NCBI Conserved Domain Search

NewSearch

CDD Home

Conserved domains on [gi\|111219562\|ref\|YP_710356.1\|]
putative adenylate cyclase [Frankia alni ACN14a]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH

of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

32297

COG2114

CyaA

Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]

Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction...

true

false

227

2e-15

80.22

78.85

5,32,44,67,103,111,22,128,133,9,137,145,42,179,188,35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562   33 KTVTIMFVDIARSTDIGEKIDSEPLQQVMWRFFTTVREVIYNHGGSVEKFIGDAVFAVFGIPVLHEDdalrAVRSALDIR 112
COG2114        45 RRVTLLFADIVGSTELSESLGDEALVELLNLYFDAVAEVVARHGGRVVKFIGDGFLAVFGRPSPLED----AVACALDLQ 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  113 AAMEALNADLQEKwglRLRVRIGIN---TGEVTVAGGGVTGDAVNVAARLESAAPPDEILIGDTTHRFIR-HSVTVTPLG 188
COG2114       121 LALRNPLARLRRE---SLRVRIGIHtgeVVVGNTGGYTVVGSAVNQAARLESLAKPGQVLLSEATYDLVRdLVDLFSGLG 197

                         170       180
                  ....*....|....*....|....*.
gi 111219562  189 PLVVQGKRDPLRVHRLTGLVDPTAGP 214
COG2114       198 SHRLKGLARPVRVYQLCHRSLRRNLE 223

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

109276

pfam00211

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

false

185

3e-12

69.59

90.81

4,34,8,90,128,98,9,137,114,41,178,159,17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562   35 VTIMFVDIARSTDIGEKIDSEPLQQVMWRFFTTVREVIYNHGGSVEKFIGDAVFAVFGIPVLHEDDALRAVRSALDIRAA 114
pfam00211       9 VTILFADIVGFTALSSRHSPEELVRLLNDLYTRFDELLDKHGVYKVKTIGDAYMAASGLPPAAAHHAALLADMALDMVET 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  115 MEALNADLQEkwglRLRVRIGIN-------TGEVTVAGGGVTGDAVNVAARLESAAPPDEILIGDTTHRFI----RHSVT 183
pfam00211      89 IEEVNVGHAN----GLRVRIGIHtgpvvagVIGARRPRYDVWGDTVNVASRMESTGVPGKIHVSEETYRLLkgeeSFQFR 164

                         170
                  ....*....|..
gi 111219562  184 VTPLGPLVVQGK 195
pfam00211     165 LEPRGEVPVKGK 176

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

128359

smart00044

CYCc

Adenylyl- / guanylyl cyclase, catalytic domain

false

194

2e-11

66.54

77.32

6,34,36,17,53,53,9,62,64,36,98,101,27,128,128,9,137,144,42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562   35 VTIMFVDIARSTDIGEKidSEPLQQVMW--RFFTTVREVIYNHGGSVEKFIGDAVFAVFGIPVLHE-DDALRAVRSALDI 111
smart00044     37 VTILFTDIVGFTTLSSE--ATPEQVVTLlnDLYSRFDRIIDRHGGYKVKTIGDAYMVVSGLPTEALvDHAELAADEALDM 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 111219562  112 RAAMEALNADLQEKwglRLRVRIGIN-------TGEVTVAGGGVTGDAVNVAARLESAAPPDEILIGDTTHRFIR 179
smart00044    115 VESLKTVLSQHRGN---GLRVRIGIHtgpvvagVVGITMPRYCLFGDTVNLASRMESVGDPGQILVSEETYSLLR 186

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

33687

COG3899

Predicted ATPase [General function prediction only]

true

false

849

4e-55

212.18

62.54

17,225,0,25,251,25,24,275,50,69,344,125,9,353,138,15,368,154,28,396,183,57,453,241,53,506,297,44,552,341,19,571,366,63,638,429,7,648,436,22,670,459,18,688,478,8,696,490,24,725,514,17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  226 PVIGRNRERRRLQDAFEAVVEERAChLFTVLGSAGIGKSRMVGEFCTSMA-TRATVLTGRCLSYGEGIAYWPLMEMVRQA 304
COG3899         1 PLYGRETELAQLLAAFDRVSKGRGE-VVLVAGESGIGKSALVNEVHKPITqQRGYFIKGKFDQFERNIPLSPLVQAFRDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  305 TGLTADESAPDGRRRLRELLDGVGQAAEIVEALAPLVGLG------GAELGPQES----FWAVRSFFQALAARR-PLILW 373
COG3899        80 MGQLLSESDTRILSWRARLLAALGENGQVIIDVIPELELIigkrppALELSPTAAqnrfNLAFLRFIQVFTAEEhPLVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  374 FDDVHWAEPTLLDLIENIADWSR-DAPIMLLCLARQELLEDRRDWGGGKFNATSMLLAPLTEARCQRLIRSLMGSDDLDP 452
COG3899       160 LEDLHWADSASLKLLQLLMDRIAiGAYRDNEVLLLHPLRPTLGEILKSATNITTITLAPLSRADTNQLVAATLGCTKLLP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  453 A-LVTRITTSAAGNPLFVEQMVAALVDDGLLRREGSRWIATGSLRNVTVPPTISS---LLAARLDRLDPPERRVLERAAV 528
COG3899       240 ApLLELIFEKTKGNPFFIEEFLKALYEEGLLVFNFDTGAWQCSIASLGILATTDAvveFLAARLQKLPGTTREVLKAAAC 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  529 VGERFYLDAVIDLSDPAERSMVnvHCLNLVRKELVHPDRSDLP------GVEAFRFLHVLLRDCAYESTAKRRRADLHQQ 602
COG3899       320 IGNRFDLDTLAALAEDSPALEA--AALLDALQEGLILPLSETYrfgsnvDIATYKFLHDRVQQAAYNLIPESQRQYLHLR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  603 FAHWLQARLVGGPGEHDELVGYHLEQAFRYRVeigqRDAETIElgrSAATCLIEAADRVRQGDETGAA-QLLKRAITLLP 681
COG3899       398 IGQLLEQNIPEAGQEEEIFDIVNQLNAGVGLI----TLEEAVD---ELAELNLLAGRKAKLRSAYSAAiSYLERGLSLLL 470

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 111219562  682 ETDPLRL-RAEIDLGW----ALYSFGRFSDAERILRQVTERARRagedgLRAHARLAHLRVLFSTD 742
COG3899       471 ADAWQNQyLLALMLHRlaaeNAYLRGQFELSESLIEVVLICAAS-----NLDGAKVYELVIQAYTA 531

-1

32733

COG2909

MalT

ATP-dependent transcriptional regulator [Transcription]

false

true

false

894

0.005

39.13

24.83

9,500,326,30,530,358,16,546,379,11,564,390,11,581,401,30,615,431,9,625,440,17,649,457,33,682,491,57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  501 PPTISSLLAARLDRLDPPERRVLERAAVVG--ERFYLDAVIDLSDPAE-----RSMVNVHCLNLvrkelvhPDRSDLPGV 573
COG2909       327 HHLFAEFLRQRLQRELAARLKELHRAAAEWfaEHGLPSEAIDHALAAGdpemaADLLEQLEWQL-------FNGSELSLL 399

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  574 EAfrflhvLLRDCAYESTAKRRRADLHQQFAHWLQARLvggpGEHDELVGYhLEQAFRYRVEIGQRDAEtielgrsAATC 653
COG2909       400 LA------WLKALPAELLASTPRLVLLQAWLLASQHRL----AEAETLIAR-LEHFLKAPMHSRQGDLL-------AEFQ 461

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111219562  654 LIEAADRVRQGDETGAAQLLKRAITLLPE-TDPLRLRAEIDLGWALYSFGRFSDAERILRQVTERARRAGEDGLRAHARL 732
COG2909       462 ALRAQVALNRGDPEEAEDLARLALVQLPEaAYRSRIVALSVLGEAAHIRGELTQALALMQQAEQMARQHDVYHLALWSLL 541


                  ....*..
gi 111219562  733 AHLRVLF 739
COG2909       542 QQSEILE 548

-1