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Conserved domains on  [gi|67460545|sp|Q8AWW5|]
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RecName: Full=Cysteine-rich motor neuron 1 protein; Short=CRIM-1; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 919-1048 6.31e-87

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


:

Pssm-ID: 437274  Cd Length: 130  Bit Score: 275.19  E-value: 6.31e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67460545    919 ENDIIHIHRDMNHLQGEYRSGNGPHPSEDASVSSVALVTVPITIALLVIIVFLLINQKKQWIPVSCYKAPTKPSCLNNQL 998
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPCYRTPTKPSCLNNQL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 67460545    999 VYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 1048
Cdd:pfam19442   81 VYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
51-102 3.30e-07

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.09  E-value: 3.30e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 67460545     51 PCDESKC-EEPKSCPGIIVLGICGCCFMCARQRNESCGGVYGLhgaCDRGLRC 102
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 831-885 4.40e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.80  E-value: 4.40e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 67460545    831 CHFNGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--INVEGSCCPMC 885
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 695-746 2.01e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.88  E-value: 2.01e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 67460545    695 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPTRTQ--DSCCPQC 746
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
415-468 2.14e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 2.14e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 67460545     415 CYANGQIQAHGDRWREDDCTFCQCINGNP-HCVATAC--GQSCLNP--VKVPGECCPVC 468
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
348-402 1.23e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.23e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 67460545     348 CIFNSMEYYDGDMFRMDACRFCRCQGGVSI-CFSAQCGE-LHC--DRYYVPEGECCPVC 402
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCpnPERVKPPGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 770-820 1.36e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 40.87  E-value: 1.36e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 67460545    770 GDIFLTAESWKPNVCTSCICMDGVIRCYSESCPPVSCERPVLRK--GQCCPYC 820
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 624-674 1.98e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 40.10  E-value: 1.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 67460545    624 DGRRHENEESWH-DGCRECYCHNGREMCALITCPVPNCGNPT--IHPGQCCPSC 674
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 551-576 5.28e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.31  E-value: 5.28e-04
                           10        20
                   ....*....|....*....|....*.
gi 67460545    551 CKPIVCDKYCPFGYLKNKHGCEICRC 576
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 579-604 1.58e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 36.77  E-value: 1.58e-03
                           10        20
                   ....*....|....*....|....*.
gi 67460545    579 CPEMPCGKICPMGFQQNSHGCVICKC 604
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 524-544 9.38e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.46  E-value: 9.38e-03
                           10        20
                   ....*....|....*....|.
gi 67460545    524 CSLDCSFGFQTDAHNCEICQC 544
Cdd:pfam02822    6 CRLKCPYGFQTDENGCPTCEC 26
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 919-1048 6.31e-87

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 275.19  E-value: 6.31e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67460545    919 ENDIIHIHRDMNHLQGEYRSGNGPHPSEDASVSSVALVTVPITIALLVIIVFLLINQKKQWIPVSCYKAPTKPSCLNNQL 998
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPCYRTPTKPSCLNNQL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 67460545    999 VYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 1048
Cdd:pfam19442   81 VYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
51-102 3.30e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.09  E-value: 3.30e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 67460545     51 PCDESKC-EEPKSCPGIIVLGICGCCFMCARQRNESCGGVYGLhgaCDRGLRC 102
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 831-885 4.40e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.80  E-value: 4.40e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 67460545    831 CHFNGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--INVEGSCCPMC 885
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 695-746 2.01e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.88  E-value: 2.01e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 67460545    695 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPTRTQ--DSCCPQC 746
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 49-107 9.01e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 44.76  E-value: 9.01e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 67460545      49 CLPCDESKC-EEPKSCPGIIVLGICGCCFMCARQRNESCgGVYGlhGACDRGLRCVIRPP 107
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPC-GVYT--PRCAPGLRCQPPPG 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
831-885 1.11e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.66  E-value: 1.11e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 67460545     831 CHFNGKTYADEERWDIDSCTHCYCLQGQT-LCSTVSCPPLPC---AEPINVEGSCCPMC 885
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDcpnPERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
415-468 2.14e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 2.14e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 67460545     415 CYANGQIQAHGDRWREDDCTFCQCINGNP-HCVATAC--GQSCLNP--VKVPGECCPVC 468
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
695-746 1.07e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.07e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 67460545     695 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPTRTQ--DSCCPQC 746
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
348-402 1.23e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.23e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 67460545     348 CIFNSMEYYDGDMFRMDACRFCRCQGGVSI-CFSAQCGE-LHC--DRYYVPEGECCPVC 402
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCpnPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 770-820 1.36e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 1.36e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 67460545    770 GDIFLTAESWKPNVCTSCICMDGVIRCYSESCPPVSCERPVLRK--GQCCPYC 820
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 624-674 1.98e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.10  E-value: 1.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 67460545    624 DGRRHENEESWH-DGCRECYCHNGREMCALITCPVPNCGNPT--IHPGQCCPSC 674
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 551-576 5.28e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.31  E-value: 5.28e-04
                           10        20
                   ....*....|....*....|....*.
gi 67460545    551 CKPIVCDKYCPFGYLKNKHGCEICRC 576
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 348-402 5.66e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.94  E-value: 5.66e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 67460545    348 CIFNSMEYYDGDMFRMDACRFCRCQGGVSICFSAQCGELHCD--RYYVPEGECCPVC 402
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
770-820 1.45e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.45e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 67460545     770 GDIFLTAESWKPNVCTSCICMDG-VIRCYSESCPPV-SCERPVLRK--GQCCPYC 820
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPpDCPNPERVKppGECCPRC 59
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 419-468 1.56e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 42.38  E-value: 1.56e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67460545    419 GQIQAHGD---RWRED---DCTFCQCIN---GNPHC--VATACGQ-SCLNPVKVPGECCPVC 468
Cdd:pfam14828  174 GQLQFHGAgalRVGPEacsDPSGCGCGNdenLERICanVLQRCPPpHCLSPLRPEGHCCDVC 235
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 579-604 1.58e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 36.77  E-value: 1.58e-03
                           10        20
                   ....*....|....*....|....*.
gi 67460545    579 CPEMPCGKICPMGFQQNSHGCVICKC 604
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
624-674 2.73e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.11  E-value: 2.73e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 67460545     624 DGRRHENEESWHDG-CRECYCHNGRE-MCALITCP-VPNCGNPT--IHPGQCCPSC 674
Cdd:smart00214    4 NGRVYNDGETWKPDpCQICTCLDGTTvLCDPVECPpPPDCPNPErvKPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 524-544 9.38e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.46  E-value: 9.38e-03
                           10        20
                   ....*....|....*....|.
gi 67460545    524 CSLDCSFGFQTDAHNCEICQC 544
Cdd:pfam02822    6 CRLKCPYGFQTDENGCPTCEC 26
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 919-1048 6.31e-87

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 275.19  E-value: 6.31e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67460545    919 ENDIIHIHRDMNHLQGEYRSGNGPHPSEDASVSSVALVTVPITIALLVIIVFLLINQKKQWIPVSCYKAPTKPSCLNNQL 998
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPCYRTPTKPSCLNNQL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 67460545    999 VYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 1048
Cdd:pfam19442   81 VYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
51-102 3.30e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.09  E-value: 3.30e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 67460545     51 PCDESKC-EEPKSCPGIIVLGICGCCFMCARQRNESCGGVYGLhgaCDRGLRC 102
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 831-885 4.40e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.80  E-value: 4.40e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 67460545    831 CHFNGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--INVEGSCCPMC 885
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 695-746 2.01e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.88  E-value: 2.01e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 67460545    695 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPTRTQ--DSCCPQC 746
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 49-107 9.01e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 44.76  E-value: 9.01e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 67460545      49 CLPCDESKC-EEPKSCPGIIVLGICGCCFMCARQRNESCgGVYGlhGACDRGLRCVIRPP 107
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPC-GVYT--PRCAPGLRCQPPPG 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
831-885 1.11e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 43.66  E-value: 1.11e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 67460545     831 CHFNGKTYADEERWDIDSCTHCYCLQGQT-LCSTVSCPPLPC---AEPINVEGSCCPMC 885
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDcpnPERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
415-468 2.14e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 2.14e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 67460545     415 CYANGQIQAHGDRWREDDCTFCQCINGNP-HCVATAC--GQSCLNP--VKVPGECCPVC 468
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
695-746 1.07e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.07e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 67460545     695 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPTRTQ--DSCCPQC 746
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
348-402 1.23e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.23e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 67460545     348 CIFNSMEYYDGDMFRMDACRFCRCQGGVSI-CFSAQCGE-LHC--DRYYVPEGECCPVC 402
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCpnPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 770-820 1.36e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 1.36e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 67460545    770 GDIFLTAESWKPNVCTSCICMDGVIRCYSESCPPVSCERPVLRK--GQCCPYC 820
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 624-674 1.98e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.10  E-value: 1.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 67460545    624 DGRRHENEESWH-DGCRECYCHNGREMCALITCPVPNCGNPT--IHPGQCCPSC 674
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 551-576 5.28e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.31  E-value: 5.28e-04
                           10        20
                   ....*....|....*....|....*.
gi 67460545    551 CKPIVCDKYCPFGYLKNKHGCEICRC 576
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 348-402 5.66e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.94  E-value: 5.66e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 67460545    348 CIFNSMEYYDGDMFRMDACRFCRCQGGVSICFSAQCGELHCD--RYYVPEGECCPVC 402
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
770-820 1.45e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.45e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 67460545     770 GDIFLTAESWKPNVCTSCICMDG-VIRCYSESCPPV-SCERPVLRK--GQCCPYC 820
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPpDCPNPERVKppGECCPRC 59
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 419-468 1.56e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 42.38  E-value: 1.56e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67460545    419 GQIQAHGD---RWRED---DCTFCQCIN---GNPHC--VATACGQ-SCLNPVKVPGECCPVC 468
Cdd:pfam14828  174 GQLQFHGAgalRVGPEacsDPSGCGCGNdenLERICanVLQRCPPpHCLSPLRPEGHCCDVC 235
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 579-604 1.58e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 36.77  E-value: 1.58e-03
                           10        20
                   ....*....|....*....|....*.
gi 67460545    579 CPEMPCGKICPMGFQQNSHGCVICKC 604
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
624-674 2.73e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.11  E-value: 2.73e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 67460545     624 DGRRHENEESWHDG-CRECYCHNGRE-MCALITCP-VPNCGNPT--IHPGQCCPSC 674
Cdd:smart00214    4 NGRVYNDGETWKPDpCQICTCLDGTTvLCDPVECPpPPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 415-468 4.35e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.63  E-value: 4.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 67460545    415 CYANGQIQAHGDRWREDDCTFCQCINGNPHCVATACGQ-SCLNP--VKVPGECCPVC 468
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 832-885 5.73e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.45  E-value: 5.73e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67460545    832 HFNGktyADEERWDIDSCTH---CYC---LQGQTLCSTVS--CPPLPCAEPINVEGSCCPMC 885
Cdd:pfam14828  177 QFHG---AGALRVGPEACSDpsgCGCgndENLERICANVLqrCPPPHCLSPLRPEGHCCDVC 235
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 524-544 9.38e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.46  E-value: 9.38e-03
                           10        20
                   ....*....|....*....|.
gi 67460545    524 CSLDCSFGFQTDAHNCEICQC 544
Cdd:pfam02822    6 CRLKCPYGFQTDENGCPTCEC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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