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Conserved domains on  [gi|302150276|gb|ADK96538|]
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acyl carrier protein [Prevotella melaninogenica ATCC 25845]

Protein Classification

acyl carrier protein( domain architecture ID 10011594)

acyl carrier protein functions as the carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Ontology:  GO:0009245|GO:0000036|GO:0000035
PubMed:  20662770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 1.35e-34

acyl carrier protein; Provisional


:

Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 112.57  E-value: 1.35e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302150276  1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEENAK 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 1.35e-34

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 112.57  E-value: 1.35e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302150276  1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEENAK 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 1-76 9.86e-27

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 92.46  E-value: 9.86e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302150276   1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEEN 76
Cdd:TIGR00517  1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEEN 76
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-78 8.77e-25

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 87.60  E-value: 8.77e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302150276  1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEENAK 78
Cdd:COG0236   3 REELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-68 1.35e-12

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 56.42  E-value: 1.35e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302150276   6 SKVKAIIVEKLGVDEAEVKPEASFTnDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGD 68
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
AcpM NF040636
meromycolate extension acyl carrier protein AcpM;
3-74 1.43e-11

meromycolate extension acyl carrier protein AcpM;


Pssm-ID: 468604  Cd Length: 93  Bit Score: 54.75  E-value: 1.43e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302150276  3 EIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIE 74
Cdd:NF040636  5 EIVAGIAEIIEEVTGIEPSEVTIEKSFVDDLDIDSLSMVEIAVQLEDKYGVKIPDEDLASLRTVGDAVAYVQ 76
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 8-56 3.01e-07

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 43.39  E-value: 3.01e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 302150276    8 VKAIIVEKLGVDEAE-VKPEASFTnDLGADSLDTVELIMEFEKEFGISIP 56
Cdd:smart00823 17 VREQVAAVLGHAAAEaIDPDRPFR-DLGLDSLMAVELRNRLEAATGLRLP 65
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 1.35e-34

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 112.57  E-value: 1.35e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302150276  1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEENAK 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 1-76 9.86e-27

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 92.46  E-value: 9.86e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302150276   1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEEN 76
Cdd:TIGR00517  1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEEN 76
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-78 8.77e-25

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 87.60  E-value: 8.77e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302150276  1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEENAK 78
Cdd:COG0236   3 REELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
acpP CHL00124
acyl carrier protein; Validated
 1-76 3.90e-23

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 83.53  E-value: 3.90e-23
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302150276  1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEEN 76
Cdd:CHL00124  3 KNDIFEKVQSIVAEQLGIEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQK 78
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 8-78 2.00e-22

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 83.59  E-value: 2.00e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302150276   8 VKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEENAK 78
Cdd:PTZ00171  75 VKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQNNM 145
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-68 1.35e-12

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 56.42  E-value: 1.35e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302150276   6 SKVKAIIVEKLGVDEAEVKPEASFTnDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGD 68
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
AcpM NF040636
meromycolate extension acyl carrier protein AcpM;
3-74 1.43e-11

meromycolate extension acyl carrier protein AcpM;


Pssm-ID: 468604  Cd Length: 93  Bit Score: 54.75  E-value: 1.43e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302150276  3 EIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIE 74
Cdd:NF040636  5 EIVAGIAEIIEEVTGIEPSEVTIEKSFVDDLDIDSLSMVEIAVQLEDKYGVKIPDEDLASLRTVGDAVAYVQ 76
PRK12449 PRK12449
acyl carrier protein; Provisional
 3-75 5.44e-11

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 52.78  E-value: 5.44e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302150276  3 EIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEE 75
Cdd:PRK12449  5 EIFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQ 77
PRK08172 PRK08172
acyl carrier protein;
3-75 1.84e-08

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 46.42  E-value: 1.84e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302150276  3 EIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEE 75
Cdd:PRK08172  4 DIEARVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMTTFADICRVVKK 76
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 8-56 3.01e-07

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 43.39  E-value: 3.01e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 302150276    8 VKAIIVEKLGVDEAE-VKPEASFTnDLGADSLDTVELIMEFEKEFGISIP 56
Cdd:smart00823 17 VREQVAAVLGHAAAEaIDPDRPFR-DLGLDSLMAVELRNRLEAATGLRLP 65
PRK06508 PRK06508
acyl carrier protein; Provisional
 1-56 1.31e-06

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 42.11  E-value: 1.31e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 302150276  1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIP 56
Cdd:PRK06508  1 MSSTFDKVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLP 56
PRK05350 PRK05350
acyl carrier protein; Provisional
 3-75 1.33e-06

acyl carrier protein; Provisional


Pssm-ID: 180033  Cd Length: 82  Bit Score: 41.51  E-value: 1.33e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302150276  3 EIESKVKAIIVEKLGVDEAEVKPEASFTNDLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEE 75
Cdd:PRK05350  6 EILERLRAILVELFEIDPEDITPEANLYEDLDLDSIDAVDLVVHLQKLTGKKIKPEEFKSVRTVQDVVDAVER 78
PRK05828 PRK05828
acyl carrier protein; Validated
 32-75 1.00e-04

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 36.77  E-value: 1.00e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 302150276 32 DLGADSLDTVELIMEFEKEFGISIPDDKAEKISTVGDAISYIEE 75
Cdd:PRK05828 34 ELKIDSLDMFSIIVSLESEFNIEFSDEKLMKLKNLADLILEVKE 77
AcpA COG3433
Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites ...
 1-55 1.39e-04

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442659 [Multi-domain]  Cd Length: 295  Bit Score: 38.19  E-value: 1.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 302150276   1 MSEIESKVKAIIVEKLGVDEAEVKPEASFTnDLGADSLDTVELIMEFEKEfGISI 55
Cdd:COG3433  217 TALTEEELRADVAELLGVDPEEIDPDDNLF-DLGLDSIRLMQLVERWRKA-GLDV 269
PRK09184 PRK09184
acyl carrier protein; Provisional
 1-76 2.56e-03

acyl carrier protein; Provisional


Pssm-ID: 181682  Cd Length: 89  Bit Score: 33.49  E-value: 2.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302150276  1 MSEIESKVKAIIVEKLGVDE---AEVKPEASFTND-LGADSLDTVELIMEFEKEFGISIPDDKAEKI---STVGDAISYI 73
Cdd:PRK09184  4 MTALERELAELIVEELNLEDvqpESIDADAPLYGEgLGLDSIDILEIALVISKRYGFQLRSDNPDNQrifASLRALAAYV 83


                ...
gi 302150276 74 EEN 76
Cdd:PRK09184 84 AAH 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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