Conserved Protein Domain Family
DASH_Hsk3
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pfam08227: DASH_Hsk3 
DASH complex subunit Hsk3 like
The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro. This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.
Links
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Statistics
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PSSM-Id: 429874
Aligned: 41 rows
Threshold Bit Score: 39.8529
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCE64119              6 QRQYSRLAEQLSQLQDNLEEATQHLDTMSKQCNTniINQLGKLHASW 52 
EPE08443             25 ARQLAQLQSQLAQLSANLSDTDSLVRVTAAQAAY--LRELGSWHAGm 69 
EEP81126             51 sRQYAHC-TPAAQLNAHLADMENLMRMTSAQAGD--MRFLGGYVGGL 94 
WGS:ACPH:TERG_01304  15 mRQYSHLHAQLAQLNANLADTQNLMRMTSAQASD--LRFLGGYVGSL 59 
EXX68201             22 lqHYNSLNNQLTRLQQNMAKLEENIKLTVEQLKN--IQRFGLAHGAi 66 
NP_001138275        179 AREKNHLILENETLCRNLSHTAEQLERMSIQCDVwrSKFLASRVMAe 225
XP_014570290         68 ARQISLLSTRLQELTLRIDAFEQLVATCSQQAVS--IRDLGVSHAAW 112
KDE08298             13 qgqIQNLSQQLATLAQQTAKLEHLTVATAEQASY--LRLLGAYHAAW 57 
EDP43004             18 ERHYAYLASRLDALAATMQHTQHHMSIASEQAAY--MKDLGVGQAAm 62 
KIS67818             16 ERHYAQLAAKLGTLANSFEITKQHLNLAAEQAFY--MRKLGIAQAST 60
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