NCBI Conserved Domain Search

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Conserved domains on [gi\|117928140\|ref\|YP_872691.1\|]
diguanylate cyclase [Acidothermus cellulolyticus 11B]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

3e-37

151.20

98.73

3,194,0,104,298,114,21,319,136,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 195 YDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLLARTGGD 274
cd01949        1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117928140 275 EFLLVLPSTTADQAAQVIERMRAA----------APDITFTAGIATWDGREPDYR-LVHRADAALYAAKAERRGT 338
cd01949       81 EFAILLPGTDLEEAEELAERLRKAieepffidgeEIRVTASIGIAEYPEDGEDLEeLLRRADKALYQAKRSGRNR 155

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

110022

pfam00990

GGDEF

GGDEF domain

false

160

3e-34

140.84

100.00

3,192,0,106,298,119,20,318,140,20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 193 AWYDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLLARTG 272
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 273 GDEFLLVLPSTTADQAAQVIERMRAA-------------APDITFTAGIATWDGREPDY-RLVHRADAALYAAKAERRGT 338
pfam00990     81 GDEFAILLPDTSLEGAQELAERIRRLlaalkiphtlsglPLYVTISIGIAAYPNDGEDAeDLLKRADQALYQAKNQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

7e-33

136.22

97.55

3,191,1,107,298,118,20,318,139,21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 192 QAWYDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLLART 271
smart00267     2 LAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLARL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928140 272 GGDEFLLVLPSTTADQAAQVIERMRAA----------APDITFTAGIATWDGREPDY-RLVHRADAALYAAKAERRGTT 339
smart00267    82 GGDEFALLLPETSLEEAIALAERILQQlrepiiihgiPLYLTISIGVAAYPNPGEDAeDLLKRADTALYQAKKAGRNQV 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

2e-30

127.93

91.16

3,184,11,114,298,135,13,311,150,26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 185 LIDRLSVQAWYDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRA 264
COG2199       12 AEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREVARRLRSNLRE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 265 GDLLARTGGDEFLLVLPSTTADQAAQVIERMRAA----------APDITFTAGIATW--DGREPDYRLVHRADAALYAAK 332
COG2199       92 GDLVARLGGDEFAVLLPGTSLEEAARLAERIRAAleepfflggeELRVTVSIGVALYpeDGSDDAELLLRRADLALYRAK 171


                 ....*
gi 117928140 333 AERRG 337
COG2199      172 RAGRN 176

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

4e-26

113.97

97.58

4,191,0,108,299,118,7,306,127,13,319,141,20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 192 QAWYDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLLART 271
TIGR00254      1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 272 GGDEFLLVLPSTTADQAAQVIERMRAAA----------PDITFTA--GIATWDGREPDYR-LVHRADAALYAAKAERRGT 338
TIGR00254     81 GGEEFVVILPGTPLEDALSKAERLRDAInskpievagsETLTVTVsiGVACYPGHGLTLEeLLKRADEALYQAKKAGRNR 160


                 .
gi 117928140 339 T 339
TIGR00254    161 V 161

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

6e-26

113.48

37.93

3,185,262,116,301,391,16,317,408,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 186 IDRLSVQAWYDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAG 265
COG3706      263 LERLQELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEVLRQVARRLRQTVRGL 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 266 DLLARTGGDEFLLVLPSTTADQAAQVIERMRAAAPD-------------ITFTAGIATWDGREPD-YRLVHRADAALYAA 331
COG3706      343 DLVARYGGEEFAVVLPDTDLEAAIAIAERIRQKINElpfvhelsrepleVTISIGVAEGKPGEDSiEELLKRADKALYKA 422


                 ....*
gi 117928140 332 KAERR 336
COG3706      423 KASGR 427

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

9e-25

109.62

33.92

4,195,294,103,298,400,2,300,412,13,313,426,23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 196 DALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLLARTGGDE 275
PRK09581     295 DGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARYGGEE 374

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117928140 276 FLLVLPSTTADQAAQVIERMRAA---AP----------DITFTAGIATWDG-REPDYRLVHRADAALYAAKAERR 336
PRK09581     375 FVVVMPDTDIEVAIAVAERIRRKiaeEPfaisdgkerlNVTVSIGVAELRPsGESIEALIKRADKALYEAKNTGR 449

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

1e-22

102.48

50.17

3,194,131,23,219,154,82,301,247,31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 195 YDALTGLPNRRLADFLLAAEMAAagRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLLARTGGD 274
PRK09894     132 MDVLTGLPGRRVLDESFDHQLRN--REPLNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRPYETVYRYGGE 209

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117928140 275 EFLLVLPSTTADQAAQVIERMRAAAPD-----------ITFTAGIATWDGREPDYRLVHRADAALYAAK 332
PRK09894     210 EFIIILKAATDEEACRAGERIRQLIANqaithsegrinITATFGVTRAFPEEPLDEVIGRADRAMYEGK 278

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

7e-21

96.31

14.43

3,188,683,116,309,799,9,318,825,19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140  189 LSVQAWYDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLL 268
PRK09776      684 LSYSASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVL 763

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140  269 ARTGGDEFLLVLPSTTADQAAQVIERMRAAAPDITFtagiaTWDGREPDY-----------------RLVHRADAALYAA 331
PRK09776      764 ARLGGDEFGLLLPDCNVESARFIATRIISAINDYRF-----PWEGRVYRVgasagitaiddnnhqasEVMSQADIACYAA 838


                  ....*.
gi 117928140  332 KAERRG 337
PRK09776      839 KNAGRG 844

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

3e-18

87.77

23.68

5,192,227,94,286,326,11,297,339,7,304,350,7,311,358,26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 193 AWYDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLLARTG 272
COG5001      228 ANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRLKAFDGAPILAARLG 307

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117928140 273 GDEFLLVLPSTTAD-----QAAQVIERMRA--AAPDITF----TAGIATW-DGREPDYRLVHRADAALYAAKAERRG 337
COG5001      308 GDEFALIIPALEDDalrvaGARALCESLQApyDLRGVRVqvgaSIGIAPFpSGADTSEQLFERADYALYHAKQNGKG 384

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

3e-17

84.56

45.01

5,187,204,101,288,309,9,297,322,7,304,331,15,319,347,24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 188 RLSVQAWYDALTGLPNRRLADFLLAAEMAAAGRHGRPLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDL 267
PRK10245     205 RLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDV 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 268 LARTGGDEFLLVLPSTTADQA----AQVIERMRA----AAPDITF--TAGIATWDGREPDYR-LVHRADAALYAAKAERR 336
PRK10245     285 IGRFGGDEFAVIMSGTPAESAitamLRVHEGLNTlrlpNAPQVTLriSVGVAPLNPQMSHYReWLKSADLALYKAKKAGR 364


                 ....*..
gi 117928140 337 GTTGIAS 343
PRK10245     365 NRTEVAA 371

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

2e-15

78.23

24.28

7,186,230,36,224,266,63,287,333,9,301,342,3,304,356,7,311,367,4,318,371,20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 187 DRLSVQAWYDALTGLPNRRLADFLLAAEMAAAGRHGrpLTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGD 266
PRK10060     231 ERLRILANTDSITGLPNRNAIQELIDHAIAQADNNQ--VGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEEDQ 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 267 LLARTGGDEFLLVLPSTTADQ----AAQVIERMRaaapdITF-----------TAGIATW----DGREpdyRLVHRADAA 327
PRK10060     309 TLARLGGDEFLVLASHTSQAAleamASRILTRLR-----LPFriglievytgcSIGIALSpehgDDSE---SLIRSADTA 380

                        170
                 ....*....|.
gi 117928140 328 LYAAKAERRGT 338
PRK10060     381 MYTAKEGGRGQ 391

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

6e-12

66.79

18.02

7,185,371,4,190,375,2,194,377,21,218,398,11,230,409,66,296,477,4,300,489,26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 186 IDRLsVQawYDALTGLPNRRLADFLLAAEMaaaGRHGRPLTIAVcDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAG 265
PRK11359     372 IEQL-IQ--FDPMTGLPNRNNLHNYLDDLV---DKAVSPVVYLI-GVDHIQDVIDSLGYAWADQALLEVVNRFREKLKPD 444

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117928140 266 DLLARTGGDEFLLVLPSTTADQAAQVIERMR--AAAP--------DITFTAGIATWDGREPDYRLVHRADA 326
PRK11359     445 QYLCRIEGTQFVLVSLENDVSNITQIADELRnvVSKPimiddkpfPLTLSIGISYDVGKNRDYLLSTAHNA 515

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

7e-05

43.47

37.84

5,192,247,32,225,279,67,292,358,17,309,376,8,318,384,17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 193 AWYDALTGLPNRRLADFLLAAEMAAAGRHGRPlTIAVCDLDELKRINDTRGHRAGDQLLARAGRTWAATLRAGDLLARTG 272
PRK09966     248 ALHDPLTGLANRAAFRSGINTLMNNSDARKTS-ALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLG 326

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117928140 273 GDEFLLVLPSTTADQAAQVI------------ERMRAAAPDITFTAGIA-TWDGREPDyRLVHRADAALYAAKAER 335
PRK09966     327 GDEFAMVLYDVQSESEVQQIcsaltqifnlpfDLHNGHQTTMTLSIGYAmTIEHASAE-KLQELADHNMYQAKHQR 401

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

9e-04

39.87

23.68

7,191,226,13,204,242,31,238,273,25,263,300,21,284,324,3,287,328,13,300,347,31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117928140 192 QAWYDALTGLPNR---RLADFLLAAEMAAAGRHGRPLTIAVCDLDELkriNDTRGHRAGDQLLARAGRTWAATLR--AGD 266
PRK11059     227 NAFLDAKTGLGNRlffDNQLDTLLEDQEKVGAHGVVMLIRLPDFDLL---QEELGESQVDELLFELINLLSTFVQryPGA 303

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117928140 267 LLARTGGDEFLLVLPSTT---ADQ-AAQVIERMRAAAP------DITFTAGIATWDGREPDYRLVHRADAALYAA 331
PRK11059     304 LLARYSRSDFAVLLPHRSlkeADSlASQLLKAVDSLPPpkmldrDDFLHIGIAAYRSGQSTEQVMEEAEMALRSA 378

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF