NCBI Conserved Domain Search

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Conserved domains on [gi\|119962652\|ref\|YP_946434.1\|]
GGDEF domain/EAL domain-containing protein [Arthrobacter aurescens TC1]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

30163

cd01948

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

true

false

true

240

5e-76

280.18

100.00

2,215,0,79,298,79,161

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 216 GELREAIRADQLVLYYQPIVELSTGRIEGCEALVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWRDh 295
cd01948        1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQA- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 296 pvtAQQDFSMRINASAADLQSLEFVDAVSAALAEEHLAPDSLVLELTESAIIQNNELDRYTLASLHRLGVGLEIDDFGAG 375
cd01948       80 ---GGPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 376 YSSMGYLRKLPVDRVKVDRQFVKDLGKDPSQLGFLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGRPL 455
cd01948      157 YSSLSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPL 236


                 ....
gi 119962652 456 PEAE 459
cd01948      237 PAEE 240

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

2e-35

145.42

98.73

2,42,0,130,172,131,24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  43 TDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVTVAMRIRSAVRENDVVTRLGGD 122
cd01949        1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119962652 123 EFAVLLPATPQNRATAVGNRILAALEPNIDLGNNSIRCGASVGLRTAEPH-HSIEDILQEADLAMEDSKNEGRNK 196
cd01949       81 EFAILLPGTDLEEAEELAERLRKAIEEPFFIDGEEIRVTASIGIAEYPEDgEDLEELLRRADKALYQAKRSGRNR 155

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

128367

smart00052

EAL

Putative diguanylate phosphodiesterase

false

241

8e-76

279.48

99.17

2,216,2,79,299,81,160

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 217 ELREAIRADQLVLYYQPIVELSTGRIEGCEALVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWRDHp 296
smart00052     3 ELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQAQ- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 297 vtaQQDFSMRINASAADLQSLEFVDAVSAALAEEHLAPDSLVLELTESAIIQNNELDRYTLASLHRLGVGLEIDDFGAGY 376
smart00052    82 ---GPPLRISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTGY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 377 SSMGYLRKLPVDRVKVDRQFVKDLGKDPSQLGFLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGRPLP 456
smart00052   159 SSLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPLP 238


                 ...
gi 119962652 457 EAE 459
smart00052   239 LDD 241

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32382

COG2200

Rtn

c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]

false

256

6e-74

273.35

98.05

2,210,0,86,301,86,165

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 211 QRQIVGELREAIRADQLVLYYQPIVELSTGRIEGCEALVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLR 290
COG2200        1 RLQLERDLRQALENGEFSLYYQPIVDLATGRIVGYEALLRWRHPDGGLISPGEFIPLAEETGLIVELGRWVLEEACRQLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 291 RWRDHPvtaqqDFSMRINASAADLQSLEFVDAVSAALAEEHLAPDSLVLELTESAIIQNNELDRYTLASLHRLGVGLEID 370
COG2200       81 TWPRAG-----PLRLAVNLSPVQLRSPGLVDLLLRLLARLGLPPHRLVLEITESALIDDLDTALALLRQLRELGVRIALD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 371 DFGAGYSSMGYLRKLPVDRVKVDRQFVKDLGKDPSQLGFLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYY 450
COG2200      156 DFGTGYSSLSYLKRLPPDILKIDRSFVRDLETDARDQAIVRAIVALAHKLGLTVVAEGVETEEQLDLLRELGCDYLQGYL 235

                        250
                 ....*....|....*.
gi 119962652 451 FGRPLPEAEFTEQLSR 466
COG2200      236 FSRPLPADALDALLSS 251

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

109613

pfam00563

EAL

EAL domain

false

236

6e-58

219.98

99.15

6,216,2,77,293,80,11,306,91,17,324,108,31,356,139,45,402,184,52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 217 ELREAIRADQLVLYYQPIVELSTGRIEGCEALVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWR-DH 295
pfam00563      3 ALREALENGEFSLYFQPIVDLRTGKVLGYEALLRWQHPDGGLIPPDEFLPLAERLGLIAELDRWVLEKALAQLAEWRgNA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 296 PVTAQQDFSmrINASAADLQSLEFVDAVsAALAEEHLAPDSLVLELTESAIIQNNELDRYtLASLHRLGVGLEIDDFGAG 375
pfam00563     83 LLPPDLPLS--VNLSPASLLDPSFLEAL-LALKQGGLPPSRLVLEITESDLDEDLRLLEA-LARLRSLGFRLALDDFGTG 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119962652 376 YSSMGYLRKLPVDRVKVDRQFVKDLGkDPSQLGFLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGRP 454
pfam00563    159 YSSLSYLSRLPPDYIKIDRSFIKDLS-DPESRALLRALIALARELGIKVVAEGVETEEQLELLKELGIDYVQGYLFSKP 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

4e-33

137.56

100.00

2,21,0,151,172,153,28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  22 HVQALMQELHQARYEQRRDALTDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVT 101
COG2199        1 ALLRLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 102 VAMRIRSAVRENDVVTRLGGDEFAVLLPATPQNRATAVGNRILAALEPNIDLGNNSIRCGASVGLRTAEPH--HSIEDIL 179
COG2199       81 VARRLRSNLREGDLVARLGGDEFAVLLPGTSLEEAARLAERIRAALEEPFFLGGEELRVTVSIGVALYPEDgsDDAELLL 160

                        170       180
                 ....*....|....*....|.
gi 119962652 180 QEADLAMEDSKNEGRNKLKVF 200
COG2199      161 RRADLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

4e-32

134.30

98.77

2,40,2,126,166,129,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  41 ALTDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVTVAMRIRSAVRENDVVTRLG 120
smart00267     3 AFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLARLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 121 GDEFAVLLPATPQNRATAVGNRILAALEPNIDLGNNSIRCGASVGL-RTAEPHHSIEDILQEADLAMEDSKNEGRNKLKV 199
smart00267    83 GDEFALLLPETSLEEAIALAERILQQLREPIIIHGIPLYLTISIGVaAYPNPGEDAEDLLKRADTALYQAKKAGRNQVAV 162


                 .
gi 119962652 200 F 200
smart00267   163 Y 163

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

110022

pfam00990

GGDEF

GGDEF domain

false

160

3e-30

128.13

100.00

3,40,0,103,143,106,23,166,130,30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  41 ALTDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVTVAMRIRSAVRENDVVTRLG 120
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 121 GDEFAVLLPATPQNRATAVGNRI---LAALEPNIDLGNNSIRCGASVGL-RTAEPHHSIEDILQEADLAMEDSKNEGRNK 196
pfam00990     81 GDEFAILLPDTSLEGAQELAERIrrlLAALKIPHTLSGLPLYVTISIGIaAYPNDGEDAEDLLKRADQALYQAKNQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

2e-26

115.51

99.39

4,40,1,108,148,113,11,161,124,11,172,136,29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  41 ALTDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVTVAMRIRSAVRENDVVTRLG 120
TIGR00254      2 AVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRYG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 121 GDEFAVLLPATPQNRATAVGNRILAALE----PNIDLGNNSIRcgASVGLRTAEPH-HSIEDILQEADLAMEDSKNEGRN 195
TIGR00254     82 GEEFVVILPGTPLEDALSKAERLRDAINskpiEVAGSETLTVT--VSIGVACYPGHgLTLEELLKRADEALYQAKKAGRN 159


                 ....*.
gi 119962652 196 KLKVFD 201
TIGR00254    160 RVVVAD 165

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

138661

PRK11596

EAL domain-containing protein; Provisional

false

255

0.001

39.69

35.29

5,366,154,39,405,195,2,408,197,12,422,209,4,426,214,30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 367 LEIDDFGAGYSSMGYLRKLPVDRVKVDRQFVKDLGKDPS--QLgFLAAIQHVIHSCglEGVW-EGIETAEQAEALRSIGC 443
PRK11596     155 LWLDDFGTGMANFSALSEVRYDYIKVARELFVMLRQSPEgrTL-FSQLLHLMNRYC--RGVIvEGVETPEEWRDVQRSPA 231

                         90
                 ....*....|...
gi 119962652 444 ASGQGYYFGRPLP 456
PRK11596     232 FAAQGYFLSRPAP 244

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

9e-83

302.80

65.46

11,19,225,11,40,236,14,54,253,15,74,268,98,172,367,30,207,397,5,214,402,3,217,412,20,238,432,56,300,488,7,307,497,162

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  20 ERHVQALMQELhqaryeqrrdALTDALTGLGNRQA---LVNSFIEAQDAAAKGavppaLLLVNLDGFKALKNSAGHAASD 96
PRK10060     226 ERRAQERLRIL----------ANTDSITGLPNRNAiqeLIDHAIAQADNNQVG-----IVYLDLDNFKKVNDAYGHMFGD 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  97 QILVTVAMRIRSAVRENDVVTRLGGDEFAVLLPATPQNRATAVGNRILAALEPNIDLGNNSIRCGASVGLRTAEPH-HSI 175
PRK10060     291 QLLQDVSLAILSCLEEDQTLARLGGDEFLVLASHTSQAALEAMASRILTRLRLPFRIGLIEVYTGCSIGIALSPEHgDDS 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 176 EDILQEADLAMEDSKNEGRNKLKVFDPatlhaQLLQRqiVGE-------LREAIRADQLVLYYQPIVELsTGRIEGCEAL 248
PRK10060     371 ESLIRSADTAMYTAKEGGRGQFCVFSP-----EMNQR--VFEylwldtnLRKALENDQLVIHYQPKITW-RGEVRSLEAL 442

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 249 VRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWRDhpvtaqQDFSMRI--NASAADLQSLEFVDAVSAA 326
PRK10060     443 VRWQSPERGLIPPLEFISYAEESGLIVPLGRWVILDVVRQAAKWRD------KGINLRVavNVSARQLADQTIFTALKQV 516

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 327 LAEEHLAPDSLVLELTESAIIQNNELDRYTLASLHRLGVGLEIDDFGAGYSSMGYLRKLPVDRVKVDRQFVKDLGKDPSQ 406
PRK10060     517 LQELNFEYCPIDVELTESCLIENEELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVS 596

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119962652 407 LGFLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGRPLPEAEFTEQLSRLRT 469
PRK10060     597 QSLVRAIVAVAQALNLQVIAEGVETAKEDAFLTKNGVNERQGFLFAKPMPAVAFERWYKRYQK 659

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

6e-81

296.55

63.20

7,35,222,107,142,330,27,170,357,3,173,362,28,202,390,13,215,404,79,301,483,158

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  36 EQRRDALTDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVTVAMRIRSAVRENDV 115
COG5001      223 ENDRLANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRLKAFDGAPIL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 116 VTRLGGDEFAVLLPATPQNRATAVGNR-ILAALEPNIDLGNNSIRCGASVGLRTAePHH--SIEDILQEADLAMEDSKNE 192
COG5001      303 AARLGGDEFALIIPALEDDALRVAGARaLCESLQAPYDLRGVRVQVGASIGIAPF-PSGadTSEQLFERADYALYHAKQN 381

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 193 GRNKLKVFDpATLHAQLLQRQIV-GELREAIRADQLVLYYQPIVELSTGRIEGCEALVRWNHPVHGLIMPDQFIPIAEAT 271
COG5001      382 GKGAAVLFD-ARHEAAIRDMAVVeQALRSADLEQELSVHFQPIVDIVSGKTIALEALARWHSPEIGPVPPDVFIGIAERS 460

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 272 GLIAELGRWVLRTAVRQLRRWRDhpvtaqqDFSMRINASAADLQSLEFVDAVSAALAEEHLAPDSLVLELTESAIIQNNE 351
COG5001      461 GQIVELTRLLLAKALREARAWPM-------DVRVSINLSARDLASMENVRRLLAIVSESCIAPHRLDFEITETAIVCDFD 533

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 352 LDRYTLASLHRLGVGLEIDDFGAGYSSMGYLRKLPVDRVKVDRQFVKDLGKDPSQLGFLAAIQHVIHSCGLEGVWEGIET 431
COG5001      534 QARDALAALHELGVRTALDDFGTGYSSLSHLRALPLDKIKIDRSFVSDLEENPTSEDIVRTVLQLGRNLRMECVVEGVET 613

                        410       420
                 ....*....|....*....|....*...
gi 119962652 432 AEQAEALRSIGCASGQGYYFGRPLPEAE 459
COG5001      614 EAQRDRVAALGATVMQGYHYARPMPAEE 641

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

6e-73

269.79

54.69

8,14,349,20,36,369,7,43,378,16,63,394,103,167,497,36,204,533,12,216,546,84,303,630,156

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  15 RIEKLERHVQALMQELHQARyeQRRDALT--DALTGLGNRQALVNSFieaqDAAAKGAVPPALLLVNLDGFKALKNSAGH 92
PRK11359     350 RVADISQHMAALALEQEKSR--QHIEQLIqfDPMTGLPNRNNLHNYL----DDLVDKAVSPVVYLIGVDHIQDVIDSLGY 423

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  93 AASDQILVTVAMRIRSAVRENDVVTRLGGDEFAVLLPATPQNRATAVGNRILAALEPNIDLGNNSIRCGASVGLrTAEPH 172
PRK11359     424 AWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSKPIMIDDKPFPLTLSIGI-SYDVG 502

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 173 HSIEDILQEADLAMEDSKNEGRNKLKVFDPAtLHAQLLQRQIVG-ELREAIRADQLVLYYQPIVELSTGRIEGCEALVRW 251
PRK11359     503 KNRDYLLSTAHNAMDYIRKNGGNGWQFFSPA-MNEMVKERLVLGaALKEAISNNQLKLVYQPQIFAETGELYGIEALARW 581

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 252 NHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWRDHPVTAQqdfSMRINASAADLQSLEFVDAVSAALAEEH 331
PRK11359     582 HDPLHGHVPPSRFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIP---ALSVNLSALHFRSNQLPNQVSDAMHAWG 658

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 332 LAPDSLVLELTESAIIQNNELDRYTLASLHRLGVGLEIDDFGAGYSSMGYLRKLPVDRVKVDRQFVKDLGKDPSQLGFLA 411
PRK11359     659 IDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLE 738

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 119962652 412 AIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGRPLPEAE 459
PRK11359     739 AITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSRPLPAEE 786

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

4e-57

217.33

68.20

12,12,202,39,52,241,9,62,250,9,73,259,8,84,267,13,97,283,31,128,315,80,210,395,7,217,404,81,302,485,82,384,570,21,408,591,55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  13 DSRIEKLERHVQALMQELHQARYEQRRDALTDALTGLGNrQALVNSFIEaQDAAAKGAVppALLLVNLDgfkALKNSAGH 92
PRK13561     203 DDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPN-KALLMALLE-QVVARKQTT--ALMIITCE---TLRDTAGV 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  93 AASDQ---ILVTVAMRIRSAVRENDVVTRLGGDEFAVLL-PATPQNRATAVGNRILAALEPNIDLGNNSIRCGASVGLRT 168
PRK13561     276 LKEAQreiLLLTLVEKLKSVLSPRMVLAQISGYDFAIIAnGVKEPWHAITLGQQVLTIINERLPIQRIQLRPSCSIGIAM 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 169 AEPHHSIEDILQEADLAMEDSKNEGRNKLKVFDPATLHAQllQRQIVGE--LREAIRADQLVLYYQPIVELSTGRIEGCE 246
PRK13561     356 FYGDLTAEQLYSRAVSAAFTARRKGKNQIQFFDPQQMEAA--QKRLTEEsdILNALENHQFAIWLQPQVEMRSGKLVSAE 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 247 ALVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWRDHPVTaqqdFSMRINASAADLQSLEFVDAVSAA 326
PRK13561     434 ALLRMQQPDGSWDLPDGLIDRIESCGLMVTVGHWVLEESCRLLAAWQERGIM----LPLSVNLSALQLMHPNMVADMLEL 509

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 327 LAEEHLAPDSLVLELTESAIIQNNELDRYTLASLHRLGVGLEIDDFGAGYSSMGYLRK---LPVDRVKVDRQFVKDLGKD 403
PRK13561     510 LTRYRIQPGTLILEVTESRRIDDPHAAVAILRPLRNAGVRIALDDFGMGYAGLRQLQHmksLPIDVLKIDKMFVDGLPED 589

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 404 PSqlgFLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGRPLPEAEFTEQ 463
PRK13561     590 SS---MVAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGVAQGFLFARPLPIEIFEER 646

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

7e-55

209.95

39.43

10,27,671,11,38,685,109,155,794,4,159,807,7,167,814,2,169,818,33,202,853,33,237,886,8,245,897,46,296,943,168

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652   28 QELHQARYEQR---RDALTDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVTVAM 104
PRK09776      672 QDVTESRAMLRqlsYSASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELAS 751

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  105 RIRSAVRENDVVTRLGGDEFAVLLPATPQNRATAVGNRILAALepnidlgnNSIR---------CGASVGLrTA--EPHH 173
PRK09776      752 LMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAI--------NDYRfpwegrvyrVGASAGI-TAidDNNH 822

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  174 SIEDILQEADLAMEDSKNEGRNKLKVFDP--ATLHAQLLQRQIVGELREAIRADQLVLYYQPIVelSTGRIEGC---EAL 248
PRK09776      823 QASEVMSQADIACYAAKNAGRGRVTVYEPqqAAAHSERRELSLAEQWRSMLEENQLMLQAQEIA--SPRIPEARnlwLIS 900

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  249 VRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRwrdhpVTAQQDFSMRINASAADLQSLEFVDAVSAALA 328
PRK09776      901 LRLWDCEGEIIDEGAFRPAAEDPALMHALDRWVIHELFQQGAR-----AVASKGLSIAIPLSVASLSSATLLPFLLEQLE 975

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  329 EEHLAPDSLVLELTESAIIQNNELDRYTLASLHRLGVGLEIDDFGAGYSSMGYLRKLPVDRVKVDRQFVKDLGKDPSQLG 408
PRK09776      976 NSPLPPRLLHLEITETALLNHAEAASRLVQKLRLAGCRVVLDDFGRGLSSFNYLKAFMADYLKIDGELCANLQGNLMDEM 1055

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119962652  409 FLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGRPLPEAEFTEQL 464
PRK09776     1056 LVSIINGIAQRLGMKTIAGPVELPLTLDTLSGIGVDLAQGYVIGRPQPLDLLLNSS 1111

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

2e-52

201.47

61.54

9,12,271,44,57,315,77,134,393,32,166,426,39,205,468,8,216,476,82,302,558,79,381,640,37,421,677,42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  13 DSRIEKLERHVQALMQELHQARYEQRRDALTDALTGLGNRQALVnSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGH 92
PRK11829     272 DDELGVLVRNYNRNQQLLADAYADMGRISHRFPVTELPNRSLFI-SLLEKEIASSTRTDHFHLLVIGIETLQEVSGAMSE 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  93 AASDQILVTVAMRIRSAVRENDVVTRLGGDEFAVLLPATPQN-RATAVGNRILAALEPNIDLGNNSIRCGASVGL-RTAE 170
PRK11829     351 AQHQQLLLTIVQRIEQCIDDSDLLAQLSKTEFAVLARGTRRSfPAMQLARRIMSQVTQPLFFDEITLRPSASIGItRYQA 430

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 171 PHHSIEDILQEADLAMEDSKNEGRNKLKVFDPATL---HAQLLQRQivgELREAIRADQLVLYYQPIVELSTGRIEGCEA 247
PRK11829     431 QQDTAESMMRNASTAMMAAHHEGRNQIMVFEPHLIektHKRLTQEN---DLLQAIENHDFTLFLQPQWDMKRQQVIGAEA 507

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 248 LVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWRDHPVTaqqdFSMRINASAADLQSLEFVDAVSAAL 327
PRK11829     508 LLRWCQPDGSYVLPSGFVHFAEEEGMMVPLGNWVLEEACRILADWKARGVS----LPLSVNISGLQVQNKQFLPHLKTLI 583

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 328 AEEHLAPDSLVLELTESAIIQNNELDRYTLASLHRLGVGLEIDDFGAGYSSMGY---LRKLPVDRVKVDRQFVKDLGKDP 404
PRK11829     584 SHYHIDPQQLLLEITETAQIQDLDEALRLLRELQGLGLLIALDDFGIGYSSLRYlnhLKSLPIHMIKLDKSFVKNLPEDD 663

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119962652 405 SQLGFLAAIQHVIHscgLEGVWEGIETAEQAEALRSIGCASGQGYYFGRPLPEAEFTEQ 463
PRK11829     664 AIARIISCVSDVLK---VRVMAEGVETEEQRQWLLEHGIQCGQGFLFSPPLPRAEFEAQ 719

-1

34551

COG4943

Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]

Predicted signal transduction protein containing sensor and EAL domains [Signal...

false

true

false

524

2e-50

195.18

47.52

3,215,270,77,296,347,56,353,403,116

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 216 GELREAIRADQLVLYYQPIVELSTGRIEGCEALVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWrdh 295
COG4943      271 RRLQRAIERRELCVHYQPIVDLATGKCVGAEALARWPQEDGTVVSPDVFIPLAEESGMIEQITDYVIRNVFRDLGDL--- 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 296 pVTAQQDFSMRINASAADLQSLEFVDAVSAALAEEHLAPDSLVLELTESAIIQNNELdRYTLASLHRLGVGLEIDDFGAG 375
COG4943      348 -LRQHRDLHVSINLSASDLASPRLIDRLNRKLAQYQVRPQQIALELTERTFADPKKM-TPIILRLREAGHEIYIDDFGTG 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 376 YSSMGYLRKLPVDRVKVDRQFVKDLGKDPSQLGFLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGRPL 455
COG4943      426 YSNLHYLQSLPVDALKIDKSFVDTLGTDSASHLIAPHIIEMAKSLGLKIVAEGVETEEQVDWLRKRGVHYGQGWLFSKAL 505

                        250
                 ....*....|....
gi 119962652 456 PEAEFTEQLSRLRT 469
COG4943      506 PAQAFLDWAEQQPA 519

-1

137979

PRK10551

hypothetical protein; Provisional

false

true

false

518

9e-38

153.29

46.33

6,216,266,79,295,346,5,304,351,25,331,376,4,335,382,19,355,401,105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 217 ELREAIRADQLVLYYQPIVELSTGRIEGCEALVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWRDH- 295
PRK10551     267 EILTAIKREQFYVVYQPVVDTQTLRVTGLEVLLRWRHPTAGEIPPDAFINYAEAQKLIVPLTQHLFELIARDAAELQKVl 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 296 PVTAQqdfsMRINASAADLQSLEFVDAVSAALAEehLAPD--SLVLELTESAIIQNNELDRyTLASLHRLGVGLEIDDFG 373
PRK10551     347 PVGAK----LGINIAPAHLHSDSFKADVQRLLAS--LPADhfQIVLEITERDMLQEEEALK-LFAWLHSQGIEIAIDDFG 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 374 AGYSSMGYLRKLPVDRVKVDRQFVKDLGKDPSQLGFLAAIQHVIHSCGLEGVWEGIETAEQAEALRSIGCASGQGYYFGR 453
PRK10551     420 TGHSALIYLERFTLDYLKIDRGFINAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLREHGVNFLQGYWISR 499


                 ....*..
gi 119962652 454 PLPEAEF 460
PRK10551     500 PLPLDDF 506

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

2e-27

118.87

46.44

4,3,233,21,25,254,125,150,382,23,173,406,29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652   4 TKPHRLVPADSRIEKLERHVQaLMQELHQARYEQRRDALTDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGF 83
COG3706      234 TKPIEEGELRARLRRQLRRKR-YERQLRESLERLQELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDF 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  84 KALKNSAGHAASDQILVTVAMRIRSAVRENDVVTRLGGDEFAVLLPATPQNRATAVGNRILAALEPN---IDLGNNSIRC 160
COG3706      313 KEINDTYGHDVGDEVLRQVARRLRQTVRGLDLVARYGGEEFAVVLPDTDLEAAIAIAERIRQKINELpfvHELSREPLEV 392

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 119962652 161 GASVGLRTAEPHH-SIEDILQEADLAMEDSKNEGRNKLKVFDP 202
COG3706      393 TISIGVAEGKPGEdSIEELLKRADKALYKAKASGRNRVVVKRA 435

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

7e-25

110.18

62.12

4,12,107,22,40,129,19,61,148,89,150,238,51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  13 DSRIEKLERHVQALMQELHQARyeqrrdALTDALTGLGNRQALVNSFieAQDAAAKGAVPPALLLVNLDGFKALKNSAGH 92
PRK09894     108 QEGLLSFTAALTDYKIYLLTIR------SNMDVLTGLPGRRVLDESF--DHQLRNREPLNLYLALLDIDRFKLVNDTYGH 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  93 AASDQILVTVAMRIRSAVRENDVVTRLGGDEFAVLLPATPQNRATAVGNRILAALEPN-IDLGNNSIRCGASVGLRTAEP 171
PRK09894     180 LIGDVVLRTLATYLASWTRPYETVYRYGGEEFIIILKAATDEEACRAGERIRQLIANQaITHSEGRINITATFGVTRAFP 259

                        170       180       190
                 ....*....|....*....|....*....|
gi 119962652 172 HHSIEDILQEADLAMEDSKNEGRNKLKVFD 201
PRK09894     260 EEPLDEVIGRADRAMYEGKQAGRNRVMFID 289

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

2e-24

108.85

35.01

3,40,291,109,149,403,24,173,428,23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  41 ALTDALTGLGNRQALVNSFIEAQDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVTVAMRIRSAVRENDVVTRLG 120
PRK09581     292 AVTDGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARYG 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 121 GDEFAVLLPATPQNRATAVGNRILAALEP---NIDLGNNSIRCGASVGLRTAEPHH-SIEDILQEADLAMEDSKNEGRNK 196
PRK09581     372 GEEFVVVMPDTDIEVAIAVAERIRRKIAEepfAISDGKERLNVTVSIGVAELRPSGeSIEALIKRADKALYEAKNTGRNR 451

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

8e-22

100.34

67.91

19,25,205,12,37,224,20,57,247,7,67,254,45,112,301,36,148,339,7,155,348,8,163,359,5,175,364,33,208,406,9,225,415,11,237,426,57,298,483,6,306,489,23,329,514,5,335,519,69,404,589,3,411,592,15,426,610,31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  26 LMQELHQARYEQ-------RRDALTDALTGLGNRQALVN---SFIEAQDaaaKGAVPPALLLVNLDGFKALKNSAGHAAS 95
PRK11059     206 LLEELQDARKERsrfdtfiRSNAFLDAKTGLGNRLFFDNqldTLLEDQE---KVGAHGVVMLIRLPDFDLLQEELGESQV 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  96 DQILVTVAMRIRSAVRE--NDVVTRLGGDEFAVLLPATPQNRATAVGNRILAALE--PNIDLGN--NSIRCGAS---VGL 166
PRK11059     283 DELLFELINLLSTFVQRypGALLARYSRSDFAVLLPHRSLKEADSLASQLLKAVDslPPPKMLDrdDFLHIGIAayrSGQ 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 167 RTaephhsiEDILQEADLAMEDSKNEGRNKLKVFDPATLHAQ---------LLQRQIVGElreairadQLVLYYQPIVEl 237
PRK11059     363 ST-------EQVMEEAEMALRSAQLQGGNSWFMYDKAQDPEKgrgsvrwrtLLEQALVRG--------GPRLYQQPVVT- 426

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 238 STGRIEGCEALVRWNHPVHGLIMPDQFIPIAEATGLIAELGRWVLRTAVRQLRRWRDhpvtAQQDFSmrINASAADLQSL 317
PRK11059     427 RDGQVHHRELMCRIRDGQGNEVRAAEFMPMVLQCGLSEQYDRQVIERVLPLLSYWPE----ESQNLS--INLSVDSLLSR 500

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 318 EFVDAVSAALAE--EHLAPdSLVLELTESAIIQNNELDRYTLASLHRLGVGLEIDDFGAGYSSMGYLRKLPVDRVKVDRQ 395
PRK11059     501 AFQRWLRDTLLQceRSQRK-RLIFELAEADVVQHIDRLRPVLRMLRGLGCRLAVDQAGLTVVSTSYIKELNVELIKLHPS 579

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119962652 396 FVKDLGKDP-SQLgflaAIQHVIHSCGLEGVW---EGIETAEQAEALRSIGCASGQGYYFGRPLPE 457
PRK11059     580 LVRNIHQRTeNQL----FVRSLVGACAGTETQvfaEGVESREEWQTLQILGVSGGQGDFFASPQPL 641

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

2e-15

78.78

45.82

5,32,199,11,43,212,10,53,226,6,63,232,111,174,344,25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  33 ARYEQRRDALT--DALTGLGNRQ----ALVNSFieaqDAAAKGAVPPALLLVNLDGFKALKNSAGHAASDQILVTVAMRI 106
PRK10245     200 AEHKRRLQVMStrDGMTGVYNRRhwetMLRNEF----DNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQL 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 107 RSAVRENDVVTRLGGDEFAVLLPATPQNRATAVGNRILAALEPNIDLGNNSIRCGASVGLRTAEPHHS-IEDILQEADLA 185
PRK10245     276 QITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLRLPNAPQVTLRISVGVAPLNPQMShYREWLKSADLA 355

                        170
                 ....*....|....
gi 119962652 186 MEDSKNEGRNKLKV 199
PRK10245     356 LYKAKKAGRNRTEV 369

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

2e-12

68.51

47.91

10,7,205,4,12,209,12,24,224,7,31,237,7,38,245,23,61,269,9,72,278,65,140,343,10,150,357,5,155,363,37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652   8 RLVPaDSRIEKLERHVQ---ALMQELH------QARYEQR-RDALTDALTGLGNRQALVNSFIE-AQDAAAKGAvpPALL 76
PRK09966     206 RRVS-EERIAEFHRFALdfnSLLDEMEewqlrlQAKNAQLlRTALHDPLTGLANRAAFRSGINTlMNNSDARKT--SALL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652  77 LVNLDGFKALKNSAGHAASDQILVTVAMRIRSAVRENDVVTRLGGDEFAVLLPATPQNRATavgNRILAALEPN----ID 152
PRK09966     283 FLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEV---QQICSALTQIfnlpFD 359

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 119962652 153 LGN-NSIRCGASVGLRTAEPHHSIEDILQEADLAMEDSKNE 192
PRK09966     360 LHNgHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQ 400

-1

33240

COG3434

Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]

Predicted signal transduction protein containing EAL and modified HD-GYP domains [...

false

true

false

407

9e-04

40.26

28.26

7,329,78,25,356,103,23,380,126,6,386,133,7,393,149,8,403,157,8,426,165,28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119962652 330 EHLAPDSLVLELTESAIIQNNELDRytLASLHRLGVGLEIDDFGAGYSSMgYLRKLP-VDRVKVD---------RQFVKD 399
COG3434       79 ELLPPDKVVIEILEDCPPTEKLLSA--IKELKQKGYLLALDDFIFSNVSE-WKPLLPlSDIVKIDfkrvtfdkaRLFDRD 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 119962652 400 LGkdPSQLGFLAaiqhvihscglegvwEGIETAEQAEALRSIGCASGQGYYFGRP 454
COG3434      156 LG--YINKKFLA---------------EKVETEEEFEQAKKAGFDLFQGYFFSKP 193

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF