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smart00020: Tryp_SPc 
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Trypsin-like serine protease
Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
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Statistics
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PSSM-Id: 128336
View PSSM: smart00020
Aligned: 189 rows
Created: 10-Apr-2009
Updated: 29-Apr-2009
Structure
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Program:
Drawing:
Aligned Rows:
smart00020 is a member of the superfamily cl00149.
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z8G_A      117 RIVGGR-DTSLGRWPWQVSLRYdg--------aHLCGGSLLSGDWVLTAAHCFpeRNRv-------lSRWRVFAGAVAQA 180
gi 82071612 469 ELTADK-DGKRRRYPWVVFINIqgk------spKKCLGSLVSSEFVLTAAHCF--IFSde------pqDVKVEIDDGKGS 533
gi 82228403 469 RIAGGD-PTKIELWPWQAQISMrvhisndhvkpAFCGGSIIAEQWILTAAHCF--DEFaitddewwrGSIDVVIGSSNKL 545
gi 74958232  39 KIRHGKpLTSIVKYPFMATVWQnd--------rKLCTASIVSPNYILSAGHCF--VKMs-------eENYIILVGTVNAK 101
gi 74958230  51 HIFKGKtIVDDKSLPWMARILSg----------VSCTATIIGPRHVLTAAHCV--EGQa-------lENFVVSYGSADAS 111
gi 71992117  15 ESCGIQqESKIKNFPWAVSFTVdg--------vNRLGGSIISPYHIITAAHG-----------------FITTIGSRGNL 69
gi 71984548  37 RIIGGN--SIDDGANWMAKLVSygdn----gqgILCGATVIDDFWLVTAAHCA--L--------------QLQTRSFVYV 94
gi 2738869   27 GVAGGH-EIPISDAPFVASIIRyknktqpkttvMIFGGSVIHERFILTAAHCF--LMYen------lTSEVIRVGSAQLG 97
gi 116116    27 LIRSGEpVQHPAEFPFIAFLTTer--------tM-CTGSLVSTRAVLTAGHCV--CSPl--------PVIRVSFLTLR-- 85
2ODP_A      222 vGNMSAnASDQERTPWHVTIKPks--------qETCRGALISDQWVLTAAHCF--RDGnd------hSLWRVNVGDPKSQ 285
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z8G_A      181 SPHGL---------------------------------------------------Q-LGVQAVV---YHGGYlpfrdpN 205
gi 82071612 534 --------------------------------------------------------KeKKVKTFK---LHPQY------N 548
gi 82228403 546 GGDKIs-------------------------------------------------pKqIIIHEGYn--RNPDA------H 568
gi 74958232 102 LEK-----------------------------------------------------GnGQQFKVE---KAHVY------S 119
gi 74958230 112 NQQHKsg------------------------------------------------vEaIKYHPKTqhyEIKDK------F 137
gi 71992117  70 CENKNwkkpnssiyrsikflrdtrkvayggtcirghtdkypndprckksdvihnkvRaVLVDGEFa--SSNCL------K 141
gi 71984548  95 REPKNnr------------------------------------------------eRsFSVKEAY---IHSGY------N 117
gi 2738869   98 VGG-----------------------------------------------------TtYEVEKVI---IHENF------N 115
gi 116116    86 --------------------------------------------------------NgDQQGIHH----QPSG------V 99
2ODP_A      286 WGKEFlie---------------------------------------------kavIsPGFDVFA---KKNQG------I 311
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z8G_A      206 S---------EENSNDIALVHLSSPlpLTE--YIQPVCLPAA--------------------------GQALVDGKIcTV 248
gi 82071612 549 VtarvkqgvaEFYDYDIALIQLERPvqLSI--SARPICIPCTket---------------------sdALRLPGSATcRD 605
gi 82228403 569 Vq-------iENLDNDIALIKLSKRltFGY--TYRPICLPCTketnaildlnsankdwttlcnihgknLIDVKKNTSlTV 639
gi 74958232 120 E---------TVFGQDIAIVKLKNSidFSDn-ATQPITLSRR--------------------------SNFTKT-DLaFI 162
gi 74958230 138 Rknt----raYLFLNDIVVIKIKNSikFSQ--NARPICLHGFhltnstksd---------gksikydeYSKFINNTQcVV 202
gi 71992117 142 G-------------HDWAIVEVEKRihFSE--NVRPICLPRP---------------------------NMYYT-KSlAV 178
gi 71984548 118 N---------QTADNDIALLRISSDlsKLG---IKPVCLVHDd-------------------------SKLLKQYKNgVV 160
gi 2738869  116 Pnnn----msLAFSHDIALLKLKEKycLHE---MYLNSLADK--------------------------DLEIVPYTLaNV 162
gi 116116   100 K---------VAPGYMPSCMSARQR--RPIaqTLSGFDIAIVm------------------------lAQMVNLQSGiRV 144
2ODP_A      312 L---------EFYGDDIALLKLAQK--VKMstHARPICLPCTm------------------------eANLALRRPQgST 356
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z8G_A      249 TGWGNTQY------Y-GQQAGVLQ----EARVPIISNDV---CNG---ADFYG-----------NQIKPKMFCAGYPE-- 298
gi 82071612 606 QEELLLKNqre-rlSfLTRTEPLVge-kDVYAKLGDNRDl--CIKkalKAKGIttt-----dpkVPVTDNFLCTGGDR-- 674
gi 82228403 640 TGFGLLEGd-------KKHAQQLQ----QATVQYAKKEV---CLKdimARFNVtee-----kaeKHITENMLCAWNAT-- 698
gi 74958232 163 AGWGRITD--------WSSPVTLQ----GANVLIWPKDEa-rCDG---------------------IMESEVCAFGED-- 206
gi 74958230 203 AGWGITKPtc---sNdDDKPLSGQl--iYGQMRMISKQK---CRElsiEYEKVftp-----sdgNPEVESMIEAFDAYs- 268
gi 71992117 179 PGWGRifn------------------esGPLIHEIPMRIdrdCKR---PWSDRl----------PADADDFICATSMNvs 227
gi 71984548 161 IGYGLTLGedssgePkLINSQTLQ----STSVPIISDDD---CVKtwrFLSLLs----------VKITGYQICAGAYL-- 221
gi 2738869  163 TGWVDLAIr--------QYFKDTT-----ASISRDKPIDe--CK-----MYP-------------WACKDEICIKSYN-- 207
gi 116116   145 ISLPQPSDip--ppGtGVFIVGYGr--dDNDRDPSRKNGg--ILK---KGrati------mecrHATNGNPICVKAGQn- 208
2ODP_A      357 CRDHENELln--kqSvPAHFVALNgsklNINLKMGVEWTs--CAE---VVSQEktmfpnltdvrEVVTDQFLCSGTQE-- 427
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1Z8G_A      299 --GGIDACQ---------GDSGGPFVCEDsisrtpRWRLCGIVSWGt----GCA---LAQKPGVYTKVS-DFREWI 355
gi 82071612 675 ---DHIACT---------GDSGGAVFKNYe----sRTIQIALVSWGtq--eICT---GGGMRETTPESRdFHINLF 729
gi 82228403 699 ----ADTCR---------GDSGGPLVLQKn----rRWIQVGIVAGGva--qHCG---KNIKSSFYTNVA-KMMPWV 751
gi 74958232 207 ---GANVCF---------GDSGGPLLVKSyd--gqRWEQIGVTSRGn---fVCE------SNGFFSCVY-IYCEWL 258
gi 74958230 269 --IKSNICVvpeqsigepGDSGGPLMSKVgk---nNWGQLGVLTKG-----DCRpknPTSTEGLFAQYApIDCEWV 334
gi 71992117 228 nySAPRTCH---------GDSGGGLEYRDdn--ygRAFLIAITSFGt---rGCP----SNMLARFTRVD-MYLNLI 284
gi 71984548 222 ----HGTAP---------GDSGGPLLIHKsn---gEYVQIGITSYGadgldGVId--QGKFPGvytriskyvpwiq 279
gi 2738869  208 ----KGSCK---------GDSGGPLTMHG--------VQVGIVSNGl----GCG-----TMPTIHTKIS-FLRPWI 252
gi 116116   209 --fGQLPAP---------GDSGGPLLPSL------QGPVLGVVSHGvt--lPNL----PDIIVEYASVA-RMLDFV 260
2ODP_A      428 ---DESPCK---------GESGGAVFLERr----fRFFQVGLVSWGly--nPCL-----GSADKNSRKR-APRSKV 479
Citing CDD
Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res. 37(D)205-10.
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