Conserved Protein Domain Family
NSRP1_N

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pfam09745: NSRP1_N 
Nuclear speckle splicing regulatory protein 1, N-terminal
This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
Statistics
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PSSM-Id: 462876
Aligned: 120 rows
Threshold Bit Score: 67.9339
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002290961  69 AEAAMAKSSLGDSAVYDYDGEYDSFASGkklEEEKKa-----AAAAARradpPkeSRYVSGLLKAAQRRTQEQEIIYERK 143
A0BIA1        28 AQQLVSSNLIEDPSLYDYDGFVSK-------KNKSEkalviqKQTEDKks-kQ--PQFLNSILEQSKRREFEREATKSRM 97  Paramecium tetr...
PDM65868      99 AERQHELAKAEDPSIFDYDANYEEDERL---KSQKMa-----DQKAKDev-rA--SKYAEAIMLSHQRRELERVSREERQ 167
Q09252        56 AEREHQKAEAEDPTIFDYDGNYDEIQAI---KNEKKe-----EARKADkn-rE--SKYAENIIKAHARRQLEQFSREERQ 124 Caenorhabditis ...
GAC71753     126 ERKKQEEAEALDASVFDYDGVYDTIKEA---ERQVKq-----SKVAEDas-kK--PKYVEGILESAELRKRDRLRAEARM 194
KIS69358      86 ERKKQEEAEQLDASIFDYDGVYDIIKDA---ERKVKq-----AKLAQDat-kK--PRYVDGILESAEQRKRDRLRAEART 154
EKD05325      90 ERKAQEAALALDASVFDYDGVYDTMKAA---ERRVEe-----AKAASEdk-tK--PKYIESFLAAAQTRKLDRLRAEEKM 158
Q5K9B4        93 ERRAQAAAQAIDQSIFDYDSHYEQMKAA---ERVAEe-----VKKKESee-rK--PKYIENFLASAQTRKLDKLRAEEKM 161 Cryptococcus ne...
EIM20574      13 LAKQLDEAKKIDESVFEYDEVFDQMQAA---REAVEs-----SRKKESat-rA--PKYIEGLAHAAEKRKLDRSRAEEKM 81 
O14009        52 AASDASKDDNYDASIYGFDEFYDSMKSA---EREQMe-----LKRLESkd-rR--PKYMENLIESAKKRKRDLLLARERA 120 Schizosaccharom...
XP_002290961 144 VAKDQAVEDAemQYDGKEKFITSSYKRKLAEREAWVQQEKEREKKEEDEDVTKK 197
A0BIA1        98 NAKEAIKS-------GKEVYISESFKQQHEQIKRFEQIEQIQEKINDESRKRSN 144 Paramecium tetraurelia
PDM65868     168 QQKEREAENG--EFADKEVFVTGAYRKQMEEVAKLREEEAYEARFNAMTAVEKQ 219
Q09252       125 QLREREKEGD--EFDDKEVFVTGAYRKQQEEVKKHREQEAEEAAFNDMTSVQKQ 176 Caenorhabditis elegans
GAC71753     195 IQKQREAEGE--EFADKEAFVTNAYKQQQAELAKAEELESKAEAKRRDTDKGMG 246
KIS69358     155 IQRQRQAEGD--EFADKESFVTNAYKEQQAELAKAEEEQHKNEEMQRSSNKGIS 206
EKD05325     159 LQREREKEGD--EFDDKEKFVTEAYKKQMEEVRKAEEEEKAREEALKRSNKGPG 210
Q5K9B4       162 LEREREKEGD--EFEGKEKFVTEAYKRQMEEVRKAEEEEKAREEALRKGQKGPG 213 Cryptococcus neoformans
EIM20574      82 IQKTREKEGD--EFAGTEEFVTEGYKQTLAEIKKAEEEEEAREKKEVESRGVGA 133
O14009       121 LLKKNELEGD----DATEKFVTSSYKKHREEVQKAIEDRKEEDEKSITDTTTGM 170 Schizosaccharomyces pombe 972h-
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