NCBI Conserved Domain Search

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Conserved domains on [gi\|117928402\|ref\|YP_872953.1\|]
periplasmic sensor signal transduction histidine kinase [Acidothermus cellulolyticus 11B]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

28956

cd00075

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

true

false

true

103

3e-12

68.81

100.00

3,496,0,22,518,23,36,554,60,43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 497 LERVLANLVANALRHSPPHLPP-AVVARIRGEKVRIDVVDHGPGIPPHARDRVFQPFQQ-LDDRRGGGVGLGLAVARGFV 574
cd00075        1 LQQVLLNLLSNAIKHTPEGGGRiTISVERDGDHLEIRVEDNGPGIPEEDLERIFERFSDgSRSRKGGGTGLGLSIVKKLV 80

                         90       100
                 ....*....|....*....|...
gi 117928402 575 EALGGEIHVLETPGGGVTMRVEL 597
cd00075       81 ELHGGRIEVESEPGGGTTFTITL 103

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

119399

cd00082

HisKA

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are...

true

false

true

4e-11

64.93

100.00

2,380,0,35,417,35,30

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117928402 381 NRMRTALLAAVSHDLRTPLASIKAGVSTLRQTDIQwsPSDVAELLSSVDQATDQLDALIANLLDMSR 447
cd00082        1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLD--DEEQREYLERIREEAERLLRLINDLLDLSR 65

cl00080

140419

HisKA

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are...

128669

smart00387

HATPase_c

Histidine kinase-like ATPases

false

111

2e-18

89.25

100.00

2,491,0,63,554,65,46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 492 TDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKVRIDVVDHGPGIPPHARDRVFQPFQQ--LDDRRGGGVGLGLAV 569
smart00387     1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHLEITVEDNGPGIPPEDLEKIFEPFFRtdGRSRKIGGTGLGLSI 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 117928402 570 ARGFVEALGGEIHVLETPGGGVTMRVELPIS 600
smart00387    81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

-1

111420

pfam02518

HATPase_c

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

false

111

2e-16

82.38

99.10

2,491,0,63,554,65,45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 492 TDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKVRIDVVDHGPGIPPHARDRVFQPFQQ--LDDRRGGGVGLGLAV 569
pfam02518      1 GDEDRLRQVLSNLLDNAIKHAPAGGEITVTLEREGGRLRITVEDNGPGIPPEDLEKIFEPFYRdgSDSRKVGGTGLGLSI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 117928402 570 ARGFVEALGGEIHVLETPGGGVTMRVELPI 599
pfam02518     81 VKKLVELHGGTITVESEPGGGTTFTLTLPL 110

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

-1

109563

pfam00512

HisKA

His Kinase A (phosphoacceptor) domain

false

5e-11

64.51

100.00

2,382,0,32,417,32,34

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928402 383 MRTALLAAVSHDLRTPLASIKAGVSTLRQTDIqwsPSDVAELLSSVDQATDQLDALIANLLDMSRIHTG 451
pfam00512      1 AKSEFLANLSHELRTPLTAIRGYLELLLDTEL---SEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66

cl00080

140419

HisKA

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are...

-1

128670

smart00388

HisKA

His Kinase A (phosphoacceptor) domain

false

1e-10

63.75

100.00

2,382,0,32,417,32,34

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928402 383 MRTALLAAVSHDLRTPLASIKAGVSTLRQTDIqwsPSDVAELLSSVDQATDQLDALIANLLDMSRIHTG 451
smart00388     1 AKREFLANLSHELRTPLTAIRGYLELLEDTEL---SEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66

cl00080

140419

HisKA

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are...

-1

32387

COG2205

KdpD

Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]

false

true

false

890

5e-49

191.23

26.74

3,372,648,105,477,756,77,554,834,52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 373 QAEALAAGNRMRTALLAAVSHDLRTPLASIKAGVSTLRQTDIQWSPSDVAELLSSVDQATDQLDALIANLLDMSRIHTGA 452
COG2205      649 QARLAAERERLRSALLASISHDLRTPLTAIMGAAETLLLDGEALSPEDRAELLSSIREESERLTRLVTNLLDMTRLQSGG 728

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 453 VQPFLRPTALEEVAPLALAGLADAE---RVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKV 529
COG2205      729 VNLKLDWVLVEEVVGEALQRLRKRFtghKIVVSVPVDLPLIHVDSPLIEQVLINLLENALKYAPPGSEIRINAGVERENV 808

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117928402 530 RIDVVDHGPGIPPHARDRVFQPFQQ-LDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISAYVPSD 606
COG2205      809 VFSVIDEGPGIPEGELERIFDKFYRgNKESATRGVGLGLAICRGIVEAHGGTISAENNPGGGAIFVFTLPVEEDPPLE 886

-1

137934

PRK10490

sensor protein KdpD; Provisional

false

true

false

895

1e-27

120.23

26.59

6,372,652,30,402,684,7,412,691,62,474,756,80,554,837,47,603,884,6

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 373 QAEALAAGNRMRTALLAAVSHDLRTPLASI--KAGVSTLrqtDIQWSPSDVAELLSSVDQATDQLDALIANLLDMSRIHT 450
PRK10490     653 QARLASEREQLRNALLAALSHDLRTPLTVLfgQAEILTL---DLASEGSPHARQASEIRQHVLNTTRLVNNLLDMARIQS 729

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 451 GAVQPFLRPTALEEVAPLALAGLA---DAERVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLPPAVVARIRGE 527
PRK10490     730 GGFNLKKEWLTLEEVVGSALQMLEpglSQHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGE 809

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 528 KVRIDVVDHGPGIPPHARDRVFQPFQQ-LDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISAyvPSD 606
PRK10490     810 NLQLDVWDNGPGIPPGQEQLIFDKFARgNKESAVPGVGLGLAICRAIVDVHGGTITAENRPEGGACFRVTLPQEK--PPE 887


