NCBI Conserved Domain Search

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Conserved domains on [gi\|15805776\|ref\|NP_294474.1\|]
sensory box/GGDEF family protein [Deinococcus radiodurans R1]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

30163

cd01948

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

true

false

true

240

1e-53

207.37

99.17

3,695,2,77,774,79,31,805,114,126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 696 LDRGLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPARFLPLAQRSDLITSIGEWVVREAVQGRTQLRDatG 775
cd01948       3 LRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQA--G 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 776 QRNWRTSVNLSLEELRREGAIERLLPLITR----PSALDIEVSASSLLDHSEETLGLLDALRARGARLIVDDFGDGASSL 851
cd01948      81 GPDLRLSVNLSARQLRDPDFLDRLLELLAEtglpPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSSL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 852 TALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQGTVSLAHSLGLTVTAVGVETYAQLDMLRDLGCDAAQGYALTPPLSAGD 931
cd01948     161 SYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPAEE 240

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

5e-13

71.85

98.73

5,523,0,27,550,31,38,589,69,25,614,97,24,638,123,32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 524 HDGLTGLLNRSGLRAALGQATAAQTGG----MVACLDIDGFGGLNAALSRTAGDLLLIQVAARLNDLAElEGGQAARLAD 599
cd01949       1 TDPLTGLPNRRAFEERLERLLARARRSgrplALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLR-ESDLVARLGG 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15805776 600 DTFAVYLPQLGAAVG---GQKLQAALREPLRTGKRLVPVTFS--LGAAPLLAAAPEQALADAEVALQHARRQGRGQ 670
cd01949      80 DEFAILLPGTDLEEAeelAERLRKAIEEPFFIDGEEIRVTASigIAEYPEDGEDLEELLRRADKALYQAKRSGRNR 155

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

32382

COG2200

Rtn

c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]

false

256

4e-53

205.17

97.66

3,690,2,75,768,77,37,805,118,134

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 691 QLRAVLDRGLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPARFLPLAQRSDLITSIGEWVVREAVQgrtQL 770
COG2200       3 QLERDLRQALENGEFSLYYQPIVDLATGRIVGYEALLRWRHPDGGLISPGEFIPLAEETGLIVELGRWVLEEACR---QL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 771 RDATGQRNWRTSVNLSLEELRREGAIERLLPLITR----PSALDIEVSASSLLDHSEETLGLLDALRARGARLIVDDFGD 846
COG2200      80 RTWPRAGPLRLAVNLSPVQLRSPGLVDLLLRLLARlglpPHRLVLEITESALIDDLDTALALLRQLRELGVRIALDDFGT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 847 GASSLTALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQGTVSLAHSLGLTVTAVGVETYAQLDMLRDLGCDAAQGYALTPP 926
COG2200     160 GYSSLSYLKRLPPDILKIDRSFVRDLETDARDQAIVRAIVALAHKLGLTVVAEGVETEEQLDLLRELGCDYLQGYLFSRP 239

                       250
                ....*....|...
gi 15805776 927 LSAGDLVTWVQGR 939
COG2200     240 LPADALDALLSSS 252

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

128367

smart00052

EAL

Putative diguanylate phosphodiesterase

false

241

6e-50

194.74

97.93

4,697,5,68,768,73,8,776,82,29,805,115,126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 698 RGLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPARFLPLAQRSDLITSIGEWVVREAVQgrtQLRDATGQ- 776
smart00052    6 QALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQ---QLAEWQAQg 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 777 RNWRTSVNLSLEELRREGAIERLLPLITR----PSALDIEVSASSLLDHSEETLGLLDALRARGARLIVDDFGDGASSLT 852
smart00052   83 PPLRISINLSARQLISPDLVPRVLELLEEtglpPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTGYSSLS 162

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15805776 853 ALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQGTVSLAHSLGLTVTAVGVETYAQLDMLRDLGCDAAQGYALTPPLSAGD 931
smart00052  163 YLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPLPLDD 241

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

109613

pfam00563

EAL

EAL domain

false

236

1e-42

170.29

100.00

6,692,0,73,768,73,11,779,88,23,802,114,38,841,152,32,874,184,52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 693 RAVLDRGLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPARFLPLAQRSDLITSIGEWVVREAVQgrtQLRD 772
pfam00563     1 EQALREALENGEFSLYFQPIVDLRTGKVLGYEALLRWQHPDGGLIPPDEFLPLAERLGLIAELDRWVLEKALA---QLAE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 773 ATGQRNW----RTSVNLSLEELRREGAIERLLPL---ITRPSALDIEVSASSLLDHSEETLGLLDALRARGARLIvDDFG 845
pfam00563    78 WRGNALLppdlPLSVNLSPASLLDPSFLEALLALkqgGLPPSRLVLEITESDLDEDLRLLEALARLRSLGFRLAL-DDFG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 846 DGASSLTALTQFPLYGVKLHPTLTTRLPgDQKSLKLVQGTVSLAHSLGLTVTAVGVETYAQLDMLRDLGCDAAQGYALTP 925
pfam00563   157 TGYSSLSYLSRLPPDYIKIDRSFIKDLS-DPESRALLRALIALARELGIKVVAEGVETEEQLELLKELGIDYVQGYLFSK 235


                .
gi 15805776 926 P 926
pfam00563   236 P 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

4e-14

75.54

98.90

5,504,2,47,551,53,37,589,90,21,610,114,28,638,145,36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 505 LRDVTTLRRAQAKLRHDASHDGLTGLLNRSGLRAALGQATAAQTGGM----VACLDIDGFGGLNAALSRTAGDLLLIQVA 580
COG2199       3 LRLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGeplaLLLLDLDHFKQINDTYGHAAGDEVLREVA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 581 ARLNDLAElEGGQAARLADDTFAVYLPQLG---AAVGGQKLQAALREPLRTGKRLVPVTFS---LGAAPLLAAAPEQALA 654
COG2199      83 RRLRSNLR-EGDLVARLGGDEFAVLLPGTSleeAARLAERIRAALEEPFFLGGEELRVTVSigvALYPEDGSDDAELLLR 161

                       170       180
                ....*....|....*....|
gi 15805776 655 DAEVALQHARRQGRGQLTVF 674
COG2199     162 RADLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

2e-11

67.27

100.00

5,519,0,31,550,35,38,589,73,20,609,96,29,638,127,36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 520 HDASHDGLTGLLNRSGLRAALGQATAAQTGG----MVACLDIDGFGGLNAALSRTAGDLLLIQVAARLNDLAElEGGQAA 595
smart00267    1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQgspfALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLR-PGDLLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 596 RLADDTFAVYLPQL---GAAVGGQKLQAALREPLRTGKRLVPVTFS--LGAAPLLAAAPEQALADAEVALQHARRQGRGQ 670
smart00267   80 RLGGDEFALLLPETsleEAIALAERILQQLREPIIIHGIPLYLTISigVAAYPNPGEDAEDLLKRADTALYQAKKAGRNQ 159


                ....
gi 15805776 671 LTVF 674
smart00267  160 VAVY 163

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

110022

pfam00990

GGDEF

GGDEF domain

false

160

6e-10

61.88

100.00

5,521,0,12,533,16,55,589,71,21,610,98,28,638,128,32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 522 ASHDGLTGLLNR----SGLRAALGQATAAQTGGMVACLDIDGFGGLNAALSRTAGDLLLIQVAARLNDLAElEGGQAARL 597
pfam00990     1 AAHDPLTGLPNRryfeEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLR-RSDLVARL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 598 ADDTFAVYLPQLG------AAVGGQKLQAALREPLRTGKRLVPVTFS--LGAAPLLAAAPEQALADAEVALQHARRQGRG 669
pfam00990    80 GGDEFAILLPDTSlegaqeLAERIRRLLAALKIPHTLSGLPLYVTISigIAAYPNDGEDAEDLLKRADQALYQAKNQGRN 159


                .
gi 15805776 670 Q 670
pfam00990   160 R 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

1e-48

190.71

66.37

11,500,215,54,554,271,29,585,300,9,594,310,18,612,331,17,631,348,4,635,356,58,697,414,19,717,433,57,776,490,29,805,523,132

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 501 LLLSLRDVTTLRRAQAKLRHDASHDGLTGLLNRSGLRAALGQATAAQTGGMVAC--LDIDGFGGLNAALSRTAGDLLLIQ 578
PRK10060    216 LICSGTDITEERRAQERLRILANTDSITGLPNRNAIQELIDHAIAQADNNQVGIvyLDLDNFKKVNDAYGHMFGDQLLQD 295

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 579 VAARLndLAELEGGQA-ARLADDTFAVYLPQLGAA---VGGQKLQAALREPLRTGkrLVPV----TFSLGAAPLLAAAPE 650
PRK10060    296 VSLAI--LSCLEEDQTlARLGGDEFLVLASHTSQAaleAMASRILTRLRLPFRIG--LIEVytgcSIGIALSPEHGDDSE 371

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 651 QALADAEVALQHARRQGRGQLTVFEPDMRAEEAQTFELEDQLRavldRGLQHEQFSLLYQPAVSLKdGRVLGAEALLRWT 730
PRK10060    372 SLIRSADTAMYTAKEGGRGQFCVFSPEMNQRVFEYLWLDTNLR----KALENDQLVIHYQPKITWR-GEVRSLEALVRWQ 446

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 731 HPELGNVSPARFLPLAQRSDLITSIGEWVVREAVQGRTQLRDATgqRNWRTSVNLSLEELRREGAIERLLPLITR----P 806
PRK10060    447 SPERGLIPPLEFISYAEESGLIVPLGRWVILDVVRQAAKWRDKG--INLRVAVNVSARQLADQTIFTALKQVLQElnfeY 524

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 807 SALDIEVSASSLLDHSEETLGLLDALRARGARLIVDDFGDGASSLTALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQGTV 886
PRK10060    525 CPIDVELTESCLIENEELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIV 604

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 15805776 887 SLAHSLGLTVTAVGVETYAQLDMLRDLGCDAAQGYALTPPLSAGDLVTWVQ 937
PRK10060    605 AVAQALNLQVIAEGVETAKEDAFLTKNGVNERQGFLFAKPMPAVAFERWYK 655

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

7e-44

174.44

63.65

10,511,217,22,533,243,50,583,295,6,592,301,19,611,324,14,625,340,70,700,410,4,704,415,70,779,485,26,805,515,124

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 512 RRAQAKLRHDASHDGLTGLLNR----SGLRAALGQATAAQTGGMVACLDIDGFGGLNAALSRTAGDLLLIQVAARL--ND 585
COG5001     218 RRLSDENDRLANLDSLTGLPNRrrffAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRLkaFD 297

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 586 LAELeggQAARLADDTFAVYLPQLGA----AVGGQKLQAALREP--LRTGKRLVPVTFSLGAAPLLAAAPEQALADAEVA 659
COG5001     298 GAPI---LAARLGGDEFALIIPALEDdalrVAGARALCESLQAPydLRGVRVQVGASIGIAPFPSGADTSEQLFERADYA 374

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 660 LQHARRQGRGQLTVFEPDMRAEEAQTFELEDQLRAVldrglQHEQ-FSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVS 738
COG5001     375 LYHAKQNGKGAAVLFDARHEAAIRDMAVVEQALRSA-----DLEQeLSVHFQPIVDIVSGKTIALEALARWHSPEIGPVP 449

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 739 PARFLPLAQRSDLITSIGEWVVREAVQGRTQLRDATgqrnwRTSVNLSLEELRREGAIERLLPLITR----PSALDIEVS 814
COG5001     450 PDVFIGIAERSGQIVELTRLLLAKALREARAWPMDV-----RVSINLSARDLASMENVRRLLAIVSEsciaPHRLDFEIT 524

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 815 ASSLLDHSEETLGLLDALRARGARLIVDDFGDGASSLTALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQGTVSLAHSLGL 894
COG5001     525 ETAIVCDFDQARDALAALHELGVRTALDDFGTGYSSLSHLRALPLDKIKIDRSFVSDLEENPTSEDIVRTVLQLGRNLRM 604

                       410       420       430
                ....*....|....*....|....*....|....*
gi 15805776 895 TVTAVGVETYAQLDMLRDLGCDAAQGYALTPPLSA 929
COG5001     605 ECVVEGVETEAQRDRVAALGATVMQGYHYARPMPA 639

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

3e-43

172.33

51.69

8,524,378,61,587,439,6,593,446,17,610,466,83,697,549,75,773,624,20,793,647,13,806,661,130

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 525 DGLTGLLNRSGLRAALGQATAAQTGGMVACLDIDGFGGLNAALSRTAGDLLLIQVAARLNDlaELEGGQ-AARLADDTFA 603
PRK11359    379 DPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFRE--KLKPDQyLCRIEGTQFV 456

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 604 VYLPQLG---AAVGGQKLQAALREPLRTGKRLVPVTFSLGAAPLLAAAPEQALADAEVALQHARRQGRGQLTVFEPDMRA 680
PRK11359    457 LVSLENDvsnITQIADELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNE 536

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 681 EEAQTFELEDQLRavldRGLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPARFLPLAQRSDLITSIGEWVV 760
PRK11359    537 MVKERLVLGAALK----EAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWVI 612

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 761 REAVQGRTQLRDaTGQRNWRTSVNLSLEELRRE---GAIERLLPLITRP-SALDIEVSASSLLDHSEETLGLLDALRARG 836
PRK11359    613 AEACRQLAEWRS-QNIHIPALSVNLSALHFRSNqlpNQVSDAMHAWGIDgHQLTVEITESMMMEHDTEIFKRIQILRDMG 691

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 837 ARLIVDDFGDGASSLTALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQGTVSLAHSLGLTVTAVGVETYAQLDMLRDLGCD 916
PRK11359    692 VGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCR 771

                       410       420
                ....*....|....*....|
gi 15805776 917 AAQGYALTPPLSAGDLVTWV 936
PRK11359    772 VIQGYFFSRPLPAEEIPGWM 791

-1

34551

COG4943

Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]

Predicted signal transduction protein containing sensor and EAL domains [Signal...

false

true

false

524

5e-33

138.55

47.14

4,691,268,82,775,350,28,803,382,37,841,419,96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 692 LRAVLDRGLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPARFLPLAQRSDLITSIGEWVVREAVQGRTQLR 771
COG4943     269 PRRRLQRAIERRELCVHYQPIVDLATGKCVGAEALARWPQEDGTVVSPDVFIPLAEESGMIEQITDYVIRNVFRDLGDLL 348

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 772 DAtgQRNWRTSVNLSLEELRREGAIERLLPLI----TRPSALDIEVSASSLLDHSEETLGLLDALRARGARLIvDDFGDG 847
COG4943     349 RQ--HRDLHVSINLSASDLASPRLIDRLNRKLaqyqVRPQQIALELTERTFADPKKMTPIILRLREAGHEIYI-DDFGTG 425

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 848 ASSLTALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQGTVSLAHSLGLTVTAVGVETYAQLDMLRDLGCDAAQGYALTPPL 927
COG4943     426 YSNLHYLQSLPVDALKIDKSFVDTLGTDSASHLIAPHIIEMAKSLGLKIVAEGVETEEQVDWLRKRGVHYGQGWLFSKAL 505

                       250
                ....*....|
gi 15805776 928 SAGDLVTWVQ 937
COG4943     506 PAQAFLDWAE 515

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

4e-27

118.72

40.40

8,662,375,15,677,391,17,699,408,66,765,476,9,778,485,27,805,516,52,857,571,19,879,590,48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 663 ARRQGRGQLTVFEPD-MRAEEAQTFELEDQLRAvldrgLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPAR 741
PRK13561    376 ARRKGKNQIQFFDPQqMEAAQKRLTEESDILNA-----LENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPDG 450

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 742 FLPLAQRSDLITSIGEWVVREAVQ--GRTQLRDATgqrnWRTSVNLSLEELRREGAIERLLPLITR----PSALDIEVSA 815
PRK13561    451 LIDRIESCGLMVTVGHWVLEESCRllAAWQERGIM----LPLSVNLSALQLMHPNMVADMLELLTRyriqPGTLILEVTE 526

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 816 SSLLDHSEETLGLLDALRARGARLIVDDFGDGASSLTALTQF---PLYGVKLHPTLTTRLPGDQkslKLVQGTVSLAHSL 892
PRK13561    527 SRRIDDPHAAVAILRPLRNAGVRIALDDFGMGYAGLRQLQHMkslPIDVLKIDKMFVDGLPEDS---SMVAAIIMLAQSL 603

                       250       260       270
                ....*....|....*....|....*....|....*
gi 15805776 893 GLTVTAVGVETYAQLDMLRDLGCDAAQGYALTPPL 927
PRK13561    604 NLQMIAEGVETEAQRDWLAKAGVGVAQGFLFARPL 638

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

3e-24

109.41

39.25

12,502,668,31,533,703,48,581,757,6,594,763,20,614,786,10,624,797,37,661,836,28,691,864,25,716,890,55,774,945,31,805,980,118,923,1100,6

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776  503 LSLRDVTTLRRAQAKLRHDASHDGLTGLLNR----SGLRAALGQATAAQTGGMVACLDIDGFGGLNAALSRTAGDLLLIQ 578
PRK09776     669 LVFQDVTESRAMLRQLSYSASHDALTGLANRasfeKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRE 748

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776  579 VAA------RLNDLAeleggqaARLADDTFAVYLPQLGAAVG---GQKLQAALRE-PLRTGKRLVPVTFSLGAAPLLAAA 648
PRK09776     749 LASlmlsmlRSSDVL-------ARLGGDEFGLLLPDCNVESArfiATRIISAINDyRFPWEGRVYRVGASAGITAIDDNN 821

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776  649 PEQALADAEVALQ--HARRQGRGQLTVFEPDMRAEEAQTFELEdqLRAVLDRGLQHEQFSLLYQPAVSLK-DGRVLGAEA 725
PRK09776     822 HQASEVMSQADIAcyAAKNAGRGRVTVYEPQQAAAHSERRELS--LAEQWRSMLEENQLMLQAQEIASPRiPEARNLWLI 899

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776  726 LLRWTHPELGNVSPARFLPLAQRSDLITSIGEWVVREAVQGRTQLRdatGQRNWRTSVNLSLEELRREGAIERLLPLITR 805
PRK09776     900 SLRLWDCEGEIIDEGAFRPAAEDPALMHALDRWVIHELFQQGARAV---ASKGLSIAIPLSVASLSSATLLPFLLEQLEN 976

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776  806 ----PSALDIEVSASSLLDHSEETLGLLDALRARGARLIVDDFGDGASSLTALTQFPLYGVKLHPTLTTRLPGDQKSLKL 881
PRK09776     977 splpPRLLHLEITETALLNHAEAASRLVQKLRLAGCRVVLDDFGRGLSSFNYLKAFMADYLKIDGELCANLQGNLMDEML 1056

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 15805776  882 VQGTVSLAHSLGLTVTAVGVETYAQLDMLRDLGCDAAQGYAL--TPPLSA 929
PRK09776    1057 VSIINGIAQRLGMKTIAGPVELPLTLDTLSGIGVDLAQGYVIgrPQPLDL 1106

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

4e-22

102.47

36.13

7,662,448,31,697,479,74,772,553,4,777,557,28,805,589,45,850,637,33,886,670,41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 663 ARRQGRGQLTVFEPDMRAEEAQTFELEDQLRavldRGLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPARF 742
PRK11829    449 AHHEGRNQIMVFEPHLIEKTHKRLTQENDLL----QAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQPDGSYVLPSGF 524

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 743 LPLAQRSDLITSIGEWVVREAVQGRTQLRdATGQrNWRTSVNLSLEELRREGAIERLLPLITR----PSALDIEVSASSL 818
PRK11829    525 VHFAEEEGMMVPLGNWVLEEACRILADWK-ARGV-SLPLSVNISGLQVQNKQFLPHLKTLISHyhidPQQLLLEITETAQ 602

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 819 LDHSEETLGLLDALRARGARLIVDDFGDGASS---LTALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQgtvSLAHSLGLT 895
PRK11829    603 IQDLDEALRLLRELQGLGLLIALDDFGIGYSSlryLNHLKSLPIHMIKLDKSFVKNLPEDDAIARIIS---CVSDVLKVR 679

                       250       260       270
                ....*....|....*....|....*....|..
gi 15805776 896 VTAVGVETYAQLDMLRDLGCDAAQGYALTPPL 927
PRK11829    680 VMAEGVETEEQRQWLLEHGIQCGQGFLFSPPL 711

-1

137979

PRK10551

hypothetical protein; Provisional

false

true

false

518

1e-17

87.42

46.33

6,697,269,55,752,328,22,779,350,15,794,368,7,801,376,39,841,415,94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 698 RGLQHEQFSLLYQPAVSLKDGRVLGAEALLRWTHPELGNVSPARFLPLAQRSDLI----TSIGEWVVREAVQGRTQLRDA 773
PRK10551    270 TAIKREQFYVVYQPVVDTQTLRVTGLEVLLRWRHPTAGEIPPDAFINYAEAQKLIvpltQHLFELIARDAAELQKVLPVG 349

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 774 TgqrnwRTSVNLSLEELRREG---AIERLLP-LITRPSALDIEVSASSLLDHSEETLGLLDALRARGARLIvDDFGDGAS 849
PRK10551    350 A-----KLGINIAPAHLHSDSfkaDVQRLLAsLPADHFQIVLEITERDMLQEEEALKLFAWLHSQGIEIAI-DDFGTGHS 423

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 850 SLTALTQFPLYGVKLHPTLTTRLPGDQKSLKLVQGTVSLAHSLGLTVTAVGVETYAQLDMLRDLGCDAAQGYALTPPLSA 929
PRK10551    424 ALIYLERFTLDYLKIDRGFINAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLREHGVNFLQGYWISRPLPL 503


                ....*.
gi 15805776 930 GDLVTW 935
PRK10551    504 DDFVKW 509

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

3e-05

46.07

34.02

5,499,247,34,533,285,55,589,340,18,607,361,17,624,381,14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 500 ELLLSLRDVTTLRRAQAKLRHDASHDGLTGLLNR----SGLRAALGQATAAQTGGMVACLDIDGFGGLNAALSRTAGDLL 575
COG3706     248 RQLRRKRYERQLRESLERLQELALVDGLTGLFNRryfdEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEV 327

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15805776 576 LIQVAARLNDLAElEGGQAARLADDTFAVYLP---QLGAAVGGQKLQAALRE---PLRTGKRLVPVTFS 638
COG3706     328 LRQVARRLRQTVR-GLDLVARYGGEEFAVVLPdtdLEAAIAIAERIRQKINElpfVHELSREPLEVTIS 395

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

1e-04

44.24

28.50

4,510,236,45,555,284,27,585,311,7,592,320,32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 511 LRRAQAKLRHDASHDGLTGLLNRSGLRAALGQATAAQTGGMVACL---DIDGFGGLNAALSRTAGDLLLIQVAARlndLA 587
PRK09966    237 LQAKNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALlflDGDNFKYINDTWGHATGDRVLIEIAKR---LA 313

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15805776 588 ELEGG--QAARLADDTFAVYLPQLGAAVGGQKLQAALRE 624
PRK09966    314 EFGGLrhKAYRLGGDEFAMVLYDVQSESEVQQICSALTQ 352

-1

129332

TIGR00229

sensory_box

PAS domain S-box

true

false

124

3e-04

42.66

79.03

5,164,24,31,195,58,29,226,87,10,236,98,16,253,114,8

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 165 FRQVSRTFLELFGLTGADVLGRTVHEVFPDH---AALAQQLDSAAAGRAVQLGDERVPSLPGHsgERWLRGSARP-YFGG 240
TIGR00229    25 ILYVNPAFEEIFGYSAEELIGRNVLELIPEEdreEVRERIERLLEGEREPYSEERRVRRKDGS--EIWVEVSVSPiRTNG 102

                        90       100
                ....*....|....*....|.
gi 15805776 241 AAAGVLWTVQDVsTEHTQTTQ 261
TIGR00229   103 GELGVVGIVRDI-TERKQAEE 122

-1

117025

pfam08448

PAS_4

PAS fold

false

true

false

110

0.001

41.25

97.27

4,150,2,44,194,49,26,224,75,15,239,92,17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 151 QLPAATAWLSAELEFRQVSRTFLELFGLTGADVLGRTVHEVFPD---HAALAQQLDSAAAGRAVQLGDERVPSlpghSGE 227
pfam08448     3 SLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPedaARLERALRRALEGEEPIDFLEELLLN----GEE 78

                        90       100       110
                ....*....|....*....|....*....|.
gi 15805776 228 RWLRGSARPYFG--GAAAGVLWTVQDVSTEH 256
pfam08448    79 RHYELRLTPLRDpdGEVIGVLVISRDITERR 109

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

0.001

41.06

33.92

10,499,262,7,508,269,6,514,277,10,524,294,9,533,307,50,583,363,3,593,366,22,618,388,5,623,400,5,628,407,10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 500 ELLLSLRdvTTLRRA--QAKLRHDASH-------DGLTGLLNR----SGLRAALGQATAAQTGGMVACLDIDGFGGLNAA 566
PRK09581    263 ELLARVR--TQIRRKryQDALRQNLEQsiemavtDGLTGLHNRryfdMHLKQLIERANERGKPLSLMMLDIDHFKQVNDT 340

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 567 LSRTAGDLLLIQVAARL------NDLaeleggqAARLADDTFAVYLPQLGAAVGGqklQAALR-------EPLRT--GKR 631
PRK09581    341 YGHDAGDEVLREFAKRLrknirgTDL-------IARYGGEEFVVVMPDTDIEVAI---AVAERirrkiaeEPFAIsdGKE 410


                ....*..
gi 15805776 632 LVPVTFS 638
PRK09581    411 RLNVTVS 417

-1

110021

pfam00989

PAS

PAS fold

false

true

false

112

0.003

39.31

95.54

4,147,5,46,193,53,30,225,83,13,238,98,14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15805776 148 LITQLPAATAWLSAELEFRQVSRTFLELFGLTGADVLGRTVHEVFP--DHAALAQQLDSAAAGRAVQLGDERVPSLPGhs 225
pfam00989     6 ILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPedDDAVAELLRQALLQGEESRGFEVSFRVSDG-- 83

                        90       100
                ....*....|....*....|....*....
gi 15805776 226 GERWLRGSARPYF--GGAAAGVLWTVQDV 252
pfam00989    84 RPRHVEVRASPVRdaGGEILGFLGVLRDI 112

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF