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Conserved domains on  [gi|1042802542|gb|ANQ62189|]
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hypothetical protein AE940_16140 [Bacteroides fragilis]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 161-212 4.32e-03

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03389:

Pssm-ID: 469784  Cd Length: 186  Bit Score: 36.92  E-value: 4.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1042802542 161 FSALFSYNPVWWLcLFILVAGILGSARIILQHHTLGEVLAGFTVGFVCSLLV 212
Cdd:cd03389   132 AAALALLFPRYRW-AFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALAL 182
 
Name Accession Description Interval E-value
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 161-212 4.32e-03

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 36.92  E-value: 4.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1042802542 161 FSALFSYNPVWWLcLFILVAGILGSARIILQHHTLGEVLAGFTVGFVCSLLV 212
Cdd:cd03389   132 AAALALLFPRYRW-AFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALAL 182
 
Name Accession Description Interval E-value
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 161-212 4.32e-03

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 36.92  E-value: 4.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1042802542 161 FSALFSYNPVWWLcLFILVAGILGSARIILQHHTLGEVLAGFTVGFVCSLLV 212
Cdd:cd03389   132 AAALALLFPRYRW-AFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALAL 182
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 149-213 6.89e-03

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 35.51  E-value: 6.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1042802542 149 AGMGGIVGGLVSFSALFSYNPVWWLCLFILVAGILGSARIILQHHTLGEVLAGFTVGFVCSLLVL 213
Cdd:cd01610    58 AAFAFALALFLALLLPRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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