6UCC


Conserved Protein Domain Family
ParcG

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pfam10274: ParcG 
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Parkin co-regulated protein
This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.
Statistics
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PSSM-Id: 431190
Aligned: 21 rows
Threshold Bit Score: 167.469
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6UCC_A        70 TAFRKFYERGDFPIALEHDSKG----NK--IAW--KVEIEKLDYH---HYLPLFFDGLCEMTFPYEFFARQGIHDMLEH- 137
XP_001421353   1 TRFRQKYDAGEIPARVAHGTGA----NA--IAW--RVDPSALDAS---AYLPLFIDGLKETKHPYRLLAVRGGIELTRAc 69 
Q19060       132 SQFRALFSRGDLHVRIIHSGGAgekpRE--LRW--AKDPSQMKNEticNLLAKFSTGMSLLDHPYRFVAETGITDLLIAl 207 Caenorhabditis ...
Q9D3X5        78 TAFAAIYSQGGIPCRLVHGSVK----HR--LQW--ECPPEILPFD---PLLITLAEGLRETKHPYTFVSKEGFRELLLVk 146 house mouse
EDO38477      21 SSFAAVYASGGVPCRLIHGSVK----HK--LQW--DTPPDNLPFD---PILITLAEGLRETKHPYTFVAREGFREMLDVe 89 
A0EGZ7        70 NSFAYVYNAGGIPCRVNHGCNT----MK--LQWnqGVEIGHLPYD---PLMVTCFEGLVEEAHPYCFIATNAIKDMLNEq 140 Paramecium tetr...
Q7QBN7        35 SRFRGFFLRGDIPISRECGTRC----VKhfIKW--HTPPEQLNYQ---RFLPLFFDGLCESTFPYREFARHGVSDLLIAg 105 Anopheles gambi...
A0CJS0       128 SDFRRYYDRGDLPIKVDHQGSV----NR--IIW--KISPEQLDYH---HYLPIFFDGLREKMDPYRFLAILGTYGLLEN- 195 Paramecium tetr...
A0CXV6        84 TLFKKYYDRGDLPIAVNFSGAV----RK--IVW--KCEPECLDYH---LYLPIFFEGLRETEDPYKFLAVNGCEELLQK- 151 Paramecium tetr...
Q9VIX9        65 TVFKIYFNRGDIPCVMSGRSSKqdptKErpVKW--HCVPENLDYC---YYLPIFVDGLADMDYDTRLLAVNGAIDLIMRs 139 fruit fly
6UCC_A       138 -----------GGnKILPVLPQLIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVLNIFKNMN-- 204
XP_001421353  70 -----------GErALLDALPRSVLPMKEALGTGDMAVTAVALELLREFVKVSPSIGEALVPYYRNLLPALNALKDVSdv 138
Q19060       208 ----------rNHqSIVTVLPQLVRGIRAGLYSFDIEKKKFCLKTLSRI-TAMQGIGAQLVPFYRQLLPPLRTVRQSR-- 274 Caenorhabditis ...
Q9D3X5       147 ----------gAPeKAIPLLPRLIPVLKAALVHSDDEVFERGLSALVQL---SVVVGPSLNGHLKLLLTSLS----KR-- 207 house mouse
EDO38477      90 ----------dSPeRTTPILPKLVFPLRAALSAPDLEVFQNSLDALVQL---SFVVREALNPHLKTLLPHVS----RR-- 150
A0EGZ7       141 vlnlnfiifqnAQeKVIPILAKLVWPLRTALSSQNDKVFMSSLEILKLL---SNTIGSHLNSHLKNLLVPLS----KR-- 211 Paramecium tetr...
Q7QBN7       106 -----------TErQIFQTIPMLILPMREALNTRNPDIIIATLNALQQLLRVGPSIGIALVPYYRQLLPMLNLYKQRR-- 172 Anopheles gambi...
A0CJS0       196 -----------GGnKILPVIPQLIIPIKTNLNTRDPSIMEVQLKVLQKLVLSGEMVGEALVPYYRQLLPIMNLYKNRN-- 262 Paramecium tetr...
A0CXV6       152 -----------GEtKILSVLPQLIIPIKKALATKNHDIMCITLKKIQKLVKSGQMIGEALVPYYRQILPVMNMYKNKR-- 218 Paramecium tetr...
Q9VIX9       140 -----------PK-KVLPVLPKLILPLKRAFQTRDKRIIISALQVIQLMVRLGPCVGQALVPFYRQLLAVCNLYKNIN-- 205 fruit fly
6UCC_A       205 ----VNSGDGIDYs---qQKRENIGDLIQETLEAFERYGGENAFINIKYVVPTYES 253
XP_001421353 139 yvslVNLTDCRSWrephrRSRRNIGSLVRATLRALERRGGADALVNIKYQIPTYQS 194
Q19060       275 -----SRSDRVHY-----DKGRQIEEIITSTLNDLERSGGPNALINIKYLLPHYES 320 Caenorhabditis elegans
Q9D3X5       208 ------------------LMDKKFKEPITSALQKLEQHGGNASLIIIKSKIPTYCS 245 house mouse
EDO38477     151 ------------------LMDKSLKEKIISSLQHIERNCGRESLPIIKLKVPTYQS 188
A0EGZ7       212 ------------------MDKKNQKEIIQDVLRQIQDNGGPDTLKVIKAAIPTYTN 249 Paramecium tetraurelia
Q7QBN7       173 ----VNIGDHIDF-----RGGRRIGDVVNATLELLEQCGGPDAYLNIKYMVPTYES 219 Anopheles gambiae str. PEST
A0CJS0       263 ----SNLGDFIEYn---qRKRVNVGDLIQETLELFEQTGGEDAYINIKYMIPTYES 311 Paramecium tetraurelia
A0CXV6       219 ----LNIGDKIDYs---qRKNENLSDLIQETLETLEKNGGEDAYINIKYMIPTYES 267 Paramecium tetraurelia
Q9VIX9       206 ----VNLGEGIDP-----DRNCRIGDVIEDTLKLLEYCGGPNAFINIKYMVPTYES 252 fruit fly
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