NCBI Conserved Domain Search

NewSearch

CDD Home

Conserved domains on [gi\|117928688\|ref\|YP_873239.1\|]
diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Acidothermus cellulolyticus 11B]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH

of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

30163

cd01948

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

true

false

true

240

2e-81

299.05

99.58

4,660,0,83,746,83,12,758,96,88,849,184,55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 661 TDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGARWQRY 740
cd01948        1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 741 AQPggvFHVAVNVSGRQL-HPRLPDIVRTALTETGMPPGALVIEVTENILVKRSEEAIAVLRQLKSFGVRVAIDDFGTGY 819
cd01948       81 GPD---LRLSVNLSARQLrDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 820 SSLSYLARFPVDVLKIDKSFVEQITDRnsgTEGTELVRTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQGYLFSR 899
cd01948      158 SSLSYLKRLPVDYLKIDRSFVRDIETD---PEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSR 234


                 ....*
gi 117928688 900 PLPAE 904
cd01948      235 PLPAE 239

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

1e-49

193.96

99.36

2,486,1,92,579,93,64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 487 DPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRRCVRPSDTVARLGGDE 566
cd01949        2 DPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGDE 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117928688 567 FAILVVGPQAEAhGVDVAERVQRALAEPFLLSGREVTLAASIGIAVTDDGTETVDQLLRNADLAMYRAKSSRKGTYV 643
cd01949       82 FAILLPGTDLEE-AEELAERLRKAIEEPFFIDGEEIRVTASIGIAEYPEDGEDLEELLRRADKALYQAKRSGRNRVV 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

29035

cd00130

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

true

103

2e-06

50.66

100.00

3,367,0,63,431,63,28,459,92,11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 368 SSDIITIVDPSGVIRYQTPSATRVLGYDPNAMVGQRFVSLVAPADVHRLEAILLDAVLRPRSThTIEFAMRHAAGHWRET 447
cd00130        1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPV-TLEVRLRRKDGSVIWV 79

                         90       100
                 ....*....|....*....|....
gi 117928688 448 ETVITSLVDDHD-IRGLVLNTRDV 470
cd00130       80 LVSLTPIRDEGGeVIGLLGVVRDI 103

cl02459

141436

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

128367

smart00052

EAL

Putative diguanylate phosphodiesterase

false

241

9e-88

320.31

99.59

4,659,0,84,746,84,13,759,98,87,849,185,55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 660 ETDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGARWQR 739
smart00052     1 ERELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 740 YAQPggvFHVAVNVSGRQLH-PRLPDIVRTALTETGMPPGALVIEVTENILVKRSEEAIAVLRQLKSFGVRVAIDDFGTG 818
smart00052    81 QGPP---LRISINLSARQLIsPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 819 YSSLSYLARFPVDVLKIDKSFVEQITDRnsgTEGTELVRTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQGYLFS 898
smart00052   158 YSSLSYLKRLPVDLLKIDKSFVRDLQTD---PEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFS 234


                 ....*.
gi 117928688 899 RPLPAE 904
smart00052   235 RPLPLD 240

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32382

COG2200

Rtn

c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]

false

256

1e-75

279.90

97.27

4,655,0,85,744,85,15,759,101,80,842,181,68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 656 RVQTETDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGA 735
COG2200        1 RLQLERDLRQALENGEFSLYYQPIVDLATGRIVGYEALLRWRHPDGGLISPGEFIPLAEETGLIVELGRWVLEEACRQLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 736 RWQRYaqpgGVFHVAVNVSGRQLH-PRLPDIVRTALTETGMPPGALVIEVTENILVKRSEEAIAVLRQLKSFGVRVAIDD 814
COG2200       81 TWPRA----GPLRLAVNLSPVQLRsPGLVDLLLRLLARLGLPPHRLVLEITESALIDDLDTALALLRQLRELGVRIALDD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 815 FGTGYSSLSYLARFPVDVLKIDKSFveqITDRNSGTEGTELVRTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQG 894
COG2200      157 FGTGYSSLSYLKRLPPDILKIDRSF---VRDLETDARDQAIVRAIVALAHKLGLTVVAEGVETEEQLDLLRELGCDYLQG 233

                        250
                 ....*....|....*.
gi 117928688 895 YLFSRPLPAEGIDTLF 910
COG2200      234 YLFSRPLPADALDALL 249

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

109613

pfam00563

EAL

EAL domain

false

236

5e-62

234.62

100.00

5,659,0,99,758,100,9,768,109,23,792,132,57,853,189,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 660 ETDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGARWQR 739
pfam00563      1 EQALREALENGEFSLYFQPIVDLRTGKVLGYEALLRWQHPDGGLIPPDEFLPLAERLGLIAELDRWVLEKALAQLAEWRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 740 YAQPGGVFHVAVNVSGRQL-HPRLPDIVRtALTETGMPPGALVIEVTENILVKrSEEAIAVLRQLKSFGVRVAIDDFGTG 818
pfam00563     81 NALLPPDLPLSVNLSPASLlDPSFLEALL-ALKQGGLPPSRLVLEITESDLDE-DLRLLEALARLRSLGFRLALDDFGTG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 819 YSSLSYLARFPVDVLKIDKSFVEQITDRNSGtegtELVRTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQGYLFS 898
pfam00563    159 YSSLSYLSRLPPDYIKIDRSFIKDLSDPESR----ALLRALIALARELGIKVVAEGVETEEQLELLKELGIDYVQGYLFS 234


                 ..
gi 117928688 899 RP 900
pfam00563    235 KP 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

2e-45

179.37

98.77

2,481,0,96,578,96,65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 482 RQAFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRRCVRPSDTVAR 561
smart00267     1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 562 LGGDEFAILVVGPQAEaHGVDVAERVQRALAEPFLLSGREVTLAASIGIAVTDDGTETVDQLLRNADLAMYRAKSSRKGT 641
smart00267    81 LGGDEFALLLPETSLE-EAIALAERILQQLREPIIIHGIPLYLTISIGVAAYPNPGEDAEDLLKRADTALYQAKKAGRNQ 159


                 ..
gi 117928688 642 YV 643
smart00267   160 VA 161

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

110022

pfam00990

GGDEF

GGDEF domain

false

160

4e-44

175.51

100.00

3,483,0,94,578,94,14,592,111,49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 484 AFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRRCVRPSDTVARLG 563
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 564 GDEFAILVVGPQAEaHGVDVAERVQRALA---EPFLLSGREVTLAASIGIAVTDDGTETVDQLLRNADLAMYRAKSSRKG 640
pfam00990     81 GDEFAILLPDTSLE-GAQELAERIRRLLAalkIPHTLSGLPLYVTISIGIAAYPNDGEDAEDLLKRADQALYQAKNQGRN 159


                 .
gi 117928688 641 T 641
pfam00990    160 R 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

4e-42

168.76

99.45

3,465,1,112,578,113,34,612,148,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 466 NTRDVSERKELERQLTRQAFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLV 545
COG2199        2 LLRLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 546 ADRLRRCVRPSDTVARLGGDEFAILVVGPQAEaHGVDVAERVQRALAEPFLLSGREVTLAASIGIAV-TDDGTETVDQLL 624
COG2199       82 ARRLRSNLREGDLVARLGGDEFAVLLPGTSLE-EAARLAERIRAALEEPFFLGGEELRVTVSIGVALyPEDGSDDAELLL 160

                        170       180
                 ....*....|....*....|.
gi 117928688 625 RNADLAMYRAKSSRKGTYVRF 645
COG2199      161 RRADLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

4e-32

135.54

98.18

5,482,0,89,573,89,7,580,97,11,591,109,10,601,120,42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 483 QAFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRRCVRPSDTVARL 562
TIGR00254      1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 563 GGDEFAILVvgPQAEAHG-VDVAERVQRAL-AEPFLLSGRE-VTLAASIGIAVTDDGTETVDQLLRNADLAMYRAKSSRK 639
TIGR00254     81 GGEEFVVIL--PGTPLEDaLSKAERLRDAInSKPIEVAGSEtLTVTVSIGVACYPGHGLTLEELLKRADEALYQAKKAGR 158


                 ....
gi 117928688 640 GTYV 643
TIGR00254    159 NRVV 162

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

138661

PRK11596

EAL domain-containing protein; Provisional

false

255

4e-08

55.49

63.92

10,734,88,13,748,101,10,758,116,4,767,120,5,773,125,3,778,128,16,798,144,9,808,153,32,842,185,6,849,191,60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 735 ARWQRYAQPGGVFhVAVNVSGRQL-----HPRLpdivrTALTEtGMPpgALVIEVTENILVKRSEeaiaVLRQLKSFGvR 809
PRK11596      89 AQKADFFVRHGLL-ASVNIDGPTLialrqQPKI-----LRLIE-RLP--WLRFELVEHIRLPKDS----TFASMCEFG-P 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 810 VAIDDFGTGYSSLSYLARFPVDVLKIDKSFVeqITDRNSgTEGTELVRTILHLGRALRLGTVAEGIETREQYAALLAMSC 889
PRK11596     155 LWLDDFGTGMANFSALSEVRYDYIKVARELF--VMLRQS-PEGRTLFSQLLHLMNRYCRGVIVEGVETPEEWRDVQRSPA 231

                        170       180
                 ....*....|....*....|
gi 117928688 890 DYGQGYLFSRPLPAEGIDTL 909
PRK11596     232 FAAQGYFLSRPAPFDTLETL 251

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

128402

smart00091

PAS

PAS domain

false

9e-06

48.16

97.01

1,359,1,65

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117928688 360 WFRSLVQNSSDIITIVDPSGVIRYQTPSATRVLGYDPNAMVGQRFVSLVAPADVHRLEAILLDAV 424
smart00091     2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDREEVQEALQRLL 66

cl02459

141436

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

4e-98

354.81

64.40

9,468,221,39,509,260,58,569,318,13,582,332,100,683,432,56,742,488,19,761,508,82,844,590,8,854,598,50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 469 DVSERKELERQLTRQAFSDPLTGLANRALFANRVEHALSerSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADR 548
PRK10060     222 DITEERRAQERLRILANTDSITGLPNRNAIQELIDHAIA--QADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLA 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 549 LRRCVRPSDTVARLGGDEFaiLVVGPQAEAHGVD-VAERVQRALAEPFLLSGREVTLAASIGIAVTDDGTETVDQLLRNA 627
PRK10060     300 ILSCLEEDQTLARLGGDEF--LVLASHTSQAALEaMASRILTRLRLPFRIGLIEVYTGCSIGIALSPEHGDDSESLIRSA 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 628 DLAMYRAKSSRKGTYVRFRTEMHDALLARVQTETDLRHALSRRELVLHYQPTVNLrTGQVVGVEALIRWYHPTRGLIQPM 707
PRK10060     378 DTAMYTAKEGGRGQFCVFSPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKITW-RGEVRSLEALVRWQSPERGLIPPL 456

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 708 DFIGMAEETGLVESIGAWAIRECCRQGARWQRyaqPGGVFHVAVNVSGRQLHPR-LPDIVRTALTETGMPPGALVIEVTE 786
PRK10060     457 EFISYAEESGLIVPLGRWVILDVVRQAAKWRD---KGINLRVAVNVSARQLADQtIFTALKQVLQELNFEYCPIDVELTE 533

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 787 NILVKRSEEAIAVLRQLKSFGVRVAIDDFGTGYSSLSYLARFPVDVLKIDKSFVEQItDRNSGTEGteLVRTILHLGRAL 866
PRK10060     534 SCLIENEELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDI-HKQPVSQS--LVRAIVAVAQAL 610

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 117928688 867 RLGTVAEGIETREQYAALLAMSCDYGQGYLFSRPLPAE 904
PRK10060     611 NLQVIAEGVETAKEDAFLTKNGVNERQGFLFAKPMPAV 648

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

7e-84

307.34

64.86

4,466,210,276,748,486,12,760,499,86,849,585,55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 467 TRDVSERKELERQLTRQAFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVA 546
COG5001      211 TQRAEETRRLSDENDRLANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVG 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 547 DRLRRCVRPSDTVARLGGDEFAILVVGPQAEAHGVDVAERVQRALAEPFLLSGREVTLAASIGIAVTDDGTETVDQLLRN 626
COG5001      291 RRLKAFDGAPILAARLGGDEFALIIPALEDDALRVAGARALCESLQAPYDLRGVRVQVGASIGIAPFPSGADTSEQLFER 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 627 ADLAMYRAKSSRKGTYVRFRTEMHDALLARVQTETDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQP 706
COG5001      371 ADYALYHAKQNGKGAAVLFDARHEAAIRDMAVVEQALRSADLEQELSVHFQPIVDIVSGKTIALEALARWHSPEIGPVPP 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 707 MDFIGMAEETGLVESIGAWAIRECCRQGARWQRYAQpggvfhVAVNVSGRQLHP-RLPDIVRTALTETGMPPGALVIEVT 785
COG5001      451 DVFIGIAERSGQIVELTRLLLAKALREARAWPMDVR------VSINLSARDLASmENVRRLLAIVSESCIAPHRLDFEIT 524

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 786 ENILVKRSEEAIAVLRQLKSFGVRVAIDDFGTGYSSLSYLARFPVDVLKIDKSFVEQITDRnsgTEGTELVRTILHLGRA 865
COG5001      525 ETAIVCDFDQARDALAALHELGVRTALDDFGTGYSSLSHLRALPLDKIKIDRSFVSDLEEN---PTSEDIVRTVLQLGRN 601

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 117928688 866 LRLGTVAEGIETREQYAALLAMSCDYGQGYLFSRPLPAE 904
COG5001      602 LRMECVVEGVETEAQRDRVAALGATVMQGYHYARPMPAE 640

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

2e-82

302.91

53.07

9,471,363,41,516,404,51,569,455,13,582,469,28,612,497,127,741,624,18,759,643,83,842,727,8,854,735,52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 472 ERKELERQLTRQAFSDPLTGLANRALFANRVEHALSERSRQpgevAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRR 551
PRK11359     364 EQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSP----VVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFRE 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 552 CVRPSDTVARLGGDEFaiLVVGPQAEAHGVD-VAERVQRALAEPFLLSGREVTLAASIGIavTDDGTETVDQLLRNADLA 630
PRK11359     440 KLKPDQYLCRIEGTQF--VLVSLENDVSNITqIADELRNVVSKPIMIDDKPFPLTLSIGI--SYDVGKNRDYLLSTAHNA 515

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 631 MYRAKSSRKGTYVRFRTEMHDALLARVQTETDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFI 710
PRK11359     516 MDYIRKNGGNGWQFFSPAMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFI 595

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 711 GMAEETGLVESIGAWAIRECCRQGARWQRyaQPGGVFHVAVNVSGRQLH-PRLPDIVRTALTETGMPPGALVIEVTENIL 789
PRK11359     596 PLAEEIGEIENIGRWVIAEACRQLAEWRS--QNIHIPALSVNLSALHFRsNQLPNQVSDAMHAWGIDGHQLTVEITESMM 673

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 790 VKRSEEAIAVLRQLKSFGVRVAIDDFGTGYSSLSYLARFPVDVLKIDKSFVEQ-ITDRNSGTegteLVRTILHLGRALRL 868
PRK11359     674 MEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRcLTEKRILA----LLEAITSIGQSLNL 749

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 117928688 869 GTVAEGIETREQYAALLAMSCDYGQGYLFSRPLPAEGI 906
PRK11359     750 TVVAEGVETKEQFEMLRKIHCRVIQGYFFSRPLPAEEI 787

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

8e-72

267.40

63.90

10,478,225,29,511,254,11,522,269,15,540,284,5,546,289,68,615,357,123,741,480,17,758,498,70,828,571,20,854,591,50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 479 QLTRQAFSDPLTGLANRALFANRVEHALSersrQPGEVAVLFLD----LDGFKGVNDAQGHAVgdhLLTLVaDRLRRCVR 554
PRK13561     226 EQNENAMRFPVSDLPNKALLMALLEQVVA----RKQTTALMIITcetlRDTAGVLKEAQREIL---LLTLV-EKLKSVLS 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 555 PSDTVARLGGDEFAILVVGPQAEAHGVDVAERVQRALAEPFLLSGREVTLAASIGIAVTDdGTETVDQLLRNADLAMYRA 634
PRK13561     298 PRMVLAQISGYDFAIIANGVKEPWHAITLGQQVLTIINERLPIQRIQLRPSCSIGIAMFY-GDLTAEQLYSRAVSAAFTA 376

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 635 KSSRKGTYVRFRTEMHDALLARVQTETDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFIGMAE 714
PRK13561     377 RRKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPDGLIDRIE 456

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 715 ETGLVESIGAWAIRECCRQGARWQryaQPGGVFHVAVNVSGRQL-HPRLPDIVRTALTETGMPPGALVIEVTENILVKRS 793
PRK13561     457 SCGLMVTVGHWVLEESCRLLAAWQ---ERGIMLPLSVNLSALQLmHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDP 533

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 794 EEAIAVLRQLKSFGVRVAIDDFGTGYSSLSYLARF---PVDVLKIDKSFVEQITDRNSgtegteLVRTILHLGRALRLGT 870
PRK13561     534 HAAVAILRPLRNAGVRIALDDFGMGYAGLRQLQHMkslPIDVLKIDKMFVDGLPEDSS------MVAAIIMLAQSLNLQM 607

                        410       420       430
                 ....*....|....*....|....*....|....
gi 117928688 871 VAEGIETREQYAALLAMSCDYGQGYLFSRPLPAE 904
PRK13561     608 IAEGVETEAQRDWLAKAGVGVAQGFLFARPLPIE 641

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

2e-63

239.61

39.70

11,456,660,117,573,780,5,582,785,11,593,797,69,662,868,31,693,900,43,738,943,6,746,949,12,758,962,87,846,1049,5,853,1054,49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688  457 DHDIRGLVLNTRDVSERKELERQLTRQAFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHA 536
PRK09776      661 DGENIGSVLVFQDVTESRAMLRQLSYSASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHA 740

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688  537 VGDHLLTLVADRLRRCVRPSDTVARLGGDEFAILVVG---PQAEAhgvdVAERVQRALAE-PFLLSGREVTLAASIGIAV 612
PRK09776      741 AGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDcnvESARF----IATRIISAINDyRFPWEGRVYRVGASAGITA 816

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688  613 TDDGTETVDQLLRNADLAMYRAKSSRKGTYVRFRTEMHDALLARVQTETD--LRHALSRRELVLHYQPTVNLRTGQVVGV 690
PRK09776      817 IDDNNHQASEVMSQADIACYAAKNAGRGRVTVYEPQQAAAHSERRELSLAeqWRSMLEENQLMLQAQEIASPRIPEARNL 896

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688  691 EAL-IRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGARwqRYAQPGgvFHVAVNVSGRQL-HPRLPDIVRT 768
PRK09776      897 WLIsLRLWDCEGEIIDEGAFRPAAEDPALMHALDRWVIHELFQQGAR--AVASKG--LSIAIPLSVASLsSATLLPFLLE 972

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688  769 ALTETGMPPGALVIEVTENILVKRSEEAIAVLRQLKSFGVRVAIDDFGTGYSSLSYLARFPVDVLKIDKSFVEQITDrNS 848
PRK09776      973 QLENSPLPPRLLHLEITETALLNHAEAASRLVQKLRLAGCRVVLDDFGRGLSSFNYLKAFMADYLKIDGELCANLQG-NL 1051

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 117928688  849 GTEgtELVRTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQGYLFSRPLP 902
PRK09776     1052 MDE--MLVSIINGIAQRLGMKTIAGPVELPLTLDTLSGIGVDLAQGYVIGRPQP 1103

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

3e-59

225.73

71.57

12,401,191,50,457,241,24,481,285,6,487,303,25,513,328,85,600,413,4,604,419,134,741,553,20,761,575,4,766,579,58,824,640,24,854,664,48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 402 QRFVSLVAPADVHRLEAILLDAVLRPRSTHTIEFAMRHAAGHWRETETVItslvddHDIRGLVLNTRDVSERKELERQLT 481
PRK11829     192 QPLAHLVLRADSFRMYQFILSALSAMLSTYLLLALVLSVSIAWCINRLII------HPLRAMAKELEDIGDHGVLHHQLT 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 482 --------------------RQAFSD------------PLTGLANRALFANRVEHALSERSRQpGEVAVLFLDLDGFKGV 529
PRK11829     266 lpahhqddelgvlvrnynrnQQLLADayadmgrishrfPVTELPNRSLFISLLEKEIASSTRT-DHFHLLVIGIETLQEV 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 530 NDAQGHAVGDHLLTLVADRLRRCVRPSDTVARLGGDEFAILVVGPQAEAHGVDVAERVQRALAEPFLLSgrEVTL--AAS 607
PRK11829     345 SGAMSEAQHQQLLLTIVQRIEQCIDDSDLLAQLSKTEFAVLARGTRRSFPAMQLARRIMSQVTQPLFFD--EITLrpSAS 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 608 IGIAVTDDGTETVDQLLRNADLAMYRAKSSRKGTYVRFRTEMHDALLARVQTETDLRHALSRRELVLHYQPTVNLRTGQV 687
PRK11829     423 IGITRYQAQQDTAESMMRNASTAMMAAHHEGRNQIMVFEPHLIEKTHKRLTQENDLLQAIENHDFTLFLQPQWDMKRQQV 502

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 688 VGVEALIRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGARWQryaQPGGVFHVAVNVSGRQLHPR--LPDI 765
PRK11829     503 IGAEALLRWCQPDGSYVLPSGFVHFAEEEGMMVPLGNWVLEEACRILADWK---ARGVSLPLSVNISGLQVQNKqfLPHL 579

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 766 vRTALTETGMPPGALVIEVTENILVKRSEEAIAVLRQLKSFGVRVAIDDFGTGYSSLSY---LARFPVDVLKIDKSFVEQ 842
PRK11829     580 -KTLISHYHIDPQQLLLEITETAQIQDLDEALRLLRELQGLGLLIALDDFGIGYSSLRYlnhLKSLPIHMIKLDKSFVKN 658

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 843 ITDRNSgtegteLVRTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQGYLFSRPLP 902
PRK11829     659 LPEDDA------IARIISCVSDVLKVRVMAEGVETEEQRQWLLEHGIQCGQGFLFSPPLP 712

-1

34551

COG4943

Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]

Predicted signal transduction protein containing sensor and EAL domains [Signal...

false

true

false

524

5e-52

201.34

45.04

7,662,272,77,740,349,4,746,353,13,759,367,28,787,397,16,806,413,48,857,461,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 663 LRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGARWQRyAQ 742
COG4943      273 LQRAIERRELCVHYQPIVDLATGKCVGAEALARWPQEDGTVVSPDVFIPLAEESGMIEQITDYVIRNVFRDLGDLLR-QH 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 743 PGgvFHVAVNVSGRQLH-PRLPDIVRTALTETGMPPGALVIEVTEN--ILVKRSEEAIAVLRQLksfGVRVAIDDFGTGY 819
COG4943      352 RD--LHVSINLSASDLAsPRLIDRLNRKLAQYQVRPQQIALELTERtfADPKKMTPIILRLREA---GHEIYIDDFGTGY 426

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 820 SSLSYLARFPVDVLKIDKSFVEQITDRNSGTEGTElvrTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQGYLFSR 899
COG4943      427 SNLHYLQSLPVDALKIDKSFVDTLGTDSASHLIAP---HIIEMAKSLGLKIVAEGVETEEQVDWLRKRGVHYGQGWLFSK 503


                 ....*
gi 117928688 900 PLPAE 904
COG4943      504 ALPAQ 508

-1

137979

PRK10551

hypothetical protein; Provisional

false

true

false

518

4e-41

165.61

47.68

8,652,257,95,749,352,10,759,363,13,774,376,4,778,382,14,793,396,50,851,446,6,857,457,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 653 LLARVQTETDLRHALSRRELVLHYQPTVNLRTGQVVGVEALIRWYHPTRGLIQPMDFIGMAEETGLVESIGAWAIRECCR 732
PRK10551     258 LSLRMRPGREILTAIKREQFYVVYQPVVDTQTLRVTGLEVLLRWRHPTAGEIPPDAFINYAEAQKLIVPLTQHLFELIAR 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 733 QGARWQRYAQPGGVFhvAVNVSGRQLH-PRLPDIVRTALTEtgMPPG--ALVIEVTENILVKRsEEAIAVLRQLKSFGVR 809
PRK10551     338 DAAELQKVLPVGAKL--GINIAPAHLHsDSFKADVQRLLAS--LPADhfQIVLEITERDMLQE-EEALKLFAWLHSQGIE 412

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 810 VAIDDFGTGYSSLSYLARFPVDVLKIDKSFVEQItdrnsgteGTELVR-----TILHLGRALRLGTVAEGIETREQYAAL 884
PRK10551     413 IAIDDFGTGHSALIYLERFTLDYLKIDRGFINAI--------GTETVTspvldAVLTLAKRLNMLTVAEGVETPEQARWL 484

                        250       260
                 ....*....|....*....|
gi 117928688 885 LAMSCDYGQGYLFSRPLPAE 904
PRK10551     485 REHGVNFLQGYWISRPLPLD 504

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

2e-32

136.20

44.37

5,462,241,19,481,267,98,580,365,13,593,379,12,605,393,41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 463 LVLNTRDVSERKELERQLT-------RQAFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGH 535
COG3706      242 LRARLRRQLRRKRYERQLReslerlqELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGH 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 536 AVGDHLLTLVADRLRRCVRPSDTVARLGGDEFAILVVGPQAEAHgVDVAERVQRALAE-PFLLSGREVTLA--ASIGIAV 612
COG3706      322 DVGDEVLRQVARRLRQTVRGLDLVARYGGEEFAVVLPDTDLEAA-IAIAERIRQKINElPFVHELSREPLEvtISIGVAE 400

                        170       180       190
                 ....*....|....*....|....*....|....
gi 117928688 613 TDDGTETVDQLLRNADLAMYRAKSSRKGTYVRFR 646
COG3706      401 GKPGEDSIEELLKRADKALYKAKASGRNRVVVKR 434

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

5e-30

128.50

36.32

8,472,281,9,482,290,20,503,310,12,515,323,52,569,375,10,579,386,13,592,400,7,599,409,38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 473 RKELERQLTrQAFSDPLTGLANRALFANRVeHALSERSRQPGE-VAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRR 551
PRK09581     282 RQNLEQSIE-MAVTDGLTGLHNRRYFDMHL-KQLIERANERGKpLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRK 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 552 CVRPSDTVARLGGDEFaiLVVGPQAEAH-GVDVAERVQRALA-EPFLLSG--REVTLAASIGIAVTDDGTETVDQLLRNA 627
PRK09581     360 NIRGTDLIARYGGEEF--VVVMPDTDIEvAIAVAERIRRKIAeEPFAISDgkERLNVTVSIGVAELRPSGESIEALIKRA 437

                        170
                 ....*....|
gi 117928688 628 DLAMYRAKSS 637
PRK09581     438 DKALYEAKNT 447

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

2e-26

116.91

66.51

20,472,213,6,478,221,4,482,226,72,554,300,17,573,317,2,575,322,3,580,325,10,590,338,8,599,346,5,606,351,10,617,361,36,654,397,2,656,401,25,682,426,55,742,481,16,758,498,21,779,520,67,849,587,10,861,597,9,870,608,32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 473 RKELER--QLTR-QAFSDPLTGLANRALFANRVEHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRL 549
PRK11059     214 RKERSRfdTFIRsNAFLDAKTGLGNRLFFDNQLDTLLEDQEKVGAHGVVMLIRLPDFDLLQEELGESQVDELLFELINLL 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 550 RRCVR--PSDTVARLGGDEFAILVvgPQ---AEAhgVDVAERVQRA---LAEPFLLSgREVTLaaSIGIAVTDDGtETVD 621
PRK11059     294 STFVQryPGALLARYSRSDFAVLL--PHrslKEA--DSLASQLLKAvdsLPPPKMLD-RDDFL--HIGIAAYRSG-QSTE 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 622 QLLRNADLAMYRAKSSRKGTYVRFRTEMHDALlAR--VQTETDLRHALSRRELVLHYQPTVNlRTGQVVGVEALIRWYHP 699
PRK11059     366 QVMEEAEMALRSAQLQGGNSWFMYDKAQDPEK-GRgsVRWRTLLEQALVRGGPRLYQQPVVT-RDGQVHHRELMCRIRDG 443

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 700 TRGLIQPMDFIGMAEETGLVESIGAWAIRECCRQGARWqryaqPGGVFHVAVNVSGRQL-HPRLPDIVRTALTETGMPPG 778
PRK11059     444 QGNEVRAAEFMPMVLQCGLSEQYDRQVIERVLPLLSYW-----PEESQNLSINLSVDSLlSRAFQRWLRDTLLQCERSQR 518

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 779 A-LVIEVTENILVKRSEEAIAVLRQLKSFGVRVAIDDFGTGYSSLSYLARFPVDVLKIDKSFVEQITDRnsgTEGTELVR 857
PRK11059     519 KrLIFELAEADVVQHIDRLRPVLRMLRGLGCRLAVDQAGLTVVSTSYIKELNVELIKLHPSLVRNIHQR---TENQLFVR 595

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 117928688 858 TIlhLGRALRLGT--VAEGIETREQYAALLAMSCDYGQGYLFSRPLP 902
PRK11059     596 SL--VGACAGTETqvFAEGVESREEWQTLQILGVSGGQGDFFASPQP 640

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

1e-24

110.57

54.61

8,475,120,11,486,132,27,515,159,56,573,215,3,576,221,4,582,225,11,593,237,23,617,260,20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 476 LERQLTRQAFS-DPLTGLANRALFANRVEHALSERSRQPgeVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRRCVR 554
PRK09894     121 YKIYLLTIRSNmDVLTGLPGRRVLDESFDHQLRNREPLN--LYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTR 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 555 PSDTVARLGGDEFAILVvgPQA---EAHGvdVAERVQRALAE-PFLLSGREVTLAASIGIAVTDDGtETVDQLLRNADLA 630
PRK09894     199 PYETVYRYGGEEFIIIL--KAAtdeEACR--AGERIRQLIANqAITHSEGRINITATFGVTRAFPE-EPLDEVIGRADRA 273


                 ....*..
gi 117928688 631 MYRAKSS 637
PRK09894     274 MYEGKQA 280

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

1e-22

103.95

39.07

4,478,242,24,503,266,92,595,359,22,618,381,20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 479 QLTRQAFSDPLTGLANRALFANRVeHALSERSRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLRRCVRPSDT 558
PRK09966     243 QLLRTALHDPLTGLANRAAFRSGI-NTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHK 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 559 VARLGGDEFAILVVGPQAEAHGVDVAERVQRALAEPF-LLSGREVTLAASIGIAVTDDGTeTVDQLLRNADLAMYRAKSS 637
PRK09966     322 AYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFdLHNGHQTTMTLSIGYAMTIEHA-SAEKLQELADHNMYQAKHQ 400


                 .
gi 117928688 638 R 638
PRK09966     401 R 401

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

2e-17

86.87

45.55

5,474,200,21,495,225,11,510,236,68,579,304,59,643,363,6

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 475 ELERQLTRQAFSDPLTGLANR----ALFANRVEHALsersRQPGEVAVLFLDLDGFKGVNDAQGHAVGDHLLTLVADRLR 550
PRK10245     201 EHKRRLQVMSTRDGMTGVYNRrhweTMLRNEFDNCR----RHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQ 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 551 RCVRPSDTVARLGGDEFAILVVGPQAEAhGVDVAERVQRALAEPFLLSGREVTLAASIGIAVTDDGTETVDQLLRNADLA 630
PRK10245     277 ITLRGSDVIGRFGGDEFAVIMSGTPAES-AITAMLRVHEGLNTLRLPNAPQVTLRISVGVAPLNPQMSHYREWLKSADLA 355

                        170
                 ....*....|....*....
gi 117928688 631 MYRAKSSRkgtyvRFRTEM 649
PRK10245     356 LYKAKKAG-----RNRTEV 369

-1

129332

TIGR00229

sensory_box

PAS domain S-box

true

false

124

3e-13

72.70

98.39

3,358,2,52,410,56,17,429,73,51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 359 KWFRSLVQNSSDIITIVDPSGVIRYQTPSATRVLGYDPNAMVGQRFVSLVAP--ADVHRLEAILLDAVLRPrsTHTIEFA 436
TIGR00229      3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEedREEVRERIERLLEGERE--PYSEERR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 117928688 437 MRHAAGHWRETETVITSLVDDHDIRGLVLNTRDVSERKELERQL 480
TIGR00229     81 VRRKDGSEIWVEVSVSPIRTNGGELGVVGIVRDITERKQAEEAL 124

-1

33240

COG3434

Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]

Predicted signal transduction protein containing EAL and modified HD-GYP domains [...

false

true

false

407

4e-09

59.14

31.45

7,750,65,15,774,80,16,792,96,24,818,120,11,829,133,7,839,140,6,853,146,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 751 VNVSGRQLHPRLPDIvrtaltetgMPPGALVIEVTENILVkrSEEAIAVLRQLKSFGVRVAIDDFGtgYSSLSYLARFP- 829
COG3434       66 INFPEELLISDLPEL---------LPPDKVVIEILEDCPP--TEKLLSAIKELKQKGYLLALDDFI--FSNVSEWKPLLp 132

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117928688 830 -VDVLKIDksfVEQITDrnsgtegtELVRTILHLGRALRLGTVAEGIETREQYAALLAMSCDYGQGYLFSRP 900
COG3434      133 lSDIVKID---FKRVTF--------DKARLFDRDLGYINKKFLAEKVETEEEFEQAKKAGFDLFQGYFFSKP 193

-1

138539

PRK11360

sensory histidine kinase AtoS; Provisional

false

true

false

607

8e-07

51.62

19.28

6,363,265,51,417,316,6,424,322,7,431,332,10,444,342,14,458,357,25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 364 LVQNSSDIITIVDPSGVIRYQTPSATRVLGYDPNAMVGQRFVSLVAPADVHrleAILLDAvLRPRSTH---TIEFAMRHA 440
PRK11360     266 IIENAADGIIAIDRQGDITTMNPAAEVITGYQRHELVGQPYSMLFDNTQFY---SPVLDT-LEHGTEHvalEISFPGRDR 341

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 117928688 441 AghwRETETVITSLVDDH-DIRGLVLNTRDVSERKELERQLTRQ 483
PRK11360     342 T---IELSVTTSRLHDTHgEMIGAVVIFSDLTARKRLQRRMARA 382

-1

117025

pfam08448

PAS_4

PAS fold

false

true

false

110

3e-06

49.72

98.18

4,366,2,52,419,54,18,438,72,20,458,93,17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 367 NSSDIITIVDPSGVIRYQTPSATRVLGYDPNAMVGQRFVSLVAPADVHRLEAiLLDAVLRPRSTHTIEFAMrHAAGHWRE 446
pfam08448      3 SLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLER-ALRRALEGEEPIDFLEEL-LLNGEERH 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 117928688 447 TETVITSLVDDH-DIRGLVLNTRDVSERKE 475
pfam08448     81 YELRLTPLRDPDgEVIGVLVISRDITERRR 110

-1

32384

COG2202

AtoS

FOG: PAS/PAC domain [Signal transduction mechanisms]

false

true

false

232

3e-05

46.12

54.74

3,352,105,79,431,185,11,442,197,35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 353 ALRTHAKWFRSLVQNSSDIITIVDPSGVIRYQTPSATRVLGYDPNAMVGQRFVSLVAPADVHRLEAILLDAVLRPRSTH- 431
COG2202      106 ALRESEERLRALLEASPDGIWVLDEDGRILYANPAAEELLGYSPEEELGRGLSDLIHPEDEERRELELARALAEGRGGPl 185

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 117928688 432 TIEFAMRHAAG-HWRETETVITSLVDDHDIRGLVLNTRDVSERKELE 477
COG2202      186 EIEYRVRRKDGeRVRWILSRISPVRDDGEIVGVVGIARDITERKQAE 232

-1

110021

pfam00989

PAS

PAS fold

false

true

false

112

5e-04

42.39

98.21

4,360,2,63,423,66,19,444,85,12,456,98,14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 361 FRSLVQNSSDIITIVDPSGVIRYQTPSATRVLGYDPNAMVGQRFVSLVAPADVHRLEAILLDA-VLRPRSTHTIEFAMRH 439
pfam00989      3 LRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEDDDAVAELLRQALlQGEESRGFEVSFRVSD 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 117928688 440 AAGhwRETETVITSLVD-DHDIRGLVLNTRDV 470
pfam00989     83 GRP--RHVEVRASPVRDaGGEILGFLGVLRDI 112

-1

117024

pfam08447

PAS_3

PAS fold

false

true

false

0.006

38.52

88.89

2,380,0,21,401,23,57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928688 381 IRYQTPSATRVLGYDPNAMVG--QRFVSLVAPADVHRLEAILLDAVLRPRSTHTIEFAMRHAAGHWRETETVITSLVDDH 458
pfam08447      1 IIYWSPRFEEILGYTPEELKSsyEDWLDLVHPEDRERVRRALQEFSLKKGEPYSGEYRIRRKDGEYRWVEARGRPIRDEN 80

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF
putative active site	0	9	9	true	29035	cd00130	PAS
heme pocket	1	7	7	true	29035	cd00130	PAS