Conserved Protein Domain Family
HU-CCDC81_euk_1
?
pfam14908: HU-CCDC81_euk_1 
CCDC81 eukaryotic HU domain 1
This is the first of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules.
Links
?
Statistics
?
PSSM-Id: 464364
Aligned: 32 rows
Threshold Bit Score: 77.6855
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_004035822   18 PGKHQNQQNRTNPDLkP--LNLMDQFKIIFKALKVYIYERMLEGNSLNLHNFGIFGFEicqdts---------------- 79  
CEM00581      266 PGPHTEPQPRTSQGLvP--MDTTRQLLLIWDAFCDYLIENMEKANSVHIPNFGTFMFEnivrvnrtgvlakdeftlsaie 343 
A0E856         20 SKIATRNGQADNGSLiA--ALDEETVSAAWNAFGLHVSRQLRMGRGVAVNKFGTFSFS---------------------- 75   Paramecium te...
Q22HG4         22 LDEVSYKSGTKIYSLqG--LLTDETVNSVWGSFGLYISKQLRSGRSVKIPHFGVFTFT---------------------- 77   Tetrahymena t...
XP_004035151   20 INEVSLMNNSKLFQLqG--VIDPEILHNVWFSLGKYIQRQLQVGRSVILPKFGLFTFS---------------------- 75  
EGR32802       24 LASVTQKSSTKLYRFkG--IFDSEDIRVSWNAFGLYLSRQLRMGRAVHIQNFGTFTFS---------------------- 79  
Q4CQT9         42 ASIVASTQGLYYHQTrG--NGGTDLLNRIWRSMGELLEEQLLLKRSCIVTDFFHASVK---------------------- 97   Trypanosoma c...
Q4Q0Q1         20 AEIVTHAGGVYMLQTkR--QGTAHQLNAIWRVLGEQLEEMLIKKRSGIVLDFLHASIK---------------------- 75   Leishmania major
Q383J9         23 ANIVAQMGGLYCHQSr---NAGPQLLCRIWRTLCESVEETLVRKRSCIIPDFLHASIK---------------------- 77   Trypanosoma b...
XP_001022528   19 LEEVAKQSQSKIYRLtGtsILDDEQVRVAWNAFGLYISRNLRMGRGVSIPNFGTFTLS---------------------- 76   Tetrahymena t...

XP_004035822   80 ----rptihSNLCEIAKDFQNNISDrlhkhrmrPFFAPDKNLKNALVRYP 125 
CEM00581      344 pinrthkqaAPDGMQYADMPTYLRPdgl--earACFNVDEKLKGVLHRFP 391 
A0E856         76 ---------APDVILDGVTNPVERDkqp---rqPVFLVAKEFVNGFNLKT 113  Paramecium tetraurelia
Q22HG4         78 ---------NPDVTLPGVTNPDIRDkql---rePVFIVQKDFLNGIPIQS 115  Tetrahymena thermophila SB210
XP_004035151   76 ---------FPDVNLQCTTNENVRNpqn---rePVFAISKEFAQGLNLKS 113 
EGR32802       80 ---------APDYKLEGCSNPWERDkql---rnPVFLVSKDFIKGGDLKQ 117 
Q4CQT9         98 ---------VQNIQYYDGKHVFYK---------LQLVLLPDFTSKFHLQN 129  Trypanosoma cruzi
Q4Q0Q1         76 ---------VQRVMLFDKSVAIELK--------PQLVLLPDFTSKFHLKN 108  Leishmania major
Q383J9         78 ---------VQRVSPFDGEINLYK---------PQMVLLPDFLSKFHVQN 109  Trypanosoma brucei
XP_001022528   77 ---------APEISLEGVTNKTLREkqg---rqPVFIVSKEFCNGKDIKS 114  Tetrahymena thermophila SB210
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap