NCBI Conserved Domain Search

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Conserved domains on [gi\|116623715\|ref\|YP_825871.1\|]
diguanylate cyclase [Solibacter usitatus Ellin6076]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

8e-33

136.18

98.09

6,187,1,23,210,28,58,268,87,16,285,103,9,297,112,15,312,128,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 188 DPLTGLKNRRRMERAVAERMGRE----QPFSVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGRWGGDE 263
cd01949        2 DPLTGLPNRRAFEERLERLLARArrsgRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGDE 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116623715 264 FVVLL-DCGPEDVGRHLERVRQwVFGDYVVQDqgvPHRLPIIASVGTAVW-QGGESMAELFARADRDMYQEKNAVRQR 339
cd01949       82 FAILLpGTDLEEAEELAERLRK-AIEEPFFID---GEEIRVTASIGIAEYpEDGEDLEELLRRADKALYQAKRSGRNR 155

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

110022

pfam00990

GGDEF

GGDEF domain

false

160

3e-29

124.28

100.00

6,184,0,27,211,31,57,268,89,16,290,105,14,304,124,8,312,133,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 185 ASLDPLTGLKNRRRMERAVAERMGREQ----PFSVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGRWG 260
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQrrqsPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 261 GDEFVVLL-DCGPEDVGRHLERVRQwvfgdyVVQDQGVPHRLPII-----ASVGTAVW-QGGESMAELFARADRDMYQEK 333
pfam00990     81 GDEFAILLpDTSLEGAQELAERIRR------LLAALKIPHTLSGLplyvtISIGIAAYpNDGEDAEDLLKRADQALYQAK 154


                 ....*.
gi 116623715 334 NAVRQR 339
pfam00990    155 NQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

2e-27

118.30

97.24

5,166,1,45,211,50,57,268,108,26,298,134,14,312,150,27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 167 MRGELRHYQARLEEAERLASLDPLTGLKNRRRMERAVAERMGREQ----PFSVVLLDLNGFKQVNDSYGHAAGDDVLKQF 242
COG2199        2 LLRLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARrhgePLALLLLDLDHFKQINDTYGHAAGDEVLREV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 243 ATELRSAFRAADDVGRWGGDEFVVLL-DCGPEDVGRHLERVRQWVFGDYVVQDqgvpHRLPIIASVGTAVW--QGGESMA 319
COG2199       82 ARRLRSNLREGDLVARLGGDEFAVLLpGTSLEEAARLAERIRAALEEPFFLGG----EELRVTVSIGVALYpeDGSDDAE 157

                        170       180
                 ....*....|....*....|
gi 116623715 320 ELFARADRDMYQEKNAVRQR 339
COG2199      158 LLLRRADLALYRAKRAGRNR 177

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

2e-27

118.12

96.32

6,182,0,29,211,33,57,268,91,16,290,107,14,304,123,9,313,133,24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 183 RLASLDPLTGLKNRRRMERAVAERMGREQ----PFSVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGR 258
smart00267     1 RLAFRDPLTGLPNRRYFEEELEQELQRAQrqgsPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 259 WGGDEFVVLL-DCGPEDVGRHLERVRQwvfgdyVVQDQGVPHRLPII--ASVGTAVWQ-GGESMAELFARADRDMYQEKN 334
smart00267    81 LGGDEFALLLpETSLEEAIALAERILQ------QLREPIIIHGIPLYltISIGVAAYPnPGEDAEDLLKRADTALYQAKK 154


                 ...
gi 116623715 335 AVR 337
smart00267   155 AGR 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

2e-24

108.19

96.97

6,183,0,28,211,32,61,272,94,20,296,114,4,300,120,14,314,135,25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 184 LASLDPLTGLKNRRRMERAVAERMGREQ----PFSVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGRW 259
TIGR00254      1 QAVRDPLTGLYNRRYLEEMLDSELKRARrfqrSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 260 GGDEFVVLLDCGP-EDVGRHLERVRQWVFGDYVVqdqgVPHR--LPIIASVGTAVWQG-GESMAELFARADRDMYQEKNA 335
TIGR00254     81 GGEEFVVILPGTPlEDALSKAERLRDAINSKPIE----VAGSetLTVTVSIGVACYPGhGLTLEELLKRADEALYQAKKA 156


                 ....
gi 116623715 336 VRQR 339
TIGR00254    157 GRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

1e-29

125.80

46.39

10,139,239,13,153,252,5,158,259,14,172,275,6,178,285,32,210,321,58,268,380,20,288,401,15,305,416,3,308,420,31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 140 DSLVLRARELQDRvDQMAR--DGQQMLAQMRGELR--HYQARL----EEAERLASLDPLTGLKNRRRMERAVAERMGRE- 210
PRK09581     240 DPRLVKALELGVN-DYLMRpiDKNELLARVRTQIRrkRYQDALrqnlEQSIEMAVTDGLTGLHNRRYFDMHLKQLIERAn 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 211 ---QPFSVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGRWGGDEFVVLL-DCGPEDVGRHLERVRQWV 286
PRK09581     319 ergKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARYGGEEFVVVMpDTDIEVAIAVAERIRRKI 398

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 116623715 287 FG-DYVVQDQGVPHRLPIiaSVG-TAVWQGGESMAELFARADRDMYQEKNAVRQR 339
PRK09581     399 AEePFAISDGKERLNVTV--SIGvAELRPSGESIEALIKRADKALYEAKNTGRNR 451

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

6e-27

116.73

72.01

7,132,73,21,153,104,16,170,120,8,183,128,27,210,157,58,268,216,28,299,244,40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 133 DDLGRIRDSLVLRARELQDRV----------DQMARDGQQMLAQMRGeLRHYQARLeeaerLASLDPLTGLKNRRRMERA 202
PRK09894      74 RLLDSAHQHMHNCARELLLAIaeghwqdadfDAFQEGLLSFTAALTD-YKIYLLTI-----RSNMDVLTGLPGRRVLDES 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 203 VAERMGRE--QPFSVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGRWGGDEFVVLL-DCGPEDVGRHL 279
PRK09894     148 FDHQLRNRepLNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRPYETVYRYGGEEFIIILkAATDEEACRAG 227

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 280 ERVRQWVFGDYVVQDQGvphRLPIIASVGTAVWQGGESMAELFARADRDMYQEKNAVRQR 339
PRK09894     228 ERIRQLIANQAITHSEG---RINITATFGVTRAFPEEPLDEVIGRADRAMYEGKQAGRNR 284

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

1e-23

105.77

43.68

6,146,239,16,170,255,40,210,299,58,268,358,30,299,388,17,316,406,23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 147 RELQDRVDQMARDGQQmlaqmrgeLRHYQARLEEAERLASLDPLTGLKNRRRMERAVAERMGRE----QPFSVVLLDLNG 222
COG3706      240 GELRARLRRQLRRKRY--------ERQLRESLERLQELALVDGLTGLFNRRYFDEHLADLWKRAlregRPLSLLMLDIDD 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 223 FKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGRWGGDEFVVLL-DCGPEDVGRHLERVRQWVFGDYVVQDQGVPhRL 301
COG3706      312 FKEINDTYGHDVGDEVLRQVARRLRQTVRGLDLVARYGGEEFAVVLpDTDLEAAIAIAERIRQKINELPFVHELSRE-PL 390

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 116623715 302 PIIASVGTAVWQGGE-SMAELFARADRDMYQEKNAVRQR 339
COG3706      391 EVTISIGVAEGKPGEdSIEELLKRADKALYKAKASGRNR 429

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

3e-16

81.22

28.05

7,157,197,7,164,205,18,182,225,30,212,259,68,287,327,15,302,347,10,312,358,25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 158 RDGQQML-AQMRGELRHYQARLEEAE--RLASLDPLTGLKNRRRMERAVAERMGREQP----FSVVLLDLNGFKQVNDSY 230
COG5001      198 REFSDMVqSQVTLTQRAEETRRLSDEndRLANLDSLTGLPNRRRFFAELDARLAAARQsgrrLVLGVIDLDGFKPVNDAF 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 231 GHAAGDDVLKQFATELRSAFRAADDVGRWGGDEFVVLLDCGPEDVGRHLErvrqwvfGDYVVQDQGVPHRLP-----IIA 305
COG5001      278 GHATGDRLLIEVGRRLKAFDGAPILAARLGGDEFALIIPALEDDALRVAG-------ARALCESLQAPYDLRgvrvqVGA 350

                        170       180       190
                 ....*....|....*....|....*....|...
gi 116623715 306 SVGTAVW-QGGESMAELFARADRDMYQEKNAVR 337
COG5001      351 SIGIAPFpSGADTSEQLFERADYALYHAKQNGK 383

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

2e-15

78.59

14.96

7,175,678,38,213,720,55,268,776,5,277,781,11,288,795,12,302,807,6,308,814,31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715  176 ARLEEAERLASLDPLTGLKNRRRMERAVAERMGREQPF----SVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFR 251
PRK09776      679 AMLRQLSYSASHDALTGLANRASFEKQLREALQTVNSThqrhALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLR 758

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715  252 AADDVGRWGGDEFVVLL-DCGPEdvgrHLERVRQWVFG---DYVVQDQGVPHRlpIIASVG-TAVWQGGESMAELFARAD 326
PRK09776      759 SSDVLARLGGDEFGLLLpDCNVE----SARFIATRIISainDYRFPWEGRVYR--VGASAGiTAIDDNNHQASEVMSQAD 832

                         170
                  ....*....|...
gi 116623715  327 RDMYQEKNAVRQR 339
PRK09776      833 IACYAAKNAGRGR 845

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

2e-14

75.54

25.04

7,169,224,11,183,235,32,215,269,60,275,334,9,297,343,7,304,355,8,312,364,26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 170 ELRHYQARLEEaerLASLDPLTGLKNRRRMERAVAERMGREQPFSV--VLLDLNGFKQVNDSYGHAAGDDVLKQFATELR 247
PRK10060     225 EERRAQERLRI---LANTDSITGLPNRNAIQELIDHAIAQADNNQVgiVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAIL 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 248 SAFRAADDVGRWGGDEFVVLLDCGPEDV-----GRHLERVRQwvfgdyvvqdqgvPHRLPII-----ASVGTAVW-QGGE 316
PRK10060     302 SCLEEDQTLARLGGDEFLVLASHTSQAAleamaSRILTRLRL-------------PFRIGLIevytgCSIGIALSpEHGD 368

                        170       180
                 ....*....|....*....|..
gi 116623715 317 SMAELFARADRDMYQEKNAVRQ 338
PRK10060     369 DSESLIRSADTAMYTAKEGGRG 390

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

2e-10

61.57

46.19

6,156,219,58,214,280,50,264,331,9,273,341,11,285,352,11,298,363,44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 157 ARDGQQMLAQMRGELRHYQARLEEAERLASLDPLTGLKNRRRMERAVAERMGREQPFS---VVLLDLNGFKQVNDSYGHA 233
PRK09966     220 ALDFNSLLDEMEEWQLRLQAKNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKtsaLLFLDGDNFKYINDTWGHA 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 234 AGDDVLKQFATELRSAFRAADDVGRWGGDEF-VVLLDCGPE-DVGRHLERVRQwVFGDYVVQDQGvpHRLPIIASVGTAV 311
PRK09966     300 TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFaMVLYDVQSEsEVQQICSALTQ-IFNLPFDLHNG--HQTTMTLSIGYAM 376

                        170       180       190
                 ....*....|....*....|....*....|.
gi 116623715 312 WQGGESMAELFARADRDMYQEKNAVRQREAK 342
PRK09966     377 TIEHASAEKLQELADHNMYQAKHQRAEKLVR 407

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

3e-09

57.98

33.42

5,213,242,63,276,306,8,287,314,12,299,327,17,317,344,22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 214 SVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGRWGGDEFVVLLDCGPEDVG-RHLERVRQwvfGDYVV 292
PRK10245     243 TLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAiTAMLRVHE---GLNTL 319

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116623715 293 QDQGVPH-RLPIIASVGTAVWQGGEsMAELFARADRDMYQEKNAVRQR 339
PRK10245     320 RLPNAPQvTLRISVGVAPLNPQMSH-YREWLKSADLALYKAKKAGRNR 366

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

1e-08

56.00

15.39

2,181,372,84,265,457,38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116623715 182 ERLASLDPLTGLKNRRRMERAVAERMGREQPFSVVLLDLNGFKQVNDSYGHAAGDDVLKQFATELRSAFRAADDVGRWGG 261
PRK11359     373 EQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEG 452

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 116623715 262 DEFV-VLLDCGPEDVGRHLERVRQWVFGDYVVQDQGVPHRLPI 303
PRK11359     453 TQFVlVSLENDVSNITQIADELRNVVSKPIMIDDKPFPLTLSI 495

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF