NCBI Conserved Domain Search

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Conserved domains on [gi\|117928947\|ref\|YP_873498.1\|]
diguanylate cyclase/phosphodiesterase [Acidothermus cellulolyticus 11B]

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List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

30163

cd01948

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

true

false

true

240

8e-76

280.56

99.58

1,546,0,239

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 547 RDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLERCGLIGNLTRYVLDAAIQEGASWYRA 626
cd01948        1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 627 GLPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAVFSRSLTASTILDALRTAGVGLSLDDFCTGYSSL 706
cd01948       81 GPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSSL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928947 707 SLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVTAEGIETKEQQRLLTDLQCDYAQGFLLAKPMPAA 785
cd01948      161 SYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPAE 239

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

3e-26

115.76

95.54

5,376,0,9,385,13,36,422,49,3,425,53,37,463,90,60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 377 TDPVTGLGN----LLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGaHPA-DLMLRSVAERLAGIVRRCDVVGRLHG 451
cd01949        1 TDPLTGLPNrrafEERLERLLARARRSGRPLALLLIDLDHFKQINDTYG-HAAgDEVLKEVARRLRSSLRESDLVARLGG 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117928947 452 AEYVLLLRELSgPEAAVAQAELAVRSLGGTITAEGLDIALDAHTGVACVPEDGTTLAEVVRRARLAMYKARA 523
cd01949       80 DEFAILLPGTD-LEEAEELAERLRKAIEEPFFIDGEEIRVTASIGIAEYPEDGEDLEELLRRADKALYQAKR 150

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

128367

smart00052

EAL

Putative diguanylate phosphodiesterase

false

241

3e-76

281.80

99.59

1,546,1,240

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 547 RDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLERCGLIGNLTRYVLDAAIQEGASWYRA 626
smart00052     2 RELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQAQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 627 GLPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAVFSRSLTASTILDALRTAGVGLSLDDFCTGYSSL 706
smart00052    82 GPPLRISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTGYSSL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 707 SLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVTAEGIETKEQQRLLTDLQCDYAQGFLLAKPMPAAL 786
smart00052   162 SYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPLPLDD 241

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32382

COG2200

Rtn

c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]

false

256

2e-69

259.49

97.66

2,543,2,84,628,86,166

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 544 QMLRDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLERCGLIGNLTRYVLDAAIQEGASW 623
COG2200        3 QLERDLRQALENGEFSLYYQPIVDLATGRIVGYEALLRWRHPDGGLISPGEFIPLAEETGLIVELGRWVLEEACRQLRTW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 624 YRAGlPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAVFSRSLTASTILDALRTAGVGLSLDDFCTGY 703
COG2200       83 PRAG-PLRLAVNLSPVQLRSPGLVDLLLRLLARLGLPPHRLVLEITESALIDDLDTALALLRQLRELGVRIALDDFGTGY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 704 SSLSLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVTAEGIETKEQQRLLTDLQCDYAQGFLLAKPMP 783
COG2200      162 SSLSYLKRLPPDILKIDRSFVRDLETDARDQAIVRAIVALAHKLGLTVVAEGVETEEQLDLLRELGCDYLQGYLFSRPLP 241

                        250
                 ....*....|.
gi 117928947 784 AALARQLFLDS 794
COG2200      242 ADALDALLSSS 252

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

109613

pfam00563

EAL

EAL domain

false

236

2e-57

219.60

100.00

5,545,0,83,628,86,24,653,110,19,673,129,54,728,183,53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 546 LRDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLERCGLIGNLTRYVLDAAIQEGASWYR 625
pfam00563      1 EQALREALENGEFSLYFQPIVDLRTGKVLGYEALLRWQHPDGGLIPPDEFLPLAERLGLIAELDRWVLEKALAQLAEWRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 626 AGL---PLSVAVNLSARNLLDEDLPRFVLDtLARHGLPADRLICEITETAvFSRSLTASTILDALRTAGVGLSLDDFCTG 702
pfam00563     81 NALlppDLPLSVNLSPASLLDPSFLEALLA-LKQGGLPPSRLVLEITESD-LDEDLRLLEALARLRSLGFRLALDDFGTG 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928947 703 YSSLSLLRERTIDEIKIDRSFVSDLgTGRRSTEIVTALIDLAHRCDIIVTAEGIETKEQQRLLTDLQCDYAQGFLLAKP 781
pfam00563    159 YSSLSYLSRLPPDYIKIDRSFIKDL-SDPESRALLRALIALARELGIKVVAEGVETEEQLELLKELGIDYVQGYLFSKP 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

110022

pfam00990

GGDEF

GGDEF domain

false

160

3e-24

108.87

96.88

3,374,0,11,385,15,85,470,102,53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 375 AHTDPVTGLGN----LLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIVRRCDVVGRLH 450
pfam00990      1 AAHDPLTGLPNrryfEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117928947 451 GAEYVLLLRELSGPEAAVAQ--AELAVRSLGGTITAEGLDIALDAHTGVACVPEDGTTLAEVVRRARLAMYKARA 523
pfam00990     81 GDEFAILLPDTSLEGAQELAerIRRLLAALKIPHTLSGLPLYVTISIGIAAYPNDGEDAEDLLKRADQALYQAKN 155

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

1e-22

103.48

94.48

5,372,0,13,385,17,36,422,53,3,425,57,37,463,94,60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 373 RAAHTDPVTGLGN----LLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGaHPA-DLMLRSVAERLAGIVRRCDVVG 447
smart00267     1 RLAFRDPLTGLPNrryfEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYG-HAVgDELLQEVAQRLSSCLRPGDLLA 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117928947 448 RLHGAEYVLLLRELSgPEAAVAQAELAVRSLGGTITAEGLDIALDAHTGVACVPEDGTTLAEVVRRARLAMYKARA 523
smart00267    80 RLGGDEFALLLPETS-LEEAIALAERILQQLREPIIIHGIPLYLTISIGVAAYPNPGEDAEDLLKRADTALYQAKK 154

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

1e-20

97.50

90.06

5,365,9,7,372,17,13,385,34,77,463,111,46,509,158,14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 366 REAEERI-RAAHTDPVTGLGN----LLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIV 440
COG2199       10 RKAEERLeRLALHDPLTGLPNrrafEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREVARRLRSNL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 441 RRCDVVGRLHGAEYVLLLRELSgPEAAVAQAELAVRSLGGTITAEGLDIALDAHTGVACVPEDGTTLAE-VVRRARLAMY 519
COG2199       90 REGDLVARLGGDEFAVLLPGTS-LEEAARLAERIRAALEEPFFLGGEELRVTVSIGVALYPEDGSDDAElLLRRADLALY 168


                 ....
gi 117928947 520 KARA 523
COG2199      169 RAKR 172

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

8e-19

90.86

93.94

4,374,1,11,385,16,73,463,89,27,490,122,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 375 AHTDPVTGLGN----LLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIVRRCDVVGRLH 450
TIGR00254      2 AVRDPLTGLYNrrylEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRYG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 451 GAEYVLLLrelsgPEAAVAQAELAVRSLGGTITAEGLDIA------LDAHTGVACVPEDGTTLAEVVRRARLAMYKARAM 524
TIGR00254     82 GEEFVVIL-----PGTPLEDALSKAERLRDAINSKPIEVAgsetltVTVSIGVACYPGHGLTLEELLKRADEALYQAKKA 156

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

138661

PRK11596

EAL domain-containing protein; Provisional

false

255

8e-05

44.70

35.29

3,693,154,34,730,188,5,735,196,48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 694 LSLDDFCTGYSSLSLLRERTIDEIKIDRSFVSDLgtgRRSTE---IVTALIDLAHRCDIIVTAEGIETKEQQRLLTDLQC 770
PRK11596     155 LWLDDFGTGMANFSALSEVRYDYIKVARELFVML---RQSPEgrtLFSQLLHLMNRYCRGVIVEGVETPEEWRDVQRSPA 231

                         90
                 ....*....|...
gi 117928947 771 DYAQGFLLAKPMP 783
PRK11596     232 FAAQGYFLSRPAP 244

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

3e-66

248.88

64.10

9,362,223,12,374,236,20,394,258,71,465,330,17,485,347,2,487,350,46,537,396,5,542,406,26,569,432,216

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 363 TLTREAEERIRA-AHTDPVTGLGNLLMLEKEFE--MSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGI 439
PRK10060     224 TEERRAQERLRIlANTDSITGLPNRNAIQELIDhaIAQADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSC 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 440 VRRCDVVGRLHGAEYVLLLRELSGPE-AAVAQAELAVRSLGGTItaeGL-DIALDAHTGVACVPEDGTTLAEVVRRARLA 517
PRK10060     304 LEEDQTLARLGGDEFLVLASHTSQAAlEAMASRILTRLRLPFRI---GLiEVYTGCSIGIALSPEHGDDSESLIRSADTA 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 518 MYKARAMDLAVYRYSSdlepPAMAQ-----VQMLRDLRTALSENQFVLHYQPKFSLrTGLPVAAEALVRWQHPQEGLISP 592
PRK10060     381 MYTAKEGGRGQFCVFS----PEMNQrvfeyLWLDTNLRKALENDQLVIHYQPKITW-RGEVRSLEALVRWQSPERGLIPP 455

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 593 AQFVPLLERCGLIGNLTRYVLDAAIQEGASWYRAGLPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETA 672
PRK10060     456 LEFISYAEESGLIVPLGRWVILDVVRQAAKWRDKGINLRVAVNVSARQLADQTIFTALKQVLQELNFEYCPIDVELTESC 535

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 673 VFSRSLTASTILDALRTAGVGLSLDDFCTGYSSLSLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVT 752
PRK10060     536 LIENEELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQVI 615

                        410       420       430
                 ....*....|....*....|....*....|...
gi 117928947 753 AEGIETKEQQRLLTDLQCDYAQGFLLAKPMPAA 785
PRK10060     616 AEGVETAKEDAFLTKNGVNERQGFLFAKPMPAV 648

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

2e-62

236.46

63.50

4,365,218,20,385,242,145,530,388,93,626,481,158

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 366 REAEERIRAAHTDPVTGLGN----LLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIVR 441
COG5001      219 RLSDENDRLANLDSLTGLPNrrrfFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRLKAFDG 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 442 RCDVVGRLHGAEYVLLLRELSGPEAAVAQAELAVRSLGGTITAEGLDIALDAHTGVACVPEDGTTLAEVVRRARLAMYKA 521
COG5001      299 APILAARLGGDEFALIIPALEDDALRVAGARALCESLQAPYDLRGVRVQVGASIGIAPFPSGADTSEQLFERADYALYHA 378

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 522 RAMDLAVYR-YSSDLEPPAMAQVQMLRDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLE 600
COG5001      379 KQNGKGAAVlFDARHEAAIRDMAVVEQALRSADLEQELSVHFQPIVDIVSGKTIALEALARWHSPEIGPVPPDVFIGIAE 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 601 RCGLIGNLTRYVLDAAIQEGASWyraGLPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAVFSRSLTA 680
COG5001      459 RSGQIVELTRLLLAKALREARAW---PMDVRVSINLSARDLASMENVRRLLAIVSESCIAPHRLDFEITETAIVCDFDQA 535

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 681 STILDALRTAGVGLSLDDFCTGYSSLSLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVTAEGIETKE 760
COG5001      536 RDALAALHELGVRTALDDFGTGYSSLSHLRALPLDKIKIDRSFVSDLEENPTSEDIVRTVLQLGRNLRMECVVEGVETEA 615

                        410       420
                 ....*....|....*....|....
gi 117928947 761 QQRLLTDLQCDYAQGFLLAKPMPA 784
COG5001      616 QRDRVAALGATVMQGYHYARPMPA 639

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

2e-61

232.42

50.94

6,377,378,97,475,475,23,500,498,33,537,531,10,547,546,84,631,631,154

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 378 DPVTGLGNLLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIVRRCDVVGRLHGAEYVLL 457
PRK11359     379 DPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLV 458

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 458 LRELSGPEAAVAQAELAvRSLGGTITAEGLDIALDAHTGVAcvPEDGTTLAEVVRRARLAMYKARAMDLAVYRYSSdlep 537
PRK11359     459 SLENDVSNITQIADELR-NVVSKPIMIDDKPFPLTLSIGIS--YDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFS---- 531

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 538 PAMAQVQMLR-----DLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLERCGLIGNLTRYV 612
PRK11359     532 PAMNEMVKERlvlgaALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWV 611

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 613 LDAAIQEGASWYRAGLPLS-VAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAVFSRSLTASTILDALRTAG 691
PRK11359     612 IAEACRQLAEWRSQNIHIPaLSVNLSALHFRSNQLPNQVSDAMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMG 691

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 692 VGLSLDDFCTGYSSLSLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVTAEGIETKEQQRLLTDLQCD 771
PRK11359     692 VGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCR 771

                        410
                 ....*....|....
gi 117928947 772 YAQGFLLAKPMPAA 785
PRK11359     772 VIQGYFFSRPLPAE 785

-1

34551

COG4943

Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]

Predicted signal transduction protein containing sensor and EAL domains [Signal...

false

true

false

524

5e-49

191.32

45.61

2,545,269,127,673,396,112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 546 LRDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLERCGLIGNLTRYVLDAAIQEGASWYR 625
COG4943      270 RRRLQRAIERRELCVHYQPIVDLATGKCVGAEALARWPQEDGTVVSPDVFIPLAEESGMIEQITDYVIRNVFRDLGDLLR 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 626 AGLPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAvFSRSLTASTILDALRTAGVGLSLDDFCTGYSS 705
COG4943      350 QHRDLHVSINLSASDLASPRLIDRLNRKLAQYQVRPQQIALELTERT-FADPKKMTPIILRLREAGHEIYIDDFGTGYSN 428

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 706 LSLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVTAEGIETKEQQRLLTDLQCDYAQGFLLAKPMPAA 785
COG4943      429 LHYLQSLPVDALKIDKSFVDTLGTDSASHLIAPHIIEMAKSLGLKIVAEGVETEEQVDWLRKRGVHYGQGWLFSKALPAQ 508

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

1e-46

183.43

66.05

6,363,219,137,501,356,30,534,386,12,546,402,167,713,572,16,732,588,61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 364 LTREAEERIRAAHTDPVTGLGNLLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIVRRC 443
PRK13561     220 LQRHYEEQNENAMRFPVSDLPNKALLMALLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPR 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 444 DVVGRLHGAEYVLLLRELSGPEAAVAQAELAVRSLGGTITAEGLDIALDAHTGVACVpEDGTTLAEVVRRARLAMYKARA 523
PRK13561     300 MVLAQISGYDFAIIANGVKEPWHAITLGQQVLTIINERLPIQRIQLRPSCSIGIAMF-YGDLTAEQLYSRAVSAAFTARR 378

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 524 MDLAVYRYssdLEPPAMAQVQML----RDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLL 599
PRK13561     379 KGKNQIQF---FDPQQMEAAQKRlteeSDILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPDGLIDRI 455

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 600 ERCGLIGNLTRYVLDAAIQEGASWYRAGLPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAVFSRSLT 679
PRK13561     456 ESCGLMVTVGHWVLEESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHA 535

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 680 ASTILDALRTAGVGLSLDDFCTGYSSLSLLRERT---IDEIKIDRSFVSDLGTgrrSTEIVTALIDLAHRCDIIVTAEGI 756
PRK13561     536 AVAILRPLRNAGVRIALDDFGMGYAGLRQLQHMKslpIDVLKIDKMFVDGLPE---DSSMVAAIIMLAQSLNLQMIAEGV 612

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 117928947 757 ETKEQQRLLTDLQCDYAQGFLLAKPMPAALARQLFLD 793
PRK13561     613 ETEAQRDWLAKAGVGVAQGFLFARPLPIEIFEERYLS 649

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

2e-46

182.60

37.72

10,372,685,21,393,710,28,422,738,3,425,742,33,463,775,21,484,801,43,527,845,21,548,868,31,579,900,43,623,943,163

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947  373 RAAHTDPVTGLGNLLMLEKEF----EMSRRSDQPLAIAVIGLDRFAEVNDILGaHPA-DLMLRSVAERLAGIVRRCDVVG 447
PRK09776      686 YSASHDALTGLANRASFEKQLrealQTVNSTHQRHALVFIDLDRFKAVNDSAG-HAAgDALLRELASLMLSMLRSSDVLA 764

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947  448 RLHGAEYVLLLrelsgPEAAVAQAELAVRSLGGTITA-----EGLDIALDAHTGVACVPEDGTTLAEVVRRARLAMYKAR 522
PRK09776      765 RLGGDEFGLLL-----PDCNVESARFIATRIISAINDyrfpwEGRVYRVGASAGITAIDDNNHQASEVMSQADIACYAAK 839

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947  523 AMDLA-VYRYSSDLEPPAMAQVQMLRD--LRTALSENQFVLHYQPKFSLRTGLPVAAEAL-VRWQHPQEGLISPAQFVPL 598
PRK09776      840 NAGRGrVTVYEPQQAAAHSERRELSLAeqWRSMLEENQLMLQAQEIASPRIPEARNLWLIsLRLWDCEGEIIDEGAFRPA 919

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947  599 LERCGLIGNLTRYVLDAAIQEGASwYRAGLPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAVFSRSL 678
PRK09776      920 AEDPALMHALDRWVIHELFQQGAR-AVASKGLSIAIPLSVASLSSATLLPFLLEQLENSPLPPRLLHLEITETALLNHAE 998

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947  679 TASTILDALRTAGVGLSLDDFCTGYSSLSLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVTAEGIET 758
PRK09776      999 AASRLVQKLRLAGCRVVLDDFGRGLSSFNYLKAFMADYLKIDGELCANLQGNLMDEMLVSIINGIAQRLGMKTIAGPVEL 1078

                         410       420
                  ....*....|....*....|....*...
gi 117928947  759 KEQQRLLTDLQCDYAQGFLLAKPMPAAL 786
PRK09776     1079 PLTLDTLSGIGVDLAQGYVIGRPQPLDL 1106

-1

137979

PRK10551

hypothetical protein; Provisional

false

true

false

518

9e-36

147.51

46.14

6,546,265,80,627,345,5,632,352,24,658,376,4,662,382,16,679,398,106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 547 RDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLERCGLIGNLTRYVLDAAIQEGASWYRA 626
PRK10551     266 REILTAIKREQFYVVYQPVVDTQTLRVTGLEVLLRWRHPTAGEIPPDAFINYAEAQKLIVPLTQHLFELIARDAAELQKV 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 627 gLPLSV--AVNLSARNLLDEDLPRFVLDTLARhgLPAD--RLICEITETAVFSRSLtASTILDALRTAGVGLSLDDFCTG 702
PRK10551     346 -LPVGAklGINIAPAHLHSDSFKADVQRLLAS--LPADhfQIVLEITERDMLQEEE-ALKLFAWLHSQGIEIAIDDFGTG 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 703 YSSLSLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAHRCDIIVTAEGIETKEQQRLLTDLQCDYAQGFLLAKPM 782
PRK10551     422 HSALIYLERFTLDYLKIDRGFINAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLREHGVNFLQGYWISRPL 501


                 ...
gi 117928947 783 PAA 785
PRK10551     502 PLD 504

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

9e-35

144.07

57.28

6,372,297,13,385,314,16,402,330,124,526,455,182,708,640,35,746,675,39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 373 RAAHTDPVTGLGN----LLMLEKEFEMSRRSDQpLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIVRRCDVVGR 448
PRK11829     298 RISHRFPVTELPNrslfISLLEKEIASSTRTDH-FHLLVIGIETLQEVSGAMSEAQHQQLLLTIVQRIEQCIDDSDLLAQ 376

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 449 LHGAEYVLLLRELSGPEAAVAQAELAVRSLGGTITAEGLDIALDAHTGVACVPEDGTTLAEVVRRARLAMYKARAMDL-A 527
PRK11829     377 LSKTEFAVLARGTRRSFPAMQLARRIMSQVTQPLFFDEITLRPSASIGITRYQAQQDTAESMMRNASTAMMAAHHEGRnQ 456

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 528 VYRYSSDLEPPAMAQVQMLRDLRTALSENQFVLHYQPKFSLRTGLPVAAEALVRWQHPQEGLISPAQFVPLLERCGLIGN 607
PRK11829     457 IMVFEPHLIEKTHKRLTQENDLLQAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQPDGSYVLPSGFVHFAEEEGMMVP 536

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 608 LTRYVLDAAIQEGASWYRAGLPLSVAVNLSARNLLDEDLPRFVLDTLARHGLPADRLICEITETAVFSRSLTASTILDAL 687
PRK11829     537 LGNWVLEEACRILADWKARGVSLPLSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITETAQIQDLDEALRLLREL 616

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 688 RTAGVGLSLDDFCTGYSSLSL---LRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLahrCDIIVTAEGIETKEQQRL 764
PRK11829     617 QGLGLLIALDDFGIGYSSLRYlnhLKSLPIHMIKLDKSFVKNLPEDDAIARIISCVSDV---LKVRVMAEGVETEEQRQW 693

                        410       420
                 ....*....|....*....|.
gi 117928947 765 LTDLQCDYAQGFLLAKPMPAA 785
PRK11829     694 LLEHGIQCGQGFLFSPPLPRA 714

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

3e-15

79.37

49.83

5,377,132,20,397,154,69,468,223,10,478,235,24,503,259,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 378 DPVTGLGNLLMLEKEFEMSR--RSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIVRRCDVVGRLHGAEYV 455
PRK09894     133 DVLTGLPGRRVLDESFDHQLrnREPLNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRPYETVYRYGGEEFI 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928947 456 LLLRELSGPEAavAQAELAVRSL--GGTITAEGLDIALDAHTGVACVPEdGTTLAEVVRRARLAMYKAR 522
PRK09894     213 IILKAATDEEA--CRAGERIRQLiaNQAITHSEGRINITATFGVTRAFP-EEPLDEVIGRADRAMYEGK 278

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

4e-15

78.81

38.39

6,362,257,23,385,284,36,422,320,3,425,324,37,463,361,9,472,373,51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 363 TLTREAEERIRAAHTDPVTGLGN----LLMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGaHPA-DLMLRSVAERLA 437
COG3706      258 QLRESLERLQELALVDGLTGLFNrryfDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYG-HDVgDEVLRQVARRLR 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 438 GIVRRCDVVGRLHGAEYVLLLRELSgPEAAVAQAE---LAVRSLGGTITAEGLDIALDAHTGVACVPEDGTTLAEVVRRA 514
COG3706      337 QTVRGLDLVARYGGEEFAVVLPDTD-LEAAIAIAErirQKINELPFVHELSREPLEVTISIGVAEGKPGEDSIEELLKRA 415


                 ....*....
gi 117928947 515 RLAMYKARA 523
COG3706      416 DKALYKAKA 424

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

7e-12

68.02

35.01

4,368,285,25,393,314,65,463,379,32,495,418,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 369 EERIRAAHTDPVTGLGNLLMLEKEF----EMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLAGIVRRCD 444
PRK09581     286 EQSIEMAVTDGLTGLHNRRYFDMHLkqliERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTD 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 445 VVGRLHGAEYVLLLrelsgPEAAVAQAELAVRSLGGTITAEGLDIALDAHT-------GVACVPEDGTTLAEVVRRARLA 517
PRK09581     366 LIARYGGEEFVVVM-----PDTDIEVAIAVAERIRRKIAEEPFAISDGKERlnvtvsiGVAELRPSGESIEALIKRADKA 440


                 ....*
gi 117928947 518 MYKAR 522
PRK09581     441 LYEAK 445

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

5e-11

65.29

66.36

17,368,214,3,371,223,3,374,227,14,388,245,54,442,300,4,446,305,27,474,332,28,503,360,14,520,374,6,526,386,11,538,397,28,567,425,64,633,489,21,654,513,6,662,519,8,671,527,9,680,537,103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 369 EER------IRA-AHTDPVTGLGNLLM----LEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAERLA 437
PRK11059     215 KERsrfdtfIRSnAFLDAKTGLGNRLFfdnqLDTLLEDQEKVGAHGVVMLIRLPDFDLLQEELGESQVDELLFELINLLS 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 438 GIVRR-CDVV-GRLHGAEYVLLLRELSGPEAAVAQAELaVRSLGGTITAEGLDIALDAHTGVACVPEdGTTLAEVVRRAR 515
PRK11059     295 TFVQRyPGALlARYSRSDFAVLLPHRSLKEADSLASQL-LKAVDSLPPPKMLDRDDFLHIGIAAYRS-GQSTEQVMEEAE 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 516 LAmykARAMDL------AVYRYSSDLEPpAMAQVQMLRDLRTALSENQFVLHYQPKFsLRTGLPVAAEALVRWQHPQEGL 589
PRK11059     373 MA---LRSAQLqggnswFMYDKAQDPEK-GRGSVRWRTLLEQALVRGGPRLYQQPVV-TRDGQVHHRELMCRIRDGQGNE 447

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 590 ISPAQFVPLLERCGLIGNLTRYVLDAAIQEGASWYRAGLPLSvaVNLSARNLLDEDLPRFVLDTL---ARHGLPadRLIC 666
PRK11059     448 VRAAEFMPMVLQCGLSEQYDRQVIERVLPLLSYWPEESQNLS--INLSVDSLLSRAFQRWLRDTLlqcERSQRK--RLIF 523

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 667 EITEtAVFSRSLTA-STILDALRTAGVGLSLDDFCTGYSSLSLLRERTIDEIKIDRSFVSDLGTGRRSTEIVTALIDLAH 745
PRK11059     524 ELAE-ADVVQHIDRlRPVLRMLRGLGCRLAVDQAGLTVVSTSYIKELNVELIKLHPSLVRNIHQRTENQLFVRSLVGACA 602

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 117928947 746 RCDIIVTAEGIETKEQQRLLTDLQCDYAQGFLLAKPMP 783
PRK11059     603 GTETQVFAEGVESREEWQTLQILGVSGGQGDFFASPQP 640

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

7e-06

47.97

44.74

4,362,194,11,373,208,13,386,225,90,477,315,45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 363 TLTREAEERIR---AAHTDPVTGLGNL----LMLEKEFEMSRRSDQPLAIAVIGLDRFAEVNDILGAHPADLMLRSVAER 435
PRK10245     195 TATKLAEHKRRlqvMSTRDGMTGVYNRrhweTMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQ 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 436 LAGIVRRCDVVGRLHGAEYVLLLRELSGPEAAVAQAELAVRsLGGTITAEGLDIALDAHTGVACVPEDGTTLAEVVRRAR 515
PRK10245     275 LQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEG-LNTLRLPNAPQVTLRISVGVAPLNPQMSHYREWLKSAD 353


                 ....*..
gi 117928947 516 LAMYKAR 522
PRK10245     354 LALYKAK 360

-1

33240

COG3434

Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]

Predicted signal transduction protein containing EAL and modified HD-GYP domains [...

false

true

false

407

4e-04

42.19

27.76

6,658,80,23,683,103,17,702,120,9,711,131,15,733,146,14,748,160,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928947 659 LPADRLICEITETAVFSRSLTAStiLDALRTAGVGLSLDDFCtgYSSLSLLRE--RTIDEIKIDRSFVSDlgtgrrsTEI 736
COG3434       81 LPPDKVVIEILEDCPPTEKLLSA--IKELKQKGYLLALDDFI--FSNVSEWKPllPLSDIVKIDFKRVTF-------DKA 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 117928947 737 VTALIDLAHRCdIIVTAEGIETKEQQRLLTDLQCDYAQGFLLAKP 781
COG3434      150 RLFDRDLGYIN-KKFLAEKVETEEEFEQAKKAGFDLFQGYFFSKP 193

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF