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Conserved domains on  [gi|499948832|ref|WP_011629566|]
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protein-L-isoaspartate(D-aspartate) O-methyltransferase [Alkalilimnicola ehrlichii]

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 11457531)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 21-219 1.15e-104

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 300.08  E-value: 1.15e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  21 VSRLAEEGIRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLIEQSiPERVLELGTGSGY 100
Cdd:COG2518    1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKP-GDRVLEIGTGSGY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832 101 QAAVLAYLGVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPDPLWDQLDEGGRL 180
Cdd:COG2518   80 QAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRL 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 499948832 181 VAPLGGAGRpQELVLIERVDGELRRRHVASVSFVPLLGG 219
Cdd:COG2518  160 VAPVGEGGV-QRLVLITRTGDGFERESLFEVRFVPLRGG 197
 
Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 21-219 1.15e-104

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 300.08  E-value: 1.15e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  21 VSRLAEEGIRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLIEQSiPERVLELGTGSGY 100
Cdd:COG2518    1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKP-GDRVLEIGTGSGY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832 101 QAAVLAYLGVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPDPLWDQLDEGGRL 180
Cdd:COG2518   80 QAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRL 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 499948832 181 VAPLGGAGRpQELVLIERVDGELRRRHVASVSFVPLLGG 219
Cdd:COG2518  160 VAPVGEGGV-QRLVLITRTGDGFERESLFEVRFVPLRGG 197
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
9-219 1.89e-99

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 287.49  E-value: 1.89e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   9 IGMTSRRTRERLVSRLAEEGIRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLIEQSIp 88
Cdd:PRK00312   1 ARLMESERFARLVLRLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPG- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  89 ERVLELGTGSGYQAAVLAYLGVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPD 168
Cdd:PRK00312  80 DRVLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPR 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499948832 169 PLWDQLDEGGRLVAPLGGAGRpQELVLIERVDGELRRRHVASVSFVPLLGG 219
Cdd:PRK00312 160 ALLEQLKEGGILVAPVGGEEQ-QLLTRVRKRGGRFEREVLEEVRFVPLVKG 209
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 11-219 9.12e-70

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 212.38  E-value: 9.12e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   11 MTSRRTRERLVSRLAEEG-IRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLiEQSIPE 89
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGyIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELL-ELKPGM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   90 RVLELGTGSGYQAAVLAYL---GVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEV 166
Cdd:TIGR00080  80 KVLEIGTGSGYQAAVLAEIvgrDGLVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKI 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499948832  167 PDPLWDQLDEGGRLVAPLGGAGrpQELVLIERVDGELRRRHVASVSFVPLLGG 219
Cdd:TIGR00080 160 PEALIDQLKEGGILVMPVGEYL--QVLKRAEKRGGEIIIKDVEPVAFVPLVGG 210
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
15-216 1.80e-65

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 201.06  E-value: 1.80e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   15 RTRERLVSRLAEEG-IRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLiEQSIPERVLE 93
Cdd:pfam01135   1 NRNEALIENLKNYGvIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELL-ELKPGMRVLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   94 LGTGSGYQAAVLA-YLGVE--VYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPDPL 170
Cdd:pfam01135  80 IGSGSGYLTACFArMVGEVgrVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEAL 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 499948832  171 WDQLDEGGRLVAPLGGAGRpQELVLIERV-DGELRRRHVASVSFVPL 216
Cdd:pfam01135 160 IDQLKEGGRLVIPVGPNGN-QVLQQFDKRnDGSVVIKDLEGVRFVPL 205
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 90-185 4.41e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.13  E-value: 4.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  90 RVLELGTGSGYQAAVLA-YLGVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEG-WAQHAPYQGIIVTAAPEEVP 167
Cdd:cd02440    1 RVLDLGCGTGALALALAsGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPLHHLV 80

