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Conserved domains on  [gi|109100934|ref|XP_001087071|]
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PREDICTED: insulin-like growth factor binding protein 2, 36kDa [Macaca mulatta]

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List of domain hits

Name Accession Description Interval E-value
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
227-307 4.23e-14

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 65.95  E-value: 4.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109100934 227 PCQQELDQVLERIstmrlpdergPLEHLYSLHIPNCDKHGLYNLKQCKMSLngqrGECWCVNPNtGKLIQGAPTIRGDPE 306
Cdd:cd00191    1 PCERERASALESL----------AGPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPN 65

                 .
gi 109100934 307 C 307
Cdd:cd00191   66 C 66
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
41-133 7.85e-25

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 95.61  E-value: 7.85e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109100934    41 FRCPPCTPERLAACGPppvappaavaavaggarmPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSEL 120
Cdd:smart00121   1 ARCPPCDPARCPPCPP------------------GCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEER 62
                           90
                   ....*....|...
gi 109100934   121 PLQALVMGEGTCE 133
Cdd:smart00121  63 PLRALLHGQGVCM 75
 
Name Accession Description Interval E-value
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
227-307 4.23e-14

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 65.95  E-value: 4.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109100934 227 PCQQELDQVLERIstmrlpdergPLEHLYSLHIPNCDKHGLYNLKQCKMSLngqrGECWCVNPNtGKLIQGAPTIRGDPE 306
Cdd:cd00191    1 PCERERASALESL----------AGPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPN 65

                 .
gi 109100934 307 C 307
Cdd:cd00191   66 C 66
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
41-133 7.85e-25

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 95.61  E-value: 7.85e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109100934    41 FRCPPCTPERLAACGPppvappaavaavaggarmPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSEL 120
Cdd:smart00121   1 ARCPPCDPARCPPCPP------------------GCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEER 62
                           90
                   ....*....|...
gi 109100934   121 PLQALVMGEGTCE 133
Cdd:smart00121  63 PLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
228-307 6.16e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 249575  Cd Length: 66  Bit Score: 73.61  E-value: 6.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109100934  228 CQQELDQVLERISTMrlpdergplEHLYSLHIPNCDKHGLYNLKQCkmslNGQRGECWCVNPNtGKLIQGAPTIRGDPEC 307
Cdd:pfam00086   1 CQVERERVLESLAAL---------ESPRGLYVPNCDENGFYKPVQC----DPQRGECWCVDAE-GKEVPGTRDVGGEPRC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
75-112 6.31e-13

Insulin-like growth factor binding protein;


Pssm-ID: 249690  Cd Length: 53  Bit Score: 62.41  E-value: 6.31e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 109100934   75 PCAELVRE--PGCGCCSVCARLEGEACGVYTPRCGQGLRC 112
Cdd:pfam00219  14 GCPPGVRLvlDGCGCCKVCARQEGESCGVYTPRCHKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
259-308 1.46e-10

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 55.85  E-value: 1.46e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 109100934   259 IPNCDKHGLYNLKQCkmslNGQRGECWCVNPnTGKLIQGAPTIRGDPECH 308
Cdd:smart00211   1 IPQCDEDGNYEPVQC----DGSSGQCWCVDA-TGREIPGTRTEGGDPDCP 45
 
Name Accession Description Interval E-value
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
227-307 4.23e-14

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 65.95  E-value: 4.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109100934 227 PCQQELDQVLERIstmrlpdergPLEHLYSLHIPNCDKHGLYNLKQCKMSLngqrGECWCVNPNtGKLIQGAPTIRGDPE 306
Cdd:cd00191    1 PCERERASALESL----------AGPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPN 65

                 .
gi 109100934 307 C 307
Cdd:cd00191   66 C 66
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
41-133 7.85e-25

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 95.61  E-value: 7.85e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109100934    41 FRCPPCTPERLAACGPppvappaavaavaggarmPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSEL 120
Cdd:smart00121   1 ARCPPCDPARCPPCPP------------------GCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEER 62
                           90
                   ....*....|...
gi 109100934   121 PLQALVMGEGTCE 133
Cdd:smart00121  63 PLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
228-307 6.16e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 249575  Cd Length: 66  Bit Score: 73.61  E-value: 6.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109100934  228 CQQELDQVLERISTMrlpdergplEHLYSLHIPNCDKHGLYNLKQCkmslNGQRGECWCVNPNtGKLIQGAPTIRGDPEC 307
Cdd:pfam00086   1 CQVERERVLESLAAL---------ESPRGLYVPNCDENGFYKPVQC----DPQRGECWCVDAE-GKEVPGTRDVGGEPRC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
75-112 6.31e-13

Insulin-like growth factor binding protein;


Pssm-ID: 249690  Cd Length: 53  Bit Score: 62.41  E-value: 6.31e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 109100934   75 PCAELVRE--PGCGCCSVCARLEGEACGVYTPRCGQGLRC 112
Cdd:pfam00219  14 GCPPGVRLvlDGCGCCKVCARQEGESCGVYTPRCHKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
259-308 1.46e-10

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 55.85  E-value: 1.46e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 109100934   259 IPNCDKHGLYNLKQCkmslNGQRGECWCVNPnTGKLIQGAPTIRGDPECH 308
Cdd:smart00211   1 IPQCDEDGNYEPVQC----DGSSGQCWCVDA-TGREIPGTRTEGGDPDCP 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.11
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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