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Conserved domains on  [gi|229577313|ref|NP_008940|]
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zona pellucida-binding protein 1 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sp38 super family cl20050
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 177-351 4.44e-83

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


The actual alignment was detected with superfamily member pfam07354:

Pssm-ID: 336682  Cd Length: 177  Bit Score: 249.79  E-value: 4.44e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577313  177 YHAAPCNSIYNISFEKKLLQILSKLLLDLSCEISLLKSECHRVKMQRAGLQNELFFAFSVSSLDT--EKGPKRCTDHNCE 254
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPgwKDLCNRSLDCEDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577313  255 PYKRLFKAKNLIERFFNQQVEILGRRAEQLPQIYYIEGTLQMVWINRCFPGYGMNVQQHPKCPECCVICSPGSYNPRDGI 334
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFETLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVVCSPGTYSPDSGI 160

                         170
                  ....*....|....*..
gi 229577313  335 HCLQCNSSLVYGAKTCL 351
Cdd:pfam07354 161 HCLQCVSSLTYGAKSCP 177
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 97-150 7.77e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


:

Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 34.61  E-value: 7.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 229577313  97 DPSFQWY-GPKGKVVSVENRTAQITSTGSLVFQNFEESMSGIYTCFLEYKPTVEE 150
Cdd:cd00096   12 PPTITWYkNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSA 66
 
Name Accession Description Interval E-value
Sp38 pfam07354
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 177-351 4.44e-83

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


Pssm-ID: 336682  Cd Length: 177  Bit Score: 249.79  E-value: 4.44e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577313  177 YHAAPCNSIYNISFEKKLLQILSKLLLDLSCEISLLKSECHRVKMQRAGLQNELFFAFSVSSLDT--EKGPKRCTDHNCE 254
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPgwKDLCNRSLDCEDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577313  255 PYKRLFKAKNLIERFFNQQVEILGRRAEQLPQIYYIEGTLQMVWINRCFPGYGMNVQQHPKCPECCVICSPGSYNPRDGI 334
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFETLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVVCSPGTYSPDSGI 160

                         170
                  ....*....|....*..
gi 229577313  335 HCLQCNSSLVYGAKTCL 351
Cdd:pfam07354 161 HCLQCVSSLTYGAKSCP 177
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 97-150 7.77e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 34.61  E-value: 7.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 229577313  97 DPSFQWY-GPKGKVVSVENRTAQITSTGSLVFQNFEESMSGIYTCFLEYKPTVEE 150
Cdd:cd00096   12 PPTITWYkNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSA 66
 
Name Accession Description Interval E-value
Sp38 pfam07354
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 177-351 4.44e-83

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


Pssm-ID: 336682  Cd Length: 177  Bit Score: 249.79  E-value: 4.44e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577313  177 YHAAPCNSIYNISFEKKLLQILSKLLLDLSCEISLLKSECHRVKMQRAGLQNELFFAFSVSSLDT--EKGPKRCTDHNCE 254
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPgwKDLCNRSLDCEDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577313  255 PYKRLFKAKNLIERFFNQQVEILGRRAEQLPQIYYIEGTLQMVWINRCFPGYGMNVQQHPKCPECCVICSPGSYNPRDGI 334
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFETLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVVCSPGTYSPDSGI 160

                         170
                  ....*....|....*..
gi 229577313  335 HCLQCNSSLVYGAKTCL 351
Cdd:pfam07354 161 HCLQCVSSLTYGAKSCP 177
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 97-150 7.77e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 34.61  E-value: 7.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 229577313  97 DPSFQWY-GPKGKVVSVENRTAQITSTGSLVFQNFEESMSGIYTCFLEYKPTVEE 150
Cdd:cd00096   12 PPTITWYkNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSA 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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