                         90
                 ....*....|....*...
gi 499948832 168 DPLWDQLDEGGRLVAPLG 185
Cdd:cd02440   81 EDLARFLEEARRLLKPGG 98
 
Name Accession Description Interval E-value
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 21-219 1.15e-104

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 300.08  E-value: 1.15e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  21 VSRLAEEGIRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLIEQSiPERVLELGTGSGY 100
Cdd:COG2518    1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKP-GDRVLEIGTGSGY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832 101 QAAVLAYLGVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPDPLWDQLDEGGRL 180
Cdd:COG2518   80 QAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRL 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 499948832 181 VAPLGGAGRpQELVLIERVDGELRRRHVASVSFVPLLGG 219
Cdd:COG2518  160 VAPVGEGGV-QRLVLITRTGDGFERESLFEVRFVPLRGG 197
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
9-219 1.89e-99

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 287.49  E-value: 1.89e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   9 IGMTSRRTRERLVSRLAEEGIRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLIEQSIp 88
Cdd:PRK00312   1 ARLMESERFARLVLRLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPG- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  89 ERVLELGTGSGYQAAVLAYLGVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPD 168
Cdd:PRK00312  80 DRVLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPR 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499948832 169 PLWDQLDEGGRLVAPLGGAGRpQELVLIERVDGELRRRHVASVSFVPLLGG 219
Cdd:PRK00312 160 ALLEQLKEGGILVAPVGGEEQ-QLLTRVRKRGGRFEREVLEEVRFVPLVKG 209
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 11-219 9.12e-70

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 212.38  E-value: 9.12e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   11 MTSRRTRERLVSRLAEEG-IRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLiEQSIPE 89
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGyIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELL-ELKPGM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   90 RVLELGTGSGYQAAVLAYL---GVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEV 166
Cdd:TIGR00080  80 KVLEIGTGSGYQAAVLAEIvgrDGLVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKI 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499948832  167 PDPLWDQLDEGGRLVAPLGGAGrpQELVLIERVDGELRRRHVASVSFVPLLGG 219
Cdd:TIGR00080 160 PEALIDQLKEGGILVMPVGEYL--QVLKRAEKRGGEIIIKDVEPVAFVPLVGG 210
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 11-218 2.75e-67

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 206.02  E-value: 2.75e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  11 MTSRRTRERLVSRLAEEGIRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLiEQSIPER 90
Cdd:PRK13942   1 MPLEEKRRVIEELIREGYIKSKKVIDALLKVPRHLFVPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELL-DLKEGMK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  91 VLELGTGSGYQAAVLAYLGVE---VYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVP 167
Cdd:PRK13942  80 VLEIGTGSGYHAAVVAEIVGKsgkVVTIERIPELAEKAKKTLKKLGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIP 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499948832 168 DPLWDQLDEGGRLVAPLGGAGrpQELVLIERVDGELRRRHVASVSFVPLLG 218
Cdd:PRK13942 160 KPLIEQLKDGGIMVIPVGSYS--QELIRVEKDNGKIIKKKLGEVAFVPLIG 208
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
15-216 1.80e-65

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 201.06  E-value: 1.80e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   15 RTRERLVSRLAEEG-IRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELLiEQSIPERVLE 93
Cdd:pfam01135   1 NRNEALIENLKNYGvIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELL-ELKPGMRVLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   94 LGTGSGYQAAVLA-YLGVE--VYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPDPL 170
Cdd:pfam01135  80 IGSGSGYLTACFArMVGEVgrVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEAL 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 499948832  171 WDQLDEGGRLVAPLGGAGRpQELVLIERV-DGELRRRHVASVSFVPL 216
Cdd:pfam01135 160 IDQLKEGGRLVIPVGPNGN-QVLQQFDKRnDGSVVIKDLEGVRFVPL 205
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 17-216 2.55e-41

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 139.56  E-value: 2.55e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  17 RERLVSRLAEEG-IRDPRVLQAILEVPRHLFVDEALASRAYDNTPLPIGHGQTISQPWVVARMTELlIEQSIPERVLELG 95
Cdd:PRK13944   2 AKRLVEELVREGiIKSERVKKAMLSVPREEFVMPEYRMMAYEDRPLPLFAGATISAPHMVAMMCEL-IEPRPGMKILEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  96 TGSGYQAAVLAYlGVE----VYTIERIKALADQARQRMRDL-RLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPDPL 170
Cdd:PRK13944  81 TGSGYQAAVCAE-AIErrgkVYTVEIVKELAIYAAQNIERLgYWGVVEVYHGDGKRGLEKHAPFDAIIVTAAASTIPSAL 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 499948832 171 WDQLDEGGRLVAPLgGAGRPQELVLIERVDGELRRRHVASVSFVPL 216
Cdd:PRK13944 160 VRQLKDGGVLVIPV-EEGVGQVLYKVVKRGEKVEKRAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 15-219 1.91e-33

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 123.63  E-value: 1.91e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   15 RTRERLVSRLAEEG-IRDPRVLQAILEVPRHLFVDEALASRAYD-NTPLPI---GHGQTIS---QPWVVARMtellIEQS 86
Cdd:TIGR04364   3 RLRAALVDELREDGvIRSPRVEAAFRTVPRHLFAPGAPLEKAYAaNRAVVTkrdEDGRALSsvsAPHIQAMM----LEQA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   87 IPE---RVLELGTGsGYQAAVLAYL---GVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVT 160
Cdd:TIGR04364  79 GVEpgmRVLEIGSG-GYNAALLAELvgpSGEVTTVDIDEDVTDRARACLAAAGYPQVTVVLADAEAGVPELAPYDRIIVT 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 499948832  161 AAPEEVPDPLWDQLDEGGRLVAPLGGAGRPQELVLiERVDGELRRRHVASVSFVPLLGG 219
Cdd:TIGR04364 158 VGAWDIPPAWLDQLAPGGRLVVPLRMRGLTRSIAF-ERAGDHLVSVSAQLCGFVPMQGS 215
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 17-184 4.24e-21

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 89.13  E-value: 4.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  17 RERLVSRLAEEGIRDpRVLQAILEVPRHLFVD-EALASRAYDNTPLPIGHGQ----TISQPWVVARMTELL-IEQSIpeR 90
Cdd:PRK13943   7 REKLFWILKKYGISD-HIAKAFLEVPREEFLTkSYPLSYVYEDIVLVSYDDGeeysTSSQPSLMALFMEWVgLDKGM--R 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  91 VLELGTGSGYQAAVLAYLGVE---VYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVP 167
Cdd:PRK13943  84 VLEIGGGTGYNAAVMSRVVGEkglVVSVEYSRKICEIAKRNVRRLGIENVIFVCGDGYYGVPEFAPYDVIFVTVGVDEVP 163

                        170
                 ....*....|....*..
gi 499948832 168 DPLWDQLDEGGRLVAPL 184
Cdd:PRK13943 164 ETWFTQLKEGGRVIVPI 180
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 90-185 4.41e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.13  E-value: 4.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  90 RVLELGTGSGYQAAVLA-YLGVEVYTIERIKALADQARQRMRDLRLHRVHVRYGDGSEG-WAQHAPYQGIIVTAAPEEVP 167
Cdd:cd02440    1 RVLDLGCGTGALALALAsGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPLHHLV 80

                         90
                 ....*....|....*...
gi 499948832 168 DPLWDQLDEGGRLVAPLG 185
Cdd:cd02440   81 EDLARFLEEARRLLKPGG 98
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 67-181 1.08e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 51.94  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  67 QTISQPWVVARMTELLIEQSIPE-RVLELGTGSGYQAAVLAYLGVEVYTIERIKALADQARQRMRDLrlhRVHVRYGDGS 145
Cdd:COG2227    3 DPDARDFWDRRLAALLARLLPAGgRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 499948832 146 EGWAQHAPYQGIIVTAAPEEVPDP------LWDQLDEGGRLV 181
Cdd:COG2227   80 DLPLEDGSFDLVICSEVLEHLPDPaallreLARLLKPGGLLL 121
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 88-181 1.40e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.14  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  88 PERVLELGTGSGYQAAVLAYLGVEVYTIERIKALADQARQRMRDLRLhRVHVRYGDgsegwAQHAPYQ-----GIIVTAA 162
Cdd:COG2226   23 GARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGD-----AEDLPFPdgsfdLVISSFV 96

                         90       100
                 ....*....|....*....|....*
gi 499948832 163 PEEVPDP------LWDQLDEGGRLV 181
Cdd:COG2226   97 LHHLPDPeralaeIARVLKPGGRLV 121
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
88-182 6.51e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 43.27  E-value: 6.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  88 PERVLELGTGSGYQAAVLA--YLGVEVYTIERIKALADQARQRMRDLRLHRvhvryGDGsEGWAQHAPYQGIIVTAAPEE 165
Cdd:COG4106    2 PRRVLDLGCGTGRLTALLAerFPGARVTGVDLSPEMLARARARLPNVRFVV-----ADL-RDLDPPEPFDLVVSNAALHW 75

                         90       100
                 ....*....|....*....|...
gi 499948832 166 VPDP------LWDQLDEGGRLVA 182
Cdd:COG4106   76 LPDHaallarLAAALAPGGVLAV 98
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 88-146 1.00e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 44.40  E-value: 1.00e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499948832  88 PERVLELGTGSGYQAAVLAYL---GVEVYTIERIKALADQARQRMRDLRL-HRVHVRYGDGSE 146
Cdd:COG4122   17 AKRILEIGTGTGYSTLWLARAlpdDGRLTTIEIDPERAAIARENFARAGLaDRIRLILGDALE 79
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 90-182 1.66e-05

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 44.38  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  90 RVLELGTGSGYQAAVLAYL----GvEVYTIERIKALADQARQRMRDLRLH-RVHVRYGDGSEGWAQHaPYQGIIV-TAAP 163
Cdd:COG2519   94 RVLEAGTGSGALTLALARAvgpeG-KVYSYERREDFAEIARKNLERFGLPdNVELKLGDIREGIDEG-DVDAVFLdMPDP 171

                         90
                 ....*....|....*....
gi 499948832 164 EEVPDPLWDQLDEGGRLVA 182
Cdd:COG2519  172 WEALEAVAKALKPGGVLVA 190
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 89-181 2.75e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 42.99  E-value: 2.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  89 ERVLELGTGSGYQAAVLA-YLGVEVYTIERIKALADQARQRMRDLRL-HRVHVRYGDGSEgWAQHAPYQGIIVTAAPEEV 166
Cdd:COG2230   53 MRVLDIGCGWGGLALYLArRYGVRVTGVTLSPEQLEYARERAAEAGLaDRVEVRLADYRD-LPADGQFDAIVSIGMFEHV 131

                         90       100
                 ....*....|....*....|...
gi 499948832 167 PDPLWDQ--------LDEGGRLV 181
Cdd:COG2230  132 GPENYPAyfakvarlLKPGGRLL 154
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 91-186 2.80e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 41.40  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   91 VLELGTGSGYQAAVLA-YLGVEVYTIERIKALADQARQRMRDLRLhRVHVRYGDGSEGWAQHAPYQGIIVTAAPEEVPDP 169
Cdd:pfam13649   1 VLDLGCGTGRLTLALArRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDP 79

                          90
                  ....*....|....*...
gi 499948832  170 LWDQ-LDEGGRLVAPlGG 186
Cdd:pfam13649  80 DLEAaLREIARVLKP-GG 96
PRK14968 PRK14968
putative methyltransferase; Provisional
 79-143 9.94e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 9.94e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499948832  79 TELLIEQSIP---ERVLELGTGSGYQAAVLAYLGVEVYTIErIKALA-DQARQ--RMRDLRLHRVHVRYGD 143
Cdd:PRK14968  12 SFLLAENAVDkkgDRVLEVGTGSGIVAIVAAKNGKKVVGVD-INPYAvECAKCnaKLNNIRNNGVEVIRSD 81
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 79-143 3.90e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 40.53  E-value: 3.90e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499948832  79 TELLIEQSI-------PERVLELGTGSGYQAAVLAYL--GVEVYTIER-IKALAdQARQRMRDLRLHRVHVRYGD 143
Cdd:PRK09328  93 TEELVEWALealllkePLRVLDLGTGSGAIALALAKErpDAEVTAVDIsPEALA-VARRNAKHGLGARVEFLQGD 166
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 88-143 1.33e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 38.59  E-value: 1.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 499948832  88 PERVLELGTGSGYQAAVLA--YLGVEVYTIERIKALADQARQRMRDLRLH-RVHVRYGD 143
Cdd:COG4123   38 GGRVLDLGTGTGVIALMLAqrSPGARITGVEIQPEAAELARRNVALNGLEdRITVIHGD 96
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 88-181 1.93e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 37.79  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   88 PERVLELGTGSGYQAAVLAYLGVEVYTIErikaLADQARQRMRDLRLHRVHvrygDGSEGWAQHAPYQGIIVTAAPEEVP 167
Cdd:pfam13489  23 PGRVLDFGCGTGIFLRLLRAQGFSVTGVD----PSPIAIERALLNVRFDQF----DEQEAAVPAGKFDVIVAREVLEHVP 94

                          90       100
                  ....*....|....*....|
gi 499948832  168 DP------LWDQLDEGGRLV 181
Cdd:pfam13489  95 DPpallrqIAALLKPGGLLL 114
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 11-158 2.02e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 38.21  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  11 MTSRRTRERLVSRLAEEGIRDPRV-----LQAILEVPRHLF---------------VDEALASRAyDNTPLP--IGH--- 65
Cdd:COG2890    1 MTIRELLRWAAARLAAAGVDSARLeaellLAHVLGLDRADLllhpdrplteeelarLEALVARRA-AGEPLAyiLGEaef 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832  66 -GQTIsqpWV-----VARM-TELLIEQSI-------PERVLELGTGSGYQAAVLAYL--GVEVYTIERIKALADQARQRM 129
Cdd:COG2890   80 yGLEF---KVdpgvlIPRPeTEELVELALallpagaPPRVLDLGTGSGAIALALAKErpDARVTAVDISPDALAVARRNA 156

                        170       180       190
                 ....*....|....*....|....*....|
gi 499948832 130 RDLRL-HRVHVRYGDGSEGWAQHAPYQGII 158
Cdd:COG2890  157 ERLGLeDRVRFLQGDLFEPLPGDGRFDLIV 186
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 92-138 2.69e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.10  E-value: 2.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 499948832   92 LELGTGSGYQAAVLAYLGVEVYTIERIKALADQARQRMRDLRLHRVH 138
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVV 47
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 90-143 3.17e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 37.01  E-value: 3.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 499948832   90 RVLELGTGSGYQAAVLAYL---GVEVYTIERIKALADQARQRMRDLRLHRVHVRYGD 143
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEElgpNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGD 62
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 79-158 9.22e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 35.64  E-value: 9.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499948832   79 TELLIE---QSIPERVLELGTGSGYQAAVLAYLG--VEVYTIErIKALA-DQARQRMRDLRLHRVHVRYGDGSEGWAQhA 152
Cdd:pfam05175  20 SRLLLEhlpKDLSGKVLDLGCGAGVLGAALAKESpdAELTMVD-INARAlESARENLAANGLENGEVVASDVYSGVED-G 97


                  ....*.
gi 499948832  153 PYQGII 158
Cdd:pfam05175  98 KFDLII 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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