NCBI Conserved Domain Search

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Conserved domains on [gi\|117927299\|ref\|YP_871850.1\|]
two component transcriptional regulator [Acidothermus cellulolyticus 11B]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

29475

cd00383

trans_reg_C

Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and a response regulator. The former autophosphorylates in a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. The C-terminal effector domain contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunite of RNA polymerase.

Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa...

true

false

true

1e-28

121.40

100.00

1,131,0,95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299 132 LEAGPVRIDIDRHVVLVRGAPVHLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPS 211
cd00383        1 LRFGDLVLDPARREVTRDGEPVELTPKEFELLELLARNPGRVLSREQLLEAVWGDDYDVDDRTVDVHISRLRKKLEDDPS 80

                         90
                 ....*....|....*
gi 117927299 212 EPRHLVTVRGVGYKF 226
cd00383       81 NPRLIKTVRGVGYRL 95

cl00209

140514

trans_reg_C

Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa...

29071

cd00156

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs; usually found N-terminal to a DNA binding effector domain; forms homodimers

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

true

false

true

113

7e-19

89.15

89.38

2,5,0,66,71,67,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   6 LVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRER-SNVPIIMLTARDS 84
cd00156        1 LIVDDDPLIRELLRRLLEKEGYEVVEAEDGEEALALLAEEKPDLILLDIMMPGMDGLELLRRIRKRgPDIPIIFLTAHGD 80

                         90       100
                 ....*....|....*....|.
gi 117927299  85 EVDKVVGLELGADDYVTKPFS 105
cd00156       81 DEDAVEALKAGADDYLTKPFS 101

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

109539

pfam00486

Trans_reg_C

Transcriptional regulatory protein, C terminal

false

7e-26

112.25

100.00

1,149,0,77

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117927299 150 GAPVHLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKF 226
pfam00486      1 GEPVELTPKEFELLELLLENPGRVVSREELLEEVWGEDFEVDDRTVDVHISRLRKKLEDDPGDPRLIKTVRGVGYRL 77

cl00209

140514

trans_reg_C

Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa...

-1

129095

smart00862

Trans_reg_C

Transcriptional regulatory protein, C terminal

false

9e-25

108.42

100.00

2,149,0,39,188,40,38

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117927299 150 GAPVHLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDY-VGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKF 226
smart00862     1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDDdDVDDNTLDVHISRLRKKLEDDGANPRLIETVRGVGYRL 78

cl00209

140514

trans_reg_C

Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa...

-1

109140

pfam00072

Response_reg

Response regulator receiver domain

false

111

5e-20

93.03

91.89

2,4,0,68,72,69,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIMLTARD 83
pfam00072      1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGEEALELLKEKRPDLILLDIRMPGMDGLELLRRIRRRPpTTPVIVLTAHG 80

                         90       100
                 ....*....|....*....|..
gi 117927299  84 SEVDKVVGLELGADDYVTKPFS 105
pfam00072     81 DEEDAVEALKAGANDFLSKPFD 102

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

-1

33505

COG3710

CadC

DNA-binding winged-HTH domains [Transcription]

false

148

5e-15

76.15

61.49

2,134,11,58,193,69,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299 135 GPVRIDIDRHVVLVRGAPVHLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTkTLDVHVKRLRSRIEDDPSEPR 214
COG3710       12 GPFVLDPKLRSLLRGDEVVKLGPRELKLLSLLLERAGEVVSKDELLDAVWPGRIVTVN-TLTQAISALRRALRDIGDGHR 90

                         90
                 ....*....|..
gi 117927299 215 HLVTVRGVGYKF 226
COG3710       91 LIATVPRRGYKF 102

cl00209

140514

trans_reg_C

Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa...

-1

31127

COG0784

CheY

FOG: CheY-like receiver [Signal transduction mechanisms]

false

130

9e-12

65.64

82.31

4,0,3,35,35,39,11,46,51,25,71,77,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   1 MVTQLLVIEDEESFSETLAYMLRREGFVVHTAGSG-TEGLELFERQG-ADLVLLDLMLPGLSGTDVCRRLRER-SNVPII 77
COG0784        4 SGLRVLVVDDEPVNRRLLKRLLEDLGYEVVEAADGeEEALELLRELPqPDLILLDINMPGMDGIELLRRLRARgPNIPVI 83

                         90       100
                 ....*....|....*....|....*..
gi 117927299  78 MLTARDSEVDKVVGLELGADDYVTKPF 104
COG0784       84 LLTAYADEADRERALAAGADDYLTKPI 110

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

-1

128724

smart00448

REC

cheY-homologous receiver domain

false

9e-06

45.26

80.00

1,4,2,44

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGAD 48
smart00448     3 ILVVDDDPLLRELLKALLEREGYEVDEATDGEEALELLKEEKPD 46

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

-1

138024

PRK10610

chemotaxis regulatory protein CheY; Provisional

false

129

5e-04

40.00

82.95

3,3,6,24,27,31,44,71,78,35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGF-VVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRER---SNVPIIML 79
PRK10610       7 KFLVVDDFSTMRRIVRNLLKELGFnNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADgamSALPVLMV 86

                         90       100
                 ....*....|....*....|....*..
gi 117927299  80 TARDSEVDKVVGLELGADDYVTKPFSS 106
PRK10610      87 TAEAKKENIIAAAQAGASGYVVKPFTA 113

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

-1

31088

COG0745

OmpR

Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]

Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-...

true

false

229

6e-53

202.10

98.25

3,4,2,41,46,43,25,71,70,157

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQgADLVLLDLMLPGLSGTDVCRRLRER--SNVPIIMLTAR 82
COG0745        3 ILLVEDDPELAELLKEYLEEEGYEVDVAADGEEALEAAREQ-PDLVLLDLMLPDLDGLELCRRLRAKkgSGPPIIVLTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPLREFEL 162
COG0745       82 DDEEDRVLGLEAGADDYLTKPFSPRELLARLRALLRRNAGASRAEASEVLVFGDLTLDPDTRTVTLNGRELTLTPKEFEL 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117927299 163 LEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKFEP 228
COG0745      162 LELLARHPGRVLSREQLLEAVWGYDFEVDSRTVDVHISRLRKKLEKDPGAGRLIRTVRGVGYRLEE 227

-1

138391

PRK11083

DNA-binding response regulator CreB; Provisional

false

true

false

229

2e-44

173.63

99.56

5,0,1,71,71,73,53,125,126,79,204,207,9,215,216,13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   1 MVTQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRER-SNVPIIML 79
PRK11083       2 QQPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLRAFhPALPVIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  80 TARDSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGdEQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPLRE 159
PRK11083      82 TARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKFA-APSPVIRIAGHFELDEPGARISYFGTPLSLTRYE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117927299 160 FELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRS--RIEDDPSEPrhLVTVRGVGYKFEP 228
PRK11083     161 FLLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAklRAINPDLSP--IRTHRGLGYSLRP 229

-1

131209

TIGR02154

PhoB

phosphate regulon transcriptional regulatory protein PhoB

false

true

false

226

7e-44

172.13

99.56

4,0,0,72,72,75,48,123,123,86,210,209,16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   1 MVTQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS---NVPII 77
TIGR02154      1 MTRRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRRRPetrAIPII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  78 MLTARDSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRdggGDEQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPL 157
TIGR02154     81 MLTARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRI---RPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGP 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927299 158 REFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDpSEPRHLVTVRGVGYKF 226
TIGR02154    158 TEFRLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPF-GLEDPVQTVRGAGYRF 225

-1

133606

CHL00148

orf27

Ycf27; Reviewed

false

true

false

240

3e-43

169.84

95.00

3,4,8,126,130,137,60,190,199,37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLTARDS 84
CHL00148       9 ILVVDDEASIRRILETRLSIIGYEVITASDGEEALKLFHQEQPDLVILDVMMPKLDGYGVCQEIRKESDVPIIMLTALGD 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  85 EVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEQRTT---VLEAGPVRIDIDRHVVLVRGAPVHLPLREFE 161
CHL00148      89 VSDRITGLELGADDYVVKPFSPKELEARIRSVLRRVNKISATSGPKnsgIIRIGFLEIDTNKKQVYKNNERIRLTGMEFS 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117927299 162 LLEMLVRHAGRVLTRQQLIDRIWGGDYVG--DTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKFE 227
CHL00148     169 LLELLISESGEIFSRATILKEVWGYTPERhiDTRVVDVHISRLRAKLEDDPSNPDLILTARGTGYLFQ 236

-1

130454

TIGR01387

cztR_silR_copR

heavy metal response regulator

false

true

false

218

4e-34

139.55

100.00

4,4,0,66,70,67,51,125,118,81,207,199,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRE-RSNVPIIMLTARD 83
TIGR01387      1 ILVVEDEQKTAEYLQQGLSESGYVVDAASNGRDGLHLALKDDYDLIILDVMLPGMDGWQILQTLRRsGKQTPVLFLTARD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  84 SEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDgggdEQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPLREFELL 163
TIGR01387     81 SVADKVKGLDLGADDYLVKPFSFSELLARVRTLLRRSH----SLNSTVLEIADLRMDSVRHRVSRGNIRITLTRKEFQLL 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117927299 164 EMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIeDDPSEPRHLVTVRGVGYKF 226
TIGR01387    157 WLLMRRTGEVLPRTVIASLVWGMNFDSDTNVVDVAIRRLRAKV-DDPFEEKLIHTIRGMGYVL 218

