NCBI Conserved Domain Search

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Conserved domains on [gi\|117929112\|ref\|YP_873663.1\|]
diguanylate cyclase/phosphodiesterase [Acidothermus cellulolyticus 11B]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

30163

cd01948

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

true

false

true

240

2e-75

279.41

98.75

2,615,0,79,700,79,158

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 616 SDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLFPETFISEAENSGIINEIGRLVLRHACAHVGGWQQh 695
cd01948        1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQA- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 696 verkpGEPPFAVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLILEITETMMLQGSDRVLRTLDLLSGFGVRLAMDDFG 775
cd01948       80 -----GGPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 776 TGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELGEALGLVTLAEGVETAQQARELERLGCRLGQGYHFAR 855
cd01948      155 TGYSSLSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSR 234


                 ...
gi 117929112 856 PVP 858
cd01948      235 PLP 237

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

3e-52

202.43

100.00

3,441,0,89,531,89,38,569,128,29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 442 HDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCLRPSDQPARLGGD 521
cd01949        1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117929112 522 EFAVIIEDAlSTQAAERIAARITEQLRAPISVHGCELHIRASIGIATS-QGVQTADELLRNADLAMYMAKADGKGRYR 598
cd01949       81 EFAILLPGT-DLEEAEELAERLRKAIEEPFFIDGEEIRVTASIGIAEYpEDGEDLEELLRRADKALYQAKRSGRNRVV 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

128367

smart00052

EAL

Putative diguanylate phosphodiesterase

false

241

1e-74

276.79

98.76

2,614,0,82,702,82,156

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 615 KSDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLFPETFISEAENSGIINEIGRLVLRHACAHVGGWQQ 694
smart00052     1 ERELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 695 HVerkpgePPFAVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLILEITETMMLQGSDRVLRTLDLLSGFGVRLAMDDF 774
smart00052    81 QG------PPLRISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 775 GTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELGEALGLVTLAEGVETAQQARELERLGCRLGQGYHFA 854
smart00052   155 GTGYSSLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFS 234


                 ....
gi 117929112 855 RPVP 858
smart00052   235 RPLP 238

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32382

COG2200

Rtn

c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]

false

256

7e-74

274.12

98.83

2,610,0,85,702,85,168

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 611 RHQLKSDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLFPETFISEAENSGIINEIGRLVLRHACAHVG 690
COG2200        1 RLQLERDLRQALENGEFSLYYQPIVDLATGRIVGYEALLRWRHPDGGLISPGEFIPLAEETGLIVELGRWVLEEACRQLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 691 GWQQHverkpgePPFAVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLILEITETMMLQGSDRVLRTLDLLSGFGVRLA 770
COG2200       81 TWPRA-------GPLRLAVNLSPVQLRSPGLVDLLLRLLARLGLPPHRLVLEITESALIDDLDTALALLRQLRELGVRIA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 771 MDDFGTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELGEALGLVTLAEGVETAQQARELERLGCRLGQG 850
COG2200      154 LDDFGTGYSSLSYLKRLPPDILKIDRSFVRDLETDARDQAIVRAIVALAHKLGLTVVAEGVETEEQLDLLRELGCDYLQG 233

                        250       260
                 ....*....|....*....|
gi 117929112 851 YHFARPVPSAGIELLLQRYA 870
COG2200      234 YLFSRPLPADALDALLSSSQ 253

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

109613

pfam00563

EAL

EAL domain

false

236

3e-59

225.76

100.00

5,614,0,89,706,89,19,726,108,24,751,132,58,810,190,46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 615 KSDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLFPETFISEAENSGIINEIGRLVLRHACAHVGGWQQ 694
pfam00563      1 EQALREALENGEFSLYFQPIVDLRTGKVLGYEALLRWQHPDGGLIPPDEFLPLAERLGLIAELDRWVLEKALAQLAEWRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 695 HVERKPGEPpfaVAVNLSPAQFAQPDLVAQIdEAVEAAGIDPNSLILEITETMMLQgSDRVLRTLDLLSGFGVRLAMDDF 774
pfam00563     81 NALLPPDLP---LSVNLSPASLLDPSFLEAL-LALKQGGLPPSRLVLEITESDLDE-DLRLLEALARLRSLGFRLALDDF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 775 GTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSpFVRAMIELGEALGLVTLAEGVETAQQARELERLGCRLGQGYHFA 854
pfam00563    156 GTGYSSLSYLSRLPPDYIKIDRSFIKDLSDPESRA-LLRALIALARELGIKVVAEGVETEEQLELLKELGIDYVQGYLFS 234


                 ..
gi 117929112 855 RP 856
pfam00563    235 KP 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

5e-47

184.76

100.00

3,437,0,93,531,93,36,567,130,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 438 QLAFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCLRPSDQPAR 517
smart00267     1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 518 LGGDEFAVIIEDAlSTQAAERIAARITEQLRAPISVHGCELHIRASIGIA-TSQGVQTADELLRNADLAMYMAKADGKGR 596
smart00267    81 LGGDEFALLLPET-SLEEAIALAERILQQLREPIIIHGIPLYLTISIGVAaYPNPGEDAEDLLKRADTALYQAKKAGRNQ 159


                 ....
gi 117929112 597 YRWF 600
smart00267   160 VAVY 163

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

110022

pfam00990

GGDEF

GGDEF domain

false

160

1e-44

177.44

100.00

3,439,0,98,537,100,32,569,133,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 440 AFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCLRPSDQPARLG 519
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 520 GDEFAVIIEDALSTQAAE--RIAARITEQLRAPISVHGCELHIRASIGIATS-QGVQTADELLRNADLAMYMAKADGKGR 596
pfam00990     81 GDEFAILLPDTSLEGAQElaERIRRLLAALKIPHTLSGLPLYVTISIGIAAYpNDGEDAEDLLKRADQALYQAKNQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

4e-44

175.31

100.00

3,420,0,110,531,110,38,569,150,31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 421 RLEQSLAQLRELEQKLTQLAFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCA 500
COG2199        1 ALLRLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 501 VAERITGCLRPSDQPARLGGDEFAVIIEDAlSTQAAERIAARITEQLRAPISVHGCELHIRASIGIATS--QGVQTADEL 578
COG2199       81 VARRLRSNLREGDLVARLGGDEFAVLLPGT-SLEEAARLAERIRAALEEPFFLGGEELRVTVSIGVALYpeDGSDDAELL 159

                        170       180
                 ....*....|....*....|..
gi 117929112 579 LRNADLAMYMAKADGKGRYRWF 600
COG2199      160 LRRADLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

2e-37

152.88

100.00

5,438,0,98,537,98,12,549,111,8,557,120,14,571,135,30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 439 LAFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCLRPSDQPARL 518
TIGR00254      1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 519 GGDEFAVIIEDALSTQAAeRIAARITEQLRA-PISVHGCE-LHIRASIGIATSQG-VQTADELLRNADLAMYMAKADGKG 595
TIGR00254     81 GGEEFVVILPGTPLEDAL-SKAERLRDAINSkPIEVAGSEtLTVTVSIGVACYPGhGLTLEELLKRADEALYQAKKAGRN 159


                 ....*.
gi 117929112 596 RYRWFR 601
TIGR00254    160 RVVVAD 165

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

138661

PRK11596

EAL domain-containing protein; Provisional

false

255

2e-06

50.09

92.16

12,618,16,7,625,28,9,636,37,3,639,41,15,658,56,22,680,79,20,704,99,8,712,108,5,717,116,9,726,132,19,764,151,2,767,153,98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 619 ERAAERG-----EFQVHYQPIvdLRT-GRPVAAEALVRWVHPerglLFPETFISEAENSGIINEIGRL-VLRHACAHVGG 691
PRK11596      17 ESLQERRfwlqcERAYTFQPI--YRTcGRLMAVELLTVVTHP----SNPSQRLSPDRYFAEITVSHRLdVVKEQLDLLAQ 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 692 WQQHVERKPgeppFAVAVNLS-PAQFA---QPDLVAQID-------EAVEAAGIDPNSLILEITEtmmlqgsdrvlrtld 760
PRK11596      91 KADFFVRHG----LLASVNIDgPTLIAlrqQPKILRLIErlpwlrfELVEHIRLPKDSTFASMCE--------------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 761 llsgFGvRLAMDDFGTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELGEALGLVTLAEGVETAQQAREL 840
PRK11596     152 ----FG-PLWLDDFGTGMANFSALSEVRYDYIKVARELFVMLRQSPEGRTLFSQLLHLMNRYCRGVIVEGVETPEEWRDV 226

                        250       260
                 ....*....|....*....|....*
gi 117929112 841 ERLGCRLGQGYHFARPVPSAGIELL 865
PRK11596     227 QRSPAFAAQGYFLSRPAPFDTLETL 251

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

128379

smart00065

GAF

Domain present in phytochromes and cGMP-specific phosphodiesterases.

true

false

149

3e-06

49.30

86.58

4,288,19,28,319,47,20,344,67,44,389,111,37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 289 DGGRLLRIRLDGHGEPRLMEAVTDPVVLawwERMTTANGPLVLQYAAKRPRkqrflARLFHDSADTSPSLEHEYLEHERV 368
smart00065    20 DRVLIYLVDEDDRGELVLVAADGLTLPL---LGLRYPLGEGLAGRVAETGR-----PLNIPDVEADPVFALDLLGRYQGV 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 117929112 369 RNAIVAPLRGETRPIGMLMVgDRPGEGASFGGQDVRLFEALANHVSVALENGRLEQSL 426
smart00065    92 RSFLAVPLVADGELVGVLAL-HNKDSPRPFTEEDEELLQALANQLAIALANAQLYEEL 148

cl00853

140972

GAF

GAF domain

-1

110584

pfam01590

GAF

GAF domain

false

153

7e-05

44.93

85.62

3,282,22,77,361,99,30,393,129,24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 283 AIIAPPDGGRLLRIRLDGHGEPRLMEAVTDPVVLAWWERMTTANGPLVLQYAAKRPRKQRFLARLFHDSADTSPSLEheY 362
pfam01590     23 AILLADADGLLLYLVAGDGLSDIPLAARGLPLGGGVVGEVIAGGNPIVVPDVQDDPRFRDLTALAEELPAPVGCHEH--Y 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 117929112 363 LEHERVRNAIVAPLRGETRPIGMLMVGDRpgEGASFGGQDVRLFEALANHVSVAL 417
pfam01590    101 LRGLGIRSCLAVPLLGGGKLIGVLVLHST--SPRAFTEEELELLQALADQVAIAL 153

cl00853

140972

GAF

GAF domain

-1

32385

COG2203

FhlA

FOG: GAF domain [Signal transduction mechanisms]

false

175

0.001

41.15

61.14

3,319,68,32,354,100,37,392,137,38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 320 ERMTTANGPLVLQYAAKRPRKQRFLARLFHDSadtSPSLEHEYLEHERVRNAIVAPLRGETRPIGMLMVGDRpGEGASFG 399
COG2203       69 ELFGLVILPACLIGIALREGRPVVVEDILQDP---RFRDNPLVLLEPPIRSYLGVPLIAQGELLGLLCVHDS-EPRRQWS 144

                         90       100       110
                 ....*....|....*....|....*....|.
gi 117929112 400 GQDVRLFEALANHVSVALENGRLEQSLAQLR 430
COG2203      145 EEELELLEELAEQVAIAIERARLYEELQEAE 175

cl00853

140972

GAF

GAF domain

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

1e-94

342.86

65.01

8,429,226,37,468,263,62,532,325,4,536,330,33,569,364,68,638,432,54,697,486,4,702,490,167

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 430 RELEQKLTQLAFHDPLTGLANRALFSERLSQVLAKAKaeGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCL 509
PRK10060     227 RRAQERLRILANTDSITGLPNRNAIQELIDHAIAQAD--NNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCL 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 510 RPSDQPARLGGDEFAVIIEDAlsTQAA-ERIAARITEQLRAPISVHGCELHIRASIGIATS-QGVQTADELLRNADLAMY 587
PRK10060     305 EEDQTLARLGGDEFLVLASHT--SQAAlEAMASRILTRLRLPFRIGLIEVYTGCSIGIALSpEHGDDSESLIRSADTAMY 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 588 MAKADGKGRYRWFRPSMRTAVVSRHQLKSDLERAAERGEFQVHYQPIVDLrTGRPVAAEALVRWVHPERGLLFPETFISE 667
PRK10060     383 TAKEGGRGQFCVFSPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKITW-RGEVRSLEALVRWQSPERGLIPPLEFISY 461

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 668 AENSGIINEIGRLVLRHACAHVGGWqqhveRKPGePPFAVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLILEITETM 747
PRK10060     462 AEESGLIVPLGRWVILDVVRQAAKW-----RDKG-INLRVAVNVSARQLADQTIFTALKQVLQELNFEYCPIDVELTESC 535

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 748 MLQGSDRVLRTLDLLSGFGVRLAMDDFGTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELGEALGLVTL 827
PRK10060     536 LIENEELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQVI 615

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 117929112 828 AEGVETAQQARELERLGCRLGQGYHFARPVPSAGIELLLQRY 869
PRK10060     616 AEGVETAKEDAFLTKNGVNERQGFLFAKPMPAVAFERWYKRY 657

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

1e-91

332.76

64.86

5,421,209,106,528,315,14,542,330,27,569,358,123,701,481,158

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 422 LEQSLAQLRELEQKLTQLAFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAV 501
COG5001      210 LTQRAEETRRLSDENDRLANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEV 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 502 AERITGCLRPSDQPARLGGDEFAVIIeDALSTQAAERIAAR-ITEQLRAPISVHGCELHIRASIGIATS-QGVQTADELL 579
COG5001      290 GRRLKAFDGAPILAARLGGDEFALII-PALEDDALRVAGARaLCESLQAPYDLRGVRVQVGASIGIAPFpSGADTSEQLF 368

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 580 RNADLAMYMAKADGKGRYRWFRPSMRTAVVSRHQLKSDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLL 659
COG5001      369 ERADYALYHAKQNGKGAAVLFDARHEAAIRDMAVVEQALRSADLEQELSVHFQPIVDIVSGKTIALEALARWHSPEIGPV 448

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 660 FPETFISEAENSGIINEIGRLVLRHACAHVGGWqqhverkpgEPPFAVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSL 739
COG5001      449 PPDVFIGIAERSGQIVELTRLLLAKALREARAW---------PMDVRVSINLSARDLASMENVRRLLAIVSESCIAPHRL 519

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 740 ILEITETMMLQGSDRVLRTLDLLSGFGVRLAMDDFGTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELG 819
COG5001      520 DFEITETAIVCDFDQARDALAALHELGVRTALDDFGTGYSSLSHLRALPLDKIKIDRSFVSDLEENPTSEDIVRTVLQLG 599

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 117929112 820 EALGLVTLAEGVETAQQARELERLGCRLGQGYHFARPVPS 859
COG5001      600 RNLRMECVVEGVETEAQRDRVAALGATVMQGYHYARPMPA 639

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

1e-78

289.82

52.69

5,430,366,38,472,404,65,538,469,33,572,502,120,697,622,165

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 431 ELEQKLTQLAFHDPLTGLANRALFSERLSQVLAKAKAEgrtcAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCLR 510
PRK11359     367 KSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSP----VVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFREKLK 442

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 511 PSDQPARLGGDEFAVIIEDALSTQAAErIAARITEQLRAPISVHGCELHIRASIGIATSQGvQTADELLRNADLAMYMAK 590
PRK11359     443 PDQYLCRIEGTQFVLVSLENDVSNITQ-IADELRNVVSKPIMIDDKPFPLTLSIGISYDVG-KNRDYLLSTAHNAMDYIR 520

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 591 ADGKGRYRWFRPSMRTAVVSRHQLKSDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLFPETFISEAEN 670
PRK11359     521 KNGGNGWQFFSPAMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEE 600

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 671 SGIINEIGRLVLRHACAHVGGWqqhveRKPGEPPFAVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLILEITETMMLQ 750
PRK11359     601 IGEIENIGRWVIAEACRQLAEW-----RSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHAWGIDGHQLTVEITESMMME 675

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 751 GSDRVLRTLDLLSGFGVRLAMDDFGTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELGEALGLVTLAEG 830
PRK11359     676 HDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEG 755

                        410       420       430
                 ....*....|....*....|....*....|..
gi 117929112 831 VETAQQARELERLGCRLGQGYHFARPVPSAGI 862
PRK11359     756 VETKEQFEMLRKIHCRVIQGYFFSRPLPAEEI 787

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

4e-67

251.61

66.05

6,420,214,11,434,225,32,470,257,230,706,487,80,786,570,14,803,584,60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 421 RLEQSLAQLREleqKLTQLAFHDPLTGLANRALFSERLSQVLAKAKaegrTCAVLFIDLDDFKTVNDTLGHDAGDELLCA 500
PRK13561     215 LNQQLLQRHYE---EQNENAMRFPVSDLPNKALLMALLEQVVARKQ----TTALMIITCETLRDTAGVLKEAQREILLLT 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 501 VAERITGCLRPSDQPARLGGDEFAVIIEDALSTQAAERIAARITEQLRAPISVHGCELHIRASIGIATSQGVQTADELLR 580
PRK13561     288 LVEKLKSVLSPRMVLAQISGYDFAIIANGVKEPWHAITLGQQVLTIINERLPIQRIQLRPSCSIGIAMFYGDLTAEQLYS 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 581 NADLAMYMAKADGKGRYRWFRPSMRTAVVSRHQLKSDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLF 660
PRK13561     368 RAVSAAFTARRKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDL 447

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 661 PETFISEAENSGIINEIGRLVLRHACAHVGGWQQHVERKPgeppfaVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLI 740
PRK13561     448 PDGLIDRIESCGLMVTVGHWVLEESCRLLAAWQERGIMLP------LSVNLSALQLMHPNMVADMLELLTRYRIQPGTLI 521

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 741 LEITETMMLQGSDRVLRTLDLLSGFGVRLAMDDFGTGYASLASLRK---LPIDIIKIAKTFTDditGNEEKSPFVRAMIE 817
PRK13561     522 LEVTESRRIDDPHAAVAILRPLRNAGVRIALDDFGMGYAGLRQLQHmksLPIDVLKIDKMFVD---GLPEDSSMVAAIIM 598

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 117929112 818 LGEALGLVTLAEGVETAQQARELERLGCRLGQGYHFARPVPSAGIE 863
PRK13561     599 LAQSLNLQMIAEGVETEAQRDWLAKAGVGVAQGFLFARPLPIEIFE 644

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

2e-59

226.51

38.71

7,423,671,107,531,778,18,549,797,17,566,815,51,617,868,31,648,900,36,691,936,167

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112  424 QSLAQLRELEQKLTQLAFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAE 503
PRK09776      672 QDVTESRAMLRQLSYSASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELAS 751

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112  504 RITGCLRPSDQPARLGGDEFAVIIEDAlSTQAAERIAARITEQLRA-PISVHGCELHIRASIGI-ATSQGVQTADELLRN 581
PRK09776      752 LMLSMLRSSDVLARLGGDEFGLLLPDC-NVESARFIATRIISAINDyRFPWEGRVYRVGASAGItAIDDNNHQASEVMSQ 830

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112  582 ADLAMYMAKADGKGRYRWFRPSMRTAVVSRHQLKSD--LERAAERGEFQVHYQPIVDLRTGRPVAAEAL-VRWVHPERGL 658
PRK09776      831 ADIACYAAKNAGRGRVTVYEPQQAAAHSERRELSLAeqWRSMLEENQLMLQAQEIASPRIPEARNLWLIsLRLWDCEGEI 910

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112  659 LFPETFISEAENSGIINEIGRLVLRHacahvggWQQHVERKPGEPPFAVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNS 738
PRK09776      911 IDEGAFRPAAEDPALMHALDRWVIHE-------LFQQGARAVASKGLSIAIPLSVASLSSATLLPFLLEQLENSPLPPRL 983

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112  739 LILEITETMMLQGSDRVLRTLDLLSGFGVRLAMDDFGTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIEL 818
PRK09776      984 LHLEITETALLNHAEAASRLVQKLRLAGCRVVLDDFGRGLSSFNYLKAFMADYLKIDGELCANLQGNLMDEMLVSIINGI 1063

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 117929112  819 GEALGLVTLAEGVETAQQARELERLGCRLGQGYHFARPVP 858
PRK09776     1064 AQRLGMKTIAGPVELPLTLDTLSGIGVDLAQGYVIGRPQP 1103

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

6e-54

208.01

56.87

6,443,303,28,472,331,101,573,433,127,706,560,76,782,639,21,806,660,57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 444 PLTGLANRALFSERLSQVLAKAKAEGRTcAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCLRPSDQPARLGGDEF 523
PRK11829     304 PVTELPNRSLFISLLEKEIASSTRTDHF-HLLVIGIETLQEVSGAMSEAQHQQLLLTIVQRIEQCIDDSDLLAQLSKTEF 382

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 524 AVIIEDALSTQAAERIAARITEQLRAPISVHGCELHIRASIGIATSQGVQ-TADELLRNADLAMYMAKADGKGRYRWFRP 602
PRK11829     383 AVLARGTRRSFPAMQLARRIMSQVTQPLFFDEITLRPSASIGITRYQAQQdTAESMMRNASTAMMAAHHEGRNQIMVFEP 462

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 603 SMRTAVVSRHQLKSDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLFPETFISEAENSGIINEIGRLVL 682
PRK11829     463 HLIEKTHKRLTQENDLLQAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQPDGSYVLPSGFVHFAEEEGMMVPLGNWVL 542

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 683 RHACAHVGGWQQHVERKPgeppfaVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLILEITETMMLQGSDRVLRTLDLL 762
PRK11829     543 EEACRILADWKARGVSLP------LSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITETAQIQDLDEALRLLREL 616

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 763 SGFGVRLAMDDFGTGYASLA---SLRKLPIDIIKIAKTFTDDITgneEKSPFVRAMIELGEALGLVTLAEGVETAQQARE 839
PRK11829     617 QGLGLLIALDDFGIGYSSLRylnHLKSLPIHMIKLDKSFVKNLP---EDDAIARIISCVSDVLKVRVMAEGVETEEQRQW 693

                        410       420
                 ....*....|....*....|....
gi 117929112 840 LERLGCRLGQGYHFARPVPSAGIE 863
PRK11829     694 LLEHGIQCGQGFLFSPPLPRAEFE 717

-1

34551

COG4943

Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]

Predicted signal transduction protein containing sensor and EAL domains [Signal...

false

true

false

524

6e-50

194.41

48.85

6,610,265,82,692,348,3,702,351,43,745,395,11,758,406,100,861,506,15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 611 RHQLKSDLERAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLFPETFISEAENSGIINEIGRLVLRHACAHVG 690
COG4943      266 YLSPRRRLQRAIERRELCVHYQPIVDLATGKCVGAEALARWPQEDGTVVSPDVFIPLAEESGMIEQITDYVIRNVFRDLG 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 691 GW-QQHverkpgePPFAVAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLILEITE-TMMLQGSDRVLrtLDLLSGFGVR 768
COG4943      346 DLlRQH-------RDLHVSINLSASDLASPRLIDRLNRKLAQYQVRPQQIALELTErTFADPKKMTPI--ILRLREAGHE 416

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 769 LAMDDFGTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELGEALGLVTLAEGVETAQQARELERLGCRLG 848
COG4943      417 IYIDDFGTGYSNLHYLQSLPVDALKIDKSFVDTLGTDSASHLIAPHIIEMAKSLGLKIVAEGVETEEQVDWLRKRGVHYG 496

                        250       260
                 ....*....|....*....|....*...
gi 117929112 849 QGYHFARPVPsagIELLLQRYAEQQAGL 876
COG4943      497 QGWLFSKALP---AQAFLDWAEQQPARE 521

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

1e-36

150.07

53.56

7,378,202,19,402,221,9,411,231,15,426,256,103,530,359,25,555,387,15,570,403,32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 379 ETRPIGMLMVGDRPGEGASfggqdVRLFEALAN-HVSVALENGRLEQSL----------AQLRELEQKLTQLAFHDPLTG 447
COG3706      203 RTRDIPIILLSSKDDDELV-----VRAFELGVNdYITKPIEEGELRARLrrqlrrkryeRQLRESLERLQELALVDGLTG 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 448 LANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCLRPSDQPARLGGDEFAVII 527
COG3706      278 LFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEVLRQVARRLRQTVRGLDLVARYGGEEFAVVL 357

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117929112 528 EDaLSTQAAERIAARITEQLRAPISVHG---CELHIRASIGIATSQ-GVQTADELLRNADLAMYMAKADGKGRYRWFRP 602
COG3706      358 PD-TDLEAAIAIAERIRQKINELPFVHElsrEPLEVTISIGVAEGKpGEDSIEELLKRADKALYKAKASGRNRVVVKRA 435

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

3e-34

142.37

37.64

8,427,279,4,431,284,6,438,290,88,526,383,7,535,390,10,548,400,9,557,411,14,571,426,25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 428 QLRE-LEQKLTqLAFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERIT 506
PRK09581     280 ALRQnLEQSIE-MAVTDGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLR 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 507 GCLRPSDQPARLGGDEFAVI-----IEDALSTqaAERIAARITEqlrAPISVHGCE--LHIRASIGIATSQG-VQTADEL 578
PRK09581     359 KNIRGTDLIARYGGEEFVVVmpdtdIEVAIAV--AERIRRKIAE---EPFAISDGKerLNVTVSIGVAELRPsGESIEAL 433

                        170
                 ....*....|....*...
gi 117929112 579 LRNADLAMYMAKADGKGR 596
PRK09581     434 IKRADKALYEAKNTGRNR 451

-1

137979

PRK10551

hypothetical protein; Provisional

false

true

false

518

7e-34

141.34

44.98

4,619,269,77,702,346,4,706,351,47,754,398,104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 620 RAAERGEFQVHYQPIVDLRTGRPVAAEALVRWVHPERGLLFPETFISEAENSGIINEIGRLVLRHACAHVGGWQQHVerk 699
PRK10551     270 TAIKREQFYVVYQPVVDTQTLRVTGLEVLLRWRHPTAGEIPPDAFINYAEAQKLIVPLTQHLFELIARDAAELQKVL--- 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 700 pgePPFA-VAVNLSPAQFAQPDLVAQIDEAVEAAGIDPNSLILEITETMMLQGSDrVLRTLDLLSGFGVRLAMDDFGTGY 778
PRK10551     347 ---PVGAkLGINIAPAHLHSDSFKADVQRLLASLPADHFQIVLEITERDMLQEEE-ALKLFAWLHSQGIEIAIDDFGTGH 422

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 779 ASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVRAMIELGEALGLVTLAEGVETAQQARELERLGCRLGQGYHFARPVP 858
PRK10551     423 SALIYLERFTLDYLKIDRGFINAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLREHGVNFLQGYWISRPLP 502

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

7e-30

127.69

64.33

13,439,227,71,510,300,19,530,319,13,546,332,11,557,350,2,563,352,22,585,387,7,592,397,7,604,404,3,617,407,19,637,426,61,706,487,19,725,507,133

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 440 AFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAERITGCLR--PSDQPAR 517
PRK11059     228 AFLDAKTGLGNRLFFDNQLDTLLEDQEKVGAHGVVMLIRLPDFDLLQEELGESQVDELLFELINLLSTFVQryPGALLAR 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 518 LGGDEFAVIIEDaLSTQAAERIAARIteqLRAPISVHGCE-------LHirasIGIATSQGVQTADELLRNADLA----- 585
PRK11059     308 YSRSDFAVLLPH-RSLKEADSLASQL---LKAVDSLPPPKmldrddfLH----IGIAAYRSGQSTEQVMEEAEMAlrsaq 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 586 --------MYMAKAD---GKGRYRWfrpsmRTAvvsrhqlksdLERAAERGEFQVHYQPIVDlRTGRPVAAEALVRWVHP 654
PRK11059     380 lqggnswfMYDKAQDpekGRGSVRW-----RTL----------LEQALVRGGPRLYQQPVVT-RDGQVHHRELMCRIRDG 443

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 655 ERGLLFPETFISEAENSGIINEIGRLVLRHACAHVGGWQQHVERkpgeppfaVAVNLSPAQFAQPDLVAQI-DEAVEAAG 733
PRK11059     444 QGNEVRAAEFMPMVLQCGLSEQYDRQVIERVLPLLSYWPEESQN--------LSINLSVDSLLSRAFQRWLrDTLLQCER 515

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 734 IDPNSLILEITETMMLQGSDRVLRTLDLLSGFGVRLAMDDFGTGYASLASLRKLPIDIIKIAKTFTDDITGNEEKSPFVR 813
PRK11059     516 SQRKRLIFELAEADVVQHIDRLRPVLRMLRGLGCRLAVDQAGLTVVSTSYIKELNVELIKLHPSLVRNIHQRTENQLFVR 595

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 117929112 814 AMIELGEALGLVTLAEGVETAQQARELERLGCRLGQGYHFARPVP 858
PRK11059     596 SLVGACAGTETQVFAEGVESREEWQTLQILGVSGGQGDFFASPQP 640

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

1e-27

120.97

61.09

6,415,105,10,426,115,12,438,128,27,467,155,68,535,226,11,549,237,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 416 ALENGRLEQSlAQLRELEQKLTQ-LAFHDPLTGLANRALFSERLSQVLAKAkaEGRTCAVLFIDLDDFKTVNDTLGHDAG 494
PRK09894     106 AFQEGLLSFT-AALTDYKIYLLTiRSNMDVLTGLPGRRVLDESFDHQLRNR--EPLNLYLALLDIDRFKLVNDTYGHLIG 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 495 DELLCAVAERITGCLRPSDQPARLGGDEFAVIIEDALSTQA---AERIAARITEQlraPISVHGCELHIRASIGIATSQG 571
PRK09894     183 DVVLRTLATYLASWTRPYETVYRYGGEEFIIILKAATDEEAcraGERIRQLIANQ---AITHSEGRINITATFGVTRAFP 259

                        170       180
                 ....*....|....*....|....*
gi 117929112 572 VQTADELLRNADLAMYMAKADGKGR 596
PRK09894     260 EEPLDEVIGRADRAMYEGKQAGRNR 284

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

4e-25

112.03

40.54

5,427,233,3,431,236,8,439,247,29,469,276,85,554,362,36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 428 QLReLEQKLTQL---AFHDPLTGLANRALFSERLSQVLAKAKAEgRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAER 504
PRK09966     234 QLR-LQAKNAQLlrtALHDPLTGLANRAAFRSGINTLMNNSDAR-KTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKR 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 505 ITGCLRPSDQPARLGGDEFAVIIEDALSTQAAERIAARITEQLRAPISVH-GCELHIRASIGIATSQGVQTADELLRNAD 583
PRK09966     312 LAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHnGHQTTMTLSIGYAMTIEHASAEKLQELAD 391


                 ....*..
gi 117929112 584 LAMYMAK 590
PRK09966     392 HNMYQAK 398

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

1e-20

96.89

46.63

5,423,193,105,531,298,10,541,310,26,567,338,3,571,341,25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 424 QSLAQLRELEQKLTQLAFHDPLTGLANRALFSERLSQVLAKAKAEGRTCAVLFIDLDDFKTVNDTLGHDAGDELLCAVAE 503
PRK10245     194 QTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 504 RITGCLRPSDQPARLGGDEFAVIIEdalSTQAAERIAA--RITEQLRAPISVHGCELHIRASIGIA--TSQgVQTADELL 579
PRK10245     274 QLQITLRGSDVIGRFGGDEFAVIMS---GTPAESAITAmlRVHEGLNTLRLPNAPQVTLRISVGVAplNPQ-MSHYREWL 349

                        170
                 ....*....|....*..
gi 117929112 580 RNADLAMYMAKADGKGR 596
PRK10245     350 KSADLALYKAKKAGRNR 366

-1

33240

COG3434

Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]

Predicted signal transduction protein containing EAL and modified HD-GYP domains [...

false

true

false

407

7e-06

48.35

27.27

6,735,82,12,749,94,25,777,119,9,786,130,2,788,133,13,809,146,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117929112 736 PNSLILEITETMmlQGSDRVLRTLDLLSGFGVRLAMDDFgtgYASLASLRK--LP-IDIIKIAKTFTDDitgneeksPFV 812
COG3434       83 PDKVVIEILEDC--PPTEKLLSAIKELKQKGYLLALDDF---IFSNVSEWKplLPlSDIVKIDFKRVTF--------DKA 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 117929112 813 RAMIELGEALGLVTLAEGVETAQQARELERLGCRLGQGYHFARP 856
COG3434      150 RLFDRDLGYINKKFLAEKVETEEEFEQAKKAGFDLFQGYFFSKP 193

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF