4DKK


Conserved Protein Domain Family
Staufen_C
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pfam16482: Staufen_C 
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Staufen C-terminal domain
This is the C-terminal domain of Staufen proteins. It consists of an N-terminal Staufen-swapping motif (SSM) comprising two alpha helices, connected by a linker region to a dsRNA-binding-like domain ('RBD'). The 'RBD' has the fold of a functional dsRNA-binding domain, but lacks the residues required to bind RNA. This domain is responsible for dimerization, the SSM from one molecule interacts with the 'RBD' of another.
Links
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Statistics
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PSSM-Id: 465131
Aligned: 6 rows
Threshold Bit Score: 165.077
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4DKK_A         5 SKATVTAMIA--RELLYGGTSPTAETILKNNISSGHvphgpLTRPSEQLDYLSRVQGFQVEYKDFPKNNKNEFVSLINCS 82  human
EEC05302     527 GDLQASSAIA--KELLDQGVSPTAEALRQAAPLTVA-----PVRPKQQLLYLAEVLGFQVHFTDFPKGNKRDFLSLVTLT 599
1_pfamImport   2 TKATVTAMIAmiAGKLYGGTLPTAKTILKNNISLGHvpqgpLTHP---LSNCPRVQGFQVEYKDFPQ-NKNKFVSCINCS 77 
NP_957219    526 PSVGNTATIA--KELLLSGTSPTAEA-LVLKGKAPAla-cgSIQPSQQLEYLAHIQGFQVQYSD--RQTDKEFMTYLTLS 599
NP_001011376 555 VSQSCTAAIA--RELLTNGTSPTAEA-IGFTGKNLMch-ssTVQPSKQLEYLAGIQGLQVNYSD--RQSGNDFLTCLTLS 628
XP_014349083 537 SNTSNTATIA--RELLLNGTSPTAEA-IGLKGKTPVsp-csAVQPFQQLEYLARIQGFQVQYSD--RQNGKECMTYLTLS 610

4DKK_A        83 SQPPLIS-HGIGKDVESCHDMAALNILKLLSELD 115 human
EEC05302     600 TCPPQVS-HGAGSSLEASHDEAALAVLRTLARRG 632
1_pfamImport  78 SQPSLIL-HGIGNNVESFHNMAALNILKLLPELD 110
NP_957219    600 --PVQMTfHGIGSSIPASHDQAALSALKQLSEQG 631
NP_001011376 629 --PVQMTfHGIGSSLEASHDQAALSALKQFSEQG 660
XP_014349083 611 --PVQMTfHGIGSSIEASHDQAALSALKQLSEQG 642
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