NCBI Conserved Domain Search

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Conserved domains on [gi\|108803858\|ref\|YP_643795.1\|]
metal dependent phosphohydrolase [Rubrobacter xylanophilus DSM 9941]

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List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

28958

cd00077

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

true

false

true

145

2e-04

42.37

63.45

3,288,19,31,319,58,19,338,85,26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108803858 289 EMGLEPRRVERLRVAAFLCDIGKLGLSGDPS--------SHPERGARMLEEAGLGELA--------VWVRYHHERPDGRG 352
cd00077       20 ELGLSEEDIELLRLAALLHDIGKPGTPDAITeeeselekDHAIVGAEILRELLLEEVIklidelilAVDASHHERLDGLG 99

                         90
                 ....*....|..
gi 108803858 353 HPYGLRGPWIPL 364
cd00077      100 YPDGLKGEEITL 111

cl00076

140417

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

110919

pfam01966

HD domain

false

108

8e-04

40.30

61.11

3,296,22,15,311,45,22,333,69,19

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 108803858 297 VERLRVAAFLCDIGK--------LGLSGDPSSHPERGARMLEEAG--LGELAVWVRYHHERPDGRG 352
pfam01966     23 PELLLLAALLHDIGKdpfgflekLEDFGIFKSHSVVGAEILRELEkrLGVDLELILEHHESWEGAG 88

cl00076

140417

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

-1

32388

COG2206

c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]

false

true

false

344

2e-16

82.49

43.90

3,288,165,29,317,209,16,333,227,89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108803858 289 EMGLEPRRVERLRVAAFLCDIGKLGLSGD---------------PSSHPERGARMLEEAG--LGELAVWVRYHHERPDGR 351
COG2206      166 KLGLSEEKIEELALAGLLHDIGKIGIPDSilnkpgklteeefeiIKKHPIYGYDILKDLPefLESVRAVALRHHERWDGT 245

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 108803858 352 GHPYGLRGPWIPLEARILAVAEAYAALVVGGPRHPATDFEAARRRLCEGAGTGFDGEVVRAFLRVLDTAPP 422
COG2206      246 GYPRGLKGEEIPLEARIIAVADVYDALTSDRPYKKAKSPEEALEELRKNSGGKFDPKVVDAFLKALSKYPI 316

-1

33243

COG3437

Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and an HD-GYP domain [...

false

true

false

360

6e-14

74.18

41.11

5,288,202,26,317,228,3,320,249,12,332,266,6,341,272,78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108803858 289 EMGLEPRRVERLRVAAFLCDIGKLGLsgdPSS------------------HPERGARMLEEA-----GLGELAvwvRYHH 345
COG3437      203 LLGLSEEEVDLIKKAAPLHDIGKVAI---PDSillkpgkltseefeimkgHPILGAEILKSSerlmqVAAEIA---RHHH 276

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 108803858 346 ERPDGRGHPYGLRGPWIPLEARILAVAEAYAALVVGGPRHPATDFEAARRRLCEGAGTGFDGEVVRAFLRVLDT 419
COG3437      277 ERWDGSGYPDGLKGDEIPLSARIVAIADVFDALVSGRPYKEAMSTEEALEIIRAQSGRLFDPKLVEAFIQVEDE 350

-1

Zn2+ binding site	0	2	4	true	28958	cd00077	HDc
Mg2+ binding site	1	1	1	true	28958	cd00077	HDc