Conserved Protein Domain Family
Dymeclin

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pfam09742: Dymeclin 
Dyggve-Melchior-Clausen syndrome protein
Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.
Statistics
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PSSM-Id: 462873
Aligned: 52 rows
Threshold Bit Score: 206.809
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54JJ6         1 MGTGSSREQ--------HLNSFNTLQKETVP-------FSSDLWKtilSQN-LEDDSLYL--------ENLKKLKNERPE 56   Dictyostelium ...
XP_002507385   1 MGAGSSTAAaayarckdDVDANLARLSDPDPttp-ddpTWDELLRfpaAITsASDADLDVvlg-------rvdFGSIAPG 72  
XP_002128944   1 MGIGCSSFAh------lEDNEYLKRLSSNVSise-ndpFWNQLFSftlSAP-RDRNEAILleeatetfCKMLVDHNQHTG 72  
EFX86578       1 MGAQCSSVAn------lNSNEHLFQLCGSTPmta-ndpTWNQLFSfnlQIP-LSSLENHEviegtaqlFQLLESNNQATR 72  
EJW84912       1 MGAKISSETl------iEENAYLRRFVGLQPisd-ndpFWNHFLSfnfLIDsNNRKEVEQfdislsdsLQSLMYNTPTTC 73  
CAP23760       1 MGSVITKETi------lQDNVYLKKLSGLEPvdd-ydpFWNKLLSfslKFDdDDEKTRIAlesalddhLQCLMYNTQTTG 73  
XP_015794564   1 MGITNSALNn------lKSNEHLNKFASNQHipv-gdsFWNEMLSfsfTKSiRTLEETRVledsvsplLNSLLSHNLNSN 73  
XP_002423085   1 MGASNSKd--------lSSNEYLLKFSGKDHisc-sdqFWNVFLSfsfKPP-SSKSENEVindklskiFENLLKNNLESG 70  
EDS43007       1 MGMNVSRQVd------lAENEYLKRFVGRDHvpaynddFWNSFLQyhiNLP-TNSQEQLSldsrleslCQSFIAHNLSSG 73  
Q7KNA0         1 MGINVSRTAd------lGSNQWLQRFVGRQHiahddeaFWNGLLNyniVLP-ENSQDQLNldsrlealCQSFIGNNLKTG 73   fruit fly
Q54JJ6        57 NLATFIKKLVNQLVLVKG----LQRETntp--------------gdfQLTSISLsyL--------SRILPIVfesgddfa 110  Dictyostelium ...
XP_002507385  73 TLDALLER---AAAALRRcs-rSDVAGsnpsrgdvanedraddawtaAINATTL--AtralrrcsRDTLRFL-------- 138 
XP_002128944  73 NFTSLLKVFLSRFSELKSs---AECDdqlf--------------iwqSRNAMFV--I--------QHLCKFL-------- 117 
EFX86578      73 NTSALLRVFLSRATELKAs---AQCDkif---------------iwqTCNALFI--V--------RVIFSHW-------- 116 
EJW84912      74 NFASFIHVLLRRTAELKAs---EIYNntif--------------lwqTGNALIV--L--------RYICKFL-------- 118 
CAP23760      74 NFAAFIRLFLRRATELKTs---EQCEnenscfs--------kiylwqTSNALLI--L--------RYIARFL-------- 124 
XP_015794564  74 NLGSLVKIFISKSAALKDelnkEASQnii---------------icqTFNSMFV--I--------RCCAKHL-------- 120 
XP_002423085  71 NFVSLIRVFINKSTDVLSa---SSTGneil--------------vwqTYNALFI--I--------RCFTRYL-------- 115 
EDS43007      74 NFGSLFNVFLVKVSELLAl---SDAEstvh--------------iwqAFNALFI--I--------RCLVKYM-------- 118 
Q7KNA0        74 NFGSLVTVFLEKTSELLSl---SDQEsnmh--------------vwqTFNALFI--I--------RSLVKYI-------- 118  fruit fly
Q54JJ6       111 dkvfwlnegieplshpsakistppsitttktteiieEQEKKDQEnkqveenkeneekkdeekkdeekkdeekkdedkken 190  Dictyostelium ...
XP_002507385 139 ------------------------------------CRRRRQ-Iand--------------------------------- 148 
XP_002128944 118 ------------------------------------AENTTEMKmmeqfgar---------------------------- 133 
EFX86578     117 ------------------------------------IRLEKEAVlikkfs------------------------------ 130 
EJW84912     119 ------------------------------------VQRLSETEfikvfhmdk--------------------------- 135 
CAP23760     125 ------------------------------------TQRMTEKEfvrifaknqenertessst---------------ss 153 
XP_015794564 121 ------------------------------------VQTLTEENvlkhfl------------------------------ 134 
XP_002423085 116 ------------------------------------VETVKEAEyirhfnvkp--------------------------- 132 
EDS43007     119 ------------------------------------IETGSEYQllqhfealpvqqdda--------------------- 141 
Q7KNA0       119 ------------------------------------NETGSEFQllqhfeampnaellqaale----------------q 146  fruit fly
Q54JJ6       191 kttttttttnttnntnnNNNsdessfdTTP-LAVKLMDSLLDLLFfp-gfTVTeslglkspkeaspdaipvlfswaggfg 268  Dictyostelium ...
XP_002507385 149 ---------------ddDAPdesggvaTAEpAVCDFMAAVVDVVAgcadeRAPr-------------------------- 187 
XP_002128944 134 ---------slverqkdLTSgsvfegtENVnYAHELLSALMDIII-----HVPi-------------------------- 173 
EFX86578     131 -----------fqeensC-----------EsLLENLAVQLVEILV-----DVPl-------------------------- 157 
EJW84912     136 --------tylekkdayDSDfeeefdgLCEnKAEELLDTLVDILV-----DLPs-------------------------- 176 
CAP23760     154 sddeddddaqqtegsdnNNGetkeaqiVFQnTAEEFTYELVSILF-----NISv-------------------------- 202 
XP_015794564 135 -----------arkdgkEgn------eTGVeVMESLINNLVSVLV-----DIPl-------------------------- 166 
XP_002423085 133 --------mmvsqtvaeQQLdnlsnkkIHEnPLESLLESLLEILI-----DVPl-------------------------- 173 
EDS43007     142 ---dveqgseavtvavtGETrtalaklIDGtKFETFLEALVNIIV-----VIPv-------------------------- 187 
Q7KNA0       147 qqqtpaesatiameateQSAaaavpviVDGsKFETFIDALVNLIV-----VIPv-------------------------- 195  fruit fly
Q54JJ6       269 vdsvptvhnKq-FWINRLSVLQCLITCL--SEQLYVPQDSVSTF-------------------K-SKWLD---------- 315  Dictyostelium ...
XP_002507385 188 ---------GchVYALRVACCRSLEAIA--DEYSTADDSKADSSsplstpsapfanetdgefdAfDVLMDavdgctavda 256 
XP_002128944 174 ---------LdfTYSLHIEALNTILVLL--SVQMFVP-SPGDNGp------------------IyRILMT---------- 213 
EFX86578     158 ---------KeeTALLHRESVQTLMLLLfvAASSYLI---NNKSi------------------IfKCLMH---------- 197 
EJW84912     177 ---------NdsTETIHIEAVKCLMVLL--SSQLYDD-DVMRPNi------------------FyRYLMQ---------- 216 
CAP23760     203 ---------NdtTLAIHVEAVRCLLTLL--SSQLYNE-SIVNTSi------------------VfRFFID---------- 242 
XP_015794564 167 ---------SdsTYALHCECINLLLVLL--SVQMYSV-KPASKSv------------------IyRCIMK---------- 206 
XP_002423085 174 ---------DfqTYSLHLEVVNCLLVFL--SAQMYTR-KPAAKLi------------------IfKTLMQ---------- 213 
EDS43007     188 ---------KefTYHLHLEAVNCLIVLL--SVSQFTQQGTEKSN-------------------IfRTIYK---------- 227 
Q7KNA0       196 ---------KefTYHLHLEAVNMLITLL--SVHLFAQ-QPTDKSi------------------VfRTVFK---------- 235  fruit fly
Q54JJ6       316 -WITHTQEYYTEALLFSLINTFATFDPI--------------GWGIpynhlMY--SDDH--------------------- 357  Dictyostelium ...
XP_002507385 257 gGDGRSGESIYRDVVAETLRLWSRRPPLprgsdawmhdpndaSGKP-----RGgfLGAMaalllgdddddddn------g 325 
XP_002128944 214 -GQCAAKAN---NFMRALLQNFIEQRPSpeags----renggGSFV-----IGiaSAVAsglwsalklggkkd------- 273 
EFX86578     198 -GPGALHAG---LLTRTLLQHYCQQQSVpvrwlr---kpeqgGSIV-----LGlaSKFVifvylaglwslis-------- 257 
EJW84912     217 -GKCSTRSL---ELSRALISNYLQRYTPcvvkh-----dkepESIV-----LG----LAasvwsavqivtgmd------d 272 
CAP23760     243 -GACAQHAA---KLTKTLLLNYLIHNSEyhmtv-----akpqESIV-----FG----LAssmwsmvqmatg--------- 295 
XP_015794564 207 --KCAIHSL---LLTKCLINNFIRQDLPpre---------dgGSVI---------LDLAsglwsaltlgy---------- 253 
XP_002423085 214 -GRPSIHSP---LLIKTLLGHFIKQEKPyer---------ggGSIV-----IG----LAsniwhilslay---------- 261 
EDS43007     228 -C---QHAN---TLMSALLHFLSRMTQVpatmf----gfgsgGSFV-----FG----IAeslwsiltfarkqpd-----v 282 
Q7KNA0       236 -C---QHAN---VLMSALLHFVARIVEVphtmf----gsssaGSFV-----FG----IAesllsiftfrkqpdilkagqa 295  fruit fly
Q54JJ6       358 -------------EICSKLSIQILNVLLTYDPIENNdqQpqqQhhhhqqqhh---------------------------- 396  Dictyostelium ...
XP_002507385 326 dddkgkdwdvsvfSPLGDAAGAALTRLLHRPARYDGvaEvgrCvanesastavvstagkvvrrepnvagsspgrsagivk 405 
XP_002128944 274 sgvskeltselgpPTIGRQSALLILALINHQSYVDPtgQp--F------------------------------------- 314 
EFX86578     258 -rnsstaesvdavSDFASQSLLLLLVLTNHCSTEKNw------------------------------------------- 293 
EJW84912     273 snslssdseitppVSLGSLSVLLLLNLACHQDPEAKl------------------------------------------- 309 
CAP23760     296 --ldsaeednkppLTLGNLCILLLLNLSCHQPVNAS-------------------------------------------- 329 
XP_015794564 254 ---gknnndetlkPVLSKLSLFLLLVLTYHCTTDS--------------------------------------------- 285 
XP_002423085 262 --knstnleppkgITLANQSLLLILVLVSHCTAEKNl------------------------------------------- 296 
EDS43007     283 ltahdlpaafkdhYPLANQSLLLILILTNHYTTKD--------------------------------------------- 317 
Q7KNA0       296 agggelsqrfrthYPLANQSLLLILILTNHCTAQD--------------------------------------------- 330  fruit fly
Q54JJ6       397 --------------------------------------qqqqqqqqSti---------------------eCRNKFIQYI 417  Dictyostelium ...
XP_002507385 406 ssrekwggglgevetvmrrasmdvdddpgspvgssrspfappgfdsGadrsglvfsknyppetppatgssiAANPFRDAL 485 
XP_002128944 315 ----------------------------------------------V--------------------------NPYKAAL 322 
EFX86578     294 ------------------------------------------------------------------------sNPYRQAL 301 
EJW84912     310 -------------------------------------------------------------------------NPYKESL 316 
CAP23760     330 -------------------------------------------------------------------------NPFKETL 336 
XP_015794564 286 -------------------------------------------------------------------------NPYREAL 292 
XP_002423085 297 ------------------------------------------------------------------------lNPYRDFL 304 
EDS43007     318 -------------------------------------------------------------------------NPYRVSL 324 
Q7KNA0       331 -------------------------------------------------------------------------NAYRTSL 337  fruit fly
Q54JJ6       418 KTLKRVR-------------------DFKFFFNAFERIMNVplIASHTklpnstkkielhqdLTYTMWLFLSYNHDFLRS 478  Dictyostelium ...
XP_002507385 486 FRLVRLErsnkdddsg--esdalrvrVLRACVLAMHSADTAgaASGASgdkshaascqqaavGVFLAYSLLYGNEGFYRA 563 
XP_002128944 323 CCFRHVQgqlqgpsn---gkqkgslpSFHINLSRLYGTACSvqVYESS---------------TLLLYSLLHGNPDVKAF 384 
EFX86578     302 LSFTDSQvspv-----------hpsaCFRLDYSVLYSTLCDrlGDERT---------------TLLLYMLLHQHQQFRNY 355 
EJW84912     317 SKFQNSQevssln--------nsetdTFKLDYSLLYERLCAtvNQQSP---------------MLFLYILLHRNVGFRNY 373 
CAP23760     337 ALFQNAQevstl---------ptqviSFKIDYNGLYERLCAtaGQEPP---------------MLLLYMLLQANSGFRNY 392 
XP_015794564 293 FNCCDLQvdsigv--------aglvsGFKMNFNQLFSTLCAtqNEDQS---------------TLILYLLLYKNPSFRAF 349 
XP_002423085 305 FTFIHNSpghlslgsnpeeipvssvsALQINFDHLYVALCNtaANECS---------------TLMLYLLLHRNENVKNF 369 
EDS43007     325 FGCADSQgaadssgs---skepeqavTFKIDFSSLYNTLCRivTIDQT---------------TLLLYLLLHRNQRFYKY 386 
Q7KNA0       338 FSCADSKdspk-----------qgavSFQIDFSAVYETLCTivTIDQA---------------TLLLYLLLHRNERFYRF 391  fruit fly
Q54JJ6       479 IVN-YENSPEFLIPLLQYMDEGR-------KSQTThgIVQ---------------------IGTFILLLLSGERDFSISL 529  Dictyostelium ...
XP_002507385 564 VVAdANAVRALVSALLRR---------------AH--ATYaevggssprgttqlnvsgvasVATATLAMLSQDPVVNRAV 626 
XP_002128944 385 VLS-KTDIDSLVTPILQILYFAP-------SQNSH--HIY---------------------MALIILLMFTEDDHFNKYV 433 
EFX86578     356 VYT-HADIQRMVIALLQELFNGD-------DQGSH--HLY---------------------MSLIILLLLSEDEGFNSNI 404 
EJW84912     374 ILS-RINLEKLVLPVLIVLSDGAqsssminSYNAH--HVY---------------------LALIVILILSEDDFFCKVA 429 
CAP23760     393 VLS-RINLENLVVPVLRILHDGVa-----tSNNSH--HVY---------------------LALIVALILSEDDIFCKII 443 
XP_015794564 350 LISrTSQLDDLTIPILKILYHSG-------EKTSH--HIY---------------------MAVIILLILSEDALFNESI 399 
XP_002423085 370 ILA-RADLEYLVVPILKTLYNIT-------ESNSH--HIY---------------------MSLIILLILSEDGGFGQTV 418 
EDS43007     387 VMA-QQNLQQLVIPILQTLYNAP-------DSTSH--HIY---------------------MSLIVLLILSEDDNFNKSV 435 
Q7KNA0       392 VMQ-QQDLEQLVIPILQTLYNAP-------DSNSH--HIY---------------------MSLIVLLILSEDEGFNKNV 440  fruit fly
Q54JJ6       530 NKP--------------------------------F-VGRIHIDIQqpq----vyS----DFVITVMYRLLVDTPDRLE- 567  Dictyostelium ...
XP_002507385 627 HSLstsqrlasssndsqlndsqlndsqlndrtdfwFnSSASAKTLSgfksigkppQqtlgSAWVLVLCRVARGGGIEKGd 706 
XP_002128944 434 HDIrlpt-------------------------vpwY-TDRILSDISl------------gDLIILVVIRTIQFNMSRMRd 475 
EFX86578     405 HNVvvrn-------------------------plwY-TDRVLNEISl------------gGLAVLVIARTIQRNIVKASd 446 
EJW84912     430 HETmikd-------------------------ttwFnSERPLGEISl------------gGLIILVFVRIIQLNTLKTKd 472 
CAP23760     444 HETvpik------------------------dlgwLdSDFSVREISl------------gGLTALVFIRAIQKNALKTKv 487 
XP_015794564 400 HDItlkn-------------------------itwY-SERTLPEISl------------gGLIILMIIRTVQYNISRTRd 441 
XP_002423085 419 HQItikn-------------------------vtwY-HEKVLTEISl------------gGLLLLVVIRTIHYNMLKMRd 460 
EDS43007     436 HEIilkn-------------------------itwY-TERSISEISl------------gGLLILVVIRTIQYNMLKMRd 477 
Q7KNA0       441 HTImlkn-------------------------itwY-TERTISEISl------------gGILILIVIRTIQYNMLKMRd 482  fruit fly
Q54JJ6       568 -----------------SIYECVLTILSNLSPYMKNLSMVTCVKLMKLFEYLSTPRFLF---ATNH-------------- 613  Dictyostelium ...
XP_002507385 707 vtsgegg---iepatssFARACALAALANSAPYFDGLTSAASQRLVAVFDVLHRRRRKR---VSAAmgrpgiepgs---- 776 
XP_002128944 476 ----------------rYLHTNCLAALANMSAHFRSLHPYAAQRIFSLVTLLTKKYRKL---TEKVlaimatsdtpgtvs 536 
EFX86578     447 ----------------kYLHTNCLATLANMAAHFRRLHPYTCQRLVSLLCTLNKRRIRV---VQQIksdvkgdsatga-- 505 
EJW84912     473 ----------------rYLHTNCLAALANMSSYFKNLSSIVCQKLIGLLEVFTRRHAKL---IENMrvraeydiiqek-- 531 
CAP23760     488 ssvflfpntiplikqdrYLHTNCLAALANMSAFFKNLAPIVCQRLISLLDLLTKRHAKM---VDHMrvssqndvagg--- 561 
XP_015794564 442 ----------------kFLHTNLLATLANMSNHFRRLSPYVCQRLVTLFEKISKKLHKIlnsQNAIngnggdsgeklsdk 505 
XP_002423085 461 ----------------kYLHTNCLAALANMSNNFCNLNSYVSQRLLSLFETLAKKYHRLeitLKTNmvkinsetrenddg 524 
EDS43007     478 ----------------kYLHTNCLAALANMSGQFRSLHPYVAQRLVSLFETLAKKHARLdqqLRQPaavaangdaaavva 541 
Q7KNA0       483 ----------------kYLHTNCLAALANMSGHFRALHPYVAQRLVSLFETLARKHTRLdaqLKEPadsavfvnvst--- 543  fruit fly
Q54JJ6           --------------------------------------------------------------------------------      Dictyostelium ...
XP_002507385 777 -----------------------------------------------------------------------dglrgrtgl 785 
XP_002128944 537 dasats------------------------------------------------------seqaeidmeperdyasnlkv 562 
EFX86578     506 ---------------------------------------------------------------------sreeleqdlsi 516 
EJW84912     532 ---------------------------------------------------------------------eshnyhkdita 542 
CAP23760     562 ---------------------------------------------------------------------qpinfhddita 572 
XP_015794564 506 dtd-------------------------------------------------------------vastvgpldptqdtsi 524 
XP_002423085 525 ekensfvemgknsttsqskpneensvketiingthesdkedmaiqiksstdldvknlsgdeavinvddnassdivqdlnv 604 
EDS43007     542 vp--------------------------------------------------------------ivagsnpddmlqdlsv 559 
Q7KNA0       544 ---------------------------------------------------------------------tpedmlqdlsv 554  fruit fly
Q54JJ6       614 NYRYVGFLLESLNNLLQ-HQYESNTRLIYAILRCQ-NQFSKLAYLKIsPVTpskpmeqitqpspistseeafgklnklsi 691  Dictyostelium ...
XP_002507385 786 PTAVAALVSAALASALV-TSASKCPELVYAALQRRdEVFAPFLDE---FLD----------------------------- 832 
XP_002128944 563 LEEVLRMLLEIVNSCLTgGALRHNANLVYALLQRR-EAFDQLRLHTV-YQD----------------------------- 611 
EFX86578     517 LEEVLRMLLEILNAAFT-HQLGCNQNLIYSVLHKR-EVLDVLRRQPA-FQD----------------------------- 564 
EJW84912     543 LEEGIRTLLEICNSCLS-SNLRSNPHFIYTILYKR-DLFDAFQNHPM-FQD----------------------------- 590 
CAP23760     573 LEEGIRTLLEIINSALC-GGLRHNTHLIYNLLYHR-ALFDAYVQHPM-FQD----------------------------- 620 
XP_015794564 525 YEEVLRMLLEIMNSTLS-SQLIHNPNLVYTLLYNR-HVFEPFQSHPS-FQD----------------------------- 572 
XP_002423085 605 LEEVLRMILEIINSCLS-NQIQHNPNLVYALLYKK-DIFDPFRTHQN-FND----------------------------- 652 
EDS43007     560 LEEVLRMVLEILNSCLS-HQLVYCPNLVYTLLYKR-NVFEAFRSHSA-FQD----------------------------- 607 
Q7KNA0       555 LEEVLRMVLEILNSCLT-NQLVYCPNLVYTLLYKR-SVFEGFRSHHA-FQD----------------------------- 602  fruit fly
Q54JJ6       692 seepstlsneksdkttdggdhqdesiskskvqskpttehpnstgatpsstnsgtptikafssttpnqespklggdgidsq 771  Dictyostelium ...
XP_002507385     --------------------------------------------------------------------------------     
XP_002128944     --------------------------------------------------------------------------------     
EFX86578         --------------------------------------------------------------------------------     
EJW84912         --------------------------------------------------------------------------------     
CAP23760         --------------------------------------------------------------------------------     
XP_015794564     --------------------------------------------------------------------------------     
XP_002423085     --------------------------------------------------------------------------------     
EDS43007         --------------------------------------------------------------------------------     
Q7KNA0           --------------------------------------------------------------------------------      fruit fly
Q54JJ6       772 sstpnkqqlpppppqqtkktqmvshfmptdewlqdikkqlPLDN------------------------------------ 815  Dictyostelium ...
XP_002507385 833 ----------------------------------------PVKDrvderkdsnpreglshegfhandpelelaihrmreh 872 
XP_002128944 612 ----------------------------------------VLQN------------------------------------ 615 
EFX86578     565 ----------------------------------------IVAN------------------------------------ 568 
EJW84912     591 ----------------------------------------LIWN------------------------------------ 594 
CAP23760     621 ----------------------------------------LLVN------------------------------------ 624 
XP_015794564 573 ----------------------------------------IIMN------------------------------------ 576 
XP_002423085 653 ----------------------------------------VIQN------------------------------------ 656 
EDS43007     608 ----------------------------------------IIQN------------------------------------ 611 
Q7KNA0       603 ----------------------------------------VIQN------------------------------------ 606  fruit fly
Q54JJ6       816 ---ILKVITHLSPQIQGLCTGSG-------SDEQKIMDYLKMSTIVGIFHNPG-------------------PIMTRRYH 866  Dictyostelium ...
XP_002507385 873 avaIHQRLEFFNARVDAAREASTnhrpgshWTMDKAMDVIRAACEEDQSKEDHskedhsstsgsappsfqyaPE-TFVYR 951 
XP_002128944 616 ---IDTVINFFTGRLDQLNQQT--------MTTDEVHSVIKDATVQLpshr-----------------lhkfPDLKFRYV 667 
EFX86578     569 ---LDTVSNYFNNRISQLNE----------PGVNEILQSIQLGCVDFpkdq-----------------lkkfPELKFRYV 618 
EJW84912     595 ---ICAVISHFASRVQLLEKG---------SSVSAILATIQKGVLHWptdr-----------------lkkfPELKFKYV 645 
CAP23760     625 ---IAAVISHFSSKVVHVPAGDG----------MTMMQIIEKEANVWptdk-----------------lakfPELKFRYV 674 
XP_015794564 577 ---FDTVLTYFSNRIAAAEDSN--------TSVAQVYEIIQNCSLQWpadk-----------------mkkfPELKFRYV 628 
XP_002423085 657 ---LDSVINYFSDKLKQVQTD---------LSVNEVLSTITQGTLVWpshk-----------------lkkfPELKFKYV 707 
EDS43007     612 ---IDMVVGFFSSRLVRVQDQRGe------LGVNEVLEVISKGASQWssdr-----------------lrkfPDLKFKYV 665 
Q7KNA0       607 ---IDMVVGFFSSRLQRVQEQRGe------LGVNEVLEVISKGASQWssdr-----------------lrkfPDLKFKYV 660  fruit fly
Q54JJ6       867 SNAITKSWFIAYMWCI 882  Dictyostelium discoideum
XP_002507385 952 EEIDAHEFFRPIVDLA 967 
XP_002128944 668 EEDSPEEFFVPYVWSL 683 
EFX86578     619 EEDQPEEFFIPYVWSM 634 
EJW84912     646 EDDNTVEFFVPYVWRL 661 
CAP23760     675 EDEYTVDFFVPYVWRL 690 
XP_015794564 629 EDDQPEEFFIPYVWSI 644 
XP_002423085 708 EEDQPENFFIPYVWNL 723 
EDS43007     666 EEDAPEEFFIPYVWTL 681 
Q7KNA0       661 EEDAPEEFFIPYVWTL 676  fruit fly
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