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pfam08357: SEFIR 
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SEFIR domain
This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.
Statistics
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PSSM-Id: 254756
View PSSM: pfam08357
Aligned: 16 rows
Threshold Bit Score: 99.7772
Threshold Setting Gi: 81570213
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:

pfam08357 is a member of the superfamily cl18038.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3VBC_A         5 IKVLVVYPS-EICFH-HTVCRFTDFLQNYC--RSEVILEAWQAAAIAEMGPVQWLTTQ----KQAADKVVFLLPSDVPTL 76
gi 20454961  380 RKVWIVYSA-DHPLYvEVVLKFAQFLITAC--GTEVALDLLEEQVISEVGVMTWVSRQkqemVESNSKIIILCSRGTQAK 456
gi 74786403  391 SNLFLVYWD-DHKLHrDVVLKLASYLQHL---GFNVFCELFEQNEIFA-DRCDWMEKR----MSQAEKVVIVWSAGAIDI 461
gi 1353171   415 VKVMIVYAD-DNDLHtDCVKKLVENLRNCA--SCDPVFDLEKLITAEQIVPSRWLVDQ----ISSLKKFIIVVSDCAEKI 487
gi 81884688  448 RPVLLLHAA-DSEAQrRLVGALAELLRTALggGRDVIVDLWEGTHVARIGPLPWLWAArervAREQGTVLLLWS------ 520
gi 229462881 584 RAALLLYSAdDSGFE-RLVGALASALCQL---PLRVAVDLWSRRELSAQGPVAWFHAQrrqtLQEGGVVVLLFSPGAVAL 659
gi 81874564  107 RTALLLHSA-DGAGYeRLVGALASALSQM---PLRVAVDLWSRRELSAHGALAWFHHQrrriLQEGGVVILLFSPAAVAQ 182
gi 317373453 410 RKVFITYSM-DTAME---VVKFVNFLLVN---GFQTAIDIFED-RIRGIDIIKWMERY----LRDKTVMIIVAI-SPKYK 476
gi 75450234    2 KKIFISYAW-DEIED-EKVIKLAEMLEDYK--EFEVSFDKWDINK--GQEVPLFMERG----IQQSDFVLIICS----ER 67
gi 81661845   13 RKVFVSYAH-TSEPHiEWILAFVADLQAN---GIEVVVDQYDL----KEGQDANTFMEkvvtDKTIDRVLIVSD----EN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3VBC_A        77 CDSACGHNEGSARENSQ------------DLFPLAFNLF---CSDFSS--QTHLHKYLVVYL-GGADLKGDYNALSV--C 136
gi 20454961  457 WKAILGWAEPAVQLRCDhwk------pagDLFTAAMNMI---LPDFKR--PACFGTYVVCYFsGICSERDVPDLFNI--T 523
gi 74786403  462 WKKCQNQQDAFEVTNs-------------DFFTPVVKKIkndLIK-----ESNLRKYCFVYF-GYVKMKEIPTIFRElsG 522
gi 1353171   488 LDTEASETHQLVQARPFa-----------DLFGPAMEMI---IRDATHnfPEARKKYAVVRF---NYSPHVPPNLAIlnL 550
gi 81884688  521 CAGPSTACSGDPQTASL----------------RTLSCA-------------APRQLLLAYFsRLCAKGDIPGPLRA--L 569
gi 229462881 660 CSEWLQDGVSGPGAHGPh-----------DAFRASLSCV---LPDFLQ--GRAPGSYVGACFdRLLHPDAVPALFRT--V 721
gi 81874564  183 CQQWLQLQTVEPGPh--------------DALAAWLSCV---LPDFLQ--GRATGRYVGVYFdGLLHPDSVPSPFRV--A 241
gi 317373453 477 QDVEGAESQLDEDEHGLh-----------TKYIHRMMQI-----EFIKqgSMNF-RFIPVLF-PNAKKEHVPTWLQN--T 536
gi 75450234   68 YKVNADKRRGGSGYEAR--------------LMSDEVLR-----------NEDKDRFIPIIL-NEKDKKNIPNFLKS--- 118
gi 81661845   81 YAAKADGRKGGVGTESQiitqklykdieeTRFIPILKER-------DDqgNACLPVFLGGRI-----------------Y 136
                        170
                 ....*....|....*.
3VBC_A       137 PQYHLMKDATAFHTEL 152
gi 20454961  524 SRYPLMDRFEEVYFRI 539
gi 74786403  523 CHFQLMKQFQEFYFQL 538
gi 1353171   551 PTFILPEQFAQLTAFL 566
gi 81884688  570 PRYRLLRDLPRLLRAL 585
gi 229462881 722 PVFTLPSQLPDFLGAL 737
gi 81874564  242 PLFSLPSQLPAFLDAL 257
gi 317373453 537 HVYSWPKNKKNILLRL 552
gi 75450234  119 ----------KLWTEL 124
gi 81661845  137 IDFSNPDAYATRLEEL 152
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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