmggpmelvdisamp 185
Cdd:pfam13672 103 VITPGGIVFFQIGDGAIVVRDRDGELQ--LLSEPDS-GEYANETTF---LTSPDALEEFRIRR----------------- 159
                         170
                  ....*....|....*..
gi 187735300  186 LLLHPGDAVLACSDGLQ 202
Cdd:pfam13672 160 LTLEPGDALALMTDGLS 176
PRK14559 PRK14559
putative protein serine/threonine phosphatase; Provisional
39-123 2.08e-08

putative protein serine/threonine phosphatase; Provisional


Pssm-ID: 237756 [Multi-domain]  Cd Length: 645  Bit Score: 53.14  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  39 IVCDGMGGHLRGDCASCVVAQEFAAVFAESGIEDIP--ERLTAALHAANRALSAIQKEPEES-----GTTLLAVFIRDHF 111
Cdd:PRK14559 418 ILCDGMGGHAAGEVASALAVETLQQYFQQHWQDELPdeETIREAIYLANEAIYDLNQQNARSgsgrmGTTLVMALVQDTQ 497
                         90
                 ....*....|..
gi 187735300 112 LWWISVGDSPLY 123
Cdd:PRK14559 498 VAVAHVGDSRLY 509
 
Name Accession Description Interval E-value
PTC1 COG0631
Serine/threonine protein phosphatase [Signal transduction mechanisms]
39-207 5.17e-21

Serine/threonine protein phosphatase [Signal transduction mechanisms]


Pssm-ID: 223704  Cd Length: 262  Bit Score: 88.57  E-value: 5.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  39 IVCDGMGGHLRGDCASC----VVAQEFAAVFAESGIEDIPERLTAALHAANRALSAIQKEPEES---GTTLLAVFIRDHF 111
Cdd:COG0631   42 AVADGMGGHAAGEVASKlaveALARLFDETNFNSLNESLEELLKEAILKANEAIAEEGQLNEDVrgmGTTLVLLLIRGNK 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300 112 LWWISVGDSPLYLWSGADSFrmdRLNEDHSmrpIADSLYRKGKMSLQGAL--RQRCILRSAVmgGPMELVDISAMPLLLH 189
Cdd:COG0631  122 LYVANVGDSRAYLLRDGELK---QLTEDHS---LVNRLEQRGIITPEEARshPRRNALTRAL--GDFDLLEPDITELELE 193
                        170
                 ....*....|....*...
gi 187735300 190 PGDAVLACSDGLqvWSEL 207
Cdd:COG0631  194 PGDFLLLCSDGL--WDVV 209
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
18-234 1.26e-17

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083  Cd Length: 254  Bit Score: 78.52  E-value: 1.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  18 GKRREQED---VVKSLPAAGGMLGIVCDGMGGHLRGDCASCVVAQEFAAVFAE---SGIEDIPERLTAALHAANRAL-SA 90
Cdd:cd00143   10 GDRKTNEDavvIKPNLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEEtltLSEEDIEEALRKAFLRADEEIlEE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  91 IQKEPEE--SGTTLLAVFIRDHFLWWISVGDSPLYLWSGADSFrmdRLNEDHSmrpIADSLYRKGKMSLQGALRQRCILR 168
Cdd:cd00143   90 AQDEPDDarSGTTAVVALIRGNKLYVANVGDSRAVLCRNGEAV---QLTKDHK---PVNEEERERIEKAGGRVSNGRVPG 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187735300 169 S-AVMG--GPMELVD-ISAMP-----LLLHPGDAVLACSDGLqvWSELlrepsflalqkardcSSRELVGIIMEQ 234
Cdd:cd00143  164 VlAVTRalGDFDLKPgVSAEPdvtvvKLTEDDDFLILASDGL--WDVL---------------SNQEAVDIVRSE 221
PP2C_SIG smart00331
Sigma factor PP2C-like phosphatases;
33-235 7.51e-11

Sigma factor PP2C-like phosphatases;


Pssm-ID: 214624  Cd Length: 193  Bit Score: 58.51  E-value: 7.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300    33 AGGMLGIVCDGMGGHLrgdcASCVVAQEFAAVFAESGIEDIPerLTAALHAANRALSaiQKEPEESGTTLLA--VFIRDH 110
Cdd:smart00331  28 EGRLLIAIADVMGKGL----AAALAMSMARSALRTLLSEGIS--LSQILERLNRAIY--ENGEDGMFATLFLalYDFAGG 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300   111 FLWWISVGDSPLYLWSgadsfrmdrlNEDHSMRPIADSlyrkgkmslqgalrqrcilrSAVMG-GPMELVDISAMPllLH 189
Cdd:smart00331 100 TLSYANAGHSPPYLLR----------ADGGLVEDLDDL--------------------GAPLGlEPDVEVDVRELT--LE 147
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 187735300   190 PGDAVLACSDGLqvWSELLREPSFLALQKARDCSSRELVGIIMEQV 235
Cdd:smart00331 148 PGDLLLLYTDGL--TEARNPERLEELLEELLGSPPAEIAQRILEEL 191
PP2C_2 pfam13672
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
34-202 9.86e-11

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 257978  Cd Length: 210  Bit Score: 58.48  E-value: 9.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300   34 GGMLGIVCDGMGGHLRGDCASCVVAQEFAAVFAES-------GIEDIPERLTAALHAANRALSAIQK-EPEESGTTLLAV 105
Cdd:pfam13672  23 DGWLIAVADGAGSAKYSDVGARLAVEAAVEALRELldsgelpELEALVRQILNDILALVRQEAAAQGlEPRDYATTLLLA 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  106 FIRDHFLWWISVGDSPLYLWSGADSFRmdRLNEDHSmRPIADSLYRkgkMSLQGALRQRCILRsavmggpmelvdisamp 185
Cdd:pfam13672 103 VITPGGIVFFQIGDGAIVVRDRDGELQ--LLSEPDS-GEYANETTF---LTSPDALEEFRIRR----------------- 159
                         170
                  ....*....|....*..
gi 187735300  186 LLLHPGDAVLACSDGLQ 202
Cdd:pfam13672 160 LTLEPGDALALMTDGLS 176
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
18-240 1.76e-10

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625  Cd Length: 252  Bit Score: 58.54  E-value: 1.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300    18 GKRREQEDVV---KSLPAAGGMLGiVCDGMGGHlrgDCAScVVAQEFAAVFAESGI--EDIPERLTAALHAANRAL-SAI 91
Cdd:smart00332  18 GVRKPMEDAHvitPDLSDSGGFFG-VFDGHGGS---EAAK-FLSKNLPEILAEELIkeKDELEDVEEALRKAFLSTdEEI 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300    92 QKEPEE-SGTTLLAVFIRDHFLWWISVGDSPLYLwSGADSFRmdRLNEDHsmRPIADSLYRKGKMSLQGALRQRCILRSA 170
Cdd:smart00332  93 LEELEAlSGSTAVVALISGNKLYVANVGDSRAVL-CRNGKAV--QLTEDH--KPSNEDERARIEAAGGFVINGRVNGVLA 167
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187735300   171 VMG--GPMEL-------VDISAMPLLLHpGDAVLACSDGLqvWSELlrepsflalqkardcSSRELVGIIMEQVKDMLE 240
Cdd:smart00332 168 LSRaiGDFFLkpyvsaePDVTVVELTEK-DDFLILASDGL--WDVL---------------SNQEVVDIVRKHLSKDPK 228
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
18-141 3.15e-03

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 249892  Cd Length: 253  Bit Score: 36.57  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300   18 GKRREQEDVVKSLPAAGGMLG-------IVCDGMGGHLRGDCAScVVAQEFAAV---FAESGIEDIPERLTAALHAANRA 87
Cdd:pfam00481  10 GWRKSMEDAHIDGKNLNSSSGkdswsffAVFDGHGGSEAAKYAG-KHLHTILALrrsFLTLRKLEDALRESFLETDEELR 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 187735300   88 LSAIQKEPEESGTTLLAVFIRDHFLWWISVGDSPLYLwSGADSFRmDRLNEDHS 141
Cdd:pfam00481  89 SDAANHEDLSSGSTAVVALIRGNKLYVANVGDSRAVL-CRNGGAI-KQLTEDHK 140
PRK14559 PRK14559
putative protein serine/threonine phosphatase; Provisional
39-123 2.08e-08

putative protein serine/threonine phosphatase; Provisional


Pssm-ID: 237756 [Multi-domain]  Cd Length: 645  Bit Score: 53.14  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187735300  39 IVCDGMGGHLRGDCASCVVAQEFAAVFAESGIEDIP--ERLTAALHAANRALSAIQKEPEES-----GTTLLAVFIRDHF 111
Cdd:PRK14559 418 ILCDGMGGHAAGEVASALAVETLQQYFQQHWQDELPdeETIREAIYLANEAIYDLNQQNARSgsgrmGTTLVMALVQDTQ 497
                         90
                 ....*....|..
gi 187735300 112 LWWISVGDSPLY 123
Cdd:PRK14559 498 VAVAHVGDSRLY 509
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.11
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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