Conserved Protein Domain Family
APP_Cu_bd

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pfam12924: APP_Cu_bd 
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Copper-binding of amyloid precursor, CuBD
This short domain, part of the extra-cellular N-terminus of the amyloid precursor protein, APP, can bind both copper and zinc, CuBD. The structure of Cu2+-bound CuBD reveals that the metal ligands are His147, His151, Tyr168 and two water molecules, which are arranged in a square pyramidal geometry. The structure of Cu+-bound CuBD is almost identical to the Cu2+-bound structure except for the loss of one of the water ligands. The geometry of the site is unfavourable for Cu+, thus providing a mechanism by which CuBD could readily transfer Cu ions to other proteins.
Links
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Statistics
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PSSM-Id: 193397
View PSSM: pfam12924
Aligned: 18 rows
Threshold Bit Score: 85.8084
Threshold Setting Gi: 74785974
Created: 30-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam12924 is a member of the superfamily cl15167.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
3KTM_A       116 KCKFLHQERMDVCETHLHWHTVAKETCS------EK-----STNLHDYGMLLPCGi-DKFRGVEFVCCP 172
gi 122114745 131 HCIFDHYHDPRVCNEFDQCNETAMSKCS------AR-----GMTTQSFAMLWPCQepGHFSGVEFVCCP 188
gi 74884299  135 SCLFDHIHNQSRCWQFARWNATAGRACA------QR-----GLRLRTFAMLLPCGi-SLFSGVEFVCCP 191
gi 157111458  78 GCLFDHIHNASRCWPFIRWNQTGAAACQ------DR-----NMQMRSFAMLLPCGi-SLFSGVEFVCCP 134
gi 426388338 149 GCRFLHQERMDQCESSTRRHQEAQEACS------SQ-----GLILHGSGMLLPCGs-DRFRGVEYVCCP 205
gi 224549203 144 vCKFYHKHDEQMCREPEYWKGVAEEDCR------GK-----KMGINSTGMLLPCGt-DKFKGVEYTCCP 200
gi 241798334 115 HCLFDHIHNQSVCQSFDDWNQTAAHSCQ------GR-----SMRLRSFAMLLPCGv-DIFSGVEFVCCP 171
gi 260836255 102 KCKFSHIHNSSVCTTFFKWRDAAKEACD------KS-----GFDLHNFAMLKPCGv-DLFTGVEFVCCP 158
gi 170588981 140 GCRFGHINDRQSCNDYAHWKDAAYKHCK------TKvvndkRMAVRSFAVLEPCGl-DLFTGVEFVCCP 201
gi 268579317 134 DCQFSHVNSRDQCNDYQHWKDEAGKQCSgkkakdTK-----SMIVRSFAVLEPCAl-DMFTGVEFVCCP 196
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