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Conserved domains on  [gi|749644062|ref|WP_040245318|]
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malonate decarboxylase acyl carrier protein [Klebsiella pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACP super family cl06082
Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial ...
 1-98 9.20e-42

Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyzes the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit. The family also contains the CitD family of citrate lyase acyl carrier proteins.


The actual alignment was detected with superfamily member PRK01220:

Pssm-ID: 446891  Cd Length: 99  Bit Score: 132.02  E-value: 9.20e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062  1 MEQITLSFPASRALSGRALVGVVGSGDMEVLYTAAQSATLNVQITTSVDNSQARWQALFDRLNLINGLPAGQLIIHDFGA 80
Cdd:PRK01220  1 METLTFEFPAGQPPRGRALVGVVGSGDLEVLLEPGDAGKLSIQVVTSVNGSAARWKALFERFFTAQTPPAANIDIHDFGA 80

                        90
                ....*....|....*...
gi 749644062 81 TPGVARIRIEQVFEEAAH 98
Cdd:PRK01220 81 TPGVVRLRLEQALEEIGH 98
 
Name Accession Description Interval E-value
PRK01220 PRK01220
malonate decarboxylase subunit delta; Provisional
 1-98 9.20e-42

malonate decarboxylase subunit delta; Provisional


Pssm-ID: 179253  Cd Length: 99  Bit Score: 132.02  E-value: 9.20e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062  1 MEQITLSFPASRALSGRALVGVVGSGDMEVLYTAAQSATLNVQITTSVDNSQARWQALFDRLNLINGLPAGQLIIHDFGA 80
Cdd:PRK01220  1 METLTFEFPAGQPPRGRALVGVVGSGDLEVLLEPGDAGKLSIQVVTSVNGSAARWKALFERFFTAQTPPAANIDIHDFGA 80

                        90
                ....*....|....*...
gi 749644062 81 TPGVARIRIEQVFEEAAH 98
Cdd:PRK01220 81 TPGVVRLRLEQALEEIGH 98
malonate_delta TIGR03130
malonate decarboxylase acyl carrier protein; Members of this protein family are the acyl ...
 2-96 6.00e-41

malonate decarboxylase acyl carrier protein; Members of this protein family are the acyl carrier protein, also called the delta subunit, of malonate decarboxylase. This subunit has the same covalently bound prosthetic group, derived from and similar to coenzyme A, as does citrate lyase, although this protein and the acyl carrier protein of citrate lyase do not show significant sequence similarity. Both malonyl and acetyl groups are transferred to the prosthetic group for catalysis.


Pssm-ID: 188283  Cd Length: 98  Bit Score: 130.10  E-value: 6.00e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062   2 EQITLSFPASRALSGR--ALVGVVGSGDMEVLYTA-AQSATLNVQITTSVDNSQARWQALFDRLNLINGLPAGQLIIHDF 78
Cdd:TIGR03130  1 ETLTFEFPAQAPARGKapALVGVVGSGDLEVLVEPgALGGKTEVQIVTSVDGFDAVWQAVLERFFARYPLAGLQIEINDF 80

                         90
                 ....*....|....*...
gi 749644062  79 GATPGVARIRIEQVFEEA 96
Cdd:TIGR03130 81 GATPAVVSLRLRQALEEL 98
ACP pfam06857
Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial ...
 15-96 5.81e-22

Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyzes the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit. The family also contains the CitD family of citrate lyase acyl carrier proteins.


Pssm-ID: 429157  Cd Length: 83  Bit Score: 81.39  E-value: 5.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062  15 SGRALVGVVGSGDMEVLYTAAQSATLNVQITTSV-DNSQARWQALFDRLNLINGLPAGQLIIHDFGATPGVARIRIEQVF 93
Cdd:pfam06857  1 KKTALAGTLESSDLEVTVEPALGGGIEIELESSVaKQFGDQIRAVIEETLEELGVKDAKVTINDKGALDCVIRARLEQAL 80


                 ...
gi 749644062  94 EEA 96
Cdd:pfam06857 81 ERA 83
CitD COG3052
Acyl-carrier protein (citrate lyase gamma subunit) [Energy production and conversion];
17-97 2.16e-09

Acyl-carrier protein (citrate lyase gamma subunit) [Energy production and conversion];


Pssm-ID: 442286  Cd Length: 91  Bit Score: 49.78  E-value: 2.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062 17 RALVGVVGSGDMEVLYTAAQSATLNVQITTSVDNsQ--ARWQAL----FDRLnlinGLPAGQLIIHDFGATPGVARIRIE 90
Cdd:COG3052   6 EAVAGTLESSDLMVTVEPADGGGIEIELTSSVEK-QfgDQIRAVvretLARL----GVTGAKVIIEDKGALDCVIRARLE 80


                ....*..
gi 749644062 91 QVFEEAA 97
Cdd:COG3052  81 TALERAL 87
 
Name Accession Description Interval E-value
PRK01220 PRK01220
malonate decarboxylase subunit delta; Provisional
 1-98 9.20e-42

malonate decarboxylase subunit delta; Provisional


Pssm-ID: 179253  Cd Length: 99  Bit Score: 132.02  E-value: 9.20e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062  1 MEQITLSFPASRALSGRALVGVVGSGDMEVLYTAAQSATLNVQITTSVDNSQARWQALFDRLNLINGLPAGQLIIHDFGA 80
Cdd:PRK01220  1 METLTFEFPAGQPPRGRALVGVVGSGDLEVLLEPGDAGKLSIQVVTSVNGSAARWKALFERFFTAQTPPAANIDIHDFGA 80

                        90
                ....*....|....*...
gi 749644062 81 TPGVARIRIEQVFEEAAH 98
Cdd:PRK01220 81 TPGVVRLRLEQALEEIGH 98
malonate_delta TIGR03130
malonate decarboxylase acyl carrier protein; Members of this protein family are the acyl ...
 2-96 6.00e-41

malonate decarboxylase acyl carrier protein; Members of this protein family are the acyl carrier protein, also called the delta subunit, of malonate decarboxylase. This subunit has the same covalently bound prosthetic group, derived from and similar to coenzyme A, as does citrate lyase, although this protein and the acyl carrier protein of citrate lyase do not show significant sequence similarity. Both malonyl and acetyl groups are transferred to the prosthetic group for catalysis.


Pssm-ID: 188283  Cd Length: 98  Bit Score: 130.10  E-value: 6.00e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062   2 EQITLSFPASRALSGR--ALVGVVGSGDMEVLYTA-AQSATLNVQITTSVDNSQARWQALFDRLNLINGLPAGQLIIHDF 78
Cdd:TIGR03130  1 ETLTFEFPAQAPARGKapALVGVVGSGDLEVLVEPgALGGKTEVQIVTSVDGFDAVWQAVLERFFARYPLAGLQIEINDF 80

                         90
                 ....*....|....*...
gi 749644062  79 GATPGVARIRIEQVFEEA 96
Cdd:TIGR03130 81 GATPAVVSLRLRQALEEL 98
ACP pfam06857
Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial ...
 15-96 5.81e-22

Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyzes the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit. The family also contains the CitD family of citrate lyase acyl carrier proteins.


Pssm-ID: 429157  Cd Length: 83  Bit Score: 81.39  E-value: 5.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062  15 SGRALVGVVGSGDMEVLYTAAQSATLNVQITTSV-DNSQARWQALFDRLNLINGLPAGQLIIHDFGATPGVARIRIEQVF 93
Cdd:pfam06857  1 KKTALAGTLESSDLEVTVEPALGGGIEIELESSVaKQFGDQIRAVIEETLEELGVKDAKVTINDKGALDCVIRARLEQAL 80


                 ...
gi 749644062  94 EEA 96
Cdd:pfam06857 81 ERA 83
CitD COG3052
Acyl-carrier protein (citrate lyase gamma subunit) [Energy production and conversion];
17-97 2.16e-09

Acyl-carrier protein (citrate lyase gamma subunit) [Energy production and conversion];


Pssm-ID: 442286  Cd Length: 91  Bit Score: 49.78  E-value: 2.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062 17 RALVGVVGSGDMEVLYTAAQSATLNVQITTSVDNsQ--ARWQAL----FDRLnlinGLPAGQLIIHDFGATPGVARIRIE 90
Cdd:COG3052   6 EAVAGTLESSDLMVTVEPADGGGIEIELTSSVEK-QfgDQIRAVvretLARL----GVTGAKVIIEDKGALDCVIRARLE 80


                ....*..
gi 749644062 91 QVFEEAA 97
Cdd:COG3052  81 TALERAL 87
PRK02103 PRK02103
malonate decarboxylase acyl carrier protein;
1-99 3.53e-09

malonate decarboxylase acyl carrier protein;


Pssm-ID: 179367  Cd Length: 105  Bit Score: 49.66  E-value: 3.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749644062   1 MEQITLSFPASRALSGR---ALVGVVGSGDMEVLY-TAAQSATLNVQITTSVDNSQARWQALFDRLNLINGLPAGQLIIH 76
Cdd:PRK02103   1 METLNYRFTARRRAKGAraaALVGVVASGNLEVLVeRVLPGGECEVEIRTAAVGFGAVWQAVVADFVERRSPGGLRISIN 80

                         90       100
                 ....*....|....*....|....*
gi 749644062  77 DFGATPGVARIRIEQVFE--EAAHA 99
Cdd:PRK02103  81 DGGARPDTVSLRLAQAVRaiEGAAA 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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