NCBI Conserved Domain Search

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Conserved domains on [gi\|117928368\|ref\|YP_872919.1\|]
diguanylate cyclase [Acidothermus cellulolyticus 11B]

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List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

7e-39

156.59

100.00

2,249,0,110,362,110,47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 250 TDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFGGE 329
cd01949        1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 330 EFVILLAGSDLEQAAVAAERVRQHIAHLTVdtpLHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGRNCVR 409
cd01949       81 EFAILLPGTDLEEAEELAERLRKAIEEPFF---IDGEEIRVTASIGIAEYPEDGEDLEELLRRADKALYQAKRSGRNRVV 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

110022

pfam00990

GGDEF

GGDEF domain

false

160

3e-37

151.24

100.00

1,247,0,160

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 248 ARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFG 327
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 328 GEEFVILLAGSDLEQAAVAAERVRQHIAHLTVDTPLHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGRNC 407
pfam00990     81 GDEFAILLPDTSLEGAQELAERIRRLLAALKIPHTLSGLPLYVTISIGIAAYPNDGEDAEDLLKRADQALYQAKNQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

8e-36

146.62

100.00

2,245,0,112,360,112,51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 246 HAARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGR 325
smart00267     1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 326 FGGEEFVILLAGSDLEQAAVAAERVRQHIAHLtvdTPLHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGR 405
smart00267    81 LGGDEFALLLPETSLEEAIALAERILQQLREP---IIIHGIPLYLTISIGVAAYPNPGEDAEDLLKRADTALYQAKKAGR 157


                 ....*.
gi 117928368 406 NCVRVA 411
smart00267   158 NQVAVY 163

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

2e-35

145.56

99.39

2,247,1,115,363,116,49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 248 ARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFG 327
TIGR00254      2 AVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRYG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 328 GEEFVILLAGSDLEQAAVAAERVRQHIAHLTVDTPlHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGRNC 407
TIGR00254     82 GEEFVVILPGTPLEDALSKAERLRDAINSKPIEVA-GSETLTVTVSIGVACYPGHGLTLEELLKRADEALYQAKKAGRNR 160


                 ....*
gi 117928368 408 VRVAT 412
TIGR00254    161 VVVAD 165

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

3e-33

137.94

98.34

3,231,3,128,362,131,22,384,154,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 232 VLVFQRTLLIAELRHAARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAG 311
COG2199        4 RLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREVAR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 312 GLTHGLRPRDFVGRFGGEEFVILLAGSDLEQAAVAAERVRQHIAHLTVdtpLHGDPVSVTVSVGVAAFRENGH-SVLELL 390
COG2199       84 RLRSNLREGDLVARLGGDEFAVLLPGTSLEEAARLAERIRAALEEPFF---LGGEELRVTVSIGVALYPEDGSdDAELLL 160

                        170       180
                 ....*....|....*....|.
gi 117928368 391 DAADAALYEAKRAGRNCVRVA 411
COG2199      161 RRADLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

2e-32

135.43

35.23

1,247,291,161

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 248 ARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFG 327
PRK09581     292 AVTDGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARYG 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 328 GEEFVILLAGSDLEQAAVAAERVRQHIAHLTVDTPLHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGRNC 407
PRK09581     372 GEEFVVVMPDTDIEVAIAVAERIRRKIAEEPFAISDGKERLNVTVSIGVAELRPSGESIEALIKRADKALYEAKNTGRNR 451


                 .
gi 117928368 408 V 408
PRK09581     452 V 452

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

9e-31

129.65

40.23

1,235,257,175

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 236 QRTLLIAELRHAARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTH 315
COG3706      258 QLRESLERLQELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEVLRQVARRLRQ 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 316 GLRPRDFVGRFGGEEFVILLAGSDLEQAAVAAERVRQHIAHLTVDTPLHGDPVSVTVSVGVAAFRENGHSVLELLDAADA 395
COG3706      338 TVRGLDLVARYGGEEFAVVLPDTDLEAAIAIAERIRQKINELPFVHELSREPLEVTISIGVAEGKPGEDSIEELLKRADK 417

                        170
                 ....*....|....*
gi 117928368 396 ALYEAKRAGRNCVRV 410
COG3706      418 ALYKAKASGRNRVVV 432

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

8e-29

123.28

45.39

3,275,155,89,366,244,15,382,259,29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 276 GGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFGGEEFVILLAGSDLEQAAVAAERVRQHIA 355
PRK09894     156 EPLNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRPYETVYRYGGEEFIIILKAATDEEACRAGERIRQLIA 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 117928368 356 HLTVDTPLHgdPVSVTVSVGVAAFREnGHSVLELLDAADAALYEAKRAGRNCVRVA 411
PRK09894     236 NQAITHSEG--RINITATFGVTRAFP-EEPLDEVIGRADRAMYEGKQAGRNRVMFI 288

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

3e-18

88.03

42.59

3,250,212,108,362,320,5,367,326,44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 251 DPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFGGEE 330
PRK10245     213 DGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDE 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 331 FVILLAGSDLEQAAVAAERVRQHIAHLTvdtpLHGDP-VSVTVSVGVAAFRENGHSVLELLDAADAALYEAKRAGRNCVR 409
PRK10245     293 FAVIMSGTPAESAITAMLRVHEGLNTLR----LPNAPqVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTE 368


                 ..
gi 117928368 410 VA 411
PRK10245     369 VA 370

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

9e-17

83.22

16.22

4,231,667,5,236,677,4,241,681,114,357,795,53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368  232 VLVFQ-----RTLLiAELRHAARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVL 306
PRK09776      668 VLVFQdvtesRAML-RQLSYSASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALL 746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368  307 RAVAGGLTHGLRPRDFVGRFGGEEFVILLAGSDLEQAAVAAERVRQHIAhlTVDTPLHGDPVSVTVSVGVAAFRENGHSV 386
PRK09776      747 RELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAIN--DYRFPWEGRVYRVGASAGITAIDDNNHQA 824

                         170       180
                  ....*....|....*....|....
gi 117928368  387 LELLDAADAALYEAKRAGRNCVRV 410
PRK09776      825 SEVMSQADIACYAAKNAGRGRVTV 848

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

4e-13

71.30

24.43

4,243,232,17,262,249,93,360,342,10,370,354,40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 244 LRHAARTDPKTGLANAAywREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFV 323
PRK10060     233 LRILANTDSITGLPNRN--AIQELIDHAIAQADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEEDQTL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 324 GRFGGEEFVILLAGSDLEQAAVAAERVRQHIAhltvdTPLHGDPVSV--TVSVGVAAFRENGHSVLELLDAADAALYEAK 401
PRK10060     311 ARLGGDEFLVLASHTSQAALEAMASRILTRLR-----LPFRIGLIEVytGCSIGIALSPEHGDDSESLIRSADTAMYTAK 385


                 ....*....
gi 117928368 402 RAGRNCVRV 410
PRK10060     386 EGGRGQFCV 394

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

7e-11

63.71

15.27

4,248,376,13,265,389,85,351,474,9,362,483,15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 249 RTDPKTGLANAAYwrevAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRPRDFVGRFGG 328
PRK11359     377 QFDPMTGLPNRNN----LHNYLDDLVDKAVSPVVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEG 452

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 117928368 329 EEFVILLAGSDLEQAAVAAERVrQHIAHLTVDtpLHGDPVSVTVSVGVA 377
PRK11359     453 TQFVLVSLENDVSNITQIADEL-RNVVSKPIM--IDDKPFPLTLSIGIS 498

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

2e-09

58.88

31.07

4,239,219,98,339,317,74,413,394,22,435,420,5

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 240 LIAELRHAARTDPKTGLANAAYWREVAEREIARARSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTHGLRP 319
COG5001      220 LSDENDRLANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRLKAFDGA 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 320 RDFVGRFGGEEFVILLAGsdLEQAAVAAERVRQHIAHLTVDTPLHGDPVSVTVSVGVAAFRENGHSVLELLDAADAALYE 399
COG5001      300 PILAARLGGDEFALIIPA--LEDDALRVAGARALCESLQAPYDLRGVRVQVGASIGIAPFPSGADTSEQLFERADYALYH 377

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 117928368 400 AKRAGRNCVRVATG---VRQQVLDLTGDTPRLIDLRTER----QPIVD 440
COG5001      378 AKQNGKGAAVLFDArheAAIRDMAVVEQALRSADLEQELsvhfQPIVD 425

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

6e-09

57.34

32.92

8,241,241,32,274,273,41,315,316,7,324,323,18,348,341,10,358,353,4,362,359,2,364,362,13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928368 242 AELRHAARTDPKTGLANAAYWREVAEREIARArSGGESVAILLVDVDHFKAVNDRFGHLIGDDVLRAVAGGLTH--GLRP 319
PRK09966     242 AQLLRTALHDPLTGLANRAAFRSGINTLMNNS-DARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEfgGLRH 320

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117928368 320 RDFvgRFGGEEFVILLAGSDLEQaavaaeRVRQHIAHLT--VDTP--LH-GDPVSVTVSVGVA 377
PRK09966     321 KAY--RLGGDEFAMVLYDVQSES------EVQQICSALTqiFNLPfdLHnGHQTTMTLSIGYA 375

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF