|
Name |
Accession |
Description |
Interval |
E-value |
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
8-443 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 841.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSES-WSFETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVG 86
Cdd:COG2873 1 MTEKkYGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 87 ALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISN 166
Cdd:COG2873 81 ALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVD-PDDPEAFEAAIDPNTKAIFGETIGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 167 PKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAAdPERFPQ 246
Cdd:COG2873 160 PALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFDWAA-NGKFPE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 247 FNQPDPSYNGLRYAPDLGvggalgaNLAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTT 326
Cdd:COG2873 239 LTEPDPSYHGLVYTEAFG-------NAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 327 RDEVESVAYAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSP 406
Cdd:COG2873 312 HPKVAWVNYPGLPSHPYHELAQKYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSE 391
|
410 420 430
....*....|....*....|....*....|....*..
gi 334684745 407 AEQAGAGVTPGLVRLAVGLENIDDILADLETGFRAAK 443
Cdd:COG2873 392 EEQAAAGVTPDLIRLSVGIEDIDDIIADLDQALAAAT 428
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
6-445 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 805.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 6 PSMSESWSFETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGV 85
Cdd:PRK07812 6 ADPTANWSFETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 86 GALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDPDDLESWRSAVQPNTKVFFAETIS 165
Cdd:PRK07812 86 AALLLASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEDPDDLDAWRAAVRPNTKAFFAETIS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 166 NPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAADpeRFP 245
Cdd:PRK07812 166 NPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTQG--RFP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 246 QFNQPDPSYNGLRYApDLGVGgalganlAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLT 325
Cdd:PRK07812 244 GFTTPDPSYHGVVFA-ELGPP-------AYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLE 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 326 TRDEVESVAYAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLS 405
Cdd:PRK07812 316 ARDEVASVNYAGLPSSPWYERAKRLAPKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLT 395
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 334684745 406 PAEQAGAGVTPGLVRLAVGLENIDDILADLETGFRAAKEV 445
Cdd:PRK07812 396 PEEQLATGVTPGLVRLAVGIEGIDDILADLEAGFAAAKAF 435
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
13-439 |
0e+00 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 726.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 13 SFETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVAS 92
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 93 GQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDIL 172
Cdd:TIGR01326 81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVD-PDDPESLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 173 DIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAAdpERFPQFNQPDP 252
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNN--GRFPLFTTPDP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 253 SYNGLRYAPDLGvggalgaNLAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVES 332
Cdd:TIGR01326 238 SYHGLVFTETLG-------NPAFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAW 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 333 VAYAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGA 412
Cdd:TIGR01326 311 VNYPGLASHPHHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKA 390
|
410 420
....*....|....*....|....*..
gi 334684745 413 GVTPGLVRLAVGLENIDDILADLETGF 439
Cdd:TIGR01326 391 GVTPGLIRLSVGIENIDDIIADLEQAL 417
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
8-445 |
0e+00 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 604.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSE--SWSFETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGV 85
Cdd:PRK08248 1 MSEerTFRLETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 86 GALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETIS 165
Cdd:PRK08248 81 GALAVSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVD-PSDPENFEAAITDKTKALFAETIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 166 NPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAADpERFP 245
Cdd:PRK08248 160 NPKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDWKGS-GKFP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 246 QFNQPDPSYNGLRYAPDLGvggalgaNLAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLT 325
Cdd:PRK08248 239 GLTEPDPSYHGLVYTDAVG-------EAAYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 326 TRDEVESVAYAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLS 405
Cdd:PRK08248 312 EHEAVEWVSYPGLPSHPSYELAKKYLPKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLS 391
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 334684745 406 PAEQAGAGVTPGLVRLAVGLENIDDILADLETGFRAAKEV 445
Cdd:PRK08248 392 EEEQLAAGVTPGLVRLSVGTEAIDDILDDLRQAIRQSQTV 431
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
14-442 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 578.21 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 14 FETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:PRK05994 8 FATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDILD 173
Cdd:PRK05994 88 HAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWAD-ADDPASFERAITPRTKAIFIESIANPGGTVTD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 174 IESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAADPeRFPQFNQPDPS 253
Cdd:PRK05994 167 IAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTFDWSKSG-KYPMLSEPRPE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 254 YNGLRYAPDLGvggalgaNLAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESV 333
Cdd:PRK05994 246 YHGLVLHETFG-------NFAFAIAARVLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 334 AYAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAG 413
Cdd:PRK05994 319 NYAGLPDDPYHALAQKYSPKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAG 398
|
410 420
....*....|....*....|....*....
gi 334684745 414 VTPGLVRLAVGLENIDDILADLETGFRAA 442
Cdd:PRK05994 399 AGPDVVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
7-441 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 552.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 7 SMSESWSFETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVG 86
Cdd:PRK05613 7 SNADQWGFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVH 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 87 ALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDPDDLESWRSAVQPNTKVFFAETISN 166
Cdd:PRK05613 87 AVAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENPDDPESWQAAVQPNTKAFFGETFAN 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 167 PKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAAdpER--- 243
Cdd:PRK05613 167 PQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTV--ERdgk 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 244 --FPQFNQPDPSYNGLRYApDLGvggalgaNLAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVA 321
Cdd:PRK05613 245 pvFPYFVTPDPAYHGLKYA-DLG-------APAFGLKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 322 EWLTTRDEVESVAYAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTH 401
Cdd:PRK05613 317 EFLNNHEKVAKVNFAGLKDSPWYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTH 396
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 334684745 402 SQLSPAEQAGAGVTPGLVRLAVGLENIDDILADLETGFRA 441
Cdd:PRK05613 397 SQSDEAGLARAGITQATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
14-445 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 552.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 14 FETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:PRK08134 9 FDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDILD 173
Cdd:PRK08134 89 QAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVK-PGDIDGWRAAIRPNTRLLFGETLGNPGLEVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 174 IESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAADpERFPQFNQPDPS 253
Cdd:PRK08134 168 IPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDWEAS-GKFPELTEPYAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 254 YNGLRYAPDLGVGgalganlAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESV 333
Cdd:PRK08134 247 FHGMVFAEESTVA-------AFLLRARREGLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 334 AYAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAG 413
Cdd:PRK08134 320 AHPELESHPDHALAKRLLPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAG 399
|
410 420 430
....*....|....*....|....*....|..
gi 334684745 414 VTPGLVRLAVGLENIDDILADLETGFRAAKEV 445
Cdd:PRK08134 400 IGEGTIRLSIGLEDADDLIDDLKRALKAAEKA 431
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
30-440 |
1.95e-176 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 497.88 E-value: 1.95e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 30 GARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASGQSAATLALLNVAESGS 109
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 110 HIVASPRLYGGTHNLLHHTFAKLGVEVTFIdDPDDLESWRSAVQPNTKVFFAETISNPKQDILDIESVAAVAHEAGVPLI 189
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFV-DPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 190 VDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSfdfaadperfpqfnqpdpsynglryapdlgvggal 269
Cdd:cd00614 160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGE----------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 270 ganlAFILKARVQLLRdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVAYAGLPSSPWHERSKK 349
Cdd:cd00614 205 ----ALIQRLRFLRLA-LGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKK 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 350 YAPrGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGVTPGLVRLAVGLENID 429
Cdd:cd00614 280 QMS-GYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVE 358
|
410
....*....|.
gi 334684745 430 DILADLETGFR 440
Cdd:cd00614 359 DLIADLEQALK 369
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
15-443 |
4.66e-176 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 499.43 E-value: 4.66e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 15 ETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASGQ 94
Cdd:PRK06084 4 ETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 95 SAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDpDDLESWRSAVQPNTKVFFAETISNPKQDILDI 174
Cdd:PRK06084 84 AAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAH-DDIAALEALIDERTKAVFCESIGNPAGNIIDI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 175 ESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAADPERFPQFNQPDPSY 254
Cdd:PRK06084 163 QALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKERFALLNTPDPSY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 255 NGLRYAPDLGVGgalganlAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVA 334
Cdd:PRK06084 243 HGVTYTEAFGPA-------AFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 335 YAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGV 414
Cdd:PRK06084 316 YAGLPDHPEHELARRYMGGKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGV 395
|
410 420
....*....|....*....|....*....
gi 334684745 415 TPGLVRLAVGLENIDDILADLETGFRAAK 443
Cdd:PRK06084 396 SRDMVRLSIGIEHIDDIIADLAQALDASK 424
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
12-442 |
5.42e-173 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 489.95 E-value: 5.42e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 12 WSFETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVA 91
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 92 SGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIdDPDDLESWRSAVQPNTKVFFAETISNPKQDI 171
Cdd:COG0626 81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFV-DPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 172 LDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfAADPErfpqfnqpd 251
Cdd:COG0626 160 VDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVV-------GRDEE--------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 252 psynglryapdlgvggaLGANLAFILKArvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVE 331
Cdd:COG0626 224 -----------------LAERLRFLQNA-------LGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVA 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 332 SVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAG 411
Cdd:COG0626 280 RVYYPGLPSHPGHELAKRQM-SGFGGMLSFELKGGREAARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAA 358
|
410 420 430
....*....|....*....|....*....|.
gi 334684745 412 AGVTPGLVRLAVGLENIDDILADLETGFRAA 442
Cdd:COG0626 359 LGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
15-440 |
5.21e-172 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 487.13 E-value: 5.21e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 15 ETRQIHAGQEADPATGARALPIYQTTSYVFNstdhaadlFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASGQ 94
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFD--------FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 95 SAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDILDI 174
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVD-TSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 175 ESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGgsfdfaadperfpqfnqpdpsy 254
Cdd:pfam01053 152 EAIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVN---------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 255 nglryapdlgvGGALGANLAFilkarvqLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVA 334
Cdd:pfam01053 210 -----------GEELGKELYF-------LQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVY 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 335 YAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGV 414
Cdd:pfam01053 272 YPGLPSHPGHELAKRQM-KGFGGMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGI 350
|
410 420
....*....|....*....|....*.
gi 334684745 415 TPGLVRLAVGLENIDDILADLETGFR 440
Cdd:pfam01053 351 TDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
8-441 |
1.62e-138 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 402.46 E-value: 1.62e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSESWSFETRQIHAGQEADPAtGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGA 87
Cdd:PRK08133 1 DDDSLGFDTLAVRAGQLRSPF-GEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 88 LLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNP 167
Cdd:PRK08133 80 VATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVD-LTDLDAWRAAVRPNTKLFFLETPSNP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 168 KQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdgGSFDFaadperfpqf 247
Cdd:PRK08133 159 LTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVV--GSKEL---------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 248 nqpdpsynglryapdlgvggalganlafiLKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTR 327
Cdd:PRK08133 227 -----------------------------MEEVFGFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAH 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 328 DEVESVAYAGLPSSPWHERSKKyAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPA 407
Cdd:PRK08133 278 PGVERVFYPGLPSHPQHELAKR-QQKGGGAIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPE 356
|
410 420 430
....*....|....*....|....*....|....
gi 334684745 408 EQAGAGVTPGLVRLAVGLENIDDILADLETGFRA 441
Cdd:PRK08133 357 ARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
14-438 |
1.01e-134 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 393.04 E-value: 1.01e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 14 FETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:PRK06234 9 FATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIdDPDDLESWRSAVQPNTKVFFAETISNPKQDILD 173
Cdd:PRK06234 89 MGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFV-DTSNLEEVRNALKANTKVVYLETPANPTLKVTD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 174 IESVAAVAHEA--GVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfaadperfpqfnqpd 251
Cdd:PRK06234 168 IKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVV--------------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 252 psynglryapdlgvggalgANLAFILKARVQLLRDL-GPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEV 330
Cdd:PRK06234 227 -------------------GKEEFINQVKLFGIKDMtGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 331 ESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQA 410
Cdd:PRK06234 288 EKVYYPGLESFEYYELAKKQM-SLPGAMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERK 366
|
410 420
....*....|....*....|....*...
gi 334684745 411 GAGVTPGLVRLAVGLENIDDILADLETG 438
Cdd:PRK06234 367 EAGISDGLVRLSVGLEDVDDIIADLKQA 394
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
8-444 |
1.17e-128 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 379.01 E-value: 1.17e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSESWSFETRQIHAGQEadPATG-ARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVG 86
Cdd:PRK06702 1 MGESWGKGTICVQGGYT--PKNGePRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 87 ALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDPDDLESWRSAVQPNTKVFFAETISN 166
Cdd:PRK06702 79 AVATASGQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTADEIVALANDKTKLVYAESLGN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 167 PKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAADpeRFPQ 246
Cdd:PRK06702 159 PAMNVLNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTNG--KYPE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 247 FNQPDPSYNGLRYAPDLGVGgalganlAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTT 326
Cdd:PRK06702 237 LVEPDPSYHGVSYVQNFGAA-------AYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLAD 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 327 RDEVESVAYAGLPSSPWHERSKKYAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSP 406
Cdd:PRK06702 310 HERIEWVNYPGLDSNENYSLAQKYLKKGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSA 389
|
410 420 430
....*....|....*....|....*....|....*...
gi 334684745 407 AEQAGAGVTPGLVRLAVGLENIDDILADLETGFRAAKE 444
Cdd:PRK06702 390 EDQRLAGVTSDLIRLSVGIEDVSDIIADLEAALVGGKQ 427
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
8-444 |
8.79e-122 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 360.27 E-value: 8.79e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSESWSFETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGA 87
Cdd:PRK07503 4 SHNNTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 88 LLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNP 167
Cdd:PRK07503 84 VALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVD-LTDPAALKAAISDKTRMVYFETPANP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 168 KQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGgsfdfAADPERFpqf 247
Cdd:PRK07503 163 NMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGG-----KALADRI--- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 248 nqpdpsynglryapdlgvggalganlafilkaRVQLLRDL-GPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTT 326
Cdd:PRK07503 235 --------------------------------RLEGLKDMtGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLAR 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 327 RDEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSP 406
Cdd:PRK07503 283 HPAVELVHYPGLPSFAQHALAQRQM-ALPGGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTP 361
|
410 420 430
....*....|....*....|....*....|....*...
gi 334684745 407 AEQAGAGVTPGLVRLAVGLENIDDILADLETGFRAAKE 444
Cdd:PRK07503 362 EERAEHGISEGLVRLSVGLEDVADILADLAQALDACAV 399
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
15-438 |
2.33e-117 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 348.37 E-value: 2.33e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 15 ETRQIHAGQEADPaTGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASGQ 94
Cdd:TIGR01325 1 ATLAVRGGMLRSG-FEETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 95 SAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDILDI 174
Cdd:TIGR01325 80 AAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVD-GTDLSAWEAALKPNTKAVFVETPSNPLQELVDI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 175 ESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIvdggsfdfAADPERFPQFNQpdpsy 254
Cdd:TIGR01325 159 AAVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAI--------LGSEEYMDEPVQ----- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 255 nglryapdlgvggalganlafilkarvQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVA 334
Cdd:TIGR01325 226 ---------------------------KLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVY 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 335 YAGLPSSPWHERSKKYApRGSGAVLAFEIkGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGV 414
Cdd:TIGR01325 279 YPGLPSHPQHELAKRQM-SGGGTVVTFDL-DCRQAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGI 356
|
410 420
....*....|....*....|....
gi 334684745 415 TPGLVRLAVGLENIDDILADLETG 438
Cdd:TIGR01325 357 GDGLVRLSVGLEDVDDLIADIDRA 380
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
14-441 |
7.75e-114 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 339.56 E-value: 7.75e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 14 FETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:TIGR01328 4 FATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIdDPDDLESWRSAVQPNTKVFFAETISNPKQDILD 173
Cdd:TIGR01328 84 MGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFI-NMAIPEEVKAHIKDNTKIVYFETPANPTMKLID 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 174 IESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdGGSFDFAadperfpqfnqpdps 253
Cdd:TIGR01328 163 MERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLIC-GKAELLQ--------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 254 ynglryapdlgvggalganlafilKARVQLLRDL-GPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVES 332
Cdd:TIGR01328 227 ------------------------QIRMVGIKDMtGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEK 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 333 VAYAGLPSSPWHERSKKYAPRGsGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGA 412
Cdd:TIGR01328 283 VYYPGFEDHPGHDIAAKQMRMG-GGMITFELKGGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAA 361
|
410 420
....*....|....*....|....*....
gi 334684745 413 GVTPGLVRLAVGLENIDDILADLETGFRA 441
Cdd:TIGR01328 362 GITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
4-436 |
7.40e-111 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 331.99 E-value: 7.40e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 4 PLPSMSESWSFETRQIHAGQEADPATGARALPIYQTTSYVfnsTDHAADLFAlkefGNIYTRIMNPTTDVVEKRLASLEG 83
Cdd:PRK07811 3 DMSDHHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFA---QDGVGGLRG----GYEYARTGNPTRTALEEQLAALEG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 84 GVGALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAET 163
Cdd:PRK07811 76 GAYGRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVD-LSDLDAVRAAITPRTKLIWVET 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 164 ISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGgsfdfaaDPEr 243
Cdd:PRK07811 155 PTNPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTN-------DEE- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 244 fpqfnqpdpsynglryapdlgvggaLGANLAFILKArvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEW 323
Cdd:PRK07811 227 -------------------------LDEAFAFLQNG-------AGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEF 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 324 LTTRDEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHsq 403
Cdd:PRK07811 275 LAGHPEVSTVLYPGLPSHPGHEVAARQM-RGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTH-- 351
|
410 420 430
....*....|....*....|....*....|....*
gi 334684745 404 lspAEQAGA--GVTPGLVRLAVGLENIDDILADLE 436
Cdd:PRK07811 352 ---ASTAGSqlEVPDDLVRLSVGIEDVADLLADLE 383
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
6-443 |
1.02e-102 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 311.30 E-value: 1.02e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 6 PSMSESWSFETRQIHAGQEADPaTGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGV 85
Cdd:PRK07504 3 TEMARKWRPATRLVHSGTLRSQ-FGETSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 86 GALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDpDDLESWRSAVQPNTKVFFAETIS 165
Cdd:PRK07504 82 DARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDG-LDLDNWEKAVRPNTKVFFLESPT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 166 NPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfaadperfp 245
Cdd:PRK07504 161 NPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVL--------------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 246 qfnqpdpsynglryapdlgvggalgANLAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLT 325
Cdd:PRK07504 226 -------------------------SDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLA 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 326 TRDEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLS 405
Cdd:PRK07504 281 GHPKVARVIYPGRADHPQADIIAKQM-TGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLS 359
|
410 420 430
....*....|....*....|....*....|....*...
gi 334684745 406 PAEQAGAGVTPGLVRLAVGLENIDDILADLETGFRAAK 443
Cdd:PRK07504 360 PEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKKVR 397
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
14-436 |
9.05e-99 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 300.99 E-value: 9.05e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 14 FETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:PRK06767 6 METALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFiDDPDDLESWRSAVQPNTKVFFAETISNPKQDILD 173
Cdd:PRK06767 86 MAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSF-CDMETEADIENKIRPNTKLIFVETPINPTMKLID 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 174 IESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfaadperfpqfnqpdps 253
Cdd:PRK06767 165 LKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTI----------------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 254 ynglryapdlgvggalGANLAFILKARVqLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESV 333
Cdd:PRK06767 222 ----------------CKTRALAEKIRP-MRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 334 AYaglpssPWHERSKKYAPRGsGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAG 413
Cdd:PRK06767 285 WY------PEGELASRQMKRG-GGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMG 357
|
410 420
....*....|....*....|...
gi 334684745 414 VTPGLVRLAVGLENIDDILADLE 436
Cdd:PRK06767 358 IYDNLIRLSVGLESWEDIVSDLE 380
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
30-442 |
4.31e-98 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 299.30 E-value: 4.31e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 30 GARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASGQSAATLALLNVAESGS 109
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 110 HIVASPRLYGGTHNLLHhTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDILDIESVAAVAHEAGVPLI 189
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFG-TLRGLGVEVTMVD-ATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 190 VDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSFDFAADPERFPQFNQPDPSYNGLryapdlgvggal 269
Cdd:PRK05939 166 VDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDWSAYPNIFPAYRKGDPQQWGL------------ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 270 ganlafiLKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVAYAGLPSSPWHERSKK 349
Cdd:PRK05939 234 -------TQIRKKGLRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATE 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 350 YApRGSGAVLAFEIKGGLEAgKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGVTPGLVRLAVGLENID 429
Cdd:PRK05939 307 LF-RHYGGLLSFELADGIDC-FDFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEA 384
|
410
....*....|...
gi 334684745 430 DILADLETGFRAA 442
Cdd:PRK05939 385 DLIADFEQALDAT 397
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
4-436 |
5.09e-95 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 291.64 E-value: 5.09e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 4 PLPsmsESWSFETRQIHAGQEADPaTGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEG 83
Cdd:PRK07810 9 ALP---DGVSQATIGVRGGLLRSG-FEETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 84 GVGALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDpDDLESWRSAV-QPNTKVFFaE 162
Cdd:PRK07810 85 AEACFATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDG-EDLSQWEEALsVPTQAVFF-E 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 163 TISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdgGSFDFAADPE 242
Cdd:PRK07810 163 TPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAIL--GDREYIDGPV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 243 RfpqfnqpdpsynglryapdlgvggalganlafilkarvQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAE 322
Cdd:PRK07810 241 Q--------------------------------------KLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAE 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 323 WLTTRDEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGK----AFVNALELHSHVANIGDVRSLVIHPAS 398
Cdd:PRK07810 283 FLEGHPAVRWVRYPFLPSHPQYDLAKRQM-SGGGTVVTFELDAPEDAAKkrafEVLDKLRVIDISNNLGDAKSLITHPAT 361
|
410 420 430
....*....|....*....|....*....|....*...
gi 334684745 399 TTHSQLSPAEQAGAGVTPGLVRLAVGLENIDDILADLE 436
Cdd:PRK07810 362 TTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLD 399
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
14-444 |
1.49e-90 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 280.09 E-value: 1.49e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 14 FETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:PRK08249 9 VGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFID--DPDDLESwrsAVQPNTKVFFAETISNPKQDI 171
Cdd:PRK08249 89 MAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCEtgDHEQIEA---EIAKGCDLLYLETPTNPTLKI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 172 LDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdgGSFDFAADPERFPQFNqpd 251
Cdd:PRK08249 166 VDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVC--GSKELMEQVYHYREIN--- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 252 psynglryapdlgvggalGANLafilkarvqllrdlgpaaSPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVE 331
Cdd:PRK08249 241 ------------------GATM------------------DPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVE 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 332 SVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAG 411
Cdd:PRK08249 285 AVYYPGLETHPNHEIAKAQM-RGFGGILSFVLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAA 363
|
410 420 430
....*....|....*....|....*....|...
gi 334684745 412 AGVTPGLVRLAVGLENIDDILADLETGFRAAKE 444
Cdd:PRK08249 364 LGIPEGLVRISVGIEDTEDLIADLEQAFAHLES 396
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
15-439 |
2.59e-89 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 276.22 E-value: 2.59e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 15 ETRQIHAGQEADPATGARALPIYQTTSYVFNStdhaadlfALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASGQ 94
Cdd:PRK07671 4 KTKLIHGGIIGDPSTGAVSVPIYQVSTYKQEA--------VGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 95 SAATlALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDpDDLESWRSAVQPNTKVFFAETISNPKQDILDI 174
Cdd:PRK07671 76 AAIT-AVMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDT-SNLEEVEEAIRPNTKAIYVETPTNPLLKITDI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 175 ESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfAADPErfpqfnqpdpsy 254
Cdd:PRK07671 154 KKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVV-------VNSPE------------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 255 nglryapdlgvggaLGANLAFILKArvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVA 334
Cdd:PRK07671 215 --------------LAEDLHFVQNS-------TGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVY 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 335 YAGLPSSPWHERSKKYApRGSGAVLAFEIkGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGV 414
Cdd:PRK07671 274 YPGLPSHPNHELAKEQA-NGFGGMISFDV-GSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGI 351
|
410 420
....*....|....*....|....*
gi 334684745 415 TPGLVRLAVGLENIDDILADLETGF 439
Cdd:PRK07671 352 TDGLIRISVGIEDGEDLIEDLAQAL 376
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
15-443 |
2.57e-86 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 268.11 E-value: 2.57e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 15 ETRQIHAGQEADPATGARALPIYQTTSY----VFNSTdhaadlfalkefGNIYTRIMNPTTDVVEKRLASLEGGVGALLV 90
Cdd:PRK08247 6 ETKLAQIGNRSDERTGTVNPPVYFSTAYrhegIGEST------------GFDYSRTGNPTRGVLEQAIADLEGGDQGFAC 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 91 ASGQsAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFiDDPDDLESWRSAVQPNTKVFFAETISNPKQD 170
Cdd:PRK08247 74 SSGM-AAIQLVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVY-VNTASLKAIEQAITPNTKAIFIETPTNPLMQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 171 ILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSfdfaadperfpqfnqp 250
Cdd:PRK08247 152 ETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQ---------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 251 dpsynglryapdlgvggALGANLAFILKArvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEV 330
Cdd:PRK08247 216 -----------------ELCERLAYYQNA-------AGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGV 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 331 ESVAYAglpsspwherskkyaprGSGAVLAFEIKGGlEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQA 410
Cdd:PRK08247 272 TDVLYP-----------------GRGGMLSFRLQDE-EWVNPFLKSLKLITFAESLGGVESFITYPATQTHADIPEEIRI 333
|
410 420 430
....*....|....*....|....*....|...
gi 334684745 411 GAGVTPGLVRLAVGLENIDDILADLETGFRAAK 443
Cdd:PRK08247 334 ANGVCNRLLRFSVGIENVEDLIADLKQAFKQVK 366
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
8-445 |
1.03e-85 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 267.41 E-value: 1.03e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSESWSFETRQIHAGQEADPATGARALPIYQTtsyvfnSTDHAadlFALKEFGNI-YTRIMNPTTDVVEKRLASLEGGVG 86
Cdd:PRK08064 1 MAMSYSIDTLLLHNQYKHDKQTGAVNVPIYHA------STFHQ---FDFDTFGKYdYSRSGNPTREALEDIIAELEGGTK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 87 ALLVASGQSAATLALLNVAEsGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISN 166
Cdd:PRK08064 72 GFAFASGMAAISTAFLLLSK-GDHVLISEDVYGGTYRMITEVLSRFGIEHTFVD-MTNLEEVAQNIKPNTKLFYVETPSN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 167 PKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfAADPErfpq 246
Cdd:PRK08064 150 PLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAV-------VKDEE---- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 247 fnqpdpsynglryapdlgvggaLGANLAFILKArvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTT 326
Cdd:PRK08064 219 ----------------------LAQKLYFLQNS-------FGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQE 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 327 RDEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIkGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSP 406
Cdd:PRK08064 270 HPKVQNVYYPGLQTHLGFDIQQSQA-TSAGAVLSFTL-QSEEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPK 347
|
410 420 430
....*....|....*....|....*....|....*....
gi 334684745 407 AEQAGAGVTPGLVRLAVGLENIDDILADLETGFRAAKEV 445
Cdd:PRK08064 348 EERDERGITDGLLRLSVGLENVDDLIADFEQALSYVEEP 386
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
35-441 |
8.55e-85 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 265.00 E-value: 8.55e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 35 PIYQTTSYVFNSTDHAADL-FALKefgniYTRIMNPTTDVVEKRLASLEGGVGALLVASGQSAATLALLNVAESGSHIVA 113
Cdd:PRK08574 23 PIYLTALFRQEGEAYPSDRgFDLK-----YSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLFFSLLKAGDRVVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 114 SPRLYGGTHNLLHhTFAKLGVEV--TFIDDPDDLESWRSavqPNTKVFFAETISNPKQDILDIESVAAVAHEAGVPLIVD 191
Cdd:PRK08574 98 PMEAYGTTLRLLK-SLEKFGVKVvlAYPSTEDIIEAIKE---GRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILVVD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 192 NTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGGSfdfaADPERFPQFNqpdpsynglryapdlgvggalga 271
Cdd:PRK08574 174 NTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSG----EFLEELWEWR----------------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 272 nlafilkarvqllRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVAYAGLPSSPWHERSKKYA 351
Cdd:PRK08574 227 -------------RRLGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLF 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 352 PRGS-GAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGVTPGLVRLAVGLENIDD 430
Cdd:PRK08574 294 GKDLyGGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVED 373
|
410
....*....|.
gi 334684745 431 ILADLETGFRA 441
Cdd:PRK08574 374 LIEDLDQALGS 384
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
13-441 |
1.43e-83 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 261.76 E-value: 1.43e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 13 SFETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAadlfalKEFGniYTRIMNPTTDVVEKRLASLEGGVGALLVAS 92
Cdd:PRK06176 2 RMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRP------KGYE--YSRSGNPTRFALEELIADLEGGVKGFAFAS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 93 GQsAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDIL 172
Cdd:PRK06176 74 GL-AGIHAVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIID-TSDLSQIKKAIKPNTKALYLETPSNPLLKIT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 173 DIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDggsfdfaadperfpqfNQPdp 252
Cdd:PRK06176 152 DLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTT----------------NNE-- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 253 synglryapdlgvggALGANLAFILKArvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVES 332
Cdd:PRK06176 214 ---------------ALAQEIAFFQNA-------IGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEK 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 333 VAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAgKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGA 412
Cdd:PRK06176 272 VYYPGLPTHPNHELAKKQM-RGFSGMLSFTLKNDSEA-VAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAA 349
|
410 420
....*....|....*....|....*....
gi 334684745 413 GVTPGLVRLAVGLENIDDILADLETGFRA 441
Cdd:PRK06176 350 GIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
16-442 |
5.79e-83 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 260.15 E-value: 5.79e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 16 TRQIHAGQEADPaTGARALPIYQTTSYVFNSTDhaadlfalkEFGNI-YTRIMNPTTDVVEKRLASLEGGVGALLVASGQ 94
Cdd:TIGR01329 3 TLLVNTDNKNDP-YDASSMPIYQTATFKQPLAI---------ENGPYdYTRSGNPTRTALESLLAKLDKADRAFAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 95 sAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDILDI 174
Cdd:TIGR01329 73 -AALDVITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVD-TTDLDKVKAALGPKTKLVLLESPTNPLQKIVDI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 175 ESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfaadperfpqFNQPdpsy 254
Cdd:TIGR01329 151 RKISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLA----------------VKGE---- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 255 nglryapdlgvggALGANLAFILKARvqllrdlGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVA 334
Cdd:TIGR01329 211 -------------EIAKKVYFLQNST-------GSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVR 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 335 YAGLPSSPWHERSKKYApRGSGAVLAFEiKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGV 414
Cdd:TIGR01329 271 YAGLPSHPGFHLHFSQA-KGAGSVLSFE-TGSVALSKRLVEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGL 348
|
410 420
....*....|....*....|....*...
gi 334684745 415 TPGLVRLAVGLENIDDILADLETGFRAA 442
Cdd:TIGR01329 349 PEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
13-445 |
1.22e-74 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 239.51 E-value: 1.22e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 13 SFETRQIHAGQEADPATGARALPIYQTTSYVFNStdhaadlfalkeFGNI----YTRIMNPTTDVVEKRLASLEGGVGAL 88
Cdd:PRK08776 12 SAATAAVRAGIDRDTAYGAVTPPIVLSSNFSFDG------------FGNKrqydYTRSGNPTRDLLGEALAELEGGAGGV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 89 LVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHhTFAKLGVEVTFIDDPDDLESWRSAVQPNTKVFFAETISNPK 168
Cdd:PRK08776 80 ITATGMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFN-ALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 169 QDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfAADPERFPQFn 248
Cdd:PRK08776 159 LRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVV-------ARDAELHQQL- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 249 qpdpsyngLRYAPDLGVGGalganlafilkarvqllrdlgpaaSPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRD 328
Cdd:PRK08776 231 --------VWWANALGLTG------------------------SPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHA 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 329 EVESVAYAGLPSSPWHERSKKyAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAE 408
Cdd:PRK08776 279 AVNQVYYPGLASHPGHALAAR-QQKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEA 357
|
410 420 430
....*....|....*....|....*....|....*..
gi 334684745 409 QAGAGVTPGLVRLAVGLENIDDILADLETGFRAAKEV 445
Cdd:PRK08776 358 RAAAGISDGLLRLSVGIESAEDLLIDLRAGLARAEAV 394
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
14-436 |
7.96e-74 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 236.72 E-value: 7.96e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 14 FETRQIHAGQEADPATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:PRK06434 9 FNTRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIdDPDDLESWRSAVQpNTKVFFAETISNPKQDILD 173
Cdd:PRK06434 89 MGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYI-DTDRLNSLDFDPS-NYDLIYAESITNPTLKVPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 174 IESVAAVAHEAGVplIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIvdggsfdfaadperfpqfnqpdps 253
Cdd:PRK06434 167 IKNVSSFCHENDV--IVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVA------------------------ 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 254 ynglryapdlgvggalGANLAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESV 333
Cdd:PRK06434 221 ----------------GTNNKSIFNNLVERRKTLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 334 AYAGLpsspwhERSKKYApRGSGAVLAFEIKGGLEAGKaFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAG 413
Cdd:PRK06434 285 YYPDT------EIGKKVL-RGFGGMLSFELRSMEDVHK-FIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLG 356
|
410 420
....*....|....*....|...
gi 334684745 414 VTPGLVRLAVGLENIDDILADLE 436
Cdd:PRK06434 357 ISDNLVRFSIGIEDIDDLIKDIE 379
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
8-440 |
2.77e-73 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 237.62 E-value: 2.77e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSESWSFETRQIHAGQEADPATgARALPIYQTTSYVFNStdhaadlfALKEFGNIYTRIMNPTTDVVEKRLASLEGGVGA 87
Cdd:PLN02509 81 IKEEASVSTLLVNLDNKFDPFD-AMSTPLYQTATFKQPS--------AIENGPYDYTRSGNPTRDALESLLAKLDKADRA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 88 LLVASGQsAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDpDDLESWRSAVQPNTKVFFAETISNP 167
Cdd:PLN02509 152 FCFTSGM-AALSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNT-TNLDEVAAAIGPQTKLVWLESPTNP 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 168 KQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIvdggsfdfAADPERfpqf 247
Cdd:PLN02509 230 RQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVL--------AVKGEK---- 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 248 nqpdpsynglryapdlgvggaLGANLAFILKARvqllrdlGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTR 327
Cdd:PLN02509 298 ---------------------LAKEVYFLQNSE-------GSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSH 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 328 DEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFeIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPA 407
Cdd:PLN02509 350 PRVKKVYYAGLPDHPGHHLHFSQA-KGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAE 427
|
410 420 430
....*....|....*....|....*....|...
gi 334684745 408 EQAGAGVTPGLVRLAVGLENIDDILADLETGFR 440
Cdd:PLN02509 428 VREARGLTEDLVRISAGIEDVDDLISDLDIAFR 460
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
26-437 |
4.60e-72 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 231.64 E-value: 4.60e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 26 DPATGARALPIYQTTSYVFNSTDHAAdlfalkefgniYTRIMNPTTDVVEKRLASLEGGVGALLVASGQSAATLALLNVA 105
Cdd:PRK06460 13 DEATGAITTPIYQTTAYHYPEGEKYR-----------YSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 106 ESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTfIDDPDDLESWRSAVQPNTKVFFAETISNPKQDILDIESVAAVAHEAG 185
Cdd:PRK06460 82 KPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVD-ASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 186 VPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIvdGGSFDFaadperfpqfnqpdpsynglryapdlgv 265
Cdd:PRK06460 161 SILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLA--AGYGKL---------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 266 ggalganlafiLKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVAYAGLPSSPWHE 345
Cdd:PRK06460 211 -----------LNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYE 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 346 RSKKYApRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAGVTPGLVRLAVGL 425
Cdd:PRK06460 280 IARRVL-KGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGI 358
|
410
....*....|..
gi 334684745 426 ENIDDILADLET 437
Cdd:PRK06460 359 EDVNDLIEDLDR 370
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
16-445 |
7.52e-71 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 229.01 E-value: 7.52e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 16 TRQIHAGQEADPATGARALPIYQTTSYVFnstdhaadlfalKEFGNI----YTRIMNPTTDVVEKRLASLEGGVGALLVA 91
Cdd:PRK08861 8 TIAVRTGIESDSQYHAVVPPIYLSTNYGF------------PAFGEVpkydYTRSGNPNRGLLEQTLSELESGKGAVVTN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 92 SGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDPDDlESWRSAVQPNTKVFFAETISNPKQDI 171
Cdd:PRK08861 76 CGTSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDA-AALDAALAKKPKLILLETPSNPLVRV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 172 LDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfAADPErfpqfnqpd 251
Cdd:PRK08861 155 VDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLI-------TKTKE--------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 252 psynglrYAPDLGVGGALganlafilkarvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVE 331
Cdd:PRK08861 219 -------HAEELAWWGNC-----------------IGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVG 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 332 SVAYAGLPSSPWHERSKKyAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAG 411
Cdd:PRK08861 275 TIYHPSLPEHPGHEIAKK-QQSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAE 353
|
410 420 430
....*....|....*....|....*....|....
gi 334684745 412 AGVTPGLVRLAVGLENIDDILADLETGFRAAKEV 445
Cdd:PRK08861 354 AGVSQQLLRLSVGLEDAQDLIADLDQAFAKAAEA 387
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
16-442 |
1.00e-69 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 225.93 E-value: 1.00e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 16 TRQIHAGQEADPATGARALPIYQTTSYVFNSTDH--AADlfalkefgniYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:PRK08045 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEprAHD----------YSRRGNPTRDVVQRALAELEGGAGAVLTNTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDPDDlESWRSAVQPNTKVFFAETISNPKQDILD 173
Cdd:PRK08045 77 MSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDE-QALRAALAEKPKLVLVESPSNPLLRVVD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 174 IESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfAADPERFPQFNQpdps 253
Cdd:PRK08045 156 IAKICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI-------AKDPDVVTELAW---- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 254 ynglrYAPDLGVGGAlganlafilkarvqllrdlgpaasPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESV 333
Cdd:PRK08045 225 -----WANNIGVTGG------------------------AFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 334 AYAGLPSSPWHERSKKyAPRGSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPASTTHSQLSPAEQAGAG 413
Cdd:PRK08045 276 YHPSLPENQGHEIAAR-QQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAG 354
|
410 420
....*....|....*....|....*....
gi 334684745 414 VTPGLVRLAVGLENIDDILADLETGFRAA 442
Cdd:PRK08045 355 ISETLLRISTGIEDGEDLIADLENGFRAA 383
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
26-442 |
3.61e-69 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 225.71 E-value: 3.61e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 26 DPA--TGARALPIYQTTSYVFNSTDHAADLF----ALKEF------GNIYTRIMNPTTDVVEKRLASLEGGVGALLVASG 93
Cdd:PRK07049 28 DPElsEGAVKPPVFLTSTFVFRSAEDGRDFFdyvsGRKEPpagegaGLVYSRFNHPNSEIVEDRLAVYEGAESAALFSSG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 94 QSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDPDDLESWRSAV-----QPNTKVFFAETISNPK 168
Cdd:PRK07049 108 MSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFADGLSEAAIGAAAeaaaaKGRVSLILIETPANPT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 169 QDILDIESVAAVAHEAG-----VPLIV-DNTIATPYLIRPLEWGADVVVHSATKYLGGHGtaiggvivdggsfdfaadpe 242
Cdd:PRK07049 188 NSLVDVAAVRRVADAIEarqghRPIIAcDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHS-------------------- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 243 rfpqfnqpdpsynglryapDLGVGGALGANlAFIlkARVQLLRD-LGPAASPFNAFLIAQGLETLSLRVERHVANAQRVA 321
Cdd:PRK07049 248 -------------------DLVAGAVLGRK-ALI--RQVRALRSaIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 322 EWLTTRDEVESVAYagLPSSPWHERSKKYAPR---GSGAVLAFEIKGGLEAGKAFVNALELHSHVANIGDVRSLVIHPAS 398
Cdd:PRK07049 306 EFLRDHPKVEKLHY--LPFLDPDSAYGAVYKRqctGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPAS 383
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 334684745 399 TTHSQLSPAEQAGAGVTPGLVRLAVGLENIDDILADLETGFRAA 442
Cdd:PRK07049 384 MTHSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
8-444 |
1.95e-62 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 207.24 E-value: 1.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSESWSFETRQIHAGQEADP-ATGARALPIYQTTSYVFNSTDHAADLFALKEFGNIYTRIMNPTTDVVEKRLASLEGGVG 86
Cdd:PRK05968 1 MNDGLDPFDLAALITAHDEGnAFDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAED 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 87 ALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIdDPDDLESWRSAVqPNTKVFFAETISN 166
Cdd:PRK05968 81 ARGFASGMAAISSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYV-DGRDEEAVAKAL-PGAKLLYLESPTS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 167 PKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdgGSfdfaadperfpq 246
Cdd:PRK05968 159 WVFELQDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVA--GS------------ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 247 fnqpdpsynglryapdlgvggalganLAFILKARVQLLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTT 326
Cdd:PRK05968 225 --------------------------KEHIARINAEAYPYLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKA 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 327 RDEVESVAYAGLPSSPwherskKYAPRGSGAVLAFEIKGGLEAgKAFVNALELHSHVANIGDVRSLVIhPASTTHSQLSP 406
Cdd:PRK05968 279 HPVVERVCHPALANHP------PAGLSGTSGLFSFIFREGIDV-RAFADALKLFRLGVSWGGHESLVV-PAEVVLQQKAQ 350
|
410 420 430
....*....|....*....|....*....|....*....
gi 334684745 407 AEQAGA-GVTPGLVRLAVGLENIDDILADLETGFRAAKE 444
Cdd:PRK05968 351 PNSAARfGVSPRSVRLHVGLEGTEALWADLEQALAAASR 389
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
8-441 |
4.51e-62 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 205.44 E-value: 4.51e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 8 MSESWSFETRQIHAGQEADPATGARALPIYQTTSYvfnstDHAadlfalkEFGNI----YTRIMNPTTDVVEKRLASLEG 83
Cdd:PRK07269 1 MSKDLHINTILAQAGIKSDEATGALVTPLHFSTTY-----QHP-------EFGQStgfdYTRTKNPTRAKLEETLAAIES 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 84 GVGALLVASGQSAATLALlNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDPDDLeswRSAVQPNTKVFFAET 163
Cdd:PRK07269 69 ADYALATSSGMSAIVLAF-SVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYANTEEEL---IAAIEEDTDIVYIET 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 164 ISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfAADPEr 243
Cdd:PRK07269 145 PTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVV-------TNDLE- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 244 fpqfnqpdpSYNGLRYApdlgvggalganlafilkarvqlLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEW 323
Cdd:PRK07269 217 ---------LYEKLFYN-----------------------LNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAF 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 324 LTTRDEVESVAYAGLpsspwherskkyaprgsGAVLAFEIkggLEAGK--AFVNALELHSHVANIGDVRSLVIHPASTTH 401
Cdd:PRK07269 265 LKKSPAVKEVLYTGK-----------------GGMISFKV---ADETRipHILNSLKVFTFAESLGGVESLITYPTTQTH 324
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 334684745 402 SQLsPAE-QAGAGVTPGLVRLAVGLENIDDILADLETGFRA 441
Cdd:PRK07269 325 ADI-PAEvRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
62-424 |
2.48e-61 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 205.00 E-value: 2.48e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 62 IYTRIMNPTTDVVEKRLASLEGGVGALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFA-KLGVEVTFId 140
Cdd:PLN02242 69 IYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPrKCNITTTFV- 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 141 DPDDLESWRSAVQPN-TKVFFAETISNPKQDILDIESVAAVAHEAGVPLIVDNTIAtPYLIRPLEWGADVVVHSATKYLG 219
Cdd:PLN02242 148 DITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFIS 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 220 GHGTAIGGVIVdgGSFDFAAdperfpqfnqpdpSYNGLRYAPdlgvggalganlafilkarvqlLRDLGPAASPFNAFLI 299
Cdd:PLN02242 227 GGADIIAGAVC--GPAELVN-------------SMMDLHHGA----------------------LMLLGPTMNPKVAFEL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 300 AQGLETLSLRVERHVANAQRVAEWLttRDEVESVAYAGLPSSPWHERSKKYAPR--GSGAVLAFEIkGGLEAGKAFVNAL 377
Cdd:PLN02242 270 SERLPHLSLRMKEHCRRAMEYAKRM--KELGLKVIYPGLEDHPQHALLKSMANKgyGFGGLLCLDM-DTEERANRLMRYL 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 334684745 378 ELHSH----VANIGDVRSLVIHPASTTHSQLSPAEQAGAGVTPGLVRLAVG 424
Cdd:PLN02242 347 QNSTQfgfmAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
12-442 |
5.91e-60 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 199.84 E-value: 5.91e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 12 WSFETRQIHAGQeADPATGARALPiyqttSYVFNSTDHaadLFALKEFG-NIYTRIMNPTTDVVEKRLASLEGGvGALLV 90
Cdd:PRK07582 2 YGDGTRSVHAGG-PEAVPGEPVLP-----GPVFAAPYH---LSPGEPTGpDTYGRASNPTWRALEAALGELEGA-EALVF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 91 ASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDDPDDLESWRSAVqpntKVFFAETISNPKQD 170
Cdd:PRK07582 72 PSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGMAEAALAGA----DLVLAETPSNPGLD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 171 ILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfAADPErfpqfnqp 250
Cdd:PRK07582 148 VCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVA-------GRDPE-------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 251 dpsynglryapdlgvggalganlafiLKARVQLLRDL-GPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDE 329
Cdd:PRK07582 213 --------------------------LMAAVERWRLLaGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 330 VESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIkGGLEAGKAFVNALELHSHVANIGDVRSLVIHPAstthsqlspaeQ 409
Cdd:PRK07582 267 VRGVRYPGLPGDPAHEVAARQM-RRFGGLVSFEL-ADAAAAERFVAASRLVVAATSFGGVHTSADRRA-----------R 333
|
410 420 430
....*....|....*....|....*....|...
gi 334684745 410 AGAGVTPGLVRLAVGLENIDDILADLETGFRAA 442
Cdd:PRK07582 334 WGDAVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
16-442 |
3.75e-55 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 187.78 E-value: 3.75e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 16 TRQIHAGQEADPATGARALPIYQTTSYVFNStdHAADLFALKEFgnIYTRIMNPTTDVVEKRLASLEGGVGALLVASGQS 95
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDS--HAAQRRAKGEL--TYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 96 AATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDILDIE 175
Cdd:TIGR01324 77 AVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYD-PLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 176 SVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVDGgsfdfaadperfpqfnqpDPSYN 255
Cdd:TIGR01324 156 AIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVAN------------------ARTWD 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 256 GLRYApdlgvggalganlafilkarvqlLRDLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVESVAY 335
Cdd:TIGR01324 218 QLREH-----------------------SYLMGQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLH 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 336 AGLPSSPWHERSKKYAPrGSGAVLAFEIKG-GLEAGKAFVNALELHSHVANIGDVRSLVIhpasTTHSQLSPAEQAGAGV 414
Cdd:TIGR01324 275 PALPSCPGHEFWKRDFS-GSSGLFSFVLQRlTQKQVHAFLDHLQLFGLGYSWGGYESLAL----CNQPELGHRPNIKRNL 349
|
410 420
....*....|....*....|....*...
gi 334684745 415 TPGLVRLAVGLENIDDILADLETGFRAA 442
Cdd:TIGR01324 350 EGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
69-445 |
6.46e-55 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 187.32 E-value: 6.46e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 69 PTTDVVEKRLASLEGGVGALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESW 148
Cdd:PRK05967 64 PTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYD-PEIGAGI 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 149 RSAVQPNTKVFFAETISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGV 228
Cdd:PRK05967 143 AKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGT 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 229 IvdggsfdfAADPERFPQFNQpdpsynglryapdlgvggALGAnlafilkarvqllrdLGPAASPFNAFLIAQGLETLSL 308
Cdd:PRK05967 223 V--------SANEKCWPQLLE------------------AHGT---------------LGLCAGPDDTYQILRGLRTMGI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 309 RVERHVANAQRVAEWLTTRDEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGK----AFVNALELHSHVA 384
Cdd:PRK05967 262 RLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDF-SGASGIFSFVLAAGPEKGKakahAFLDALEIFGLGY 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334684745 385 NIGDVRSLVIHpASTTHSQLSPAEQAGAgvtpgLVRLAVGLENIDDILADLETGFRAAKEV 445
Cdd:PRK05967 341 SWGGYESLALH-VKLGDRTVAKAPYAGP-----VIRLQIGLEDVPDLKADLERGFAAASAV 395
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
15-439 |
6.34e-52 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 179.54 E-value: 6.34e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 15 ETRQIHAGQEADPATGARALPIYQTTSYVFNSTD---HAADLFALKEFgnIYTRIMNPTTDVVEKRLASLEGGVGALLVA 91
Cdd:PRK09028 6 ATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAemrHAAKNRANGEM--FYGRRGTPTHFAFQAAIVELEGGAGTALYP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 92 SGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAETISNPKQDI 171
Cdd:PRK09028 84 SGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYD-PMIGEGIRELIRPNTKVLFLESPGSITMEV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 172 LDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfaADPERFPQFNqpD 251
Cdd:PRK09028 163 QDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTAT--------ANEKHWDQLR--E 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 252 PSYNglryapdlgvggalganlafilkarvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAEWLTTRDEVE 331
Cdd:PRK09028 233 HSYL-------------------------------MGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVD 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 332 SVAYAGLPSSPWHERSKKYApRGSGAVLAFEIK-GGLEAGKAFVNALELHSHVANIGDVRSLVIhpASTTHSQLSPAEQA 410
Cdd:PRK09028 282 HVRHPAFETCPGHEFFKRDF-SGSNGLFSFVLKqGDPKAVTALVEGMQHFKMGFSWGGFESLIL--GVFGINKLRTATNW 358
|
410 420
....*....|....*....|....*....
gi 334684745 411 GAGVTpgLVRLAVGLENIDDILADLETGF 439
Cdd:PRK09028 359 DFSKP--LIRLHIGLEDVDDLIADLEAGF 385
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
7-436 |
8.34e-45 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 160.66 E-value: 8.34e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 7 SMSESWsfETRQIHAGQEADPATGARALPIYQTTSYVFnstDHAADLFALKEFGNIYTRI---MNPTTDVVEKRLASLEG 83
Cdd:PRK07050 5 TPKRAL--QTRIVQPDDQIPPGFRSFVTPVARASTVVF---PDLATMRALDWRQDVQWRYglhATPTSLALAQRLAEIEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 84 GVGALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIDdPDDLESWRSAVQPNTKVFFAET 163
Cdd:PRK07050 80 GRHALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYD-PLIGAGIADLIQPNTRLIWLEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 164 ISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLIRPLEWGADVVVHSATKYLGGHGtaiggvivdggsfdfaadper 243
Cdd:PRK07050 159 PGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGS--------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 244 fpqfnqpdpsynglryapDLGVGGALGANLAfiLKARVQLLR-DLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVAE 322
Cdd:PRK07050 218 ------------------DVLMGATITADAE--LHAKLKLARmRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAE 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 323 WLTTRDEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGLEAGK--AFVNALELHSHVANIGDVRSLVIhPASTT 400
Cdd:PRK07050 278 WLKARPEIATVLHPALPDCPGHAFWMRDF-TGAGGLFSVVFDERYSPAQvdAFVEALELFAIGWSWGGACSLAM-PYDVA 355
|
410 420 430
....*....|....*....|....*....|....*.
gi 334684745 401 HsqLSPAEQAGAGvtpGLVRLAVGLENIDDILADLE 436
Cdd:PRK07050 356 S--MRTAKWPHRG---TLVRLYIGLEDEADLIADLE 386
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
9-440 |
5.01e-44 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 158.71 E-value: 5.01e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 9 SESWSFETRQIHAGQEADPATGARALPIYQTTSYVFNSTD---HAADLFALKEFgnIYTRIMNPTTDVVEKRLASLEGGV 85
Cdd:PRK08114 1 MTDKKLDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEakkHATRNRANGEL--FYGRRGTLTHFSLQEAMCELEGGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 86 GALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNLLHHTFAKLGVEVTFIdDPDDLESWRSAVQPNTKVFFAETIS 165
Cdd:PRK08114 79 GCALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWF-DPLIGADIAKLIQPNTKVVFLESPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 166 NPKQDILDIES-VAAVAHEAgvPLIV---DNTIATPYLIRPLEWGADVVVHSATKYLGGHGTAIGGVIVdggsfdfaADP 241
Cdd:PRK08114 158 SITMEVHDVPAiVAAVRSVN--PDAVimiDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAV--------ANA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 242 ERFPQfnqpdpsyngLRYAPDLgvggalganlafilkarvqllrdLGPAASPFNAFLIAQGLETLSLRVERHVANAQRVA 321
Cdd:PRK08114 228 RCWEQ----------LRENSYL-----------------------MGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 322 EWLTTRDEVESVAYAGLPSSPWHERSKKYApRGSGAVLAFEIKGGL--EAGKAFVNALELHSHVANIGDVRSLVIHPAST 399
Cdd:PRK08114 275 EWLAEHPEVARVNHPALPGCKGHEFWKRDF-TGSSGLFSFVLKKKLtdEQLANYLDNFSLFSMAYSWGGFESLILANQPE 353
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 334684745 400 THSQLSPAeqAGAGVTPGLVRLAVGLENIDDILADLETGFR 440
Cdd:PRK08114 354 EIAAIRPA--GEVDFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
75-231 |
1.55e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 62.79 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 75 EKRLASL--EGGVGALLVASGQSAATLALLNVAESGSHIVASPRLYGGTHNllhHTFAKLGVEVTFIDDPDD-------L 145
Cdd:cd01494 6 EEKLARLlqPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYW---VAAELAGAKPVPVPVDDAgyggldvA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 146 ESWRSAVQPNTKVFFAETISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPY----LIRPLEWGADVVVHSATKYLGGH 221
Cdd:cd01494 83 ILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKNLGGE 162
|
170
....*....|
gi 334684745 222 GTaiGGVIVD 231
Cdd:cd01494 163 GG--GVVIVK 170
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
133-244 |
1.15e-08 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 56.71 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 133 GVEVTFID-DPD---DLESWRSAVQPNTKVFFAETISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLirPL---EW 205
Cdd:cd06453 113 GAKLKVVPvDDDgqlDLEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVDGAQSAGHM--PVdvqDL 190
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 334684745 206 GADVVVHSATKYLGGHGTAI----------------GGVIVDGGSFD---FAADPERF 244
Cdd:cd06453 191 GCDFLAFSGHKMLGPTGIGVlygkeelleemppyggGGEMIEEVSFEettYADLPHKF 248
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
133-244 |
7.23e-05 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 44.74 E-value: 7.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 133 GVEVTFIDDPD----DLESWRSAVQPNTKVFFAETISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPYLirPL---EW 205
Cdd:COG0520 128 GAEVRVIPLDEdgelDLEALEALLTPRTKLVAVTHVSNVTGTVNPVKEIAALAHAHGALVLVDGAQSVPHL--PVdvqAL 205
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 334684745 206 GADVVVHSATKYLGGHGTAI-----------------GGVI--VDGGSFDFAADPERF 244
Cdd:COG0520 206 GCDFYAFSGHKLYGPTGIGVlygkrellealppflggGGMIewVSFDGTTYADLPRRF 263
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
69-244 |
2.48e-04 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 43.09 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 69 PTTDVVEKRLASLEGGVGALLVASGQSAATLALLNVAESGSHIVASPRlyggTHNLLHHTFAK---LGVEVTFIDDPD-- 143
Cdd:cd06502 32 PTTAKLEARAAELFGKEAALFVPSGTAANQLALAAHTQPGGSVICHET----AHIYTDEAGAPeflSGVKLLPVPGENgk 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 144 -DLESWRSAVQPNTKVFFAET----ISN--------PKQDILDIesvAAVAHEAGVPLIVDNT----IATPYLIRPLEW- 205
Cdd:cd06502 108 lTPEDLEAAIRPRDDIHFPPPslvsLENtteggtvyPLDELKAI---SALAKENGLPLHLDGArlanAAAALGVALKTYk 184
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 334684745 206 -GADVVVHSATKylgGHGTAIGGVIVdgGSFDFAADPERF 244
Cdd:cd06502 185 sGVDSVSFCLSK---GGGAPVGAVVV--GNRDFIARARRR 219
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
58-325 |
2.79e-04 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 42.99 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 58 EFGNIYT------------RIMNPTTDVVEkrLASLEGGVGALLVASGQSA-ATLALLNVAESGSHIVASPRLYGGTHNL 124
Cdd:cd00613 46 EFYTAYTpyqpeisqgrlqALFELQTMLCE--LTGMDVANASLQDEATAAAeAAGLAAIRAYHKRNKVLVPDSAHPTNPA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 125 LHHTFAK-LGVEVTFID-DP---DDLESWRSAVQPNTkvfFAETISNPKQD--ILD-IESVAAVAHEAGVPLIV--DNTI 194
Cdd:cd00613 124 VARTRGEpLGIEVVEVPsDEggtVDLEALKEEVSEEV---AALMVQYPNTLgvFEDlIKEIADIAHSAGALVYVdgDNLN 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 195 ATpYLIRPLEWGADVVVHSATKYLGGHGtaiGGvivdGGSFDFAADPERFpqfnqpdpsyngLRYAPD--LGVGGALGAN 272
Cdd:cd00613 201 LT-GLKPPGEYGADIVVGNLQKTGVPHG---GG----GPGAGFFAVKKEL------------VRFLPGrlVGVTKDAEGN 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334684745 273 LAFIL--KARVQ-LLRDLGPAASPFNAFLIA------------QGLETLSLRVerhVANAQRVAEWLT 325
Cdd:cd00613 261 RAFRLalQTREQhIRREKATSNICTGQALLAlmaamyivylgpEGLKEIAERA---HLNANYLAKRLK 325
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
127-211 |
3.16e-04 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 42.71 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 127 HTFAK-LGVEVTFIDDPD---DLESWRSAVQPNTkvfFAETISNPKQD--ILDIESVAAVAHEAGVPLIVD-NTIATPYL 199
Cdd:COG0403 173 KTYAEpLGIEVVEVPDEDgvtDLEALKALLDDDV---AGVLVQYPNFFgvIEDLRAIAEAAHAAGALVIVAaDPLSLGLL 249
|
90
....*....|..
gi 334684745 200 IRPLEWGADVVV 211
Cdd:COG0403 250 KPPGELGADIVV 261
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
101-226 |
1.75e-03 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 40.50 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 101 LLNVAESGSHIVASPRLYGGTHNLLHHtfaklgVEVTfIDDPDDLESWRSAVQPNTKVFFAETISNPKQDILDIESVAAV 180
Cdd:PLN02855 126 ILSVAEHHSNIVPWQLVAQKTGAVLKF------VGLT-PDEVLDVEQLKELLSEKTKLVATHHVSNVLGSILPVEDIVHW 198
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 334684745 181 AHEAGVPLIVDNTIATPYL---IRPLewGADVVVHSATKYLGghGTAIG 226
Cdd:PLN02855 199 AHAVGAKVLVDACQSVPHMpvdVQTL--GADFLVASSHKMCG--PTGIG 243
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
131-230 |
6.88e-03 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 38.38 E-value: 6.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334684745 131 KLGVEVTFID-DPD---DLESWRSAVQPNTKVFFAETISNPKQDILDIESVAAVAHEAGVPLIVDNTIATPYliRPL--- 203
Cdd:pfam00266 111 RTGARVRVLPlDEDgllDLDELEKLITPKTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAAQAIGH--RPIdvq 188
|
90 100
....*....|....*....|....*..
gi 334684745 204 EWGADVVVHSATKYLGGHGtaIGGVIV 230
Cdd:pfam00266 189 KLGVDFLAFSGHKLYGPTG--IGVLYG 213
|
|
| |
