NCBI Conserved Domain Search

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Conserved domains on [gi\|117927767\|ref\|YP_872318.1\|]
signal transduction histidine kinase [Acidothermus cellulolyticus 11B]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

28956

cd00075

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

true

false

true

103

5e-07

51.09

91.26

5,398,3,13,411,18,30,441,56,8,449,70,11,461,81,16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEHG--RGSVVEVRAAQHGRTLEVVVADDGPGLPPG--------FSLARSSR------LGLQIVRTLVEgD 462
cd00075        4 VLLNLLSNAIKHTpeGGGRITISVERDGDHLEIRVEDNGPGIPEEdleriferFSDGSRSRkgggtgLGLSIVKKLVE-L 82

                         90
                 ....*....|....*
gi 117927767 463 LHGVFELRPRDSRGT 477
cd00075       83 HGGRIEVESEPGGGT 97

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

128669

smart00387

HATPase_c

Histidine kinase-like ATPases

false

111

5e-09

57.66

84.68

5,398,8,13,411,22,28,439,59,10,449,75,11,461,86,16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEHG-RGSVVEVRAAQHGRTLEVVVADDGPGLP---------PGFSLARSSR------LGLQIVRTLVEgD 462
smart00387     9 VLSNLLDNAIKYTpEGGRITVTLERDGDHLEITVEDNGPGIPpedlekifePFFRTDGRSRkiggtgLGLSIVKKLVE-L 87

                         90
                 ....*....|....*
gi 117927767 463 LHGVFELRPRDSRGT 477
smart00387    88 HGGEISVESEPGGGT 102

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

-1

111420

pfam02518

HATPase_c

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

false

111

2e-08

55.80

90.09

5,398,8,13,411,22,29,440,60,9,449,75,11,461,86,22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEHG-RGSVVEVRAAQHGRTLEVVVADDGPGLPP---------GFSLARSSR------LGLQIVRTLVEgD 462
pfam02518      9 VLSNLLDNAIKHApAGGEITVTLEREGGRLRITVEDNGPGIPPedlekifepFYRDGSDSRkvggtgLGLSIVKKLVE-L 87

                         90       100
                 ....*....|....*....|.
gi 117927767 463 LHGVFELRPRDSRGTLAIARI 483
pfam02518     88 HGGTITVESEPGGGTTFTLTL 108

cl00075

140416

HATPase_c

Histidine kinase-like ATPases; This family includes several ATP-binding proteins for...

-1

116187

pfam07568

HisKA_2

Histidine kinase

true

false

3e-04

42.14

87.06

2,294,0,55,349,56,18

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117927767 295 EIHHRVKNNLQTVAALLRLQARRLAVPEAQAALEEAVRRVRAIALVHETLSHTLD-GPVNFDEVADQLLAMVRD 367
pfam07568      1 EIHHRVKNNLQVISSLLRLQARRAKDEEVKEALRESQNRVLSIALIHEELYKSEDlDTVDFSEYLEKLTENLFS 74

cl06527

125044

HisKA_2

Histidine kinase

-1

33706

COG3920

Signal transduction histidine kinase [Signal transduction mechanisms]

true

false

221

3e-14

75.32

97.29

7,273,1,14,287,17,52,340,69,27,369,96,46,415,148,33,449,181,24,475,205,11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 274 RDVTELRRRERALV--SKDATIREIHHRVKNNLQTVAALLRLQARRLAVPEAQAALEEAVRRVRAIALvHETLSHTLDGP 351
COG3920        2 LLTTARKETEERLAesEKELLLREIHHRVKNNLQIISSLLRLQARKFEDEVLEALRESQNRIQSLALI-HELLYKSGDDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 352 VNFDEVADQLLAMVRDvgTAEGAASADVRRAGSFGLLPAALATPLAMVLVELLQNAMEHGRGSV------VEVRAAQHGR 425
COG3920       81 WDFASYLELLASNLFP--SYGGKDIRLILDSGPNVFLDPDTAVPLGLIVHELVTNALKHAFLSRpggeirITLSREGDGG 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117927767 426 TLEVVVADDGPGLPPGFSLARSSrLGLQIVRTLVEGDLHGVFELRPRDsrGTLAIARIGLP 486
COG3920      159 RFLLTVWDEGGGPPVEAPLSRGG-FGLQLVERLVPEQLGGELEDERPD--GTEFRLRFPLS 216

-1

106506

PRK13560

hypothetical protein; Provisional

false

true

false

807

3e-11

65.08

25.90

9,274,586,10,284,600,65,349,666,19,369,685,42,411,732,4,415,737,9,425,746,35,461,781,4,467,785,10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 275 DVTELRRRER----ALVSKDATIREIHHRVKNNLQTVAALLRLQARRLAVPEAQAALEEAVRRVRAIALVHETLSHTLD- 349
PRK13560     587 DISERKHAEEkikaALTEKEVLLKEIHHRVKNNLQIISSLLDLQAEKLHDEEAKCAFAESQDRICAMALAHEKLYQSEDl 666

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 350 GPVNFDEVADQLLAMVRDVgTAEGAASADVRRAGSFGLLPAALATPLAMVLVELLQNAMEHG-----RGSV-VEVRAAQH 423
PRK13560     667 ADIDFLDYIESLTAHLKNS-FAIDFGRIDCKIDADDGCLDIDKAIPCGLIISELLSNALKHAfpdgaAGNIkVEIREQGD 745

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 117927767 424 GrTLEVVVADDGPGLPPGFSLARSSRLGLQIVRTLVEgDLHGvfELRPRDSRGT 477
PRK13560     746 G-MVNLCVADDGIGLPAGFDFRAAETLGLQLVCALVK-QLDG--EIALDSRGGA 795

-1

30987

COG0642

BaeS

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

336

4e-06

47.86

30.36

4,398,231,43,441,282,8,449,294,12,462,306,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEHGRGSVVEVRAAQHGRTLEVVVADDGPGLPPG--------FSLARSSR----LGLQIVRTLVEGdLHGV 466
COG0642      232 VLVNLLSNAIKYTPGGEITISVRQDDEQVTISVEDTGPGIPEEelerifepFFRTDKSRsgtgLGLAIVKRIVEL-HGGT 310

                         90       100
                 ....*....|....*....|...
gi 117927767 467 FELRPRDSRGTLAIARIGLPATP 489
COG0642      311 ISVESEPGKGTTFTIRLPLAPAA 333

-1

32387

COG2205

KdpD

Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]

false

true

false

890

8e-06

47.16

11.69

5,398,778,12,410,791,31,441,836,20,462,856,14,478,870,12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEH-GRGSVVEVRAAQHGRTLEVVVADDGPGLPPG--------------FSLARSSRLGLQIVRTLVEGdL 463
COG2205      779 VLINLLENALKYaPPGSEIRINAGVERENVVFSVIDEGPGIPEGelerifdkfyrgnkESATRGVGLGLAICRGIVEA-H 857

                         90       100
                 ....*....|....*....|....*..
gi 117927767 464 HGVFELRPRDSRGtlAIARIGLPATPG 490
COG2205      858 GGTISAENNPGGG--AIFVFTLPVEED 882

-1

138019

PRK10600

nitrate/nitrite sensor protein NarX; Provisional

false

true

false

569

2e-05

45.88

12.83

3,401,475,39,442,514,19,462,533,15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117927767 402 ELLQNAMEHGRGSVVEVRAAQHGRTLEVVVADDGPGLPPgfSLARSSRLGLQIVRTLVEGdLHGVFELRPRDSRGT 477
PRK10600     476 EALSNALKHAQASEVVVTVAQNDNQVKLSVQDNGCGVPE--NAERSNHYGLIIMRDRAQS-LRGDCSVRRRESGGT 548

-1

34223

COG4585

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

365

4e-05

44.81

23.01

3,397,281,44,444,325,16,461,341,24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 398 MVLVELLQNAMEHGRGSVVEVRAAQHGRTLEVVVADDGPGLPPGfslARSSRLGLQIVRTLVEgDLHGVFELRPRDSRGT 477
COG4585      282 RIVQEALTNAIRHAQATEVRVTLERTDDELRLEVIDNGVGFDPD---KEGGGFGLLGMRERVE-ALGGTLTIDSAPGQGT 357


                 ....*...
gi 117927767 478 LAIARIGL 485
COG4585      358 TVTITLPL 365

-1

33640

COG3850

NarQ

Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]

Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction...

false

true

false

574

4e-05

44.50

13.76

3,398,484,42,442,526,18,461,544,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEHGRGSVVEVRAAQHGRTLEVVVADDGPGLPPgfSLARSSRLGLQIVRTLVEgDLHGVFELRPRDSRGTL 478
COG3850      485 IVREALSNAIKHAQASEIKVTVSQNDGQVTLTVEDNGVGIDE--AAEPSGHYGLNIMRERAQ-RLGGQLRIRRREGGGTE 561


                 ..
gi 117927767 479 AI 480
COG3850      562 VS 563

-1

138403

PRK11100

sensory histidine kinase CreC; Provisional

false

true

false

475

7e-05

43.69

21.89

7,397,370,14,411,385,30,441,424,5,446,435,14,462,449,2,464,452,12,478,464,10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 398 MVLVELLQNAMEHG-RGSVVEVRAAQHGRTLEVVVADDGPGLPPG---------FSLAR------SSRLGLQIVRTLVEg 461
PRK11100     371 QALGNLLDNAIDFTpEGGTITLSAERDGEQVALSVEDSGPGIPDYalpriferfYSLPRpangrkSTGLGLAFVREVAR- 449

                         90       100
                 ....*....|....*....|....*...
gi 117927767 462 dLH-GVFELRPRDSRGtlAIARIGLPAT 488
PRK11100     450 -LHgGEVTLRNRPEGG--VLATLTLPRH 474

-1

137934

PRK10490

sensor protein KdpD; Provisional

false

true

false

895

0.002

38.95

8.94

5,398,781,12,410,794,31,441,833,8,449,847,11,462,858,3

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEH-GRGSVVEVRAAQHGRTLEVVVADDGPGLPPG--------FSLARSSR------LGLQIVRTLVEgdL 463
PRK10490     782 VLINLLENAVKYaGAQAEIGIDAHVEGENLQLDVWDNGPGIPPGqeqlifdkFARGNKESavpgvgLGLAICRAIVD--V 859


                 ..
gi 117927767 464 HG 465
PRK10490     860 HG 861

-1

34605

COG5000

NtrY

Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]

Signal transduction histidine kinase involved in nitrogen fixation and metabolism...

false

true

false

712

0.003

38.78

45.79

14,176,381,16,195,397,9,204,407,29,239,436,17,256,454,36,293,490,11,305,501,52,357,559,41,398,603,12,410,623,32,442,665,18,461,683,11,472,695,4,478,699,8

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 177 GLIRLDPEGRVDYASPnavSAYRRLGHT-GDLVGVHLGETTARLARPVDLLDEPVAWLvsglggRDAEVEIEAQGAVVRL 255
COG5000      382 GVIGFDNRGCITTVNP---SAEQILGKPfDQLLGQSLSAIAPELEEVFAEAGAAARTD------KRVEVKLAREGEERTL 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 256 R-SIPLLPGGKRVGTLVLLRDVTELRRRERALVSKDATiREIHHRVKNNLqTVAALLRLQARRLAVPEAQAALEEAVRRV 334
COG5000      453 NvQATREPEDNGNGYVVTFDDITDLVIAQRSAAWGDVA-RRIAHEIKNPL-TPIQLSAERLLRKLGKEIDEDREVFDRCT 530

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 335 RAIALVHETLSHTLDGPVNFDEV------ADQLLAMVRDVGTAEGAASADVRRAGSFGLLPAALATPLAM---VLVELLQ 405
COG5000      531 DTIIRQVEDIKRMVDEFRAFARMpapkleKSDLRALLKEVSFLYEIGNDHIVFAAEFGGEPLIGMADATLlgqVFGNLLK 610

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 406 NAMEH--------GRGSVVEVRAAQHGRTLEVVVADDGPGLPPGF----------SLARSSRLGLQIVRTLVEgDLHGVF 467
COG5000      611 NAAEAieaveaeeRRTALIRVSLDDADGRIVVDVIDNGKGFPRENrhralepyvtTREKGTGLGLAIVKKIVE-EHGGRL 689

                        330       340
                 ....*....|....*....|
gi 117927767 468 ELRPR-DSRGtlAIARIGLP 486
COG5000      690 ELHNApDFDG--AMIRIKFP 707

-1

137309

PRK09467

envZ

osmolarity sensor protein; Provisional

false

true

false

437

0.003

38.36

22.43

8,398,336,17,416,353,25,441,386,2,443,391,6,449,400,13,463,413,9,473,422,5,479,427,7

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEHGRGSVvEVRAAQHGRTLEVVVADDGPGLPPG--------FS---LARSSR---LGLQIVRTLVEGDlH 464
PRK09467     337 ALANLVVNAARYGNGWI-KVSSGTEGNRAWFQVEDNGPGIPEEqikhlfqpFTrgdSARGSSgtgLGLAIVKRIVDQH-Q 414

                         90       100
                 ....*....|....*....|..
gi 117927767 465 GVFELRPRdSRGTLaIARIGLP 486
PRK09467     415 GKVELGNR-EEGGL-SARAWLP 434

-1

33641

COG3851

UhpB

Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]

Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction...

false

true

false

497

0.005

37.97

13.08

1,398,413,65

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117927767 399 VLVELLQNAMEHGRGSVVEVRAAQHGRTLEVVVADDGPGLPPGFSLARSSRLGLQIVRTLVEGDL 463
COG3851      414 LCQELLNNICKHADASAVTIQLWQQDERLMLEIEDDGSGLPPGSGVQGFGLTGMRERVSALGGTL 478

-1

33926

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [...

false

true

false

603

0.005

37.56

15.26

3,349,453,27,378,480,29,407,512,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 350 GPVNFDEVADQLLAMVRDVGTAEGAASadVRRAGSFGLLPAALATPLAMVLVELLQNA---MEHGRGSVVEVRAAQHGRT 426
COG4191      454 GPVSLREAIEGALELLRGRLRAAGVEL--ELDLPDAPLWVMANEIRLEQVLVNLLQNAldaMAGQEDRRLSIRAQREGGQ 531

                         90
                 ....*....|....
gi 117927767 427 LEVVVADDGPGLPP 440
COG4191      532 VVLTVRDNGPGIAP 545

-1

117025

pfam08448

PAS_4

PAS fold

true

false

110

0.007

37.39

99.09

7,168,1,4,175,5,15,192,20,20,212,45,16,237,61,10,247,75,14,261,90,20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 169 DSSPragDGLIRLDPEGRVDYAspNAVSAYRRLGHTGDLVGVHL-----GETTARLARPVDLLDEpvawlvsglGGRDAE 243
pfam08448      2 DSLP---DALAVLDPDGRVRYA--NAAAAELFGLPPEELLGKTLaellpPEDAARLERALRRALE---------GEEPID 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 117927767 244 VEIE----AQGAVVRLRSIPLL-PGGKRVGTLVLLRDVTELRR 281
pfam08448     68 FLEElllnGEERHYELRLTPLRdPDGEVIGVLVISRDITERRR 110

-1

34607

COG5002

VicK

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

459

0.007

37.22

17.86

5,398,345,14,412,360,29,441,397,8,449,413,12,463,425,2

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927767 399 VLVELLQNAMEHGR-GSVVEVRAAQHGRTLEVVVADDGPGLPPG--------FSLARSSR--------LGLQIVRTLVEG 461
COG5002      346 VLDNIISNALKYSPdGGRITVSVKQRETWVEISISDQGLGIPKEdlekifdrFYRVDKARsrkmggtgLGLAIAKEIVQA 425


                 ....
gi 117927767 462 dlHG 465
COG5002      426 --HG 427

-1

ATP binding site	0	15	17	true	28956	cd00075	HATPase_c
Mg2+ binding site	1	1	1	true	28956	cd00075	HATPase_c
G-X-G motif	2	3	4	true	28956	cd00075	HATPase_c