NCBI Conserved Domain Search

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Conserved domains on [gi\|116623992\|ref\|YP_826148.1\|]
adenylate/guanylate cyclase [Solibacter usitatus Ellin6076]

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List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

32297

COG2114

CyaA

Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]

Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction...

true

false

227

3e-18

88.69

93.83

6,161,0,65,227,65,52,279,118,16,302,134,19,326,153,21,348,174,39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992 162 QFAVQAAAAIKNARRLRELAAHMGLYTRELGGDLLGLLSQTARREDTTVMFADMRGFTQVCQSQEdPAHTQAIVNDLLTM 241
COG2114        1 IAAVLNLLAKEAKVAAAGLRSDLVLRLYLARVVGRLLARGGAGDRRVTLLFADIVGSTELSESLG-DEALVELLNLYFDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992 242 LAEQVLTHGGVVNKFLGDAVLAFFRKENGPKQAVRCAF-GMLERFESLRQRWGESsnqdleyLDLGIGIATDRVALGAFG 320
COG2114       80 VAEVVARHGGRVVKFIGDGFLAVFGRPSPLEDAVACALdLQLALRNPLARLRRES-------LRVRIGIHTGEVVVGNTG 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116623992 321 SasvrdFTAIGTAVNRAAAFEHAARDGrRVLVDRRTWDAAREIIADHAEPERFELRKPGQGSGVVYW 387
COG2114      153 G-----YTVVGSAVNQAARLESLAKPG-QVLLSEATYDLVRDLVDLFSGLGSHRLKGLARPVRVYQL 213

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

128359

smart00044

CYCc

Adenylyl- / guanylyl cyclase, catalytic domain

false

194

5e-12

68.08

83.51

8,203,32,19,223,51,43,266,96,25,295,121,7,302,129,23,326,152,18,345,170,17,368,187,7

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992 204 RREDTTVMFADMRGFTQVCqSQEDPAHTQAIVNDLLTMLAEQVLTHGGVVNKFLGDAVLAFFR--KENGPKQAVRCAFGM 281
smart00044    33 SYDNVTILFTDIVGFTTLS-SEATPEQVVTLLNDLYSRFDRIIDRHGGYKVKTIGDAYMVVSGlpTEALVDHAELAADEA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992 282 LERFESLRQRwgesSNQDLEY-LDLGIGIATDRVALGAFGSASVRdFTAIGTAVNRAAAFEHAArDGRRVLVDRRTWDAA 360
smart00044   112 LDMVESLKTV----LSQHRGNgLRVRIGIHTGPVVAGVVGITMPR-YCLFGDTVNLASRMESVG-DPGQILVSEETYSLL 185

                        170
                 ....*....|....*
gi 116623992 361 REiiadhaEPERFEL 375
smart00044   186 RR------RGPRFVF 194

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

128379

smart00065

GAF

Domain present in phytochromes and cGMP-specific phosphodiesterases.

true

false

149

2e-11

65.48

95.30

5,32,6,22,54,29,17,79,46,45,125,91,23,148,116,32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992  33 DAILDRACQMTGSPDGSVLLFD-NERGGLFFAAAKGEKGPslleawgeYSSQRVPVSGSKAGLVYTTGETIVEQRLDDDT 111
smart00065     7 QTILEELRQLLGADRVLIYLVDeDDRGELVLVAADGLTLP--------LLGLRYPLGEGLAGRVAETGRPLNIPDVEADP 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116623992 112 DHFKGVDEQTRRTsQSMVCAPLETGGSRIGAIQILNK--PEPYSDRDLALLKQFAVQAAAAIKNARRLREL 180
smart00065    79 VFALDLLGRYQGV-RSFLAVPLVADGELVGVLALHNKdsPRPFTEEDEELLQALANQLAIALANAQLYEEL 148

cl00853

140972

GAF

GAF domain

-1

109276

pfam00211

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

false

185

3e-11

65.35

95.68

8,205,6,17,223,23,40,263,67,26,296,93,24,321,117,23,345,140,7,355,147,23,378,174,9

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992 206 EDTTVMFADMRGFTQVCqSQEDPAHTQAIVNDLLTMLAEQVLTHGGVVNKFLGDAVLA----FFRKENGPKQAVRCAFGM 281
pfam00211      7 DNVTILFADIVGFTALS-SRHSPEELVRLLNDLYTRFDELLDKHGVYKVKTIGDAYMAasglPPAAAHHAALLADMALDM 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992 282 LERFESLRqrwgessNQDLEYLDLGIGIATDRVALGAFGsASVRDFTAIGTAVNRAAAFEHAArDGRRVLVdrrTWDAAR 361
pfam00211     86 VETIEEVN-------VGHANGLRVRIGIHTGPVVAGVIG-ARRPRYDVWGDTVNVASRMESTG-VPGKIHV---SEETYR 153

                        170       180       190
                 ....*....|....*....|....*....|
gi 116623992 362 EIIADHAEPERFELRKP----GQGSGVVYW 387
pfam00211    154 LLKGEESFQFRLEPRGEvpvkGKGPMETYF 183

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

110584

pfam01590

GAF

GAF domain

false

153

1e-08

56.48

98.04

4,29,3,46,82,49,43,125,106,23,148,130,23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992  30 RLADAILDRACQMTGSPDGSVLLFDNERGGLFFAAAKGEKGPSLLEawgeyssQRVPVSGSKAGLVYTTGETIVEQRLDD 109
pfam01590      4 ELLQTILEELRELLGADRCAILLADADGLLLYLVAGDGLSDIPLAA-------RGLPLGGGVVGEVIAGGNPIVVPDVQD 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116623992 110 DTDHFKGVDEQTRRTS--------------QSMVCAPLETGGSRIGAIQILNK-PEPYSDRDLALLKQFAVQAAAAI 171
pfam01590     77 DPRFRDLTALAEELPApvgchehylrglgiRSCLAVPLLGGGKLIGVLVLHSTsPRAFTEEELELLQALADQVAIAL 153

cl00853

140972

GAF

GAF domain

-1

32385

COG2203

FhlA

FOG: GAF domain [Signal transduction mechanisms]

false

175

5e-08

54.64

94.86

3,17,8,44,63,52,84,147,138,36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992  18 TAGQLATEADQARLADAILDRACQMTGSPDGSVLLFDNERGGLFfaAAKGEKGPSLLEAWGEYSSQRVPVSGSKAGLVYT 97
COG2203        9 LAAKIAQDLDLEEILQAALELLAELLGADRGLIYLLDEDGLLDG--ALVAEAAEAGLEQLIDELFGLVILPACLIGIALR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623992  98 TGETIVEQRLDDDTDHFKGVDEQTRRTSQSMVCAPLETGGSRIGAIQILN--KPEPYSDRDLALLKQFAVQAAAAIKNAR 175
COG2203       87 EGRPVVVEDILQDPRFRDNPLVLLEPPIRSYLGVPLIAQGELLGLLCVHDsePRRQWSEEELELLEELAEQVAIAIERAR 166


                 ....*...
gi 116623992 176 RLRELAAH 183
COG2203      167 LYEELQEA 174

cl00853

140972

GAF

GAF domain

-1