Conserved Protein Domain Family
A2M_N_2

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pfam07703: A2M_N_2 
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Alpha-2-macroglobulin family N-terminal region
This family includes a region of the alpha-2-macroglobulin family.
Statistics
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PSSM-Id: 254373
View PSSM: pfam07703
Aligned: 185 rows
Threshold Bit Score: 72.575
Threshold Setting Gi: 122981360
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
pfam07703 is a member of the superfamily cl19929.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PN5_A        404 IKL-ELK--SPIKRNKLMRFMVT--CTERm-----TFF---VYYVMsKGNIIDAG---FMR-PNKQPKy----------- 455
gi 121686696  459 LHLsQVSe-GIPEVGDVISFKVY--STNA------GTV---FYDVFaNGRTVYSA--------TSDEP------------ 506
gi 75570883   441 MHI-DVA--RIMRLGETLNVFLT--AKTTqln-avTHF---TYMVLtRGVIVKTN---RKTkESGGGPs----------- 497
gi 74834548   477 LGI-QLKk-QFVDVGDTVSVELRlgDVSP------TDI---RYYVVsRGEIVYAQ---TKEiTENGDV------------ 530
gi 74819938   384 LQI-LASr-HTVTVRRTFQLTFTfgSSRP------TDI---RYYVVaRGGIVLSS---VVRlTPLNRQk----------- 438
gi 74844201   472 LTV-TPNp-HTVDVGREVHITLA--FNQPt----pAEI---RFYVVsRGSVVLVG---RIVpPANSHNi----------- 526
gi 29337194   470 LSI-EPLdlRSPRVGDTFVLSLR--TVGIpmp-tfSHY---YYMIIsRGQIMAMS-------REPRRAl----------- 524
gi 74843786   487 LQI-TTEe-NSVVPGNMATVTIR--TTEAv-----SEF---TILIIsRGEILSERkfqTLSgVPENSH------------ 542
gi 74838485   435 IQV-PEEt-IGCSPGKYRKHLID--ILYSanntqsALL---HFQIIsRGKVQRWW---SLPvDFKPTKlpfdtqqlvetp 504
gi 194380608  473 lsierPDs-RPPRVGDTLNLNLR--AVGSg-----ATFshyYYMILsRGQIVFMN---REP--KRTLT------------ 527
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PN5_A        456 -------------LLQLNATEKMIPRAKILI-AtVAgr--tVVYDFADLAFQE--LRNNFDLSIDE-QEIKPGRQIELSM 516
gi 121686696  507 -------------QINILVTPQMSPSAKVVA-Y-LInpnneVSADSLPFDVKFs-TQVDLSTGFDE-EMVAPGDAVSVEL 569
gi 75570883   498 -------------NVRIPITPDMAPRFRFLA-Y-YIlpggeIVADSVTVEVTEl-CKSQVSLSLKGrPTLEPKAMLTLDL 561
gi 74834548   531 -------------AIDFEVTHKMVPFSRVVA-YyFLng--eVTANSAWFDVTDq-CLEEITIEPQS-QTAKPGEDFKFTV 592
gi 74819938   439 -------------TINVWPSQAMVPFARVVA-YyFKdn--eVVSGSLWFDVVDq-CKRELSIEVAP--LVTPGATFPITI 499
gi 74844201   527 -------------VQIIQVTQAMVPSMRVIA-YfLHga--eVVSNSAFVNVVNr-CETELTVTTNR-NTVKPGAPITYTI 588
gi 29337194   525 ------------tSISVLVDHHLAPSFYFVA-YfYHqg--lPVANSLLINVQPgdCEGKLELKVDGaKEYRNGDSMKLQL 589
gi 74843786   543 -------------LFEFSVEYDMIPGVQVLA-S-YVrddgeIVADYIKLTVTAe-LENQVSITSSS-TNIDAGEDVSIRV 605
gi 74838485   505 pqnsqgpivtgsvRLPITLPPTTSPTVKVLI-W-YTrddgeVVSDSVELKRDRc-LLHETRLTWST-SREQPGEEVTLSV 580
gi 194380608  528 -------------SVSVFVDHHLAPSFYFVAfY-YHgd--hpVANSLRVDVQAgaCEGKLELSVDGaKQYRNGESVKLHL 591
                         170       180
                  ....*....|....*....|.
2PN5_A        517 SG-RPGAYVGLAAYDKALLLF 536
gi 121686696  570 DA-GTKSMIGLSIVDESVYAL 589
gi 75570883   562 IG-EPDARVGLLAVDQAVYAV 581
gi 74834548   593 SG-PANAKIEFSAVDRAAYFV 612
gi 74819938   500 S--APHALVRLSGVDKAAYYL 518
gi 74844201   589 EG-AQNADVLLYGVDRAAYFL 608
gi 29337194   590 QT-DSEALVALGAVDTALYAV 609
gi 74843786   606 QTsSSGAYVGARAIDQSVLLL 626
gi 74838485   581 QA-GTDAICSVGVVDKSADLL 600
gi 194380608  592 ET-DSLALVALGALDTALYAa 611
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