-1

137310

PRK09468

ompR

osmolarity response regulator; Provisional

false

true

false

239

2e-32

133.97

96.23

3,2,5,71,73,77,49,122,129,106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   3 TQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSN-VPIIMLTA 81
PRK09468       6 YKILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNpTPIIMLTA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  82 RDSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDG---GGDEQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPLR 158
PRK09468      86 KGEEVDRIVGLEMGADDYLPKPFNPRELLARIRAVLRRQAPelpGAPSQEEEVIAFGEFSLNLGTRELFRGDEPIPLTTG 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299 159 EFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKFEP 228
PRK09468     166 EFAVLKALVRHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIEPDPAHPRYIQTVWGLGYVFVP 235

-1

137960

PRK10529

DNA-binding transcriptional activator KdpE; Provisional

false

true

false

225

8e-32

131.89

99.56

2,2,1,121,125,122,103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   3 TQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLTAR 82
PRK10529       2 TNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGgdEQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPLREFEL 162
PRK10529      82 SEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSAT--PAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRL 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117927299 163 LEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKFEP 228
PRK10529     160 LAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPTRPRHFITETGIGYRFMP 225

-1

138611

PRK11517

transcriptional regulatory protein YedW; Provisional

false

true

false

223

1e-28

121.58

97.31

3,3,1,117,125,118,81,207,199,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLTARD 83
PRK11517       2 KILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAKQTPVICLTARD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  84 SEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRdgggdEQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPLREFELL 163
PRK11517      82 SVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQH-----HALNSTLEISGLRMDSVSQSVSRDNISITLTRKEFQLL 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117927299 164 EMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIeDDPSEPRHLVTVRGVGYKF 226
PRK11517     157 WLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKV-DDPFPEKLIATIRGMGYSF 218

-1

138454

PRK11173

two-component response regulator; Provisional

false

true

false

237

2e-28

120.94

96.20

5,3,4,102,105,108,26,134,134,4,138,143,4,142,148,84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLTARD 83
PRK11173       5 HILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANVALMFLTGRD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  84 SEVDKVVGLELGADDYVTKPFS--SRELVARIRAVLRRRDGGGDEQRTTVleaGPVR-----IDID-RHVVLVRGAPVHL 155
PRK11173      85 NEVDKILGLEIGADDYITKPFNprELTIRARNLLSRTMNLGTVSEERRSV---ESYKfngweLDINsRSLISPDGEQYKL 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117927299 156 PLREFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKF 226
PRK11173     162 PRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRF 232

-1

138104

PRK10710

DNA-binding transcriptional regulator BaeR; Provisional

false

true

false

240

4e-27

116.38

93.75

2,0,8,130,132,138,95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   1 MVTQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLT 80
PRK10710       9 NTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  81 ARDSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEQRTTvlEAGPVRIDIDRHVVLVRGAPVHLPLREF 160
PRK10710      89 AKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQD--AESPLIIDESRFQASWRGKMLDLTPAEF 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117927299 161 ELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKFE 227
PRK10710     167 RLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWE 233

-1

137546

PRK09836

DNA-binding transcriptional activator CusR; Provisional

false

true

false

226

6e-27

115.89

97.79

4,3,1,70,73,72,60,136,132,73,210,205,17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSN-VPIIMLTAR 82
PRK09836       2 KLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKgMPILLLTAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEQRTTVLEagpVRIDIDRHVVLVRGAPVHLPLREFEL 162
PRK09836      82 GTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQFQVAD---LMVDLVSRKVTRSGTRITLTSKEFTL 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117927299 163 LEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDpSEPRHLVTVRGVGYKFE 227
PRK09836     159 LEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDND-FEPKLIQTVRGVGYMLE 222

-1

138153

PRK10766

DNA-binding transcriptional regulator TorR; Provisional

false

true

false

224

3e-26

113.60

100.00

3,0,0,121,121,129,85,211,214,10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   1 MVTQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLT 80
PRK10766       1 MSYHILVVEDEPVTRARLQGYFEQEGYRVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  81 ARDSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRD--------GGGDEQRTTVLEAGPVRIDIDRHVVLVRGAP 152
PRK10766      81 GRTDSIDRIVGLEMGADDYVTKPFELRELLVRVKNLLWRISlarqaqavAEQPETQDNCYRFAGYCLNVNRRTLERNGEP 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927299 153 VHLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIeddpsEPRHLVTVRG 221
PRK10766     161 IKLTKAEYELLVAFVTNPGQVLSRERLLRMLSHRVEDPNDRTIDVLIRRLRHKL-----NPDLFVTVHG 224

-1

104359

PRK10161

transcriptional regulator PhoB; Provisional

false

true

false

229

9e-26

111.73

98.25

4,0,0,72,72,75,55,130,130,82,213,212,13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   1 MVTQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS---NVPII 77
PRK10161       1 MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESmtrDIPVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  78 MLTARDSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEQrttVLEAGPVRIDIDRHVVLVRGAPVHLPL 157
PRK10161      81 MLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEE---VIEMQGLSLDPTSHRVMAGEEPLEMGP 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927299 158 REFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEpRHLVTVRGVGYKF 226
PRK10161     158 TEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHD-RMVQTVRGTGYRF 225

-1

138305

PRK10955

DNA-binding transcriptional regulator CpxR; Provisional

false

true

false

232

2e-23

104.14

96.55

3,3,2,40,44,42,84,128,130,96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFErQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLTARD 83
PRK10955       3 KILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLD-DSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTARG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  84 SEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEQR----TTVLEAGPVRIDIDRHVVLVRGAPVHLPLRE 159
PRK10955      82 SELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNndngSPTLEVDALSLNPGRQEASFDGQTLELTGTE 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117927299 160 FELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGY 224
PRK10955     162 FTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGY 226

-1

138051

PRK10643

DNA-binding transcriptional regulator BasR; Provisional

false

true

false

222

6e-23

102.48

97.30

4,3,1,70,73,72,54,131,126,78,214,204,13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSN-VPIIMLTAR 82
PRK10643       2 KILIVEDDTLLLQGLILAAQTEGYACDGVSTAREAEQSLESGHYSLVVLDLGLPDEDGLHFLARIRQKKYtLPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEQrttvLEAGPVRIDIDRHVVLVRGAPVHLPLREFEL 162
PRK10643      82 DTLEDRIAGLDVGADDYLVKPFALEELHARIRALLRRHNNQGESE----LQVGNLTLNLGRQQVWLDGQELILTPKEYAL 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117927299 163 LEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDpseprHLVTVRGVGYKFE 227
PRK10643     158 LSRLMLKAGSPVHREILYNDIYNWDNEPSTNTLEVHIHNLRDKVGKD-----RIRTVRGFGYMLV 217

-1

138099

PRK10701

DNA-binding transcriptional regulator RstA; Provisional

false

true

false

240

2e-22

100.56

97.50

5,2,1,98,100,101,34,134,141,6,140,148,7,148,155,80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   3 TQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLTAR 82
PRK10701       2 NTIVFVEDDAEVGSLIAAYLAKHDIDVTVEPRGDRAEETILREQPDLVLLDIMLPGKDGMTICRDLRPKWSGPIVLLTSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKVVGLELGADDYV--TKPFSSRELVARIRAVLRRRDGGGDEQRTTVLEA------GPVRID-IDRHVVLvRGAPV 153
PRK10701      82 DSDMNHILALEMGACDYIlkTTPPAVLLARLRLHLRQNEQATQAKGLQETSLTPykalhfGTLTIDpINRVVTL-AGEEI 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117927299 154 HLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKFEP 228
PRK10701     161 SLSTADFELLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLDNAAEPYRIKTVRNKGYLFAP 235

-1

138195

PRK10816

DNA-binding transcriptional regulator PhoP; Provisional

false

true

false

223

6e-22

99.12

98.65

5,3,1,69,72,71,54,130,125,78,208,204,5,215,209,12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIMLTAR 82
PRK10816       2 RVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDvSLPILVLTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEqrttVLEAGPVRIDIDRHVVLVRGAPVHLPLREFEL 162
PRK10816      82 ESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQ----VISLPPFQVDLSRRELSINDEVIKLTAFEYTI 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117927299 163 LEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIED-DPSEPrhLVTVRGVGYKFE 227
PRK10816     158 METLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAqYPQEV--ITTVRGQGYLFE 221

-1

137827

PRK10336

DNA-binding transcriptional regulator QseB; Provisional

false

true

false

219

3e-21

96.93

97.26

4,3,1,69,72,71,50,126,121,83,214,204,10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIMLTAR 82
PRK10336       2 RILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGqREPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDGggdeQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPLREFEL 162
PRK10336      82 DALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNG----QASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFAL 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117927299 163 LEMLVRHAGRVLTRQQLIDRIWGGDYVGDTKTLDVHVKRLRSRIEDDpseprHLVTVRGVGY 224
PRK10336     158 LELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSD-----FIRTVHGIGY 214

-1

139916

PRK13856

two-component response regulator VirG; Provisional

false

true

false

241

3e-16

80.25

93.78

6,3,2,77,80,80,26,106,107,74,180,183,3,184,186,7,192,193,35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLT-AR 82
PRK13856       3 HVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLSSETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISgDR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKVVGLELGADDYVTKPFSS-RELVARIRAVLRRRDGGGDEQRTTVLEAGPVRIDIDRHVVLVRGAPVHLPLREFE 161
PRK13856      83 LEEADKVVALELGATDFIAKPFGTrEFLARIRVALRVRPNVVRTKDRRSFCFADWTLNLRQRRLISEAGGEVKLTAGEFN 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117927299 162 LLEMLVRHAGRVLTRQQLI--DRIwGGDYVGDtKTLDVHVKRLRSRIEDDPSEPRHLVTVRGVGYKFE 227
PRK13856     163 LLVAFLEKPRDVLSREQLLiaSRV-REEEVYD-RSIDVLILRLRRKLEQDPANPQLIKTARGAGYFFD 228

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

2e-14

74.19

23.19

2,0,0,69,69,72,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   1 MVTQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLR---ERSNVPII 77
PRK09581       1 MTARILVVDDIPANVKLLEAKLLAEYYTVLTASSGAEAIEICEREQPDIILLDVMMPGMDGFEVCRRLKsdpATAHIPVV 80

                         90       100
                 ....*....|....*....|....*.
gi 117927299  78 MLTARDSEVDKVVGLELGADDYVTKP 103
PRK09581      81 MVTALDDPSDRVRGLEAGADDFLTKP 106

-1

32386

COG2204

AtoC

Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]

Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding...

false

true

false

464

4e-13

69.94

22.84

2,0,2,72,72,75,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   1 MVTQLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIML 79
COG2204        3 MMARILVVDDDPDIRELLEQALELAGYEVVTAESAEEALEALSESPFDLVLLDIRMPGMDGLELLKEIKSRDpDLPVIVM 82

                         90       100
                 ....*....|....*....|....*.
gi 117927299  80 TARDSEVDKVVGLELGADDYVTKPFS 105
COG2204       83 TGHGDIDTAVEALRLGAFDFLEKPFD 108

-1

33243

COG3437

Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and an HD-GYP domain [...

false

true

false

360

4e-11

63.39

29.17

2,4,16,68,72,88,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS----NVPIIMLT 80
COG3437       17 VLLVDDEPDNLEALRQLLRMIGYRVIEAENGEEALKLLQEEPPDLVLLDVRMPEMDGAEVLNKLKAMSpstrRIPVILLT 96

                         90       100
                 ....*....|....*....|....*
gi 117927299  81 ARDSEVDKVVGLELGADDYVTKPFS 105
COG3437       97 AYADSEDRQRALEAGADDYLSKPIS 121

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

2e-09

58.01

23.91

2,4,134,67,71,204,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRER---SNVPIIMLTA 81
COG3706      135 ILVVDDDATQRERLRRILQVEGFRVVEATDGEEALLQLAELPPDLVLLDANMPDMDGLELCTRLRQLertRDIPIILLSS 214

                         90       100
                 ....*....|....*....|....
gi 117927299  82 RDSEVDKVVGLELGADDYVTKPFS 105
COG3706      215 KDDDELVVRAFELGVNDYITKPIE 238

-1

34205

COG4567

Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]

Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [..

false

true

false

182

3e-09

56.90

54.95

2,4,11,66,70,78,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRE-RSNVPIIMLTARD 83
COG4567       12 LLLVDDDTPFLRTLARAMERRGFAVVTAESVEEALAAARTAPPAYAVVDLKLGDGSGLAVIEALRErRADMRIVVLTGYA 91

                         90       100
                 ....*....|....*....|
gi 117927299  84 SEVDKVVGLELGADDYVTKP 103
COG4567       92 SIATAVEAVKLGACDYLAKP 111

-1

138091

PRK10693

response regulator of RpoS; Provisional

false

true

false

337

6e-09

56.25

29.97

4,3,8,70,73,79,10,83,91,6,91,97,12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSN-VPIIMLTAR 82
PRK10693       9 QILIVEDEPVFRSLLDSWFSSLGATTVLAADGVDALELLGGFTPDLMICDIAMPRMNGLKFVEHLRNRGDqTPVLVISAT 88

                         90       100
                 ....*....|....*....|...
gi 117927299  83 D--SEVDKVvgLELGADDYVTKP 103
PRK10693      89 EnmADIAKA--LRLGVEDVLLKP 109

-1

138540

PRK11361

acetoacetate metabolism regulatory protein AtoC; Provisional

false

true

false

457

1e-08

55.24

22.10

2,4,6,67,71,74,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRER-SNVPIIMLTARD 83
PRK11361       7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHeTRTPVILMTAYA 86

                         90       100
                 ....*....|....*....|.
gi 117927299  84 SEVDKVVGLELGADDYVTKPF 104
PRK11361      87 EVETAVEALRCGAFDYVIKPF 107

-1

32379

COG2197

CitB

Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]

Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain...

false

true

false

211

2e-08

54.19

49.76

3,3,1,23,26,26,45,71,72,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREG--FVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRER-SNVPIIMLT 80
COG2197        2 KVLIVDDHPLVREGLRQLLELEPdlEVVGEASNGEEALDLARELKPDVVLLDLSMPGMDGLEALKQLRARgPDIKVVVLT 81

                         90       100
                 ....*....|....*....|....*
gi 117927299  81 ARDSEVDKVVGLELGADDYVTKPFS 105
COG2197       82 AHDDPAYVIRALRAGADGYLLKDAS 106

-1

34367

COG4753

Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]

Response regulator containing CheY-like receiver domain and AraC-type DNA-binding...

false

true

false

475

2e-06

47.23

22.11

6,4,3,18,22,23,5,27,29,45,72,75,11,84,86,5,89,92,16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYML--RREGF-VVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIMLT 80
COG4753        4 VLIVDDEPLIREGLKSLIdwEALGIeVVGTAANGKEALELIQETQPDIVITDINMPGMDGLDLIKAIKEQSpDTEFIILS 83

                         90       100
                 ....*....|....*....|....*.
gi 117927299  81 ARDsEVDKV-VGLELGADDYVTKPFS 105
COG4753       84 GYD-EFEYAkKAMKLGVKDYLLKPVD 108

-1

33728

COG3947

Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]

Response regulator containing CheY-like receiver and SARP domains [Signal transduction...

false

true

false

361

3e-06

46.89

60.39

8,3,1,67,70,69,18,90,87,44,134,132,4,144,136,10,154,147,37,191,185,15,208,200,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRE-RSNVPIIMLTAR 82
COG3947        2 RIIIVDDDAAIVKLLSVILSRAGHEVRSCSHPVEALDLLEVFKPDLIFLDIVMPYMNGIEFAEQVRDiESAVPIIFISSH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  83 DSEVDKvvGLELGADDYVTKPFSSRELVARIRAVLRRRDGGGDEQRTTVLEA-GPVRididrhVVLVRGAPVH-LPLREF 160
COG3947       82 AEYADD--SFGMNLDDYLPKPVTPEKLNRAIDRRLKRVELTAEEESGTQISCfGGTE------VVLRQGQQVKwISRKAL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117927299 161 ELLEMLVRHAGRVLTRQQLIDRIWGGDYVGD-TKTLDVHVKRLRSRIedDPSEPRHLVTVRGVGYKFE 227
COG3947      154 ELFAYLVEHKGKEVTSWEAIEALWPEKDEKKaSSLLHTTVYQLRKAL--SRLNANEAVTSQDRKYKLD 219

-1

131922

TIGR02875

spore_0_A

sporulation transcription factor Spo0A

false

true

false

262

3e-06

46.71

40.46

4,3,3,16,19,21,50,69,73,6,75,80,29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLA--YMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLR--ERSNVP-IIM 78
TIGR02875      4 RIVIADDNKEFCNLLKeyLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNeiELSARPrVIM 83

                         90       100
                 ....*....|....*....|....*.
gi 117927299  79 LTARDSEVDKVVGLELGADDYVTKPF 104
TIGR02875     84 LSAFGQEKITQRAVALGADYYVLKPF 109

-1

34204

COG4566

TtrR

Response regulator [Signal transduction mechanisms]

false

true

false

202

7e-06

46.00

49.50

2,6,8,65,71,74,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   7 VIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRER-SNVPIIMLTARDSE 85
COG4566        9 VVDDDESVRDALAFLLESAGFQVKCFASAEEFLAAAPLDRPGCLLLDVRMPGMSGLELQDRLAERgIRLPVIFLTGHGDI 88

                         90       100
                 ....*....|....*....|
gi 117927299  86 VDKVVGLELGADDYVTKPFS 105
COG4566       89 PMAVQAMKAGAVDFLEKPFS 108

-1

130877

TIGR01818

ntrC

nitrogen regulation protein NR(I)

false

true

false

463

1e-05

45.11

21.81

2,4,0,68,72,69,32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIMLTARD 83
TIGR01818      1 VWVVDDDRSIRWVLEKALSRAGYEVRTFGNAASVLRALARGQPDLLITDVRMPGEDGLDLLPQIKKRHpQLPVIVMTAHS 80

                         90       100
                 ....*....|....*....|.
gi 117927299  84 SEVDKVVGLELGADDYVTKPF 104
TIGR01818     81 DLDTAVAAYQRGAFEYLPKPF 101

-1

138058

PRK10651

transcriptional regulator NarL; Provisional

false

true

false

216

1e-05

45.05

35.19

2,27,33,45,72,79,30

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117927299  28 VVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIMLTARDSEVDKVVGLELGADDYVTK 102
PRK10651      34 VVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSlSGRIVVFSVSNHEEDVVTALKRGADGYLLK 109

-1

138914

PRK12370

invasion protein regulator; Provisional

false

true

false

553

2e-05

44.84

14.47

3,144,25,47,192,72,11,204,83,22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299 145 VVLVRGAPVHLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDtKTLDVHVKRLRsRIEDDPSEPRHLVTVRGVGY 224
PRK12370      26 SLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNE-ESLTRCIYALR-RILSEDKEHRYIETLYGQGY 103


                 ..
gi 117927299 225 KF 226
PRK12370     104 RF 105

-1

137244

PRK09390

fixJ

response regulator FixJ; Provisional

false

true

false

202

2e-05

43.86

49.50

2,6,7,63,69,71,36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   7 VIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLR-ERSNVPIIMLTARDSE 85
PRK09390       8 VVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKaRGSPLPVIVMTGHGDV 87

                         90       100
                 ....*....|....*....|
gi 117927299  86 VDKVVGLELGADDYVTKPFS 105
PRK09390      88 PLAVEAMKLGAIDFIEKPFE 107

-1

136271

PRK07239

bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated

false

true

false

381

3e-05

43.47

24.15

3,127,279,60,189,339,19,212,358,13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299 128 RTTVLEAGPVRIDIDRHVVLVRGAPVHLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDyvGDTKTLDVHVKRLRSRIE 207
PRK07239     280 RARTLRAAGHRLEIRGHAVLVDGEVKPLSPAPMALLRALAARPGRVVSRADLLRALPGGG--TDEHAVETAVARLRTALG 357

                         90
                 ....*....|....*...
gi 117927299 208 DdpsePRHLVTVRGVGYK 225
PRK07239     358 D----PKLVQTVVKRGYR 371

-1

134369

PRK00742

chemotaxis-specific methylesterase; Provisional

false

true

false

345

5e-05

42.85

23.48

4,27,29,51,78,83,8,86,93,1,90,94,16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  28 VVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIM---LTARDSEV--DkvvGLELGADDYVTK 102
PRK00742      30 VVGTARDGLEAVEKIKKLNPDVITLDVEMPVMDGIEALRKIMALRPTPVVMvssLTERGAEItlE---ALELGAVDFVPK 106


                 ....
gi 117927299 103 PFSS 106
PRK00742     107 PFLG 110

-1

34203

COG4565

CitB

Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]

Response regulator of citrate/malate metabolism [Transcription / Signal transduction...

false

true

false

224

6e-05

42.89

45.98

6,4,2,20,24,23,3,27,27,45,72,73,9,82,82,7,89,90,15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   5 LLVIEDEESFSETLAYMLRR-EGF-VVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIMLTA 81
COG4565        3 VLIIEDDPMVAEIHRRYVKQiPGFsVVGTAGTLEEAKMIIEEFKPDLILLDIYMPDGNGIELLPELRSQHyPVDVIVITA 82

                         90       100
                 ....*....|....*....|....
gi 117927299  82 rDSEVDKV-VGLELGADDYVTKPF 104
COG4565       83 -ASDMETIkEALRYGVVDYLIKPF 105

-1

137718

PRK10153

DNA-binding transcriptional activator CadC; Provisional

false

true

false

512

7e-05

42.35

14.26

4,152,26,39,197,65,2,199,72,9,208,82,17

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927299 153 VHLPLREFELLEMLVRHAGRVLTRQQLIDRIWGGDYVGDtktldvHV-----KRLRSRIED-DPSEPRHLVTVRGVGYK 225
PRK10153      27 VTLEPRLINLLVFLAQHSGEVFSRDELIDHVWDGAIVTD------QVvtqsiFELRKSLRDgREDNPEYIVTVPKRGYK 99

-1

132001

TIGR02956

TMAO_torS

TMAO reductase sytem sensor TorS

false

true

false

968

2e-04

40.92

10.95

4,3,703,66,69,773,13,82,788,7,91,795,14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLR----ERSNVPIIML 79
TIGR02956    704 RVLLVEDNEVNQMVAQGFLTRLGHKVTLAESGQSALECFHQHAFDLALLDINLPDGDGVTLLQQLRaiygAKNEVKFIAF 783

                         90       100
                 ....*....|....*....|....*...
gi 117927299  80 TAR--DSEVDKVvgLELGADDYVTKPFS 105
TIGR02956    784 SAHvfNEDVAQY--LAAGFDGFLAKPVV 809

-1

137850

PRK10365

transcriptional regulatory protein ZraR; Provisional

false

true

false

441

4e-04

40.01

23.13

2,3,6,67,70,74,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRE-RSNVPIIMLTAR 82
PRK10365       7 DILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKAlNPAIPVLIMTAY 86

                         90       100
                 ....*....|....*....|..
gi 117927299  83 DSEVDKVVGLELGADDYVTKPF 104
PRK10365      87 SSVETAVEALKTGALDYLIKPL 108

-1

32383

COG2201

CheB

Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]

Chemotaxis response regulator containing a CheY-like receiver domain and a...

false

true

false

350

4e-04

39.88

29.43

3,5,4,21,26,27,64,90,93,14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   6 LVIEDEESFSETLAYMLRREG--FVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLTARD 83
COG2201        5 LVVDDSALMRKVISDILNSDPdiEVVGTARNGREAIDKVKKLKPDVITLDVEMPVMDGLEALRKIMRLRPLPVIMVSSLT 84

                         90       100
                 ....*....|....*....|...
gi 117927299  84 SEVDKVV--GLELGADDYVTKPF 104
COG2201       85 EEGAEATleALELGAVDFIAKPS 107

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

0.003

37.21

17.93

2,24,10,49,74,59,29

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117927299  25 EGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNvPIIMLTARDSEVDKVVGLELGADDYVTKP 103
COG3706       11 EYKEVATAKKGLIALAILLDHKPDYKLLDVMMPGMDGFELCRRLKAEPA-TVVMVTALDDSAPRVRGLKAGADDFLTKP 88

-1

138212

PRK10841

hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional

false

true

false

947

0.005

36.56

10.88

2,3,825,69,72,895,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   4 QLLVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERS-NVPIIMLTAR 82
PRK10841     826 MILVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLSDVNMPNMDGYRLTQRIRQLGlTLPVIGVTAN 905

                         90       100
                 ....*....|....*....|...
gi 117927299  83 DSEVDKVVGLELGADDYVTKPFS 105
PRK10841     906 ALAEEKQRCLEAGMDSCLSKPVT 928

-1

139064

PRK12555

chemotaxis-specific methylesterase; Provisional

false

true

false

340

0.006

36.14

22.94

2,27,28,63,90,93,13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117927299  28 VVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNVPIIMLTARDSEVDKVV--GLELGADDYVTKP 103
PRK12555      29 VLGVATDGLQARDLCKAQPPDVVLLDLEMPRMDGLTFLRRIMRRRPCPVLIVSSLTEAGASITyeALGAGALDAVDKP 106

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

0.008

35.67

21.88

3,5,158,20,26,178,43,69,224,34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   6 LVIEDEESFSETLAYMLRREgFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLR---ERSNVPIIMLTAR 82
PRK09581     159 LLVDDDVSQAERIANILKEE-FRVDVLSDPEEALIRAAEGNYDLIIVSASFENYDPLRLCSQLRskeRTRYVPILLLVDE 237

                         90       100
                 ....*....|....*....|.
gi 117927299  83 DSEVDKVVGLELGADDYVTKP 103
PRK09581     238 DEDPRLVKALELGVNDYLMRP 258

-1

138397

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

false

true

false

779

0.010

35.35

20.80

5,5,528,69,74,601,7,82,608,39,124,647,20,156,667,23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299   6 LVIEDEESFSETLAYMLRREGFVVHTAGSGTEGLELFERQGADLVLLDLMLPGLSGTDVCRRLRERSNV----PIIMLTA 81
PRK11091     529 LLVEDIELNVIVARSLLEKLGNSVDVAMTGKDALEMFKPGEYDLVLLDIQLPDMTGLDVARELRERYGRedlpPLVALTA 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117927299  82 rDSEVDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRDgggDEQRTTVLEAGPVRIDIDRHvvlvrgapvhlpLREFE 161
PRK11091     609 -NVLKDKQEYLDAGMDDVLSKPLSVPALTAMIKKFWDTQD---KEESTVTTEESSKSMQINEA------------LLDIP 672

                        170
                 ....*....|....*...
gi 117927299 162 LLEMLVRHAGRVLTRQQL 179
PRK11091     673 MLEQYVELVGPKLITDSL 690

-1

DNA binding site	0	9	9	true	29475	cd00383	trans_reg_C
active site	0	8	8	true	29071	cd00156	REC
phosphorylation site	1	1	1	true	29071	cd00156	REC
intermolecular recognition site	2	5	5	true	29071	cd00156	REC
dimerization interface	3	3	3	true	29071	cd00156	REC