NCBI Conserved Domain Search

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Conserved domains on [gi\|117927375\|ref\|YP_871926.1\|]
diguanylate cyclase with GAF sensor [Acidothermus cellulolyticus 11B]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

9e-57

216.69

100.00

2,510,0,114,625,114,43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 511 TDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVARYGGE 590
cd01949        1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117927375 591 EFVVILPETDADGAAHTAERLRQAVRGTPFHVEQmDIPVTASIGIAVFPRHGSSAAILLRAADEALYVAKHSGRDAWR 668
cd01949       81 EFAILLPGTDLEEAEELAERLRKAIEEPFFIDGE-EIRVTASIGIAEYPEDGEDLEELLRRADKALYQAKRSGRNRVV 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

100122

cd06225

HAMP

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.

Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain...

true

false

true

2e-09

59.96

100.00

1,283,0,48

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 117927375 284 ISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRR 331
cd06225        1 ILRPLRRLAEAAQRIAAGDLDVRLPVTGRDEIGELARAFNQMAERLRE 48

cl01054

141075

HAMP

Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain...

110022

pfam00990

GGDEF

GGDEF domain

false

160

5e-49

191.30

99.38

2,508,0,108,616,110,49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 509 SLTDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVARYG 588
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927375 589 GEEFVVILPETDADGAAHTAERLRQAVR--GTPFHVEQMDIPVTASIGIAVFPRHGSSAAILLRAADEALYVAKHSGRD 665
pfam00990     81 GDEFAILLPDTSLEGAQELAERIRRLLAalKIPHTLSGLPLYVTISIGIAAYPNDGEDAEDLLKRADQALYQAKNQGRN 159

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

2e-48

189.38

100.00

2,506,0,110,617,110,53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 507 RLSLTDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVAR 586
smart00267     1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 587 YGGEEFVVILPETDADGAAHTAERLRQAVRgTPFHVEQMDIPVTASIGIAVFPRHGSSAAILLRAADEALYVAKHSGRDA 666
smart00267    81 LGGDEFALLLPETSLEEAIALAERILQQLR-EPIIIHGIPLYLTISIGVAAYPNPGEDAEDLLKRADTALYQAKKAGRNQ 159


                 ....
gi 117927375 667 WRFA 670
smart00267   160 VAVY 163

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

4e-46

181.38

100.00

2,507,0,119,626,120,45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 508 LSLTDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVARY 587
TIGR00254      1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 588 GGEEFVVILPETDADGAAHTAERLRQAVRGTPFHVEQMD-IPVTASIGIAVFPRHGSSAAILLRAADEALYVAKHSGRDA 666
TIGR00254     81 GGEEFVVILPGTPLEDALSKAERLRDAINSKPIEVAGSEtLTVTVSIGVACYPGHGLTLEELLKRADEALYQAKKAGRNR 160


                 ....*
gi 117927375 667 WRFAR 671
TIGR00254    161 VVVAD 165

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

7e-44

174.15

98.90

3,491,2,125,617,127,26,643,154,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 492 ASVAIENVLLHQEAERLSLTDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELA 571
COG2199        3 LRLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 572 RRLHTTVREVDTVARYGGEEFVVILPETDADGAAHTAERLRQAVRgTPFHVEQMDIPVTASIGIAVFPRHGS-SAAILLR 650
COG2199       83 RRLRSNLREGDLVARLGGDEFAVLLPGTSLEEAARLAERIRAALE-EPFFLGGEELRVTVSIGVALYPEDGSdDAELLLR 161

                        170       180
                 ....*....|....*....|
gi 117927375 651 AADEALYVAKHSGRDAWRFA 670
COG2199      162 RADLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128599

smart00304

HAMP

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

false

6e-10

61.50

100.00

1,281,0,53

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 117927375 282 RLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRRYIG 334
smart00304     1 RRILRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53

cl01054

141075

HAMP

Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain...

-1

128379

smart00065

GAF

Domain present in phytochromes and cGMP-specific phosphodiesterases.

true

false

149

1e-09

60.47

98.66

5,358,0,35,393,37,33,428,70,6,434,81,33,471,114,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 359 NLPGILAVIVDTAMASVRASAGLVALFESDGVLHV--KVSRGLPELAPDAVVPLGAGIIGRVAERGTPVHgvVGDGPG-- 434
smart00065     1 DLEELLQTILEELRQLLGADRVLIYLVDEDDRGELvlVAADGLTLPLLGLRYPLGEGLAGRVAETGRPLN--IPDVEAdp 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117927375 435 ---LRPIPEEPRRRTVLAVPLRQAGRISGVLAVYDQeetgDGGAAFTENDVRTLGTFAGQASVAIENVLLHQE 504
smart00065    79 vfaLDLLGRYQGVRSFLAVPLVADGELVGVLALHNK----DSPRPFTEEDEELLQALANQLAIALANAQLYEE 147

cl00853

140972

GAF

GAF domain

-1

109717

pfam00672

HAMP

HAMP domain

false

1e-09

60.32

77.14

1,277,16,54

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 117927375 278 RFLARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRR 331
pfam00672     17 WLLARRLLRPLRRLAEAARRIASGDLDDRVPVSGPDEIGELARAFNQMADRLRE 70

cl01054

141075

HAMP

Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain...

-1

32385

COG2203

FhlA

FOG: GAF domain [Signal transduction mechanisms]

false

175

3e-06

49.24

96.00

6,346,5,49,395,59,12,407,73,18,427,91,4,431,101,41,476,142,31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 347 LERLGAALAQTHNLPGILAVIVDTAMASVRASAGLVALFESDGVLHVKV-----SRGLPELAPDAV--VPLGAGIIGRVA 419
COG2203        6 LNELAAKIAQDLDLEEILQAALELLAELLGADRGLIYLLDEDGLLDGALvaeaaEAGLEQLIDELFglVILPACLIGIAL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 420 ERGTPVhgVVGD------GPGLRPIPEEPRRRTVLAVPLRQAGRISGVLAVYDQEETGDggaaFTENDVRTLGTFAGQAS 493
COG2203       86 REGRPV--VVEDilqdprFRDNPLVLLEPPIRSYLGVPLIAQGELLGLLCVHDSEPRRQ----WSEEELELLEELAEQVA 159

                        170
                 ....*....|....
gi 117927375 494 VAIENVLLHQEAER 507
COG2203      160 IAIERARLYEELQE 173

cl00853

140972

GAF

GAF domain

-1

32631

COG2770

ResE

FOG: HAMP domain [Signal transduction mechanisms]

false

7e-06

47.71

72.29

1,277,23,60

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 278 RFLARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRRYIGQLE 337
COG2770       24 LAAARRVTRPLRRLADLAQNLALGDLSAEIPQPMLDEIGELAKAFNRMRDSLQRALSALE 83

cl01054

141075

HAMP

Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain...

-1

110584

pfam01590

GAF

GAF domain

false

153

3e-04

42.62

100.00

5,358,0,39,397,40,10,407,51,18,425,87,45,475,132,21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 359 NLPGILAVIVDTAMASVRASAGLVALFESDGVLHVKVSR-GLPELAPDAV-VPLGAGIIGRVAERGTPV----------- 425
pfam01590      1 DLEELLQTILEELRELLGADRCAILLADADGLLLYLVAGdGLSDIPLAARgLPLGGGVVGEVIAGGNPIvvpdvqddprf 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117927375 426 -------HGVVGDGPGLRPIPEEPRRRTVLAVPLRQAGRISGVLAVYDQEETgdggaAFTENDVRTLGTFAGQASVAI 496
pfam01590     81 rdltalaEELPAPVGCHEHYLRGLGIRSCLAVPLLGGGKLIGVLVLHSTSPR-----AFTEEELELLQALADQVAIAL 153

cl00853

140972

GAF

GAF domain

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

4e-51

198.22

34.79

2,507,290,119,626,411,38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 508 LSLTDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVARY 587
PRK09581     291 MAVTDGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARY 370

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927375 588 GGEEFVVILPETDADGAAHTAERLRQAVRGTPFHVEQMD--IPVTASIGIAVFPRHGSSAAILLRAADEALYVAKHSGR 664
PRK09581     371 GGEEFVVVMPDTDIEVAIAVAERIRRKIAEEPFAISDGKerLNVTVSIGVAELRPSGESIEALIKRADKALYEAKNTGR 449

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

9e-46

180.50

39.54

2,502,263,126,628,391,44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 503 QEAERLSLTDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVD 582
COG3706      264 ERLQELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEVLRQVARRLRQTVRGLD 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 583 TVARYGGEEFVVILPETDADGAAHTAERLRQAVRGTPFHVEQMDIP--VTASIGIAVFPRHGSSAAILLRAADEALYVAK 660
COG3706      344 LVARYGGEEFAVVLPDTDLEAAIAIAERIRQKINELPFVHELSREPleVTISIGVAEGKPGEDSIEELLKRADKALYKAK 423

                        170
                 ....*....|..
gi 117927375 661 HSGRDAWRFARA 672
COG3706      424 ASGRNRVVVKRA 435

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

9e-31

130.60

51.54

3,511,132,19,532,151,106,639,257,26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 512 DALTGLWNYRYLTMTLGHEieRATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVARYGGEE 591
PRK09894     133 DVLTGLPGRRVLDESFDHQ--LRNREPLNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRPYETVYRYGGEE 210

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117927375 592 FVVILPETDADGAAHTAERLRQAVRGTPFHVEQMDIPVTASIGIAVFpRHGSSAAILLRAADEALYVAKHSGRD 665
PRK09894     211 FIIILKAATDEEACRAGERIRQLIANQAITHSEGRINITATFGVTRA-FPEEPLDEVIGRADRAMYEGKQAGRN 283

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

2e-25

112.90

24.59

4,505,230,5,510,238,21,533,259,83,617,342,51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 506 ERLSL---TDALTGLWNYRYLTMTLGHEIerATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVD 582
PRK10060     231 ERLRIlanTDSITGLPNRNAIQELIDHAI--AQADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEEDQ 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 583 TVARYGGEEFVVILPETDADGAAHTAERLRQAVRgTPFHVEQMDIPVTASIGIAVFPRHGSSAAILLRAADEALYVAKHS 662
PRK10060     309 TLARLGGDEFLVLASHTSQAALEAMASRILTRLR-LPFRIGLIEVYTGCSIGIALSPEHGDDSESLIRSADTAMYTAKEG 387


                 ....*.
gi 117927375 663 GRDAWR 668
PRK10060     388 GRGQFC 393

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

2e-25

112.49

13.71

1,511,690,153

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375  512 DALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVARYGGEE 591
PRK09776      691 DALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDE 770

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117927375  592 FVVILPETDADGAAHTAERLRQAVRGTPFHVEQMDIPVTASIGIAVFPRHGSSAAILLRAADEALYVAKHSGR 664
PRK09776      771 FGLLLPDCNVESARFIATRIISAINDYRFPWEGRVYRVGASAGITAIDDNNHQASEVMSQADIACYAAKNAGR 843

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

8e-25

110.89

27.45

4,494,213,103,597,318,8,606,326,11,618,337,58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 495 AIENVLLHQEAERLSLTDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRL 574
COG5001      214 AEETRRLSDENDRLANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRL 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 575 HTTVREVDTVARYGGEEFVVILP--ETDADGAAhTAERLRQAVRGtPFHVEQMDIPVTASIGIAVFPRHGSSAAILLRAA 652
COG5001      294 KAFDGAPILAARLGGDEFALIIPalEDDALRVA-GARALCESLQA-PYDLRGVRVQVGASIGIAPFPSGADTSEQLFERA 371

                        170       180
                 ....*....|....*....|....
gi 117927375 653 DEALYVAKHSGRDAWRFARAGGET 676
COG5001      372 DYALYHAKQNGKGAAVLFDARHEA 395

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

2e-21

99.59

42.86

3,505,206,111,616,322,3,625,325,40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 506 ERLSLTDALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVA 585
PRK10245     207 QVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIG 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 586 RYGGEEFVVILPETDADGAAHTAERLRQAVR-----GTPfhveqmDIPVTASIGIAVFPRHGSSAAILLRAADEALYVAK 660
PRK10245     287 RFGGDEFAVIMSGTPAESAITAMLRVHEGLNtlrlpNAP------QVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK 360


                 ....*
gi 117927375 661 HSGRD 665
PRK10245     361 KAGRN 365

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

5e-21

97.99

27.53

8,438,309,17,455,327,12,469,339,10,482,349,37,519,390,18,545,408,66,612,474,25,639,499,30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 439 PEEPRRRTVLAVPLRQA-GRISGVLAVYDQeeTGDGGAAFTEndvRTLGTFAGQASVAIENVLLHQEAERLSLTDALTGL 517
PRK11359     310 GAEVQNAQSWSATIRQRdGAPAGILQIKTS--SGAETSAFIE---RVADISQHMAALALEQEKSRQHIEQLIQFDPMTGL 384

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 518 WN----YRYLTMTLGHEIERATRFrrplallmIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVARYGGEEFV 593
PRK11359     385 PNrnnlHNYLDDLVDKAVSPVVYL--------IGVDHIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFV 456

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117927375 594 VILPETDADGAAHTAERLrQAVRGTPFHVEQMDIPVTASIGIAVfpRHGSSAAILLRAADEALYVAKHSGRDAWRF 669
PRK11359     457 LVSLENDVSNITQIADEL-RNVVSKPIMIDDKPFPLTLSIGISY--DVGKNRDYLLSTAHNAMDYIRKNGGNGWQF 529

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

3e-12

69.28

37.84

4,506,245,13,520,258,104,624,363,17,642,380,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 507 RLSLTDALTGLWNyRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVAR 586
PRK09966     246 RTALHDPLTGLAN-RAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYR 324

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117927375 587 YGGEEFVVILPETDADGAAHTAERLRQAVRGTPFHVEQ-MDIPVTASIGIAVFPRHgSSAAILLRAADEALYVAKH 661
PRK09966     325 LGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNgHQTTMTLSIGYAMTIEH-ASAEKLQELADHNMYQAKH 399

-1

34605

COG5000

NtrY

Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]

Signal transduction histidine kinase involved in nitrogen fixation and metabolism...

false

true

false

712

3e-11

65.75

10.81

2,279,300,35,314,336,41

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117927375 280 LARLISQPVAELSEAASRVAGGDLDITLPVRSRDE-VGRLAAAFNHMTAELRRYIGQLERSHAELRENLERLGAALA 355
COG5000      301 FARRIVRPIRKLIEAADEVADGDLDVQVPVRRVDEdVGRLSKAFNKMTEQLSSQQEALERAKDALEQRRRFLEAVLS 377

-1

31182

COG0840

Tar

Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]

Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction...

false

true

false

408

2e-08

56.15

24.02

1,277,77,98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 278 RFLARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRRYIGQLERSHAELRENLERLGAALAQT 357
COG0840       78 ILLLRAILEPISDLLEVVERIAAGDLTKRIDESSNDEFGQLAKSFNEMILNLRQIIDAVQDNAEALSGASEEIAASATEL 157

                         90
                 ....*....|....*...
gi 117927375 358 HNLPGILAVIVDTAMASV 375
COG0840      158 SARADQQAESLEEVASAI 175

-1

33640

COG3850

NarQ

Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]

Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction...

false

true

false

574

1e-07

53.36

35.02

7,277,168,52,336,220,23,362,243,9,372,252,14,388,266,7,405,273,59,473,332,37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 278 RFLARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELrryigqlERSHAELRENLERLGAALAQT 357
COG3850      169 YWLRRRVVRPLNQLTSAAQRIGRRQFDQRPTDTGRNELGLLGRAFNQMSGEL-------KKLYADLEQRVEEKTRDLEQK 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 358 HNlpgILAVIVDTAmASVRASAGLVALFEsdGVLHVKVsrglpelapdAVVPLGAGIIGRVAERGTPVHGVVGDGPGLRP 437
COG3850      242 NQ---RLSFLYQSS-RRLHTSQIDDERLR--HVLNRLQ----------NLTGLAAVRLELYGGDDERNHQEHAEQWDISE 305

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117927375 438 IPEEPRRRTVLAVPLRQAGRISGVLAVydqeetgdgGAAFTENDVRTLGTFAGQASVAIENVLLHQEAERLSL 510
COG3850      306 GDQPSGLKWPQEDPLTQQGHLLGTLPW---------QRSLPEDDQQLLDTLVQQLGRTLALNKQQEQQQQLLL 369

-1

138290

PRK10935

nitrate/nitrite sensor protein NarQ; Provisional

false

true

false

568

5e-07

51.42

11.44

1,277,169,65

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117927375 278 RFLARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRRYIGQLERSHAE 342
PRK10935     170 RFTRRQVVAPLNQLVTASQQIQKGQFDIPLDTTLPNELGLLAKAFNQMASELHKLYRSLESQVEE 234

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

2e-05

46.62

21.70

2,506,297,33,540,330,125

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 507 RLSLTDALTGLWNYRYLTMTLGHEIERATRFRRpLALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREVDTVAR 586
PRK11829     298 RISHRFPVTELPNRSLFISLLEKEIASSTRTDH-FHLLVIGIETLQEVSGAMSEAQHQQLLLTIVQRIEQCIDDSDLLAQ 376

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927375 587 YGGEEFVVILPETDADGAAHTAERLRQAVRGTPFHVEQMDIPVTASIGIAVFPRHGSSAAILLRAADEALYVAKHSGRD 665
PRK11829     377 LSKTEFAVLARGTRRSFPAMQLARRIMSQVTQPLFFDEITLRPSASIGITRYQAQQDTAESMMRNASTAMMAAHHEGRN 455

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

2e-05

46.03

29.28

10,491,198,10,501,213,7,508,225,3,511,230,67,578,298,6,584,305,13,597,321,8,607,329,22,631,351,7,639,358,28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 492 ASVAIENVLL-----HQEAERL-----SLT--DALTGLWNYRYLTMTLGHEIERATRFRRPLALLMIDLDRFKDINDRHG 559
PRK11059     199 ASRALDHLLEelqdaRKERSRFdtfirSNAflDAKTGLGNRLFFDNQLDTLLEDQEKVGAHGVVMLIRLPDFDLLQEELG 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 560 HQAGDAVLVELARRLHTTV-REVDTV-ARYGGEEFVVILP---ETDADGAAhtAERLRQAVRGTPFHVEQMDIPVtaSIG 634
PRK11059     279 ESQVDELLFELINLLSTFVqRYPGALlARYSRSDFAVLLPhrsLKEADSLA--SQLLKAVDSLPPPKMLDRDDFL--HIG 354

                        170       180       190
                 ....*....|....*....|....*....|...
gi 117927375 635 IAVFpRHGSSAAILLRAADEALYVAKHSGRDAW 667
PRK11059     355 IAAY-RSGQSTEQVMEEAEMALRSAQLQGGNSW 386

-1

132001

TIGR02956

TMAO_torS

TMAO reductase sytem sensor TorS

false

true

false

968

8e-05

44.38

8.16

3,277,349,42,319,394,24,343,421,7

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927375 278 RFLARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLA---AAFNHMTAELRRYIGQLERSHAEL---RENLERL 350
TIGR02956    350 RVVYRSVILRLNQHTQALLRLALGDLDISLDARGDDELAHMGraiEAFRDTAAHNLKLQADERQVAQELqehKESLEQL 428

-1

137977

PRK10549

signal transduction histidine-protein kinase BaeS; Provisional

false

true

false

467

3e-04

42.40

11.13

1,279,184,52

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 117927375 280 LARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRR 331
PRK10549     185 LARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEK 236

-1

34607

COG5002

VicK

Signal transduction histidine kinase [Signal transduction mechanisms]

false

true

false

459

3e-04

42.62

16.99

3,278,48,52,337,100,18,357,118,8

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 279 FLARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRryigqleRSHAELRENLERLGAALAqtH 358
COG5002       49 LLARTITKPITDMRKQAVDMARGNYSRKVKVYGTDEIGELADSFNDLTKRVQ-------EAQANTEQERRKLDSVLA--Y 119


                 ....*..
gi 117927375 359 NLPGILA 365
COG5002      120 MTDGVIA 126

-1

33404

COG3604

FhlA

Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]

Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [...

false

true

false

550

3e-04

42.22

32.36

7,337,23,15,352,41,37,390,78,9,399,90,34,433,130,31,465,161,6,475,167,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 338 RSHAELRENLERLGA---ALAQTHNLPGILAVIVDTAMASVRASAGLVALFESDGvLHVKVSRGL---PELAPDAVVPLG 411
COG3604       24 RVSLELLADIRILVEltnALLSPLRLERLLAEVAKELHSLFGCDASALLRLDSKN-LIPLATDGLskdHLGREQRFVVEG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 412 AGIIGRVAERGTPVHGVVGDGP------GLRPIPEEPRRRTVLAVPLRQAGRISGVLAVyDQEETGdggaAFTENDVRTL 485
COG3604      103 HPLLEQILKAGRPLVFHPADSLfpdpydGLLPDTEGNKKHACIGVPLKSGDKLIGALTL-DHTEPD----QFDEDLDEEL 177

