NCBI Conserved Domain Search

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Conserved domains on [gi\|117928627\|ref\|YP_873178.1\|]
diguanylate cyclase/phosphodiesterase [Acidothermus cellulolyticus 11B]

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List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

30163

cd01948

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

true

false

true

240

2e-82

302.13

99.58

2,383,0,77,463,77,162

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 384 EDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLRTALQHRVAWtpr 463
cd01948        1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARW--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 464 LHCRQDFCVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFIDEEAGTLAVLRALRDLGVRIALDDFGTGY 543
cd01948       78 QAGGPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 544 SALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKPMP 623
cd01948      158 SSLSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLP 237


                 ..
gi 117928627 624 AD 625
cd01948      238 AE 239

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

5e-42

167.76

100.00

2,208,0,88,297,88,69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 209 HDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVARIGGD 288
cd01949        1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117928627 289 EFGVLVTGlAAPNEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASRGIEPAELLADADLAMTEAKNTGKGRCV 366
cd01949       81 EFAILLPG-TDLEEAEELAERLRKAIEEPFFIDGEEIRVTASIGIAEYPEDGEDLEELLRRADKALYQAKRSGRNRVV 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

128367

smart00052

EAL

Putative diguanylate phosphodiesterase

false

241

1e-85

312.61

100.00

2,382,0,82,467,82,159

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 383 EEDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLRTALQHRVAWTP 462
smart00052     1 ERELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 463 RLhcrQDFCVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFIDEEAGTLAVLRALRDLGVRIALDDFGTG 542
smart00052    81 QG---PPLRISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 543 YSALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKPM 622
smart00052   158 YSSLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPL 237


                 ....
gi 117928627 623 PADT 626
smart00052   238 PLDD 241

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32382

COG2200

Rtn

c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]

false

256

3e-77

284.91

98.05

2,381,3,79,464,82,172

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 382 LEEDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLRTALQHRVAWt 461
COG2200        4 LERDLRQALENGEFSLYYQPIVDLATGRIVGYEALLRWRHPDGGLISPGEFIPLAEETGLIVELGRWVLEEACRQLRTW- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 462 prlHCRQDFCVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFIDEEAGTLAVLRALRDLGVRIALDDFGT 541
COG2200       83 ---PRAGPLRLAVNLSPVQLRSPGLVDLLLRLLARLGLPPHRLVLEITESALIDDLDTALALLRQLRELGVRIALDDFGT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 542 GYSALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKP 621
COG2200      160 GYSSLSYLKRLPPDILKIDRSFVRDLETDARDQAIVRAIVALAHKLGLTVVAEGVETEEQLDLLRELGCDYLQGYLFSRP 239

                        250
                 ....*....|....*
gi 117928627 622 MPADTLPAHCPSSAS 636
COG2200      240 LPADALDALLSSSQS 254

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

109613

pfam00563

EAL

EAL domain

false

236

4e-64

241.17

100.00

4,382,0,108,491,108,22,514,130,55,570,185,51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 383 EEDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLRTALQHRVAWTP 462
pfam00563      1 EQALREALENGEFSLYFQPIVDLRTGKVLGYEALLRWQHPDGGLIPPDEFLPLAERLGLIAELDRWVLEKALAQLAEWRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 463 RLHCRQDFCVSVNVSVRQLAEPGFVDVVtDALAASGVPPEVLVLEMTESVFiDEEAGTLAVLRALRDLGVRIALDDFGTG 542
pfam00563     81 NALLPPDLPLSVNLSPASLLDPSFLEAL-LALKQGGLPPSRLVLEITESDL-DEDLRLLEALARLRSLGFRLALDDFGTG 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928627 543 YSALSYLRRFPVDILKLDRSFIAGLLGtAQDQAVTRAVIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKP 621
pfam00563    159 YSSLSYLSRLPPDYIKIDRSFIKDLSD-PESRALLRALIALARELGIKVVAEGVETEEQLELLKELGIDYVQGYLFSKP 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

3e-37

152.02

100.00

2,204,0,92,297,92,71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 205 HLASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVAR 284
smart00267     1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 285 IGGDEFGVLVTGlAAPNEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASRGIEPAELLADADLAMTEAKNTGKGR 364
smart00267    81 LGGDEFALLLPE-TSLEEAIALAERILQQLREPIIIHGIPLYLTISIGVAAYPNPGEDAEDLLKRADTALYQAKKAGRNQ 159


                 ....
gi 117928627 365 CVVF 368
smart00267   160 VAVY 163

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

7e-35

144.11

97.79

3,191,4,105,297,109,48,345,158,23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 192 AVHARRRAETARYHLASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQR 271
COG2199        5 LLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREVARR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 272 MTAIVRPTDTVARIGGDEFGVLVTGlAAPNEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASRGIEPAE-LLADA 350
COG2199       85 LRSNLREGDLVARLGGDEFAVLLPG-TSLEEAARLAERIRAALEEPFFLGGEELRVTVSIGVALYPEDGSDDAElLLRRA 163

                        170
                 ....*....|....*...
gi 117928627 351 DLAMTEAKNTGKGRCVVF 368
COG2199      164 DLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

110022

pfam00990

GGDEF

GGDEF domain

false

160

9e-35

143.54

100.00

2,206,0,90,296,92,68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 207 ASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVARIG 286
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 287 GDEFGVLVTG--LAAPNEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASRGIEPAELLADADLAMTEAKNTGKGR 364
pfam00990     81 GDEFAILLPDtsLEGAQELAERIRRLLAALKIPHTLSGLPLYVTISIGIAAYPNDGEDAEDLLKRADQALYQAKNQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

3e-29

125.53

99.39

4,205,0,91,297,91,19,316,111,4,320,116,48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 206 LASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVARI 285
TIGR00254      1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 286 GGDEFGVLVTGlAAPNEAEAIALRLRDAFRT-PFAV-DGRSVHLSASIGVATSASRGIEPAELLADADLAMTEAKNTGKG 363
TIGR00254     81 GGEEFVVILPG-TPLEDALSKAERLRDAINSkPIEVaGSETLTVTVSIGVACYPGHGLTLEELLKRADEALYQAKKAGRN 159


                 ....*
gi 117928627 364 RCVVF 368
TIGR00254    160 RVVVA 164

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

138661

PRK11596

EAL domain-containing protein; Provisional

false

255

8e-05

44.31

37.25

3,532,153,10,542,166,8,553,174,74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 533 RIALDDFGTG---YSALSYLRrfpVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEGIETYDQLEILRQLG 609
PRK11596     154 PLWLDDFGTGmanFSALSEVR---YDYIKVARELFVMLRQSPEGRTLFSQLLHLMNRYCRGVIVEGVETPEEWRDVQRSP 230

                         90
                 ....*....|....*...
gi 117928627 610 CRLGQGFLLQKPMPADTL 627
PRK11596     231 AFAAQGYFLSRPAPFDTL 248

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

29035

cd00130

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

true

103

8e-05

44.11

89.32

2,21,3,44,65,52,43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627  22 GMALLDVAGRFRAVNDAFAELVGVEADALIGSEETTFIRPDDRH-----WADWGIGGEPQRLQVRMCRADGTEIHVIRIL 96
cd00130        4 GVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREelrerLENLLSGGEPVTLEVRLRRKDGSVIWVLVSL 83

                         90
                 ....*....|..
gi 117928627  97 TAAADEEPFVLG 108
cd00130       84 TPIRDEGGEVIG 95

cl02459

141436

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

3e-92

334.77

63.95

6,196,226,33,231,259,69,301,328,104,406,432,57,463,490,4,471,494,156

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 197 RRAETARYHLASHDALTGLVNRTTFAARVADAVgqAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIV 276
PRK10060     227 RRAQERLRILANTDSITGLPNRNAIQELIDHAI--AQADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCL 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 277 RPTDTVARIGGDEFGVLVTGLAAPnEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASRGIEPAELLADADLAMTE 356
PRK10060     305 EEDQTLARLGGDEFLVLASHTSQA-ALEAMASRILTRLRLPFRIGLIEVYTGCSIGIALSPEHGDDSESLIRSADTAMYT 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 357 AKNTGKGRCVVFRPALRRAAAQRIALEEDLRAAVEAGAFRLDFQPIVELaTGMWVGAEALLRWPHPTRGLVPPLDFIPLA 436
PRK10060     384 AKEGGRGQFCVFSPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKITW-RGEVRSLEALVRWQSPERGLIPPLEFISYA 462

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 437 EDSGLVVPLGEWVLRTALQHRVAWTPR-LHCRqdfcVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFID 515
PRK10060     463 EESGLIVPLGRWVILDVVRQAAKWRDKgINLR----VAVNVSARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIE 538

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 516 EEAGTLAVLRALRDLGVRIALDDFGTGYSALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEG 595
PRK10060     539 NEELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEG 618

                        410       420       430
                 ....*....|....*....|....*....|..
gi 117928627 596 IETYDQLEILRQLGCRLGQGFLLQKPMPADTL 627
PRK10060     619 VETAKEDAFLTKNGVNERQGFLFAKPMPAVAF 650

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

3e-78

288.08

63.80

2,196,217,269,471,486,154

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 197 RRAETARYHLASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIV 276
COG5001      218 RRLSDENDRLANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRLKAFD 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 277 RPTDTVARIGGDEFGVLVTGLAAPNEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASRGIEPAELLADADLAMTE 356
COG5001      298 GAPILAARLGGDEFALIIPALEDDALRVAGARALCESLQAPYDLRGVRVQVGASIGIAPFPSGADTSEQLFERADYALYH 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 357 AKNTGKGRCVVFRPALRRAAAQRIALEEDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLA 436
COG5001      378 AKQNGKGAAVLFDARHEAAIRDMAVVEQALRSADLEQELSVHFQPIVDIVSGKTIALEALARWHSPEIGPVPPDVFIGIA 457

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 437 EDSGLVVPLGEWVLRTALQHRVAWTPRLHcrqdfcVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFIDE 516
COG5001      458 ERSGQIVELTRLLLAKALREARAWPMDVR------VSINLSARDLASMENVRRLLAIVSESCIAPHRLDFEITETAIVCD 531

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 517 EAGTLAVLRALRDLGVRIALDDFGTGYSALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEGI 596
COG5001      532 FDQARDALAALHELGVRTALDDFGTGYSSLSHLRALPLDKIKIDRSFVSDLEENPTSEDIVRTVLQLGRNLRMECVVEGV 611

                        410       420
                 ....*....|....*....|....*....
gi 117928627 597 ETYDQLEILRQLGCRLGQGFLLQKPMPAD 625
COG5001      612 ETEAQRDRVAALGATVMQGYHYARPMPAE 640

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

1e-69

259.39

54.82

7,182,350,15,199,365,6,205,374,30,239,404,51,291,455,51,344,506,116,462,622,166

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 183 VRSISSVVCAVHARRraETARYH---LASHDALTGLVNRTTFAARVADAVGQAERGrghlCVLMVDIDGFKRVNDSLGHL 259
PRK11359     351 VADISQHMAALALEQ--EKSRQHieqLIQFDPMTGLPNRNNLHNYLDDLVDKAVSP----VVYLIGVDHIQDVIDSLGYA 424

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 260 HGDRLLRDIAQRMTAIVRPTDTVARIGGDEFgVLVTGLAAPNEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASR 339
PRK11359     425 WADQALLEVVNRFREKLKPDQYLCRIEGTQF-VLVSLENDVSNITQIADELRNVVSKPIMIDDKPFPLTLSIGISYDVGK 503

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 340 GIEpaELLADADLAMTEAKNTGKGRCVVFRPALRRAAAQRIALEEDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRW 419
PRK11359     504 NRD--YLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARW 581

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 420 PHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLRTALQHRVAWtpRLHCRQDFCVSVNVSVRQLAEPGFVDVVTDALAASGV 499
PRK11359     582 HDPLHGHVPPSRFIPLAEEIGEIENIGRWVIAEACRQLAEW--RSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHAWGI 659

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 500 PPEVLVLEMTESVFIDEEAGTLAVLRALRDLGVRIALDDFGTGYSALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRA 579
PRK11359     660 DGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEA 739

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 117928627 580 VIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKPMPADTLP 628
PRK11359     740 ITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSRPLPAEEIP 788

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

2e-63

238.90

64.67

7,194,220,10,206,230,28,238,258,100,339,358,124,466,482,86,552,571,15,570,586,55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 195 ARRRAETARYhlASHDALTGLVNRTTFAARVADAVGQAERgrghLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTA 274
PRK13561     221 QRHYEEQNEN--AMRFPVSDLPNKALLMALLEQVVARKQT----TALMIITCETLRDTAGVLKEAQREILLLTLVEKLKS 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 275 IVRPTDTVARIGGDEFGVLVTGLAAPNEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASrGIEPAELLADADLAM 354
PRK13561     295 VLSPRMVLAQISGYDFAIIANGVKEPWHAITLGQQVLTIINERLPIQRIQLRPSCSIGIAMFYG-DLTAEQLYSRAVSAA 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 355 TEAKNTGKGRCVVFRPALRRAAAQRIALEEDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIP 434
PRK13561     374 FTARRKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPDGLID 453

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 435 LAEDSGLVVPLGEWVLRTALQHRVAWTPRlhcRQDFCVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFI 514
PRK13561     454 RIESCGLMVTVGHWVLEESCRLLAAWQER---GIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRI 530

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 515 DEEAGTLAVLRALRDLGVRIALDDFGTGYSALSYLRRF---PVDILKLDRSFIAGLlgtAQDQAVTRAVIGLAQQLDLDL 591
PRK13561     531 DDPHAAVAILRPLRNAGVRIALDDFGMGYAGLRQLQHMkslPIDVLKIDKMFVDGL---PEDSSMVAAIIMLAQSLNLQM 607

                        410       420       430
                 ....*....|....*....|....*....|....
gi 117928627 592 VAEGIETYDQLEILRQLGCRLGQGFLLQKPMPAD 625
PRK13561     608 IAEGVETEAQRDWLAKAGVGVAQGFLFARPLPIE 641

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

9e-63

236.53

38.17

7,204,685,97,302,782,14,316,797,67,383,866,20,403,890,7,413,897,43,460,940,171

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627  205 HLASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVAR 284
PRK09776      686 YSASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLAR 765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627  285 IGGDEFGVLVTGLAAPNeAEAIALRLRDAFRT-PFAVDGRSVHLSASIGVATSASRGIEPAELLADADLAMTEAKNTGKG 363
PRK09776      766 LGGDEFGLLLPDCNVES-ARFIATRIISAINDyRFPWEGRVYRVGASAGITAIDDNNHQASEVMSQADIACYAAKNAGRG 844

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627  364 RCVVFRPALRRAAAQRIALE--EDLRAAVEAGAFRLDFQPIV----ELATGMWvgaEALLRWPHPTRGLVPPLDFIPLAE 437
PRK09776      845 RVTVYEPQQAAAHSERRELSlaEQWRSMLEENQLMLQAQEIAspriPEARNLW---LISLRLWDCEGEIIDEGAFRPAAE 921

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627  438 DSGLVVPLGEWVLRTALQHrvawTPRLHCRQDFCVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFIDEE 517
PRK09776      922 DPALMHALDRWVIHELFQQ----GARAVASKGLSIAIPLSVASLSSATLLPFLLEQLENSPLPPRLLHLEITETALLNHA 997

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627  518 AGTLAVLRALRDLGVRIALDDFGTGYSALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEGIE 597
PRK09776      998 EAASRLVQKLRLAGCRVVLDDFGRGLSSFNYLKAFMADYLKIDGELCANLQGNLMDEMLVSIINGIAQRLGMKTIAGPVE 1077

                         410       420       430
                  ....*....|....*....|....*....|....
gi 117928627  598 TYDQLEILRQLGCRLGQGFLLQKPMPADTLPAHC 631
PRK09776     1078 LPLTLDTLSGIGVDLAQGYVIGRPQPLDLLLNSS 1111

-1

34551

COG4943

Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]

Predicted signal transduction protein containing sensor and EAL domains [Signal...

false

true

false

524

7e-56

213.67

44.85

3,385,272,75,463,347,55,519,402,105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 386 LRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLRTALQHRVAWtprLH 465
COG4943      273 LQRAIERRELCVHYQPIVDLATGKCVGAEALARWPQEDGTVVSPDVFIPLAEESGMIEQITDYVIRNVFRDLGDL---LR 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 466 CRQDFCVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFIDEEAgTLAVLRALRDLGVRIALDDFGTGYSA 545
COG4943      350 QHRDLHVSINLSASDLASPRLIDRLNRKLAQYQVRPQQIALELTERTFADPKK-MTPIILRLREAGHEIYIDDFGTGYSN 428

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928627 546 LSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKPMPA 624
COG4943      429 LHYLQSLPVDALKIDKSFVDTLGTDSASHLIAPHIIEMAKSLGLKIVAEGVETEEQVDWLRKRGVHYGQGWLFSKALPA 507

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

6e-52

200.70

57.69

5,211,304,23,235,327,228,466,555,82,548,640,19,570,659,65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 212 LTGLVNRTTFAARVADAVGQAERgRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVARIGGDEFG 291
PRK11829     305 VTELPNRSLFISLLEKEIASSTR-TDHFHLLVIGIETLQEVSGAMSEAQHQQLLLTIVQRIEQCIDDSDLLAQLSKTEFA 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 292 VLVTGLAAPNEAEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASRGIEPAELLADADLAMTEAKNTGKGRCVVFRPA 371
PRK11829     384 VLARGTRRSFPAMQLARRIMSQVTQPLFFDEITLRPSASIGITRYQAQQDTAESMMRNASTAMMAAHHEGRNQIMVFEPH 463

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 372 LRRAAAQRIALEEDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLR 451
PRK11829     464 LIEKTHKRLTQENDLLQAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQPDGSYVLPSGFVHFAEEEGMMVPLGNWVLE 543

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 452 TALQHRVAWTPRlhcRQDFCVSVNVSVRQLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFIDEEAGTLAVLRALRDLG 531
PRK11829     544 EACRILADWKAR---GVSLPLSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITETAQIQDLDEALRLLRELQGLG 620

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 532 VRIALDDFGTGYSALSY---LRRFPVDILKLDRSFIAGLlgtAQDQAVTRAVIGLAQQLDLDLVAEGIETYDQLEILRQL 608
PRK11829     621 LLIALDDFGIGYSSLRYlnhLKSLPIHMIKLDKSFVKNL---PEDDAIARIISCVSDVLKVRVMAEGVETEEQRQWLLEH 697

                        410       420
                 ....*....|....*....|....*..
gi 117928627 609 GCRLGQGFLLQKPMPADTLPAHCPSSA 635
PRK11829     698 GIQCGQGFLFSPPLPRAEFEAQYFSSA 724

-1

137979

PRK10551

hypothetical protein; Provisional

false

true

false

518

3e-40

161.76

47.30

6,388,270,68,460,338,4,464,344,32,498,376,5,503,383,16,520,399,116

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 389 AVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLRTALQHrvawTPRL--HC 466
PRK10551     271 AIKREQFYVVYQPVVDTQTLRVTGLEVLLRWRHPTAGEIPPDAFINYAEAQKLIVPLTQHLFELIARD----AAELqkVL 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 467 RQDFCVSVNVSVRQLAEPGFVDVVTDALAAsgVPPEV--LVLEMTESVFIDEEAGtLAVLRALRDLGVRIALDDFGTGYS 544
PRK10551     347 PVGAKLGINIAPAHLHSDSFKADVQRLLAS--LPADHfqIVLEITERDMLQEEEA-LKLFAWLHSQGIEIAIDDFGTGHS 423

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 545 ALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRAVIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKPMPA 624
PRK10551     424 ALIYLERFTLDYLKIDRGFINAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLREHGVNFLQGYWISRPLPL 503

                        250
                 ....*....|..
gi 117928627 625 DTLPAHCPSSAS 636
PRK10551     504 DDFVKWLKKPYS 515

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

4e-28

121.56

38.16

4,204,267,93,298,360,17,315,378,9,324,389,44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 205 HLASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVAR 284
COG3706      268 ELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEVLRQVARRLRQTVRGLDLVAR 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 285 IGGDEFGVLVTGLaAPNEAEAIALRLRDAFR-TPFAVDGRS--VHLSASIGVATSASRGIEPAELLADADLAMTEAKNTG 361
COG3706      348 YGGEEFAVVLPDT-DLEAAIAIAERIRQKINeLPFVHELSRepLEVTISIGVAEGKPGEDSIEELLKRADKALYKAKASG 426


                 ....*..
gi 117928627 362 KGRCVVF 368
COG3706      427 RNRVVVK 433

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

3e-25

111.94

35.67

5,205,290,89,294,381,5,302,386,12,314,399,8,322,409,44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 206 LASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVARI 285
PRK09581     291 MAVTDGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARY 370

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 286 GGDEFGVLV--TGLAApneAEAIALRLRDAF-RTPFAVDG--RSVHLSASIGVATSASRGIEPAELLADADLAMTEAKNT 360
PRK09581     371 GGEEFVVVMpdTDIEV---AIAVAERIRRKIaEEPFAISDgkERLNVTVSIGVAELRPSGESIEALIKRADKALYEAKNT 447


                 ....*.
gi 117928627 361 GKGRCV 366
PRK09581     448 GRNRVV 453

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

2e-23

106.33

54.27

5,205,128,24,231,152,65,297,217,19,316,237,17,334,254,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 206 LASHDALTGLVNRTTFAARVADAVgqAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVARI 285
PRK09894     129 RSNMDVLTGLPGRRVLDESFDHQL--RNREPLNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRPYETVYRY 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 286 GGDEFGVLVTGlAAPNEAEAIALRLRDAFRT-PFAVDGRSVHLSASIGVaTSASRGIEPAELLADADLAMTEAKNTGKGR 364
PRK09894     207 GGEEFIIILKA-ATDEEACRAGERIRQLIANqAITHSEGRINITATFGV-TRAFPEEPLDEVIGRADRAMYEGKQAGRNR 284


                 ...
gi 117928627 365 CVV 367
PRK09894     285 VMF 287

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

7e-15

77.75

31.45

3,206,247,19,226,266,94,320,361,14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 207 ASHDALTGLVNRTTFAARVaDAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIVRPTDTVARIG 286
PRK09966     248 ALHDPLTGLANRAAFRSGI-NTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLG 326

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 117928627 287 GDEFGVLVTGLAAPNEAEAIALRLRDAFRTPFAV-DGRSVHLSASIGVA 334
PRK09966     327 GDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLhNGHQTTMTLSIGYA 375

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

1e-14

76.85

64.64

16,206,227,61,267,289,15,282,305,17,300,322,7,307,332,17,324,350,2,330,352,5,335,362,13,363,375,22,385,407,18,403,434,15,421,449,3,431,452,25,457,477,9,470,486,30,500,517,125

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 207 ASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRD-IAQRMTAIVRPTDTV-AR 284
PRK11059     228 AFLDAKTGLGNRLFFDNQLDTLLEDQEKVGAHGVVMLIRLPDFDLLQEELGESQVDELLFElINLLSTFVQRYPGALlAR 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 285 IGGDEFGVLVTGLAApNEAEAIA---LRLRDAFRTPFAVDGRS-VHlsasIGVAT-----SASRGIEPAELLAdadlamt 355
PRK11059     308 YSRSDFAVLLPHRSL-KEADSLAsqlLKAVDSLPPPKMLDRDDfLH----IGIAAyrsgqSTEQVMEEAEMAL------- 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 356 eakntgkgRCVVFRPALRRAAAQRIALEED----------LRAAVEAGAFRLDFQPIV---------ELATGMWVGAEAL 416
PRK11059     376 --------RSAQLQGGNSWFMYDKAQDPEKgrgsvrwrtlLEQALVRGGPRLYQQPVVtrdgqvhhrELMCRIRDGQGNE 447

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 417 LRwphPTRglvppldFIPLAEDSGLVVPLGEWVLRTALQHrVAWTPRLHCrqdfCVSVNVSVRQLAEPGFVDVVTDALAA 496
PRK11059     448 VR---AAE-------FMPMVLQCGLSEQYDRQVIERVLPL-LSYWPEESQ----NLSINLSVDSLLSRAFQRWLRDTLLQ 512

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 497 SGVP-PEVLVLEMTESVFIDEEAGTLAVLRALRDLGVRIALDDFGTGYSALSYLRRFPVDILKLDRSFIAGLLGTAQDQA 575
PRK11059     513 CERSqRKRLIFELAEADVVQHIDRLRPVLRMLRGLGCRLAVDQAGLTVVSTSYIKELNVELIKLHPSLVRNIHQRTENQL 592

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 117928627 576 VTRAVIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKPMPAD 625
PRK11059     593 FVRSLVGACAGTETQVFAEGVESREEWQTLQILGVSGGQGDFFASPQPLD 642

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

8e-13

70.70

45.01

5,195,202,6,205,208,96,304,304,7,311,316,8,322,324,45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 196 RRRAETaryhLASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAI 275
PRK10245     203 KRRLQV----MSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQIT 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 276 VRPTDTVARIGGDEFGVLVTGLAAPNeaeAIALRLR-----DAFRTPFAvdgRSVHLSASIGVATSASRGIEPAELLADA 350
PRK10245     279 LRGSDVIGRFGGDEFAVIMSGTPAES---AITAMLRvheglNTLRLPNA---PQVTLRISVGVAPLNPQMSHYREWLKSA 352

                        170
                 ....*....|....*..
gi 117928627 351 DLAMTEAKNTGKGRCVV 367
PRK10245     353 DLALYKAKKAGRNRTEV 369

-1

129332

TIGR00229

sensory_box

PAS domain S-box

true

false

124

8e-10

60.76

93.55

3,8,1,63,71,70,27,98,99,18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627   9 EARFGETYRRVAIGMALLDVAGRFRAVNDAFAELVGVEADALIGSEETTFIRPDDRHWADWGI------GGEPQRLQVRM 82
TIGR00229      2 EERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIerllegEREPYSEERRV 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 117928627  83 CRADGTEIHVIRILTA--AADEEPFVLGHYIDVTEH 116
TIGR00229     82 RRKDGSEIWVEVSVSPirTNGGELGVVGIVRDITER 117

-1

33240

COG3434

Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]

Predicted signal transduction protein containing EAL and modified HD-GYP domains [...

false

true

false

407

3e-08

55.67

31.94

7,484,63,10,494,76,23,519,99,20,540,119,13,553,133,7,566,140,9,577,149,44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928627 485 GFVDVVTDAL---AASGVPPEVLVLEMTESVFIDEEagTLAVLRALRDLGVRIALDDFgTGYSALSYLRRFP-VDILKLD 560
COG3434       64 CFINFPEELLisdLPELLPPDKVVIEILEDCPPTEK--LLSAIKELKQKGYLLALDDF-IFSNVSEWKPLLPlSDIVKID 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117928627 561 rsfiagLLGTAQDQAvtRAVIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKP 621
COG3434      141 ------FKRVTFDKA--RLFDRDLGYINKKFLAEKVETEEEFEQAKKAGFDLFQGYFFSKP 193

-1

117024

pfam08447

PAS_3

PAS fold

false

true

false

0.004

38.52

85.56

3,34,3,22,56,27,8,64,41,39

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117928627  35 VNDAFAELVGVEADALIGSEET--TFIRPDDR------HWADWGIGGEPQRLQVRMCRADGTEIHVIRILTAAADEE 103
pfam08447      4 WSPRFEEILGYTPEELKSSYEDwlDLVHPEDRervrraLQEFSLKKGEPYSGEYRIRRKDGEYRWVEARGRPIRDEN 80

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

0.008

37.38

5.65

1,2,296,63

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117928627    3 ADLHAIEARFGETYRRVAIGMALLDVAGRFRAVNDAFAELVGVEADALIGSEETTFIRPDDRH 65
PRK09776      297 KHISESETRFRNAMEYSAIGMALVGTEGQWLQVNKALCQFLGYSQEELRGLTFQQLTWPEDLN 359

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF
putative active site	0	9	9	true	29035	cd00130	PAS
heme pocket	1	5	7	true	29035	cd00130	PAS