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pfam08477: Miro 
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Miro-like protein
Mitochondrial Rho proteins (Miro-1 and Miro-2), are atypical Rho GTPases. They have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (pfam00036), that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.
Statistics
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PSSM-Id: 254820
View PSSM: pfam08477
Aligned: 17 rows
Threshold Bit Score: 90.9517
Threshold Setting Gi: 74543497
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:

pfam08477 is a member of the superfamily cl17170.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IWR_A         9 RLGVLGDARSGKSSLIHRFLTGSYQv------------lEKTESEQYKKEMLVDGQTHL----------VLIREEAGA-- 64
gi 90111816    6 RVVVVGGKKVGKTAILRQVACVEDVtnk--------pyePTIEDTYQVLLEEPDKAREI----------LILHDTAGVsn 67
gi 731284    450 NCFVIGKPCCGKSSLLEAFLGRSFSee----------ysPTIKPRIAVNSLELKGGKQYy---------LILQELGEQ-- 508
gi 81902092  128 KVGIVGNLSSGKSALVHRYLTGTYVq------------eESPEGGRFKKEIVVDGQSYL----------LLIRDEGGP-- 183
gi 145558869  57 KIFVSGKSGVGKTALVAKLAGLEVP--------------VVHHETTGIQTTVVFWPAKLqassrvvmfrFEFWDCGES-- 120
gi 75181042   16 RVAVAGDKGTGKSSLISAVASETFPdnvprvlppitlpaDAFPDYIP----ITIVDTPS--------------SIDNR-- 75
gi 75330755   19 RIVVVGDKGTGKSSLIVAAATDSFPpnvppvlpdyklpiEFFPDGIP----VTIVDTSS--------------RPEDR-- 78
gi 731284      7 RVVICGDEGVGKSSLIVSLTKAEFIptiqdvlppisiprDFSSSPTYSPKNTVLIDTSD----------------SDL-- 68
gi 74676012    5 RVVICGDQGVGKSSLISALIQEDNVtsipkvfpiisipsNPDSNDDVS---LVLVDTQS--------------DSNER-- 65
gi 75208668  103 KISLLGDCQTGKTTFVVKYVGDENQsf-----------lEMTGLNLMDKTFYVQGVTIS----------FSIWDVGGD-- 159
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
2IWR_A        65 ---PDAKF-------SGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEgrggLALALVGTQDR 119
gi 90111816   68 ygpIELKKa-----yVQAADAFVLVYSSADYESFNRVDLLKKWIDRQFGKdkkeVPIVVLANMRD 127
gi 731284    509 ---EYAILenk--dkLKECDVICLTYDSSDPESFSYLVSLLDKFTHLQD-----LPLVFVASKAD 563
gi 81902092  184 ---PELQF-------AAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNas--eVPMVLVGTQDA 236
gi 145558869 121 ---ALKKFdhmllacMENTDAFLFLFSFTDRASFEDLPGQLARIAGEAPG----VVRMVIGSKFD 178
gi 75181042   76 ---IKLIEe------FRKADVVLLTYACDQPSTLDRLSSY--WLPELRRLei-kAPVIVVGCKLD 128
gi 75330755   79 ---DIVAEe------LKRADAVVLTYACDRPETLERLSEY--WLPELRRLev-kIPIIVAGCKLD 131
gi 731284     69 ---IALDHe------LKSADVIWLVY--CDHESYDHVSLF--WLPHFRSLgl-nIPVILCKNKCD 119
gi 74676012   66 ---EYLAAe------IKKANVICLVY--SDNYSYERVSIF--WLPYFRSLgv-nVPIVLCENKSE 116
gi 75208668  160 ---EKRSKdhi-piaCKDAVAILFMFDLTSRSTLNSV---FGWYSQARKWnktaIP-ILIGTKFD 216
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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