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Conserved domains on  [gi|38304890|gb|AAR16185|]
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aquaporin 1 splice variant 2, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 1-39 5.21e-20

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member pfam00230:

Pssm-ID: 444743 [Multi-domain]  Cd Length: 223  Bit Score: 81.59  E-value: 5.21e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 38304890     1 CGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 39
Cdd:pfam00230 185 ASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 1-39 5.21e-20

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 81.59  E-value: 5.21e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 38304890     1 CGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 39
Cdd:pfam00230 185 ASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 1-39 5.49e-17

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 73.49  E-value: 5.49e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 38304890     1 CGINPARSFGSAVITH--NFSNHWIFWVGPFIGGALAVLIY 39
Cdd:TIGR00861 176 TGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 1-42 1.09e-16

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 73.06  E-value: 1.09e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 38304890   1 CGINPARSFGSAVITHNFS---NHWIFWVGPFIGGALAVLIYDFI 42
Cdd:cd00333 184 ASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
PLN00027 PLN00027
aquaporin TIP; Provisional
 3-42 1.40e-13

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 65.19  E-value: 1.40e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 38304890    3 INPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFI 42
Cdd:PLN00027 198 MNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 3-44 2.30e-13

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 63.99  E-value: 2.30e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 38304890   3 INPARSFGSAVI------THNFSNHWIFWVGPFIGGALAVLIYDFILA 44
Cdd:COG0580 185 INPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALFG 232
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 1-39 5.21e-20

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 81.59  E-value: 5.21e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 38304890     1 CGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 39
Cdd:pfam00230 185 ASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 1-39 5.49e-17

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 73.49  E-value: 5.49e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 38304890     1 CGINPARSFGSAVITH--NFSNHWIFWVGPFIGGALAVLIY 39
Cdd:TIGR00861 176 TGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 1-42 1.09e-16

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 73.06  E-value: 1.09e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 38304890   1 CGINPARSFGSAVITHNFS---NHWIFWVGPFIGGALAVLIYDFI 42
Cdd:cd00333 184 ASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
PLN00027 PLN00027
aquaporin TIP; Provisional
 3-42 1.40e-13

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 65.19  E-value: 1.40e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 38304890    3 INPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFI 42
Cdd:PLN00027 198 MNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
PLN00166 PLN00166
aquaporin TIP2; Provisional
 3-39 1.84e-13

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 64.96  E-value: 1.84e-13
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 38304890    3 INPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 39
Cdd:PLN00166 196 MNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIY 232
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 3-44 2.30e-13

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 63.99  E-value: 2.30e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 38304890   3 INPARSFGSAVI------THNFSNHWIFWVGPFIGGALAVLIYDFILA 44
Cdd:COG0580 185 INPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PLN00167 PLN00167
aquaporin TIP5; Provisional
 3-52 4.61e-11

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 58.38  E-value: 4.61e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 38304890    3 INPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTD 52
Cdd:PLN00167 199 MNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFPTQDDRGS 248
PRK05420 PRK05420
aquaporin Z; Provisional
 3-47 8.04e-07

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 46.11  E-value: 8.04e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 38304890    3 INPARSFGSAVITHNF--SNHWIFWVGPFIGGALAVLIYDFILAPRS 47
Cdd:PRK05420 185 VNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLLEKDD 231
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 3-42 2.83e-06

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 44.90  E-value: 2.83e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 38304890    3 INPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFI 42
Cdd:PLN00182 213 MNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLI 252
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 3-42 9.06e-05

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 40.61  E-value: 9.06e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 38304890    3 INPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFI 42
Cdd:PLN00183 215 MNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLL 254
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 2-45 1.15e-04

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 40.11  E-value: 1.15e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 38304890    2 GINPARSF----------GSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAP 45
Cdd:PTZ00016 238 ALNPARDLgprlfsailwGSEVFTKDNYYFWVPLVAPFVGAVLGMFLYDKFIPP 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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