CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942    13 GGSLFLFDRKVLRYFRKDGHNWRKKKDGKTVKEAHERLKAGSIDVLHCYYAHGEENENFQRRSYWMLEEDLsHIVLVHYR 92
Cdd:pfam03859   34 SGSLFLFDRKKLRYFRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIHCYYAHSEDNPTFQRRIYWLLDSDY-HIVLVHYL 112

                   ..
gi 823206942    93 DV 94
Cdd:pfam03859  113 NV 114

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942   462 SIIDFSPNWAYVGSEIKVLITGR-FLKSQGHAenckwSCMFGEVEVPAEVIADGVLRCHTPKHEAGRVPFYVTCSNRLAC 540
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDL-----KVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIS 76

                   .
gi 823206942   541 S 541
Cdd:pfam01833   77 S 77

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.

                          10        20
                  ....*....|....*....|...
gi 823206942  870 ERVHAAAIRIQNKFRGWKGRKEF 892
Cdd:cd23767     6 QRMNRAATLIQALWRGYKVRKEL 28

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942    13 GGSLFLFDRKVLRYFRKDGHNWRKKKDGKTVKEAHERLKAGSIDVLHCYYAHGEENENFQRRSYWMLEEDLsHIVLVHYR 92
Cdd:pfam03859   34 SGSLFLFDRKKLRYFRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIHCYYAHSEDNPTFQRRIYWLLDSDY-HIVLVHYL 112

                   ..
gi 823206942    93 DV 94
Cdd:pfam03859  113 NV 114

Ankyrin repeat [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942  646 WLLQKivegGKGPSILDKGGQGVIHFASALGYDWALEPTIVAGVSVNFRDVNGWNALHWAASSGRERTVASLISLGAapg 725
Cdd:COG0666   138 LLLEA----GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA--- 210

                          90       100       110
                  ....*....|....*....|....*....|...
gi 823206942  726 altDPTPEYPLGRTPADLASANGHKGISGYLAE 758
Cdd:COG0666   211 ---DVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

Ankyrin repeats (3 copies);

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942   669 IHFASALGYDWALEPTIVAGVSVNFRDVNGWNALHWAASSGRERTVASLISLGAApgaltDPTPEyplGRTPADLASANG 748
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV-----NLKDN---GRTALHYAARSG 72

                           90
                   ....*....|..
gi 823206942   749 HKGISGYLAECD 760
Cdd:pfam12796   73 HLEIVKLLLEKG 84

IQ calmodulin-binding motif; Calmodulin-binding motif.

                           10        20
                   ....*....|....*....|.
gi 823206942   896 RQRIVKIQAHVRGHQVRKNYR 916
Cdd:pfam00612    1 RKAAIKIQAAWRGYLARKRYK 21

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.

                          10        20
                  ....*....|....*....|...
gi 823206942  870 ERVHAAAIRIQNKFRGWKGRKEF 892
Cdd:cd23767     6 QRMNRAATLIQALWRGYKVRKEL 28

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942    13 GGSLFLFDRKVLRYFRKDGHNWRKKKDGKTVKEAHERLKAGSIDVLHCYYAHGEENENFQRRSYWMLEEDLsHIVLVHYR 92
Cdd:pfam03859   34 SGSLFLFDRKKLRYFRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIHCYYAHSEDNPTFQRRIYWLLDSDY-HIVLVHYL 112

                   ..
gi 823206942    93 DV 94
Cdd:pfam03859  113 NV 114

Ankyrin repeat [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942  646 WLLQKivegGKGPSILDKGGQGVIHFASALGYDWALEPTIVAGVSVNFRDVNGWNALHWAASSGRERTVASLISLGAapg 725
Cdd:COG0666   138 LLLEA----GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA--- 210

                          90       100       110
                  ....*....|....*....|....*....|...
gi 823206942  726 altDPTPEYPLGRTPADLASANGHKGISGYLAE 758
Cdd:COG0666   211 ---DVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

ankyrin-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942  648 LQKIVEGGKGPSILDKGGQGVIHFASALGYDWA--LEPTIVAGVSVNFRDVNGWNALHWAASSGRERTVASLISLGAAPG 725
Cdd:PHA03095  205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284

                          90       100
                  ....*....|....*....|....
gi 823206942  726 ALTdptpeyPLGRTPADLASANGH 749
Cdd:PHA03095  285 AVS------SDGNTPLSLMVRNNN 302

Ankyrin repeats (3 copies);

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 823206942   647 LLQKIVEGGKGPSILDKGGQGVIHFASALGYDWALEpTIVAGVSVNFRDvNGWNALHWAASSGRERTVASLISLGA 722
Cdd:pfam12796   12 LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVK-LLLEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGA 85

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823206942   462 SIIDFSPNWAYVGSEIKVLITGR-FLKSQGHAenckwSCMFGEVEVPAEVIADGVLRCHTPKHEAGRVPFYVTCSNRLAC 540
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDL-----KVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIS 76

                   .
gi 823206942   541 S 541
Cdd:pfam01833   77 S 77

IQ calmodulin-binding motif; Calmodulin-binding motif.

                           10        20
                   ....*....|....*....|.
gi 823206942   896 RQRIVKIQAHVRGHQVRKNYR 916
Cdd:pfam00612    1 RKAAIKIQAAWRGYLARKRYK 21

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.

                          10        20
                  ....*....|....*....|...
gi 823206942  870 ERVHAAAIRIQNKFRGWKGRKEF 892
Cdd:cd23767     6 QRMNRAATLIQALWRGYKVRKEL 28

calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, which are actin-based motor molecules with ATPase activity, include unconventional myosins that serve in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Myosin-VI appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP (DOCK7-Induced Septin disPlacement) complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant non-syndromic hearing loss. This family also includes Drosophila melanogaster unconventional myosin VI Jaguar (Jar; also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. Jar may link endocytic vesicles to microtubules and possibly be involved in transport in the early embryo and in the dynamic process of dorsal closure; its function is believed to change during the life cycle. This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 823206942  877 IRIQNK--FRgwkgrkefliiRQRIVKIQAHVRGHQVRKNYR 916
Cdd:cd21759    35 IKLKNKilYR-----------REALIKIQKTVRGYLARKKHR 65