5D0F


Conserved Protein Domain Family
hDGE_amylase

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pfam14701: hDGE_amylase 
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Glycogen debranching enzyme, glucanotransferase domain
This is a glucanotransferase catalytic domain of the eukaryotic variant of the glycogen debranching enzyme (GDE). The eukaryotic GDEs performs two functions: 4-alpha-D-glucanotransferase, EC:2.4.1.25, and Amylo-alpha-1,6-glucosidase, EC:3.2.1.33, performed by the, respectively N- and C- terminal halves of eukaryotic GDE enzymes. The domain is a catalytic domain responsible for the glucanotransferase function. It belongs to the alpha-amylase clan and is predicted to have a structure of a 8-stranded alpha/beta barrel (TIM barrel) where strands are interrupted by long loops and additional mini-domains. In most other amylases, the catalytic domain is followed by a beta- barrel substrate binding domain, but presence of such a domain cannot be verified in the human (and other eukaryotic) GDE enzymes.
Statistics
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PSSM-Id: 434141
Aligned: 54 rows
Threshold Bit Score: 529.48
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5D0F_B                    139 KFIPLNSIAMQSVVSKWMGpTIKDWEKVFARVASKKYNMIHFTPLQHRGESNSPYSIYDQLEFDPTVF------KSek-e 211  [...
XP_002050859              289 KIIPLNSIRCQTVMAKLLG-PLHTWEAKLRVAKESGYNVIHFTPIQELGGSRSGYSLRDQLSVNPNFAakk-geRVtfdd 366 
EFN82290                  130 EDLSLDCIQIQTILAKCLG-PFSTWEDKLLVARNSGYNALHFTPIQELGHSKSSYSLSDQMKLNPSFhdn--nkIItyhd 206 
XP_002427706              152 DILPLNSIAVQTVLAKSLG-KFENWKNVLKVSKESGYNMVHFTPIQELGGSNSSYCIKDQLNLNPAFnsd--ncCPnyed 228 
O62334                    107 KCLPLDGIACQTYLTKLLG-PLSEWKERLEVAHQTGYNMIHLTPIHELGISNSSYSLSDHHSLIKTIqsq--dqKFgfed 183  C...
P35573                    120 HVLPLDCVTLQTFLAKCLG-PFDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSLANQLELNPDFsrp--nrKYtwnd 196  h...
Q0IHS6                    120 RALPLDCITLQTYLSKCLG-PLDEWEDRLKVAKEAGYNMIHFTPLQTLGESRSCYSLADQLQLNPDFsrp--gkVYgwdd 196  t...
XP_015146234              120 HVLPLDCVTLQTFLAKCLG-PFHEWENRLKVAKETGYNMIHFTPLQKLGLSRSCYSLADQLEVNPEFssh--nkKCtwnd 196 
EEN59872                  232 DVLPLDSICIQTVLSKCIG-PFSNWERCVRVSKETGYNMVHFTPIQALGESNSSYCISDQMRINPAFeed--grTLtydd 308 
WGS:AAFB:cds.EHI_098360A  109 KRIPINGLTIQTHIVKIMG-KIDTWEEHYRTMKECGYNCIHLTPIQKIGPSGSAYSISEHLDIENNIFkeemskEEkyqk 187 
5D0F_B                    212 VADMVERLRTEHNILSLTDIVFNHTANNSQWLLDHPEAGYNHKTSPHLISAIELDKKLLDFSEQMea-----lgYPVDLK 286  [...
XP_002050859              367 VEKVIKKCRQEWGVASICDIVLNHTANESDWLLKHPDATYSCATCPYLRPAFLLDAALAQCSEDIaagklehvgVPEIID 446 
EFN82290                  207 IERFVNMMRTEWKMLSICDIVLNHTANESPFLVSHPECTYNCVNSPHLRPAYILDAALFELSIQVasgdwefkgIPAVIE 286 
XP_002427706              229 VMKLTSEMRKEWRILSISDVVLNHTANETPWLQVHPECTYNAITAPYLIPAAILDGHLHVLTKEIssgkheeigIPSEIY 308 
O62334                    184 VQALVGDLERSWNILTVQDVVWNHAAKNATWLLEHPESAYNCLNSPHLRPAYVIDRVYHEFGKQIgegvwehrgVPPVVD 263  C...
P35573                    197 VGQLVEKLKKEWNVICITDVVYNHTAANSKWIQEHPECAYNLVNSPHLKPAWVLDRALWRFSCDVaegkykekgIPALIE 276  h...
Q0IHS6                    197 VGKLVEKMRKEWNMLSITDVVYNHTAANSKWIQQHPECGYNLVNSPHLKPAWLLDRALWHLTCDAaegkyaakgLPALIK 276  t...
XP_015146234              197 IGALVEKMKNEWNMLCITDVVYNHTAANSEWLRMHPECGYNLVNSPHLKPAWVLDRALWHLSCMVadgrcidkgVPPLIE 276 
EEN59872                  309 VGEFVRRIHKDWGVLTVTDLVLNHTSWDSPWLVEHPECGYNLLNSPHLRPAYLLDRALAYFSGQVadgqwegqgVPANIT 388 
WGS:AAFB:cds.EHI_098360A  188 IEESIYQLRNKYQIGSIIDIVLSHISSKSPLVIEHPEICYTIEKCPHLKIGYKFDSLIHQCIIDIikdky---peglgIF 264 
5D0F_B                    287 -TVDDLIKVMDGIKEHVIGELKLWEFYVVDVKQTVSELREKWgnskswsdDNIP--SKDdstn---laqFVRD---NAte 357  [...
XP_002050859              447 -QECHLEALKYQLHHAYLSKVNIHELYQCDVMKYVNEFMSQV--------RTREppKNVakesrfqeiqLIQD---PAyr 514 
EFN82290                  287 -TEDHLNAIRHALHSHFLPLVKIHEMYIVDIHEIIAEFLNLA----------RNemPQDvsdakgkdisVIQD---PNfr 352 
XP_002427706              309 -THDHLEAVKNYLTKNLIPQLRLHEFYTADVTKLSDEFLEKA-----------KaqIPTletcsrtelkLINN---FNgr 373 
O62334                    264 -NIHHVNAIEYLLRAEVLPKADLHEFYQVDLKAMVNLFEV-----------------------------FIKQssgPTtn 313  C...
P35573                    277 -NDHHMNSIRKIIWEDIFPKLKLWEFFQVDVNKAVEQFRRLL----------TQenRRVtksdpnqhltIIQD---PEyr 342  h...
Q0IHS6                    277 -TDQQLNSIRGIVWEEIYPRIKLWEFYQVEVDKAVKQFRALL---------TSGaqKKGnksdp-khlmIIQD---PEyk 342  t...
XP_015146234              277 -NDHHLNCIRKIIWEDIYPKIKLWEFFQVDVNKAVQQFRTLL-----------TkgKIGtksdpnqhlqIVQD---PDyr 341 
EEN59872                  389 -NDGHIRAMERILLEQVLPELKLWEFYCADVEDLVQQFKEAC---------EEVgnALPeaggkkyqltVVQD---PAyr 455 
WGS:AAFB:cds.EHI_098360A  265 hTENDVYRFMEYFKEKYIIPGEFWLYYVIDVNKHKEEYLK-----------------------------YEKE---HKeg 312 
5D0F_B                    358 pgfg------------------slgergSNKINIDKFAAILKKLHsedy-----nngiEELATKILNDINLPFYKEYDDD 414  [...
XP_002050859              515 --------------------------rlGSTIDFELALDIFNAFHgdcfdeesrfrkcAETLRHHLDALNDQIRAELQGH 568 
EFN82290                  353 --------------------------klKSTINMQLALQKYNTYRadcfdedtrlkrcAEDLKHKLEELNEVIINDLRNH 406 
XP_002427706              374 ---------------------------nKATVNLDLALKIFNIIRndttdeetrlaenVNDFKKRILDLNSEIKNEIGIH 426 
O62334                    314 pldgedve----------ieqdlecrrfGNTVDFERSARIFNRHRgdakseeervekcVRSFEEALNNKNLEAARESWEV 383  C...
P35573                    343 --------------------------rfGCTVDMNIALTTFIPHDkgpaa----ieecCNWFHKRMEELNSEKHRLINYH 392  h...
Q0IHS6                    343 --------------------------rfGCSVDMDTALNTFIPHSngpsa----ieecCTWFRKRLEELNAEKHRQMNFH 392  t...
XP_015146234              342 --------------------------rfGCTVDMNIALATFIPHSngpga----ieecCNWFRKRIEELNAEQYRHIHHH 391 
EEN59872                  456 --------------------------rlMSSVDLGRALTIFNVERtdaetekeriqkcSEAFRKHLEKLNADVTRDLQHH 509 
WGS:AAFB:cds.EHI_098360A  313 krgkegspeelakrlekyvmvdgsyeknHIRINIEkgfe---------------evpnLEGFIKAIDVLNVDNYRKYDED 377 
5D0F_B                    415 INEVLEQLFNRIKYLRIDDHGPKQGpITKKLPLSEPYFTRF-------KAKdg-------eeYALANNGWIWD-GNPLVD 479  [...
XP_002050859              569 LNYAIENCLAGVRYERVQQDGPRVReISITHPVFMTYFTHTrtegkslQEIeedmy-gpageFFMAHNGWVMGsSDPLLD 647 
EFN82290                  407 LNAAVENTVASIRYFRVQSDGPKIKeISEKNPLVPRYFTDYgap-rslTERentmy-sdngcYLMAHNGWVMN-SNPLKN 483 
XP_002427706              427 LSSAIENCIANMRYFRIQEDGPKIKsVSEENPLVPRYFTGKfenydsvENEvlk-----ngqYVMAHNGWVMN-SDPLKN 500 
O62334                    384 ILAGLAAVMGGITYERIADNGPKKGlVSPENPLTTDYFLHLead-lgwKSEekfaydpekskFLMAFNGWVMS-SDPMKN 461  C...
P35573                    393 QEQAVNCLLGNVFYERLAGHGPKLGpVTRKHPLVTRYFTFPfee-idfSMEesmihlpnkacFLMAHNGWVMG-DDPLRN 470  h...
Q0IHS6                    393 HEQAVNCILGTMTYERLAGQGPKLGpITKKDPIVTRYFTFPfkd-mslSEEesmmhqpdkacYFLAHNGWVMG-DDPLRN 470  t...
XP_015146234              392 QEQAVNCLAGTVVYERLAGHGPKLGpISRKYPLVTRYFTYPfkd-ltvEEEqsmmhqpdkacYFMAHNGWVMG-DDPLRN 469 
EEN59872                  510 LKAAVENCGKGVGYERLDGQGPKLGpVTRQKPLVTEYFRLLngqndswQADeklmn-kkdarHILAHNGWVMG-DDPLRN 587 
WGS:AAFB:cds.EHI_098360A  378 INAAIQNCTNTIKYKCFDEAGPRIEkVSKEEHILPYYFEVIdgknsk----------gekvhIVAAHHGWVFG-GDPFFD 446 
5D0F_B                    480 FASSQ---SKAYLRREVIVWGDCVKLRYGKGPSDSPYLWERMSKYVEMNARIFNGFRIDNCHSTPLHVGQYFLDVARRVN 556  [...
XP_002050859              648 FAEEQvnrGNVYLKRELIAWGDSVKLRFGKRPEDSPYLWQHMTEYVEKTARIFDGVRLDNCHSTPLHVAEYLLDAARKIN 727 
EFN82290                  484 FADPD---SNVYIRRELIAWGDSVKLRYGEKPEDCPFLWRHMTAYVEQIAQIFDGIRLDNCHSTPIPVAEYMLDAARKIR 560 
XP_002427706              501 FAESD---SNVYLRRELIAWGDSVKLRYGKSYQDCPFLWNHMEKYVEKTAEIFDGIRLDNCHSTPLHVAEYLLDCARKIN 577 
O62334                    462 FALKE---SQVYLRRELVCWGDSVKLNYGNKEADSPFLWQYMKEYTQQAARIFHGLRIDNAHGTPIHVAEKLLKTAREVR 538  C...
P35573                    471 FAEPG---SEVYLRRELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEITATYFQGVRLDNCHSTPLHVAEYMLDAARNLQ 547  h...
Q0IHS6                    471 FAGPD---SNVYVRRELICWGDSVKLRYGDKPSDCPYLWEHMKKYTEITAKHFHGVRLDNCHSTPIHVAEEMLAAARSVR 547  t...
XP_015146234              470 FAEPG---SNVYLRRELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEITAKHFHGVRLDNCHSTPIHVAEEMLATARSVR 546 
EEN59872                  588 FAEAG---SNVYLRRELLAWGDNVKLRYGKRPEDCPFLWKHMLEYTMATARIFHGVRIDNCHSTPIHVAEFMLDAARQVN 664 
WGS:AAFB:cds.EHI_098360A  447 FVGDNk--SKVYIRREAVVWEDSLKLNYGRKYEENKFLWDYMGEYGMSNAKIFNGFRLDNCHSVPLEALEFIIEKSREVN 524 
5D0F_B                    557 PNLY 560  [Candida] glabrata CBS 138
XP_002050859              728 PELY 731 
EFN82290                  561 PNLY 564 
XP_002427706              578 PDLY 581 
O62334                    539 PDIY 542  Caenorhabditis elegans
P35573                    548 PNLY 551  human
Q0IHS6                    548 PNLY 551  tropical clawed frog
XP_015146234              547 PNLY 550 
EEN59872                  665 PDLY 668 
WGS:AAFB:cds.EHI_098360A  525 PELI 528 
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