NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|668968670|gb|KFC85560|]
View 

biotin carboxyl carrier protein of acetyl-CoA carboxylase [Ewingella americana ATCC 33852]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein( domain architecture ID 11489220)

acetyl-CoA carboxylase biotin carboxyl carrier protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

CATH:  2.40.50.100
Gene Ontology:  GO:0003989|GO:0006633
SCOP:  4002909
TCDB:  3.B.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-155 7.36e-63

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


:

Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 190.05  E-value: 7.36e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670    1 MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAQAYPMMQQAYAmPAPQQQPGLAAAVAPAAAPAEAAPAA-ISG 79
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKEEEFSVRLSKAAAAASFSVVQQAAA-PVPAQVPAQSSAAVPAPAPAAPAPAAdIKG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 668968670   80 HIVRSPMVGTFYRTPSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:TIGR00531  80 HIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
 
Name Accession Description Interval E-value
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-155 7.36e-63

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 190.05  E-value: 7.36e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670    1 MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAQAYPMMQQAYAmPAPQQQPGLAAAVAPAAAPAEAAPAA-ISG 79
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKEEEFSVRLSKAAAAASFSVVQQAAA-PVPAQVPAQSSAAVPAPAPAAPAPAAdIKG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 668968670   80 HIVRSPMVGTFYRTPSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:TIGR00531  80 HIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-155 7.76e-60

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 181.63  E-value: 7.76e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670   9 LIELVEESGISELEISEGEESVRISRAAPAQAYPMMQQAYAMPAPQQQPglaaavapaaaPAEAAPAAISGHIVRSPMVG 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVAAPAAAAPAAAAPA-----------AAAAAAAASGGGAVKSPMVG 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 668968670  89 TFYRTPSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:COG0511   70 TFYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-155 1.34e-30

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 111.08  E-value: 1.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670   3 IRKIKKLIELVEESGISELEI--SEGEESVR----ISRAAPAQAYPMMQQAY-------AMPAPQQQPGLAAAVAPAAAP 69
Cdd:PLN02983 106 MTQVSSLVKLVDSRDIVELQLkqLDCELVIRkkeaLPQPPPPAPVVMMQPPPphamppaSPPAAQPAPSAPASSPPPTPA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670  70 AEAAPAAI-SGH-IVRSPMVGTFYRTPSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEF 147
Cdd:PLN02983 186 SPPPAKAPkSSHpPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDGKPVSV 265


                 ....*...
gi 668968670 148 DEPLVVIE 155
Cdd:PLN02983 266 DTPLFVIE 273
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 82-154 6.50e-26

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 93.25  E-value: 6.50e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 668968670  82 VRSPMVGTFYRTpspdakaFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:cd06850    2 VTAPMPGTVVKV-------LVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 82-154 1.53e-22

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 84.96  E-value: 1.53e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 668968670   82 VRSPMVGTFYRtpSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:pfam00364   3 IKSPMIGESVR--EGVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
 
Name Accession Description Interval E-value
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-155 7.36e-63

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 190.05  E-value: 7.36e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670    1 MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAQAYPMMQQAYAmPAPQQQPGLAAAVAPAAAPAEAAPAA-ISG 79
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKEEEFSVRLSKAAAAASFSVVQQAAA-PVPAQVPAQSSAAVPAPAPAAPAPAAdIKG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 668968670   80 HIVRSPMVGTFYRTPSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:TIGR00531  80 HIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-155 7.76e-60

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 181.63  E-value: 7.76e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670   9 LIELVEESGISELEISEGEESVRISRAAPAQAYPMMQQAYAMPAPQQQPglaaavapaaaPAEAAPAAISGHIVRSPMVG 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVAAPAAAAPAAAAPA-----------AAAAAAAASGGGAVKSPMVG 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 668968670  89 TFYRTPSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:COG0511   70 TFYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-155 1.34e-30

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 111.08  E-value: 1.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670   3 IRKIKKLIELVEESGISELEI--SEGEESVR----ISRAAPAQAYPMMQQAY-------AMPAPQQQPGLAAAVAPAAAP 69
Cdd:PLN02983 106 MTQVSSLVKLVDSRDIVELQLkqLDCELVIRkkeaLPQPPPPAPVVMMQPPPphamppaSPPAAQPAPSAPASSPPPTPA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670  70 AEAAPAAI-SGH-IVRSPMVGTFYRTPSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEF 147
Cdd:PLN02983 186 SPPPAKAPkSSHpPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDGKPVSV 265


                 ....*...
gi 668968670 148 DEPLVVIE 155
Cdd:PLN02983 266 DTPLFVIE 273
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 82-155 1.44e-28

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 109.55  E-value: 1.44e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 668968670  82 VRSPMVGTFYrtpspdaKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:PRK09282 525 VTSPMPGTVV-------KVKVKEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIE 591
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 82-154 6.50e-26

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 93.25  E-value: 6.50e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 668968670  82 VRSPMVGTFYRTpspdakaFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:cd06850    2 VTAPMPGTVVKV-------LVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
80-155 5.48e-23

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 86.22  E-value: 5.48e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 668968670  80 HIVRSPMVGTFYRTPSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:PRK07051   4 HEIVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARIE 79
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 82-154 1.53e-22

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 84.96  E-value: 1.53e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 668968670   82 VRSPMVGTFYRtpSPDAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:pfam00364   3 IKSPMIGESVR--EGVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 98-154 1.29e-18

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 74.79  E-value: 1.29e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 668968670  98 AKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:cd06663   17 VKWLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKVEGDTPLVKI 73
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 79-154 8.43e-16

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 73.19  E-value: 8.43e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 668968670   79 GHIVrSPMVGTFyrtpspdAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:COG1038  1077 GHIG-APMPGTV-------VKVLVKEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 79-155 3.86e-15

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 71.32  E-value: 3.86e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 668968670   79 GHIVrSPMVGTFyrtpspdAKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:PRK12999 1077 GHVG-APMPGSV-------VTVLVKEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRVLVKAGDQVEAGDLLVELE 1145
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
78-154 1.30e-12

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 64.18  E-value: 1.30e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 668968670  78 SGHIVRSPMVGTFYrtpspdaKAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:PRK14040 523 AGEPVTAPLAGNIF-------KVIVTEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDTLLTL 592
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 13-152 5.63e-12

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 59.88  E-value: 5.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670  13 VEESGISELEISEGEESVRISRAAPAQAYPMMQQAYAMPAPQQQPGLAAAVA-PAAAPAEAAPAAISGHIVRSPMVGTFY 91
Cdd:PRK05641  17 VEELGPGKFRVSFEGKTYEVEAKGLGIDLSAVQEQVPTPAPAPAPAVPSAPTpVAPAAPAPAPASAGENVVTAPMPGKIL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 668968670  92 RTpspdakaFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLV 152
Cdd:PRK05641  97 RI-------LVREGQQVKVGQGLLILEAMKMENEIPAPKDGVVKKILVKEGDTVDTGQPLI 150
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 36-154 2.72e-10

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 54.82  E-value: 2.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 668968670  36 APAQAYPMMQqayamPAPQQQPGLAAAVAPAAAPAEAAPAAISGHIVRSPMVGTFyrtpspdAKAFVEVGQKVNAGDTLC 115
Cdd:PRK06549  23 APAQAAAPAQ-----PASTPVPVPTEASPQVEAQAPQPAAAAGADAMPSPMPGTI-------LKVLVAVGDQVTENQPLL 90

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 668968670 116 IVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:PRK06549  91 ILEAMKMENEIVASSAGTVTAIHVTPGQVVNPGDGLITI 129
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 101-154 1.68e-09

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 51.25  E-value: 1.68e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 668968670 101 FVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:cd06849   21 LVKEGDSVEEGDVLAEVETDKATVEVEAPAAGVLAKILVEEGDTVPVGQVIAVI 74
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 101-154 2.43e-08

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 48.14  E-value: 2.43e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 668968670 101 FVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:COG0508   23 LVKEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDTVPVGAVIAVI 76
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 99-155 2.11e-07

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 45.55  E-value: 2.11e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 668968670  99 KAFVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:PRK08225  14 KIVVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFVNEGDVLLEIE 70
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 102-155 3.09e-05

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 42.79  E-value: 3.09e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 668968670 102 VEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:PRK14042 541 VSAGDEVKAGQAVLVIEAMKMETEIKAPANGVVAEILCQKGDKVTPGQVLIRVE 594
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 104-154 1.56e-04

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 40.44  E-value: 1.56e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 668968670 104 VGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVI 154
Cdd:PTZ00144  68 VGDYVKEDEVICIIETDKVSVDIRAPASGVITKIFAEEGDTVEVGAPLSEI 118
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 101-155 1.65e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 40.58  E-value: 1.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 668968670 101 FVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:PRK11855 139 LVKVGDTVEEDQSLITVETDKATMEIPSPVAGVVKEIKVKVGDKVSVGSLLVVIE 193
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 101-155 7.14e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 38.65  E-value: 7.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 668968670 101 FVEVGQKVNAGDTLCIVEAMKMMNQIEADKSGVVKAILVESGQPVEFDEPLVVIE 155
Cdd:PRK11855  22 LVKEGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEIKVKVGDTVSVGGLLAVIE 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH