Conserved Protein Domain Family
Pkinase_Tyr

?
pfam07714: Pkinase_Tyr 
Click on image for an interactive view with Cn3D
Protein tyrosine kinase
Statistics
?
PSSM-Id: 285015
View PSSM: pfam07714
Aligned: 123 rows
Threshold Bit Score: 210.818
Threshold Setting Gi: 73920239
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam07714 is classified as a model that may span more than one domain.
pfam07714 is not assigned to any domain superfamily.
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_I         21 VKIEEVIGAGEFGEVYKGRLK----------LPGKREIYVAIKTLkaGYSEKq--RRDFLSEASIMGQF-DHPNIIRLEG 87
gi 74996665  1057 VAIVEKVGAGSFANVFLGIWN---------------GYKVAIKILknESISN---DEKFIKEVSSLIKS-HHPNVVTFMG 1117
gi 73920239    16 FEIYEEIAQGVNAKVFRAKEL-------------DNDRIVALKIQ--HYDEEh--QVSIEEEYRTLRDYcDHPNLPEFYG 78
4L01_B         27 LVQGEHLGRGTRTHIYSGTLMdykd---degTSEEKKIKVILKVLdpSHRDI---SLAFFEAASMMRQV-SHKHIVYLYG 99
gi 21263757   580 IVQGEHLGRGTRTNIYAGILKpksdd-eddlGGYSQEVKVVLKVL--GSGHRd-iSLAFFETASMMRQI-SHKHTALLYG 654
4FVR_A         10 LIFNESLGQGTFTKIFKGVRRev------gdYGQLHETEVLLKVL--DKAHRn-ySESFFEAASMMSKL-SHKHLVLNYG 79
gi 2499671    517 LEWHENLGHGSFTKIFHGHRRev-------vDGETHDTEVLLKVM--DSRHQn-cMESFLEAASLMSQV-SYPHLVLLHG 585
gi 34761802   368 lQTTEGLGQGTFTQVFRGIRRev------gdYGEVHKMEVVMKILdkSHRNY---TESFFESASMMSQL-SHKHLLLNYG 437
gi 47222167   586 iEQEEHLGRGTRTNIYSGTLRvkseededagYSSFQEVKVVLKLLsyGHRDI---SLAFFETASMMRQV-SHKHIVLLYG 661
gi 195391974  716 LHLLERIGQGRFGTVHRALWH----------------GDVAVKLLneDYLQDehmLESFRNEVANFKKT-RHENLVLFMG 778
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_I         88 VVT-Ksr-----pVMIITEFMENG---ALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS-- 156
gi 74996665  1118 ACId--------pPCIFTEYLQGG---SLYDVLHIQKIKLNPLMMYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDE-- 1184
gi 73920239    79 VYK-LskpngpdeIWFVMEYCAGGtavDMVNKLLKLDRRMREEHIAYIIRETCRAAIELNRNHVLHRDIRGDNILLTK-- 155
4L01_B        100 VCF-Rdv-----eNIMVEEFVEGG---PLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAReg 170
gi 21263757   655 VCVrHqe------nIMVEEFVQYG---PLDLFMRRQTTPLSTAWKFQVAKQLASALSYLEDKKMVHGYVCSKNILVARdg 725
4FVR_A         80 VCFcGde------nILVQEFVKFG---SLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIRee 150
gi 2499671    586 VCM-Agd------sIMVQEFVYLG---AIDTYLRKRGHLVPASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAReg 655
gi 34761802   438 ICV-Cad-----eHIMVQEYVRFG---SLDTYLKRNRNTINITWKLEVAKQLAWALHHLEEKSLTHGNVCARNVLVTRee 508
gi 47222167   662 VCV-Hhq-----eNIMVEEFVQLG---PLDVFMRRQQNPLSIPWKFQVAKQLASALSYLEDKKLVHGFVCAKNILLARdg 732
gi 195391974  779 ACM-Npp-----yLAIVTALCKGN---TLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHARDIIHKDLRTKNIFIE--- 846
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_I        157 ------NL-VCKVSDFGLSRYLqddtsDPTYTSSLGGKIPVRWT---APEAIAYRK----------FTSASDVWSYGIVM 216
gi 74996665  1185 ------FK-NIKIADFGLATTL-------SDDMTLSGITNPRWR---SPELTKGLV----------YNEKVDVYSFGLVV 1237
gi 73920239   156 ------NG-RVKLCDFGLSRQV-----DSTLGKRGTCIGSPCWM---APEVVSAMEsre-----pdITVRADVWALGITT 215
4L01_B        171 id-secGP-FIKLSDPGIPITV---------LSRQECIERIPWI---APECVEDSKn---------LSVAADKWSFGTTL 227
gi 21263757   726 l--dgeGGpFIKLSDPGIPITV---------LSREECVDRIPWI---APECVKDTAn---------LTIAADKWSFGTTL 782
4FVR_A        151 dr-ktgNPpFIKLSDPGISITV---------LPKDILQERIPWV---PPECIENPKn---------LNLATDKWSFGTTL 208
gi 2499671    656 v---dgNPpFIKLSDPGVSPTV---------LSLEMLTDRIPWV---APECLQEAGt---------LNLEADKWGFGATT 711
gi 34761802   509 drktgtPP-FIKLSDPGISITV---------QPREILLERIPWV---PPECVKDSRn---------LSLAADKWSFGTTL 566
gi 47222167   733 mgtdegGP-FIKLSDPGIPITV-------LTRE--ECVHRIPWI---APECVKNVSa---------LSVAADKWGFGTTL 790
gi 195391974  847 ------NG-KVIITDFGLFSST------KLLYCDMGLGVPQNWLcylAPELIRALQpckppgecleFTSYSDVYSFGTVW 913
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_I        217 WEVMSFGERPyw-dmSNQDVINAI-EQDYR--LPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI--VNTL 280
gi 74996665  1238 YEIYT-GKIPfegldGTASAAKAA-FENYR--PAIPPDCPVSLRKLITKCWASDPSQRPSFTEI--LTEL 1301
gi 73920239   216 IELAD-GKPPfa-dmHPTRAMFQI-IRNPPptLMRPTNWSQQINDFISESLEKNAENRPMMVEMveHPFL 282
4L01_B        228 WEICYNGEIPlk-dkTLIEKERFY-ESRCR--PVTPS--CKELADLMTRCMNYDPNQRPFFRAI--MRDI 289
gi 21263757   783 WEICYNGEIPlk-dkKLSE-KERFyAAQCQ--LATPD--CDELAKLMTHCMTYDPRQRLFFRAI--VRDI 844
4FVR_A        209 WEICSGGDKPls-alDSQR-KLQFyEDRHQ--LPAPK--AAELANLINNCMDYEPDHRPSFRAI--IRDL 270
gi 2499671    712 WEVFSGAPMHit-slEPAK-KLKFyEDRGQ--LPALK--WTELEGLIAQCMAYDPGRRPSFRAI--LRDL 773
gi 34761802   567 WEIYCGGEQPla-ayDTAKKLLFY-EDKHQ--LPAPK--WTELASVINSCMDYEPLHRPSFRAL--IRDL 628
gi 47222167   791 WEICYDGEVPlk-ekKLTEKERFY-ETECQ--LATPD--CTELAELMTHCMNYDPKKRPFFRAI--VRDi 852
gi 195391974  914 YELIC-GEFTfk-dqPAESIIWQVgRGMKQ--SLANLQSGRDVKDLLMLCWTYEKEHRPDFARL--LSLL 977
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
Click on image for an interactive view with Cn3D