                 ...
gi 117928402 607 IDA 609
PRK10490     888 LDE 890

-1

30987

COG0642

BaeS

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

336

2e-27

119.50

69.35

7,372,103,41,417,144,35,452,184,16,469,200,14,483,215,30,514,245,40,555,285,51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 373 QAEALAAGNRMRTALLAAVSHDLRTPLASIKAGVSTLRQTDiqwsPSDVAELLSSVDQATDQLDALIANLLDMSRIHTGA 452
COG0642      104 LERLERLLRRAKREFLANISHELRTPLTAIRGLLELLLEGL----LDPQRELLEIIEEEAERLLRLVNDLLDLSRLEAGT 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 453 -----VQPFLRPTALEEVAPLaLAGLADAERVQLDI-PEDLPLIATDPGLLERVLANLVANALRHSPpHLPPAVVARIRG 526
COG0642      180 klkllLELVDLAELLEEVVRL-LAPLAQEKGIELAVdLPELPYVLGDPERLRQVLVNLLSNAIKYTP-GGEITISVRQDD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 527 EKVRIDVVDHGPGIPPHARDRVFQPFQQlDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISAYVPSD 606
COG0642      258 EQVTISVEDTGPGIPEEELERIFEPFFR-TDKSRSGTGLGLAIVKRIVELHGGTISVESEPGKGTTFTIRLPLAPAAADA 336

-1

137202

PRK09303

adaptive-response sensory kinase; Validated

false

true

false

378

2e-19

93.10

59.26

6,386,151,42,428,194,7,435,204,12,447,221,78,525,300,26,551,327,48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 387 LLAAVSHDLRTPLASIKAGVSTLRQTDIQWSPSDVAELLSSV-DQATDQL---DALIANLLDMSR-----IHTGAVQPFL 457
PRK09303     152 LLAMLAHDLRTPLTAASLAVETLELGQIDPSEELSPALIEQLqDQARRQLeeiERLITDLLEVGRtrweaLQFNPQKLDL 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 458 RPTALEEVAPLALAGLADAERVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLPPAVVARIR-GEKVRIDVVDH 536
PRK09303     232 GSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQRRIRQVLLNLLDNAIKYTPEGGTITLTMLHRtTQKVQVSICDT 311

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117928402 537 GPGIPPHARDRVFQP-FQQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPI 599
PRK09303     312 GPGIPEEEQERIFEDrVRLPRDEGTEGYGIGLSVCRRIVEVHYGQIWVDSEPGQGSCFHFTLPV 375

-1

132001

TIGR02956

TMAO_torS

TMAO reductase sytem sensor TorS

false

true

false

968

7e-19

90.99

25.00

10,372,451,6,378,458,36,417,494,45,462,543,10,473,553,8,481,563,7,488,571,27,518,598,7,525,608,29,554,638,55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 373 QAEALA-AGNRMRTALLAAVSHDLRTPLASIKAGVSTLRQTDIqwsPSDVAELLSSVDQATDQLDALIANLLDMSRIHTG 451
TIGR02956    452 KARAEAeEANRAKSAFLATMSHEIRTPLNGILGTLELLGDTGL---TSQQQQYLQVINRSGESLLDILNDILDYSKIEAG 528

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 452 AVQPFLRPTAL----EEVAPLALAGlADAERVQL--DIPEDLP-LIATDPGLLERVLANLVANALRHSPPHlppAVVARI 524
TIGR02956    529 HLSISPRPFDLnallDDVHHLMVSR-AQLKGIQLrlNIPEQLPnWWQGDGPRIRQVLINLVGNAIKFTDRG---SVVLRV 604

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 525 R---GEKVRIDVVDHGPGIPPHARDRVFQPFQQ-LDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPIS 600
TIGR02956    605 SlndDSSLLFEVEDTGCGIAEEEQATLFDAFTQaDGRRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLT 684


                 ....*....
gi 117928402 601 AYVPSDIDA 609
TIGR02956    685 RGKPAEDSA 693

-1

33926

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [...

false

true

false

603

1e-18

89.56

37.65

5,372,376,12,388,388,89,477,478,48,525,528,27,553,555,48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 373 QAEALAAGNRMRtallAAVSHDLRTPLASIKAGVSTLRQTDIQWSPSDVAELLSSVDQATDQLDALIANLLDMSRIHTGA 452
COG4191      377 QAGKLAALGQMS----AGIAHELNQPLAAIRTYADNARLLLERGRTEEARENLERISALTERMAAITAHLKSFARKSRDA 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 453 VQPFLRPTALEEVAPLALAGLADAE-RVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLPPAVVARIR--GEKV 529
COG4191      453 AGPVSLREAIEGALELLRGRLRAAGvELELDLPDAPLWVMANEIRLEQVLVNLLQNALDAMAGQEDRRLSIRAQreGGQV 532

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117928402 530 RIDVVDHGPGIPPHARDRVFQPFqQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISA 601
COG4191      533 VLTVRDNGPGIAPEALPHLFEPF-FTTKPVGKGLGLGLAISQNIARDLGGSLEVANHPEGGASFTIELRRAA 603

-1

138403

PRK11100

sensory histidine kinase CreC; Provisional

false

true

false

475

2e-18

89.53

48.63

8,381,244,6,387,259,16,404,275,10,416,285,36,460,321,13,473,345,79,554,424,23,577,451,24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 382 RMRTAL---------LAAVSHDLRTPLASIKaGVSTLRQTDIqwSPSDVAELLSSVDQATDQLDALIANLLDMSRIHTGA 452
PRK11100     245 SMRVKLegkayveqyVQTLTHELKSPLAAIR-GAAELLQEDP--PPEDRQRFTGNILAQSARLQQLIDRLLELARLEQRQ 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 453 vqpflrptALEEVAPLALAGL-----------ADAERVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLPPAVV 521
PRK11100     322 --------ELEVLEPVALAALleelveareaqAAAKGITLRLRPDDAAVLGDPFLLRQALGNLLDNAIDFTPEGGTITLS 393

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 522 ARIRGEKVRIDVVDHGPGIPPHARDRVFQPFqqLDDRRGGGVGLGLAVARGFVEAL----GGEIHVLETPGGGVTMRVEL 597
PRK11100     394 AERDGEQVALSVEDSGPGIPDYALPRIFERF--YSLPRPANGRKSTGLGLAFVREVarlhGGEVTLRNRPEGGVLATLTL 471


                 ....
gi 117928402 598 PISA 601
PRK11100     472 PRHF 475

-1

138021

PRK10604

sensor protein RstB; Provisional

false

true

false

433

1e-17

86.28

48.96

7,383,211,30,421,241,33,456,274,7,464,281,13,477,300,39,518,339,34,552,376,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 384 RTALLAAVSHDLRTPLASIKAGVSTLRQTDiqwspsdvAELLSSVDQATDQLDALIANLLDMSRIHTGAVQpfLRPTALE 463
PRK10604     212 KKQLIDGIAHELRTPLVRLRYRLEMSDNLS--------AAESQALNRDIGQLEALIEELLTYARLDRPQNE--LHLSEPD 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 464 eVAPLALAGLADAE------RVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLppAVVARIRGEKVRIDVVDHG 537
PRK10604     282 -LPAWLSTHLADIQavtpekTVRLKTPHQGDYGALDMRLMERVLDNLLNNALRYSHSTV--ETSLLLDGDQATLIVEDDG 358

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117928402 538 PGIPPHARDRVFQPF---QQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPI 599
PRK10604     359 PGIAPEERERIFEPFvrlDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDTSELGGARFSFSWPV 423

-1

132011

TIGR02966

phoR_proteo

phosphate regulon sensor kinase PhoR

false

true

false

333

3e-17

85.34

52.25

7,381,111,30,416,141,10,426,152,8,434,163,27,464,190,13,477,211,14,492,225,60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 382 RMRTALLAAVSHDLRTPLASIKAGVSTLRQtdiqwSPSDVAELLS-SVDQATDQ---LDALIANLLDMSRIHTGAVQPFL 457
TIGR02966    112 QMRRDFVANVSHELRTPLTVLRGYLETLAD-----GPDEDPEEWNrALEIMLEQsqrMQSLVEDLLTLSRLESAASPLED 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 458 RPTAleeVAPLALAGLADAE--------RVQLDIPEDLPLIAtDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKV 529
TIGR02966    187 EPVD---MPALLDHLRDEAEalsqgknhQITFEIDGGVDVLG-DEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGA 262

                        170       180
                 ....*....|....*....|...
gi 117928402 530 RIDVVDHGPGIPPHARDRVFQPF 552
TIGR02966    263 EFSVTDTGIGIAPEHLPRLTERF 285

-1

33974

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal...

false

true

false

750

2e-16

82.68

31.60

6,373,513,75,450,588,26,476,615,10,486,626,39,525,666,29,554,696,54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 374 AEALAAGNRMRTALLAAVSHDLRTPLASIKAGVSTLRQTDIQWSPSDVAELLSSVDQATDQLDALIANLLDMSRIhtGAV 453
COG4251      514 RRELERSNAELRAFAYVASHDLQEPLRQISNYAQLLSERYSDALDEEAKEFITFISRLTSLMQQLIDDLLTYSKL--GLT 591

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 454 QPFLRPTALEEVAPLALAGLADA-ERVQLDIPED-LPLIATDPGLLERVLANLVANALRHSPPHLPPAVVARIR-GEKVR 530
COG4251      592 EAPLQPTDVQKVVDKVLLELSQRiADTGAEIRIApLPVVAADATQLGQVFQNLIANAIKFGGPENPDIEISAERqEDEWT 671

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928402 531 IDVVDHGPGIPPHARDRVFQPFQQ-LDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISAYVPSDID 608
COG4251      672 FSVRDNGIGIDPAYFERIFVIFQRlHSRDEYLGTGLGLAICKKIAERHQGRIWVESTPGEGSTFYFTLPVGGEEPGSSS 750

-1

137977

PRK10549

signal transduction histidine-protein kinase BaeS; Provisional

false

true

false

467

4e-16

81.69

50.75

7,373,230,55,430,285,2,434,287,20,456,307,22,478,336,13,492,349,60,552,412,55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 374 AEALAAGNRMRTALLAAVSHDLRTPLASIKAGVSTLRQTDIQWSPSDVAELLSSVdqATdqLDALIANLLDMSRIHTGAV 453
PRK10549     231 ASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEV--GT--LTKLVDDLHQLSLSDEGAL 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 454 QpfLRPTALEEVAPLALAGLADAER-------VQLDIPEDLPLIAtDPGLLERVLANLVANALRHSPPHLPPAVVARIRG 526
PRK10549     307 A--YQKTPVDLVPLLEVAGGAFRERfasrgltLQFSLPDSATVFG-DPDRLMQLFNNLLENSLRYTDSGGSLHISAEQHD 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 527 EKVRIDVVDHGPGIPPHARDRVFQPF---QQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISAYV 603
PRK10549     384 KTLRLTFADSAPGVSDEQLQKLFERFyrtEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDL 463


                 ....
gi 117928402 604 PSDI 607
PRK10549     464 QREV 467

-1

138539

PRK11360

sensory histidine kinase AtoS; Provisional

false

true

false

607

4e-16

81.66

36.08

7,372,380,10,386,390,25,414,415,62,477,477,4,481,483,39,520,523,32,555,555,44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 373 QAEALAAGNRmrtaLLAAVSHDLRTPLASIKAGVSTLRQtdiQWSPSDVAELLSSVDQATDQLDALIANLLDMSRIHTGA 452
PRK11360     381 RAERLAALGE----LMAGVAHEIRNPLTAIRGYVQILRQ---QTSDPIHQEYLSVVLREVDSLNKVIQQLLEFSRPRHSQ 453

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 453 VQPFLRPTALEEVAPLALAGLADAeRVQL--DIPEDLPLIATDPGLLERVLANLVANALRHSPPHLPPAV-VARIRGEKV 529
PRK11360     454 WQQVSLNALVEEVLVLVQTAGVQA-RVDFitELDNELPPINADRELLKQVLLNILINAVQAISARGKIRIrTWQYSDSQQ 532

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 530 RIDVVDHGPGIPPHARDRVFQPFqqlDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPI 599
PRK11360     533 AISIEDNGCGIDLELLKKIFDPF---FTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGTTFTLILPI 599

-1

34607

COG5002

VicK

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

459

2e-15

79.21

51.20

6,381,222,28,411,250,19,430,270,24,456,294,13,469,315,83,552,401,56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 382 RMRTALLAAVSHDLRTPLASIKAGVSTLrqTDIQWSPSDVAELLSSVDQ-ATDQLDALIANLLDMSRIHTGAVQpfLRPT 460
COG5002      223 RERREFVANVSHELRTPLTSMKSYLEAL--EEGAWEDKEIAPRFLRVTLnETERMIRLVNDLLQLSRMDNARYQ--LNKE 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 461 ALEEVAPLA--------LAGLADAERVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKVRID 532
COG5002      299 WINFTAFLNeiinrfemILKKETIARFVRDIPKQDIWVEIDPDKMTQVLDNIISNALKYSPDGGRITVSVKQRETWVEIS 378

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928402 533 VVDHGPGIPPHARDRVFQPF---QQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISAYVPSDID 608
COG5002      379 ISDQGLGIPKEDLEKIFDRFyrvDKARSRKMGGTGLGLAIAKEIVQAHGGRIWAESEEGKGTTFSFTLPYSGEAGDDWD 457

-1

33642

COG3852

NtrB

Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]

false

true

false

363

7e-15

77.64

65.01

7,371,119,54,427,173,3,431,176,86,517,272,11,528,287,24,555,311,32,588,343,12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 372 SQAEALAAGNRMRTALLAAVSHDLRTPLASIKAGVSTLRQTDIQWSPSDVAELLssVDQaTDQLDALIANLLDMSRIHTG 451
COG3852      120 DREQTQHAQQRAVKGLVRGLAHEIKNPLGGIRGAAQLLERALPDEALRELTQLI--IEE-ADRLRNLVDRLEVLGPQRPG 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 452 AVQPFLRPTALEEVAPLALAGLADAERVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLP----------PAVV 521
COG3852      197 DRVPVNIHEVLERVRALVEAEFADNVRLIRDYDPSLPEVLGDRDQLIQVFLNLVRNAAQALGGRADeggeiilrtrTGIQ 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 522 ARIRGEK----VRIDVVDHGPGIPPHARDRVFQPFqqlDDRRGGGVGLGLAVARGFVEALGGEIHVLETPgGGVTMRVEL 597
COG3852      277 LTIAGTRyrlaLPLEVIDNGPGVPPDLQDHLFYPM---VSGREGGTGLGLALAQNLIDQHGGKIEFDSWP-GRTVFRVLL 352


                 ...
gi 117928402 598 PIS 600
COG3852      353 PIR 355

-1

131962

TIGR02916

PEP_his_kin

putative PEP-CTERM system histidine kinase

false

true

false

679

7e-15

77.45

31.37

8,371,466,17,392,483,18,412,501,26,444,527,33,477,561,10,488,571,55,543,627,10,556,637,42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 372 SQAEALAAGNRMRTALLaavsHDLRTPLASIKAGVSTLRqtDIQWSPSDVAELLSSVDQATDQLDALianlldMSRIHTG 451
TIGR02916    467 AEARQFEAFNRMSAFVV----HDLKNLVAQLSLLLRNAE--RHKDNPEFQDDMLETVENAVNRMKKL------LAQLRSK 534

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 452 AVQPFLRPTALEEVAPLALAGLADAE-RVQLDIPEDLpLIATDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKVR 530
TIGR02916    535 GLEEEKLCVDLVDLLRRAIASKRAQGpRPEVSIDTDL-SVRADRERLERVLGHLVQNALEATPGEGRVAIRVERECGAAR 613

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928402 531 IDVVDHGPGIPPH-ARDRVFQPFQqldDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELP 598
TIGR02916    614 IEIEDSGCGMSPAfIRERLFKPFD---TTKGAGMGIGVYECRQYVEEIGGRIEVESTPGQGTIFTLVLP 679

-1

138589

PRK11466

hybrid sensory histidine kinase TorS; Provisional

false

true

false

912

1e-14

76.99

25.22

10,371,432,8,380,440,41,424,481,29,453,516,3,457,519,24,481,545,7,488,553,27,518,580,7,525,589,29,555,618,44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 372 SQAEALAAgNRMRTALLAAVSHDLRTPLASIKAGVSTLRQTDIQWSPSDVaelLSSVDQATDQLDALIANLLDMSRIHTG 451
PRK11466     433 ARAEAEKA-SQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDD---LRAITDSGESLLTILNDILDYSAIEAG 508

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 452 AV------QPFlRPTALEEVAPLALAGLADAERVQL--DIPEDLP-LIATDPGLLERVLANLVANALRHSPPHlppAVVA 522
PRK11466     509 GKnvsvsdEPF-EPRPLLESTLQLMSGRVKGRPIRLatDIADDVPsALMGDPRRIRQVITNLLSNALRFTDEG---SIVL 584

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928402 523 RIR--GEKVRIDVVDHGPGIPPHARDRVFQPFQQlDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPI 599
PRK11466     585 RSRtdGEQWLVEVEDSGCGIDPAKLAEIFQPFVQ-VSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662

-1

137309

PRK09467

envZ

osmolarity sensor protein; Provisional

false

true

false

437

4e-14

74.95

46.91

7,383,230,26,416,256,4,421,260,32,456,292,23,479,316,37,518,353,36,554,390,45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 384 RTALLAAVSHDLRTPLASIKAGVSTLrqtdiqwSPSDvAELLSSVDQATDQLDALIANLLDMSRIHTGAVqpfLRPTALE 463
PRK09467     231 RALLMAGVSHDLRTPLTRIRLATEMM-------SEED-GYLAESINKDIEECNAIIEQFIDYLRTDQEMP---MEMADLN 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 464 EVAPLALAGLADAERV-QLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHLppAVVARIRGEKVRIDVVDHGPGIPP 542
PRK09467     300 ALLGEVIAAESGYEREiETALYPGPIEVPMNPIAIKRALANLVVNAARYGNGWI--KVSSGTEGNRAWFQVEDNGPGIPE 377

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 117928402 543 HARDRVFQPFQQ-LDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPI 599
PRK09467     378 EQIKHLFQPFTRgDSARGSSGTGLGLAIVKRIVDQHQGKVELGNREEGGLSARAWLPL 435

-1

33927

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]

Signal transduction histidine kinase regulating phosphoglycerate transport system [...

false

true

false

673

3e-13

72.03

26.60

6,372,443,15,391,458,56,449,514,20,469,537,43,513,580,7,520,590,32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 373 QAEALAAGNRMRTALlaavSHDLRTPLASIKAGVSTLRQTDIQWSPSDVAELLSSVDQATDQLDALIANLLDMSRihTGA 452
COG4192      444 QAAKLAVVGQTMTSL----AHEINQPLNAMSAYLFSARLALEEAPSAQAATSLDKIENLTERMGKIVNSLRQFAR--KNS 517

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 453 VQPFLRPTALEEVAPLA---LAGLADAERVQLDIPEDLPLIATDPGLLERVLANLVANALRHSpPHLPPAV---VARIRG 526
COG4192      518 SDESLQPVRLNSVVEQAwelLQTKHKRRQIKLINPTDDLMVMGDAVSIEQVLVNLIVNALDAS-THFAPWIkliALGTEQ 596

                        170       180
                 ....*....|....*....|....*.
gi 117928402 527 EKVRIDVVDHGPGIPPHARDRVFQPF 552
COG4192      597 EMLRIAIIDNGQGWPHELVDKLLTPF 622

-1

130453

TIGR01386

cztS_silS_copS

heavy metal sensor kinase

false

true

false

457

2e-12

69.72

35.89

7,388,245,14,408,259,9,417,269,5,422,277,40,462,318,7,469,327,22,492,349,60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 389 AAVSHDLRTPLASIkagvstLRQTDIQWS-PSDVA---ELLSSVDQATDQLDALIANLLDMSRIHTGAVQPFLRPTAL-E 463
TIGR01386    246 ADLAHELRTPLTNL------LGQTQVALSqPRTGEeyrEVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLaA 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 464 EVAPLA--LAGLADAERVQLDIPEDLPLIAtDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKVRIDVVDHGPGIP 541
TIGR01386    320 ELAKVAeyFEPLAEERGVRIRVEGEGLVRG-DPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIP 398

                        170
                 ....*....|.
gi 117928402 542 PHARDRVFQPF 552
TIGR01386    399 PEHLSRLFDRF 409

-1

138397

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

false

true

false

779

2e-11

66.17

29.91

12,373,272,29,403,301,4,407,306,8,418,314,46,464,361,4,468,366,6,475,372,2,477,378,11,488,390,27,518,417,7,525,427,24,549,455,50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 374 AEALAAGNRMRTALLAAVSHDLRTPLASIkAGVS-TLRQTDIQwspSDVAELLSSVDQATDQLDALIANLLDMSRIHTGA 452
PRK11091     273 QDALEKASRDKTTFISTISHELRTPLNGI-VGLSrMLLDTELT---AEQEKYLKTIHVSAITLGNIFNDIIDMDKMDRRK 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 453 VQPFLRPTALEE-VAPL-ALAGLAdAE----RVQLDIPEDLP-LIATDPGLLERVLANLVANALRHSPPHlppAVVARIR 525
PRK11091     349 LQLDNQPVDFTDfLADLeNLSGLQ-AEqkglRFDLEPLLPLPhKVITDGTRLRQILWNLISNAVKFTQQG---QVTVRVR 424

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 526 ---GEKVRIDVVDHGPGIPPHARDRVF----QPFQQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELP 598
PRK11091     425 yedGDMLHFEVEDSGIGIPEDELDKIFamyyQVKDSHGGKPATGTGIGLAVSRRLAQNMGGDITVTSEEGKGSTFTLTIH 504


                 .
gi 117928402 599 I 599
PRK11091     505 A 505

-1

138212

PRK10841

hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional

false

true

false

947

1e-10

63.14

19.64

9,372,456,7,379,465,23,403,488,12,417,500,55,472,556,10,482,570,6,488,577,26,514,608,2,522,610,32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 373 QAEALAA--GNRMRTALLAAVSHDLRTPLASIkAGVSTLRQTDIQwsPSDVAELLSSVDQATDQLDALIANLLDMSRIHT 450
PRK10841     457 QEMAQAAeqASQSKSMFLATVSHELRTPLYGI-IGNLDLLQTKEL--PKGVDRLVTAMNNSSSLLLKIISDILDFSKIES 533

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 451 GAVQPFLRPTALEEVAPLALAG-LADAERVQLD----IPEDLP-LIATDPGLLERVLANLVANALRHSPP-----HLppa 519
PRK10841     534 EQLKIEPREFSPREVMNHITANyLPLVVKKQLGlycfIEPDVPvSLNGDPMRLQQVISNLLSNAIKFTDTgciilHV--- 610

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 117928402 520 vvaRIRGEKVRIDVVDHGPGIPPHARDRVFQPFQQ 554
PRK10841     611 ---RVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQ 642

-1

137312

PRK09470

cpxA

two-component sensor protein; Provisional

false

true

false

461

4e-10

61.53

40.78

12,373,219,7,380,229,6,386,245,27,418,272,6,425,278,22,447,302,15,462,318,3,467,321,6,474,327,8,482,340,6,489,346,27,518,373,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 374 AEALAAG---NRMRTA----------LLAAVSHDLRTPLASIKAGVSTLRQTDiqwspSDVAELlSSVDQATDQLDALIA 440
PRK09470     220 QEFRAAGasfNQMVTAlermmssqqrLLSDISHELRTPLTRLQLATALLRRRQ-----GESKEL-ERIETEAQRLDSMIN 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 441 NLLDMSR--IHTGAVQPFLRPTAL-EEVapLALAGLaDAERVQLD-----IPEDLPlIATDPGLLERVLANLVANALRHS 512
PRK09470     294 DLLVLSRnqVKNHLVRETIKANSLwSEV--LEDAAF-EAEQMGKSltvnqPPGPWP-INGNPNALESALENIVRNALRYS 369

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 117928402 513 PPHLppAVVARIRGEKVRIDVVDHGPGIPPHARDRVFQPF 552
PRK09470     370 HTKI--EVGFSVDKDGLTITVDDDGPGVPEEEREQIFRPF 407

-1

137849

PRK10364

sensor protein ZraS; Provisional

false

true

false

455

1e-09

59.94

46.37

6,386,240,18,408,258,11,419,271,49,469,320,15,484,337,68,555,405,46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 387 LLAAVSHDLRTPLASIKAgvstLRQTDIQWSPS--DVAELLSSVDQATDQLDALIANLLDMSRIHTGAVQPFLRPTALEE 464
PRK10364     241 LAAGVAHEIRNPLSSIKG----LAKYFAERAPAggEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNTLINH 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 465 VAPLaLAGLADAERVQLDIP--EDLPLIATDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKVRIDVVDHGPGIPP 542
PRK10364     317 SLQL-VSQDANSREIQLRFTanDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAA 395

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 117928402 543 HARDRVFQPFqqlDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISA 601
PRK10364     396 DQLEAIFTPY---FTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNI 451

-1

139897

PRK13837

two-component VirA-like sensor kinase; Provisional

false

true

false

831

2e-09

59.70

23.83

5,419,490,14,437,504,77,514,587,11,525,607,27,555,634,54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 420 DVAELLSSVDQATDqldaLIANLLDMSRIHTGAVQPFLRPTALEEVAPLALAGLADAERVQLDIPEDLPLIATDPGLLER 499
PRK13837     491 HIDEIISSGDRARL----IIDQILTFGRKGERRTKPFSLSELVTEIAPLLRVSLPPTVELDFDFDQEPAVVEGNPAQLQQ 566

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 500 VLANLVANALRHSPP------HLPPAVVARIR---------GEKVRIDVVDHGPGIPPHARDRVFQPFqqlDDRRGGGVG 564
PRK13837     567 VILNLCKNAAQAMDEngrvdiRLSRVDLRKPKvlahgtappGRYVLLRVSDTGRGIDEAVLPHIFEPF---FTTRARGTG 643

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 117928402 565 LGLAVARGFVEALGGEIHVLETPGGGVTMRVELPISAYVPSDIDA 609
PRK13837     644 LGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKVPVAPDA 688

-1

137612

PRK09959

hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional

false

true

false

1197

9e-09

57.43

18.80

7,383,711,31,416,742,38,456,780,4,460,789,28,488,820,40,528,864,26,554,891,45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402  384 RTALLAAVSHDLRTPLASIKAGVSTLRQTDIqwSPSDVAELLSSVDQATDQLDALIANLLDMSRIHTGAVQpfLRPT--- 460
PRK09959      712 KSQFLATMSHEIRTPISSIMGFLELLSGSGL--SKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQ--LQPQwvd 787

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402  461 --ALEEVAPLALAGLADAERVQLDIPEDLP---LIATDPGLLERVLANLVANALRHSPPHLPPAVVARIRGEK----VRI 531
PRK09959      788 ipTLVQNTCHSFGAIAASKSIALSCSSTFPehyLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHIDDnhavIKM 867

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928402  532 DVVDHGPGIPPHARDRVFQPFQQ-LDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPI 599
PRK09959      868 TIMDSGSGLSQEEQQQLFKRYSQtSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936

-1

138409

PRK11107

hybrid sensory histidine kinase BarA; Provisional

false

true

false

920

3e-08

55.67

25.87

17,380,289,19,403,308,6,409,315,3,412,319,9,422,328,32,454,364,2,456,367,4,461,371,7,469,378,12,481,392,7,488,401,3,492,404,22,514,429,8,523,437,6,529,445,25,554,473,44,598,519,8

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 381 NRMRTALLAAVSHDLRTPLasikAGVSTL-RQT-DIQWSPSDVaELLSSVDQATDQLDALIANLLDMSRIHTGAVQ---- 454
PRK11107     290 ARIKSEFLANMSHELRTPL----NGVIGFtRQTlKTPLTPTQR-DYLQTIERSANNLLAIINDILDFSKLEAGKLIleni 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 455 PF-LRPTaLEEVAPLaLAGLADAERVQL--DIPEDLP--LIAtDPGLLERVLANLVANALRHSPP---HLPPAVVArIRG 526
PRK11107     365 PFsLRET-LDEVVTL-LAHSAHEKGLELtlNIDPDVPdnVIG-DPLRLQQIITNLVGNAIKFTESgniDILVELRA-LSD 440

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 527 EKV--RIDVVDHGPGIPPHARDRVFQPFQQ---LDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELP--I 599
PRK11107     441 EKVqlEVQIRDTGIGISERQQSQLFQAFRQadaSISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPldL 520


                 ....*..
gi 117928402 600 SAYVPSD 606
PRK11107     521 NPNPIID 527

-1

138144

PRK10755

sensor protein BasS/PmrB; Provisional

false

true

false

355

3e-08

55.46

45.35

9,388,147,27,419,174,15,438,189,10,448,203,9,460,212,5,465,218,3,468,223,7,475,232,40,516,272,36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 389 AAVSHDLRTPLASIKAGVSTLRQTDIQwspsDVAELLSSVDQATDQldalIANLLDMSRI----HTGAVQPFLrptALEE 464
PRK10755     148 ADVAHELRTPLAGVRLHLELLAKTHHI----DVAPLIARLDQMMHS----VSQLLQLARAgqsfSSGNYQTVK---LLED 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 465 V-APL--ALAGLAD--AERVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHlPPAVVARIRGEKVRIDVVDHGPG 539
PRK10755     217 ViLPSydELSTMLEqrQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEG-SNITIKLQEDGGAVMAVEDEGPG 295

                        170
                 ....*....|...
gi 117928402 540 IPPHARDRVFQPF 552
PRK10755     296 IDESKCGELSKAF 308

-1

138336

PRK11006

phoR

phosphate regulon sensor protein; Provisional

false

true

false

431

1e-07

53.56

37.35

7,382,202,40,424,242,29,459,271,7,466,280,4,470,291,7,477,299,23,501,322,41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 383 MRTALLAAVSHDLRTPLASIKAGVSTLRQTDIQWSPSDVAelLSSVDQATDQLDALIANLLDMSRIHTGAVqpflrpTAL 462
PRK11006     203 ARRNFFANVSHELRTPLTVLQGYLEMMEEQPLEGPMREKA--LHTMREQTQRMEGLVKQLLTLSKIEAAPT------HLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 463 EEVA--PLAL-------AGLADAE-RVQLDIPEDLPLIATDPGLLERVlANLVANALRHSPPHLPPAVVARIRGEKVRID 532
PRK11006     275 NEKVdvPMMLrvlereaQTLSQKKhTITFEVDDSLKVLGNEDQLRSAI-SNLVYNAVNHTPEGTHITVRWQRVPHGAEFS 353

                        170
                 ....*....|
gi 117928402 533 VVDHGPGIPP 542
PRK11006     354 VEDNGPGIAP 363

-1

138388

PRK11073

glnL

nitrogen regulation protein NR(II); Provisional

false

true

false

348

3e-07

52.03

37.93

7,427,171,4,432,175,11,450,186,10,460,201,51,511,253,4,515,263,13,528,280,23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 428 VDQAtDQLDALIANLLdmsrihtGAVQPFLRPT-----ALEEVAPLALAGLADAERVQLDIPEDLPLIATDPGLLERVLA 502
PRK11073     172 IEQA-DRLRNLVDRLL-------GPQRPGTHITesihkVAERVVQLVSLELPDNVRLIRDYDPSLPELAHDPDQIEQVLL 243

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 503 NLVANALRH-SPPH------LPPAVVARIRGEK----VRIDVVDHGPGIPPHARDRVFQP 551
PRK11073     244 NIVRNALQAlGPEGgeitlrTRTAFQLTLHGERyrlaARIDIEDNGPGIPPHLQDTLFYP 303

-1

137828

PRK10337

sensor protein QseC; Provisional

false

true

false

446

4e-07

51.70

35.87

7,391,241,14,405,257,27,436,284,37,473,322,14,487,339,5,492,345,38,534,383,18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 392 SHDLRTPLASIKAG--VSTLRQTDIQWSPSDVAELLSSVDQATdqldALIANLLDMSRIHTGAVQPFLRPTALEEVAPLA 469
PRK10337     242 AHELRSPLTALKVQteVAQLSDDDPQARKKALLQLHSGIDRAT----RLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSA 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 470 LAGL-ADAERVQLDIPEDL---PLIAT-DPGLLERVLANLVANALRHSPPHLPPAVVARIRGEKVRidvvDHGPGIPPHA 544
PRK10337     318 VMDIyHTAQQAKIDVRLTLnahGIKRTgQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNARNFTVR----DNGPGVTPEA 393


                 ....*...
gi 117928402 545 RDRVFQPF 552
PRK10337     394 LARIGERF 401

-1

137545

PRK09835

sensor kinase CusS; Provisional

false

true

false

482

1e-06

50.22

34.23

7,388,266,14,408,280,9,417,293,45,462,339,7,469,348,46,517,394,22,539,418,13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 389 AAVSHDLRTPLASIkagvstLRQTDIQWS----PSDVAELLSSVDQATDQLDALIANLLDMSRIHTGAVQPFLRPTAL-E 463
PRK09835     267 ADIAHEIRTPITNL------ITQTEIALSqsrsQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLaD 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 464 EVAPLA--LAGLADAERVQLDIPEDLPLIATDPGLLERVLANLVANALRHSPPHlpPAVVARIRGEKVRIDVVDHGPG-- 539
PRK09835     341 EVGKVFdfFEALAEDRGVELRFVGDPCQVAGDPLMLRRALSNLLSNALRYTPEG--EAIVVRCQTVDHQVQVVVENPGtp 418

                        170
                 ....*....|...
gi 117928402 540 IPPHARDRVFQPF 552
PRK09835     419 IAPEHLPRLFDRF 431

-1

34223

COG4585

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

365

3e-06

49.04

36.71

6,456,231,12,468,244,28,496,279,21,518,300,24,545,324,15,573,339,26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 457 LRPTALEEVAPL-ALAGLADAERVQLDIPEDLPLIATDPGL-------LERVLANLVANALRHSPPHLPpAVVARIRGEK 528
COG4585      232 LRPVELEGLGLVeALRALLADFEERTGITVDLSLGSELERLppeaedaLFRIVQEALTNAIRHAQATEV-RVTLERTDDE 310

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117928402 529 VRIDVVDHGPGIPPharDRVFQPFQQLDDRRGggvglglavargfVEALGGEIHVLETPGGGVTMRVELPI 599
COG4585      311 LRLEVIDNGVGFDP---DKEGGGFGLLGMRER-------------VEALGGTLTIDSAPGQGTTVTITLPL 365

-1

138194

PRK10815

sensor protein PhoQ; Provisional

false

true

false

484

1e-05

47.01

43.39

11,380,263,7,388,270,22,410,294,21,438,315,15,456,330,12,469,342,7,476,354,2,478,360,20,499,380,17,518,397,33,552,430,43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 381 NRMRTALlAAVSHDLRTPLASIKAGVSTLR--QTDIQWSPSDVAELLSSVDQAtdqldalIANLLDMSRIHTGAVqpfLR 458
PRK10815     264 DKYRTTL-TDLTHSLKTPLAVLQSTLRSLRteKMSVSDAEPVMLEQISRISQQ-------IGYYLHRASMRGEGT---LL 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 459 PTALEEVAPLaLAGLADA-----ER----VQLDIPEDLPLIATDPGLLErVLANLVANALRHSPPHLppAVVARIRGEKV 529
PRK10815     333 SRELHPVAPL-LDNLTSAlnkvyQRkgvnISLDISPEISFVGEQNDFME-VMGNVLDNACKYCLEFV--EISARQTDEHL 408

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117928402 530 RIDVVDHGPGIPPHARDRVFQPfQQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRV 595
PRK10815     409 HIVVEDDGPGIPESKRELIFDR-GQRVDTLRPGQGVGLAVAREITEQYEGKIVASESPLGGARMEV 473

-1

34605

COG5000

NtrY

Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]

Signal transduction histidine kinase involved in nitrogen fixation and metabolism...

false

true

false

712

1e-05

46.87

24.02

7,390,492,21,414,513,4,418,520,19,438,539,29,467,570,10,477,581,34,511,622,41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 391 VSHDLRTPLASIKAGVSTLRQtdiQWSP---SDVAELLSSVDQATDQLDAlIANLLDMSRIHTGAVQPFLRPTALEEVAP 467
COG5000      493 IAHEIKNPLTPIQLSAERLLR---KLGKeidEDREVFDRCTDTIIRQVED-IKRMVDEFRAFARMPAPKLEKSDLRALLK 568

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 468 --LALAGLADAE-RVQLDIPEDLPLIATDPGLLERVLANLVANALRH-------SPPHLPPAVVARIRGEKVRIDVVDHG 537
COG5000      569 evSFLYEIGNDHiVFAAEFGGEPLIGMADATLLGQVFGNLLKNAAEAieaveaeERRTALIRVSLDDADGRIVVDVIDNG 648

                        170
                 ....*....|....*
gi 117928402 538 PGIPPHARDRVFQPF 552
COG5000      649 KGFPRENRHRALEPY 663

-1

131984

TIGR02938

nifL_nitrog

nitrogen fixation negative regulator NifL

false

true

false

494

2e-05

46.44

44.33

7,382,275,9,392,284,17,409,302,10,423,312,8,434,320,51,485,376,24,509,404,90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 383 MRTALLAAVsHDLRTPLASIKAGVSTL-RQTDIQWSPSdvaeLLSSVDQAtdqLDALIANLLDMSRIHTGAVQPFLRPTA 461
TIGR02938    276 IRETLSAAI-HRLQGPMNLISAAISVLqRRGDDAGNPA----SAAMLQQA---LSAGREHMEALRQVIPQSPQEIVVPVN 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 462 LEEVAPLALAGLADAERVQLDIPE-----DLPLIATDPGLLERVLANLVANAL----RHSPPHLPPAVVARIRGEKVRID 532
TIGR02938    348 LNQILRDVITLSTPRLLAAGIVVDwqpaaTLPAILGRELQLRSLFKALVDNAIeamnIKGWKRRELSITTALNGDLIVVS 427

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117928402 533 VVDHGPGIPPHARDRVFQPFQQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELPI 599
TIGR02938    428 ILDSGPGIPQDLRYKVFEPFFTTKGGSRKHIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFRV 494

-1

139663

PRK13557

histidine kinase; Provisional

false

true

false

538

6e-05

44.72

45.35

8,374,149,11,385,162,17,403,179,26,429,208,79,509,287,6,516,293,9,525,319,27,553,346,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 375 EALAAGNRMRT--ALLAAVSHDLRTPLASIkAGVSTLRQTDIQWSPSDVAELLSSVD---QATDQLDALIANLLDMSRIH 449
PRK13557     150 DALRQAQKMEAlgQLTGGIAHDFNNLLQVM-SGYLDVLQMALSKPDADRERIARSVEhirAAAERAATLTQQLLAFARKQ 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 450 TGAVQPFLRPTALEEVAPLALAGLADAERVQLDIPEDLPLIATDPGLLERVLANLVANAlRHSPPHlPPAVVARIR---- 525
PRK13557     229 KLDGRVVNLNGLVSGMGEMAERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINA-RDAMPE-GGRVTVRTEnvei 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 526 -------------GEKVRIDVVDHGPGIPPHARDRVFQPFqQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVT 592
PRK13557     307 tehdlamyhqlppGRYVSIAVTDTGSGMPPEILARVMEPF-FTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTT 385


                 ....*...
gi 117928402 593 MRVELPIS 600
PRK13557     386 VRLYFPAS 393

-1

33099

COG3290

CitA

Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]

Signal transduction histidine kinase regulating citrate/malate metabolism [Signal...

false

true

false

537

2e-04

42.52

40.97

9,405,310,8,419,318,19,438,350,11,451,361,13,464,384,9,473,400,19,492,423,30,522,456,28,552,484,46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 406 VSTLRQTDiqwspsDVAELLSSVDQATDQLDAL-------------IANLLDMSRIHtgAVQPFLRPTALEE-------- 464
COG3290      311 IITFRDKT------EIKKLTEQLTGVRQYAEALraqshefmnklhtILGLLQLGEYD--DALDYIQQESEEQqelidsls 382

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 465 --VAPLALAGL-------ADAERVQLDIPEDLPLIAT----DPGLLERVLANLVANALRHSPPHLPPAVVA---RIRGEK 528
COG3290      383 ekIKDPVLAGFllgkisrARELGVSLIIDPNSQLPQLpselQPHDLVTILGNLIDNALEALLAPEENKEIElslSDRGDE 462

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 529 VRIDVVDHGPGIPPHARDRVFQpfQQLDDRRGGGVGLGLAVARGFVEALGGEIHVLETPGGGVTMRVELP 598
COG3290      463 LVIEVADTGPGIPPEVRDKIFE--KGVSTKNTGGRGIGLYLVKQLVERLGGSIEVESEKGQGTRFSIYIP 530

-1

138393

PRK11086

sensory histidine kinase DcuS; Provisional

false

true

false

541

3e-04

42.24

18.30

3,499,435,11,510,448,40,553,488,46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928402 500 VLANLVANALR--HSPPHLPPAVVARIRGEKVRIDVVDHGPGIPPHARDRVFQpfqQLDDRRGGGVGLGLAVARGFVEAL 577
PRK11086     436 ILGNLIENALEavSNEEGGEISVSLHYRHGWLHIEVSDDGPGIAPEEIEAIFD---KGYSTKGSNRGVGLYLVKQSVENL 512

                         90       100
                 ....*....|....*....|..
gi 117928402 578 GGEIHVLETPGGGVTMRVELPI 599
PRK11086     513 GGSIAVESEPGIGTQFFVQIPW 534

-1

ATP binding site	0	17	17	true	28956	cd00075	HATPase_c
Mg2+ binding site	1	1	1	true	28956	cd00075	HATPase_c
G-X-G motif	2	4	4	true	28956	cd00075	HATPase_c
phosphorylation site	0	1	1	true	119399	cd00082	HisKA
dimer interface	1	12	12	true	119399	cd00082	HisKA