NCBI Conserved Domain Search

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Conserved domains on [gi\|117928182\|ref\|YP_872733.1\|]
putative signal transduction histidine kinase [Acidothermus cellulolyticus 11B]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

28956

cd00075

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

true

false

true

103

1e-07

53.40

100.00

3,456,0,33,489,35,17,506,70,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 457 LLRIAQEAITNARRHAGATNLWIRCRVDPPFAH--LRVEDDGRGLGPARLDS------------------FGLEVMHERA 516
cd00075        1 LQQVLLNLLSNAIKHTPEGGGRITISVERDGDHleIRVEDNGPGIPEEDLERiferfsdgsrsrkgggtgLGLSIVKKLV 80

                         90       100
                 ....*....|....*....|...
gi 117928182 517 DRIGATLSISPRPGGGTIVEVRL 539
cd00075       81 ELHGGRIEVESEPGGGTTFTITL 103

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

111420

pfam02518

HATPase_c

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

false

111

2e-10

62.73

96.40

3,452,1,22,474,24,32,506,75,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 453 VETELLRIAQEAITNARRHAGA-TNLWIRCRVDPPFAHLRVEDDGRGLGPARLDS-------------------FGLEVM 512
pfam02518      2 DEDRLRQVLSNLLDNAIKHAPAgGEITVTLEREGGRLRITVEDNGPGIPPEDLEKifepfyrdgsdsrkvggtgLGLSIV 81

                         90       100
                 ....*....|....*....|....*..
gi 117928182 513 HERADRIGATLSISPRPGGGTIVEVRL 539
pfam02518     82 KKLVELHGGTITVESEPGGGTTFTLTL 108

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

-1

128669

smart00387

HATPase_c

Histidine kinase-like ATPases

false

111

2e-08

56.12

95.50

3,453,2,21,474,24,32,506,75,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 454 ETELLRIAQEAITNARRHAGA-TNLWIRCRVDPPFAHLRVEDDGRGLGPARLDS-------------------FGLEVMH 513
smart00387     3 PDRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDHLEITVEDNGPGIPPEDLEKifepffrtdgrsrkiggtgLGLSIVK 82

                         90       100
                 ....*....|....*....|....*.
gi 117928182 514 ERADRIGATLSISPRPGGGTIVEVRL 539
smart00387    83 KLVELHGGEISVESEPGGGTTFTITL 108

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

-1

34223

COG4585

Signal transduction histidine kinase [Signal transduction mechanisms]

true

false

365

1e-28

123.39

50.96

3,355,177,17,372,195,133,505,329,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 356 IHDGIAQELASLGYRID-DQIANATAAPGLAADLRAIRADVSRLITELRLSIFDLRSEVGTQTSLGAALADYVRSIGPGI 434
COG4585      178 LHDSVGQSLTAISMLLAlLLLLADEDAEKAQEELKEIEKLLREALQEVRALVRDLRPVELEGLGLVEALRALLADFEERT 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 435 GLAVHVILDESVDRLPIPVETELLRIAQEAITNARRHAGATNLWIRCRVDPPFAHLRVEDDGRGLGPARLD-SFGLEVMH 513
COG4585      258 GITVDLSLGSELERLPPEAEDALFRIVQEALTNAIRHAQATEVRVTLERTDDELRLEVIDNGVGFDPDKEGgGFGLLGMR 337

                        170       180
                 ....*....|....*....|....*.
gi 117928182 514 ERADRIGATLSISPRPGGGTIVEVRL 539
COG4585      338 ERVEALGGTLTIDSAPGQGTTVTITL 363

-1

33640

COG3850

NarQ

Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]

Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction...

false

true

false

574

2e-21

99.20

57.67

10,177,235,40,219,275,23,244,298,3,257,301,12,286,313,31,320,344,47,369,391,28,397,430,9,414,439,88,502,529,37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 178 RSYHVAHALLQQLRDISRQLSEGLDAVAVAHGLLHTIRSRlaFGRGAVLIRSDGGHLVALAVDGApdAHWvpteetsltl 257
COG3850      236 RDLEQKNQRLSFLYQSSRRLHTSQIDDERLRHVLNRLQNL--TGLAAVRLELYGGDDERNHQEHA--EQW---------- 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 258 RDALADQRAVTAhgrfgagvpsdgtpvqgWQAVYPLRVGDRQIGAVVLDGDGAPPGPALItdvDAVVEDAGIRLETALLF 337
COG3850      302 DISEGDQPSGLK-----------------WPQEDPLTQQGHLLGTLPWQRSLPEDDQQLL---DTLVQQLGRTLALNKQQ 361

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 338 GEVRSLATTEERRRLAREIHDGIAQELASLgyRIDDQIANATAAPGLAADLRAIRADVSR-----------LITELRLSI 406
COG3850      362 EQQQQLLLMEERATIARELHDSIAQSLSFL--KIQVTLLKTAIPEELPEKAREIIAQIRQglndayrqlreLLTTFRLTL 439

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 407 fdlrsevgTQTSLGAALADYVRSIGPGIGLAVHVILDESVDRLPIPVETELLRIAQEAITNARRHAGATNLWIRCRVDPP 486
COG3850      440 --------QEAELPPALEQMLAEFSNQTGITVTLDYQLPPRALPAHQQVHLLQIVREALSNAIKHAQASEIKVTVSQNDG 511

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 117928182 487 FAHLRVEDDGRGLGPA--RLDSFGLEVMHERADRIGATLSISPRPGGGTIVEVRL 539
COG3850      512 QVTLTVEDNGVGIDEAaePSGHYGLNIMRERAQRLGGQLRIRRREGGGTEVSLTF 566

-1

34202

COG4564

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

459

3e-15

78.49

40.96

5,355,257,32,389,289,9,398,301,105,503,410,26,530,436,9

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 356 IHDGIAQELASLGYRIDDQIANATAAPGLAADlrAIRADVSRL---ITELRLSIFDLRSEVGTQTSLGAALADYVRSIGP 432
COG4564      258 LHDGISQNLVSVKCALELAARQLNPPKGGAHP--AIEKAADALngaIKEVRRISHDLRPRALDDLGLTAALEALLEDFKE 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 433 GIGLAVHVILDESVDRLPIPVETELLRIAQEAITNARRHAGATNLWIRCRVDPPFAHLRVEDDGRGLGPAR----LDSFG 508
COG4564      336 RTGIEITLEFDTQPGKLKPEVATALYRVVQEALTNIERHAGATRVTILLQQMGDMVQLMVRDNGVGFSVKEalqkRHGIG 415

                        170       180       190
                 ....*....|....*....|....*....|.
gi 117928182 509 LEVMHERADRIGATLSISPRPgGGTIVEVRL 539
COG4564      416 LRNMRERMAHFGGELEVESSP-QGTELTVLL 445

-1

138290

PRK10935

nitrate/nitrite sensor protein NarQ; Provisional

false

true

false

568

3e-15

78.38

15.14

3,456,474,33,489,508,13,502,523,37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 457 LLRIAQEAITNARRHAGATNLWIRCRVDPPFAH-LRVEDDGRGLGPA--RLDSFGLEVMHERADRIGATLSISPRPGGGT 533
PRK10935     475 LLQIIREATLNAIKHANASEIAVSCVTNPDGEVtVSIRDDGVGIGELkePEGHYGLNIMHERASRLGGTLTFSQNPGGGT 554


                 ....*.
gi 117928182 534 IVEVRL 539
PRK10935     555 TVSLTF 560

-1

138019

PRK10600

nitrate/nitrite sensor protein NarX; Provisional

false

true

false

569

1e-10

63.21

32.51

5,355,368,18,373,387,30,403,419,8,414,427,88,502,517,36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 356 IHDGIAQELASLGYRIDD-QIANATAAPGLAADLRAIRADVSRLITELR--LSIFDLRSevgTQTSLGAALADYVRSIGP 432
PRK10600     369 LHDSIAQSLSCMKMQVSClQMQGDALPESSRELLSQIRNELNASWAQLRelLTTFRLQL---TEPGLRPALEASCEEFSA 445

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 433 GIGLAVHVILDESVDRLPIPVETELLRIAQEAITNARRHAGATNLWIRCRVDPPFAHLRVEDDGRGLGPA--RLDSFGLE 510
PRK10600     446 RFGFPVKLDYQLPPRLVPSHQAIHLLQIAREALSNALKHAQASEVVVTVAQNDNQVKLSVQDNGCGVPENaeRSNHYGLI 525

                        170       180
                 ....*....|....*....|....*...
gi 117928182 511 VMHERADRIGATLSISPRPGGGTIVEVR 538
PRK10600     526 IMRDRAQSLRGDCSVRRRESGGTEVVVT 553

-1

33641

COG3851

UhpB

Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]

Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction...

false

true

false

497

4e-10

61.47

36.42

7,355,309,12,369,321,18,394,339,14,408,361,25,434,386,18,452,406,49,501,456,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 356 IHDGIAQELASLgyRIDDQIANATAAPGLAADlrairadVSRLITELRLSIFD--------LRSEVGTQTSLGAALADYV 427
COG3851      310 LHDEIGQNITAI--RTQAGIVKRAADNAQVKQ-------AASLIEQLSLRIYDsvrqllgrLRPRQLDDLTLEQAIRSLL 380

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 428 RSIGPGiGLAVHVILDESVDRLPIP--VETELLRIAQEAITNARRHAGATNLWIRCRVDPPFAHLRVEDDGRGLGP-ARL 504
COG3851      381 REMELE-ERGIHCQLDWRINETALDetQRVTLYRLCQELLNNICKHADASAVTIQLWQQDERLMLEIEDDGSGLPPgSGV 459

                        170       180       190
                 ....*....|....*....|....*....|.
gi 117928182 505 DSFGLEVMHERADRIGATLSISPRPGGGTIV 535
COG3851      460 QGFGLTGMRERVSALGGTLTLSSQHGTRVIV 490

-1

138693

PRK11644

sensory histidine kinase UhpB; Provisional

false

true

false

497

1e-08

56.57

28.77

5,397,344,11,408,363,25,434,388,18,452,408,51,503,460,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 398 LITELRLSIFD--------LRSEVGTQTSLGAALADYVRSIGPGiGLAVHVILDESVDRLPIP--VETELLRIAQEAITN 467
PRK11644     345 LIEQLSLGVYDavrrllgrLRPRQLDDLTLEQAIRSLMRELELE-DRGIVSHLDWQIDESALSetQRVTLFRVCQEGLNN 423

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117928182 468 ARRHAGATNLWIRCRVDPPFAHLRVEDDGRGLGPAR-LDSFGLEVMHERADRIGATLSISPRPG 530
PRK11644     424 IVKHADASAVTIQGWQQDERLMLVIEDNGSGLPPGSgQQGFGLRGMQERVSALGGTLTISCTHG 487

-1

138021

PRK10604

sensor protein RstB; Provisional

false

true

false

433

9e-07

50.46

45.73

12,357,216,7,364,227,8,373,235,9,382,246,23,409,269,9,418,285,7,426,292,8,438,300,20,458,321,17,476,338,26,502,374,3,505,387,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 358 DGIAQEL----ASLGYRIDdQIANATAAP--GLAADLRAIRADVSRLITELRLSifdlRSEVGTQTS-------LGAALA 424
PRK10604     217 DGIAHELrtplVRLRYRLE-MSDNLSAAEsqALNRDIGQLEALIEELLTYARLD----RPQNELHLSepdlpawLSTHLA 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 425 DyVRSIGPGIglavHVILDESVDRLPIPVETELL-RIAQEAITNARRHAGATnLWIRCRVDPPFAHLRVEDDGRGLGPA- 502
PRK10604     292 D-IQAVTPEK----TVRLKTPHQGDYGALDMRLMeRVLDNLLNNALRYSHST-VETSLLLDGDQATLIVEDDGPGIAPEe 365

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 117928182 503 ---------RLD----------SFGLEVMHERADRIGATLSISPRPGGG 532
PRK10604     366 rerifepfvRLDpsrdratggcGLGLAIVHSIALAMGGSVNCDTSELGG 414

-1

30987

COG0642

BaeS

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

336

5e-06

47.86

51.49

3,383,154,54,437,209,69,506,294,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 384 LAADLRAIRADVSRLITELRLSIFDLRSEVGTQTSLGAALADYVRSIGPGIGLA-VHVILDESVDRLPIPVETELLRIAQ 462
COG0642      155 IEEEAERLLRLVNDLLDLSRLEAGTKLKLLLELVDLAELLEEVVRLLAPLAQEKgIELAVDLPELPYVLGDPERLRQVLV 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928182 463 EAITNARRHAGATNLWIRCRVDPPFAHLRVEDDGRGLGPARLDS----------------FGLEVMHERADRIGATLSIS 526
COG0642      235 NLLSNAIKYTPGGEITISVRQDDEQVTISVEDTGPGIPEEELERifepffrtdksrsgtgLGLAIVKRIVELHGGTISVE 314

                        170
                 ....*....|...
gi 117928182 527 PRPGGGTIVEVRL 539
COG0642      315 SEPGKGTTFTIRL 327

-1

ATP binding site	0	16	17	true	28956	cd00075	HATPase_c
Mg2+ binding site	1	1	1	true	28956	cd00075	HATPase_c
G-X-G motif	2	3	4	true	28956	cd00075	HATPase_c