                        170       180
                 ....*....|....*....|....
gi 117927375 486 GTFAGQASVAIENVLLHQEAERLS 509
COG3604      178 RFLAALAALAVANALLHRELSSLK 201

-1

137312

PRK09470

cpxA

two-component sensor protein; Provisional

false

true

false

461

4e-04

41.89

17.57

6,279,185,26,305,216,7,313,223,3,319,226,19,338,250,2,341,252,14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 280 LARLISQPVAELSEAASRVAGGDLDI-----TLPVRSRdEVGrlaAAFNHMTAELRRYIGQLER-----SHaELRENLER 349
PRK09470     186 LAWSLAKPARKLKNAADEVAQGNFRQhpeleAGPQEFR-AAG---ASFNQMVTALERMMSSQQRllsdiSH-ELRTPLTR 260


                 ....*.
gi 117927375 350 LGAALA 355
PRK09470     261 LQLATA 266

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

0.001

40.14

25.04

3,501,223,36,541,259,97,639,356,30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 502 HQEAERLSLTDALTGLWNYRYLTMTLGHEIERATRFrrplALLMIDLDRFKDINDRHGHQAGDAVLVELARRLHTTVREV 581
PRK13561     224 YEEQNENAMRFPVSDLPNKALLMALLEQVVARKQTT----ALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPR 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 582 DTVARYGGEEFVVILPETDADGAAHTAERLRQAVRGTPFHVEQMDIPVTASIGIAVFpRHGSSAAILLRAADEALYVAKH 661
PRK13561     300 MVLAQISGYDFAIIANGVKEPWHAITLGQQVLTIINERLPIQRIQLRPSCSIGIAMF-YGDLTAEQLYSRAVSAAFTARR 378


                 ....*...
gi 117927375 662 SGRDAWRF 669
PRK13561     379 KGKNQIQF 386

-1

33405

COG3605

PtsP

Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]

Signal transduction protein containing GAF and PtsI domains [Signal transduction...

false

true

false

756

0.002

39.90

22.35

6,346,4,43,389,48,18,407,67,19,426,87,14,440,103,30,475,133,40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 347 LERLGAALAQTHNLPGILAVIVDTAMASVRASAGLVALFESDG-VLHVKVSRGLPELAPDAV-VPLGAGIIGRVAERGTP 424
COG3605        5 LRRIVEKVASALELQEALDIIVRDIALAMVTEVCSVYLLRADRrVLELMATEGLNKPAVHLVqLAFGEGLVGLVGRSAEP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 425 VH-GVVGDGPGLRPIPE--EPRRRTVLAVPLRQAGRISGVLAVYDQEETgdggaAFTENDVRTLGTFAGQASVAIENVLL 501
COG3605       85 LNlADAQSHPSFKYLPEtgEERYHSFLGVPIIRRGRLLGVLVVQQRELR-----QYDEDEVEFLVTLAMQLAEIVAQSQL 159

                        170
                 ....*....|....
gi 117927375 502 HQEAERLSLTDALT 515
COG3605      160 TGATRGGYRELDLI 173

-1

138019

PRK10600

nitrate/nitrite sensor protein NarX; Provisional

false

true

false

569

0.004

38.94

12.30

1,278,143,70

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927375 279 FLARLISQPVAELSEAASRVAGGDLDITLPVRSRDEVGRLAAAFNHMTAELRRYIGQLERSHAELRENLE 348
PRK10600     144 WLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAELAESYAVLEQRVQEKTAGLE 213

-1

138589

PRK11466

hybrid sensory histidine kinase TorS; Provisional

false

true

false

912

0.007

37.70

8.33

3,277,349,31,308,384,24,332,412,13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117927375 278 RFLARLISQPVAELSEAASRVAGGDLDITLP----VRSRDEVGRLAAAFNHMTAELRRY----IGQLERSHAELRE 345
PRK11466     350 RVVYRSVTRPLAEQTQALQRLLDGDIDSPFPetagVRELDTIGRLMDAFRSNVHALNRHreqlAAQVKARTAELQE 425

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF
dimerization interface	0	19	19	true	100122	cd06225	HAMP