Conserved Protein Domain Family
Lipin_N

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pfam04571: Lipin_N 
lipin, N-terminal conserved region
Mutations in the lipin gene lead to fatty liver dystrophy in mice. The protein has been shown to be phosphorylated by the TOR Ser/Thr protein kinases in response to insulin stimulation. The conserved region is found at the N-terminus of the member proteins.
Statistics
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PSSM-Id: 252678
View PSSM: pfam04571
Aligned: 10 rows
Threshold Bit Score: 149.049
Threshold Setting Gi: 75171699
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam04571 is a member of the superfamily cl04599.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821836    1 MNYVgqlaETVFGTVKELYRGLNPATLSGGIDVLVVRQRDGSFRCSPFHVRFGKL-GVLRSREKVVDIEINGEPVDLHMK 79
gi 74622110    1 MGIV----HKLITSVSGLYNNINPITLSGVNDVIVVEDKDGNLRCTEFQLRFGRL-YFYGINNQTVHLFVNGKMCDITMS 75
gi 26397245    1 MQYV----GRAFDSVTKTWNAINPSTLSGAIDVIVVEQEDKTLACSPFHVRFGKF-SLLLPSDKKVEFSVNGQLTGFNMK 75
gi 417782      1 MQYV----GRALGSVSKTWSSINPATLSGAIDVIVVEHPDGRLSCSPFHVRFGKF-QILKPSQKKVQVFINEKLSNMPMK 75
gi 75204297    1 MSLVgrvgSLISQGVYSVATPFH--PFGGAIDVIVVQQQDGSFRSTPWYVRFGKFqGVLKGAEKFVRISVNGTEADFHMY 78
gi 75171699    1 MNAVgrigSYIYRGVGTVSGPFH--PFGGAIDIIVVEQPDGTFKSSPWYVRFGKFqGVLKNGRNLIRIDVNGVDSGFNMY 78
gi 75029407    1 MDYa----YRVFKNVKYFYNSINPATLSGAIDVVVVEQPNGEYKSTPFHVRFGKY-GVFSYSDKYVDIAVNGVEIDLKMK 75
gi 74866081    1 MNSL----ARVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKL-GVLRSREKVVDIEINGVPVDIQMK 75
gi 2495724     1 MNYVgqlaGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKL-GVLRSKEKVIDIEINGSAVDLHMK 79
gi 23821834    1 MNYVgqlaGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGSLQCSPFHVRFGKM-GVLRSREKVVDIEINGESVDLHMK 79
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 23821836   80 LGDSGEAFFVQEL-DSDEEDvpPRLCTSPIPWGGLS 114
gi 74622110   76 ITSQGELFFEKDT-EDDLGI--DYDVILEYNNKLSA 108
gi 26397245   76 LGDGGEAFFVFAT----ENAvpRELQTSPIVSPTTS 107
gi 417782     76 LSDSGEAYFVFEM-GDQVTDvpDELLVSPVMSATSS 110
gi 75204297   79 LDNSGEAYFIREV-DPAANDtnNLISGSENNNGNQN 113
gi 75171699   79 LAHTGQAYFLREV-EDVVGE-------SESGEVYTL 106
gi 75029407   76 LADSGVAFFVEEA-DDQv---pDYLLTSPLPEQETP 107
gi 74866081   76 LGDSGEAFFVEEClEDEDEElpANLATSPIPNSFLA 111
gi 2495724    80 LGDNGEAFFVEET-EEEYEKlpAYLATSPIPTEDQF 114
gi 23821834   80 LGDNGEAFFVQET-DNDQEIipMYLATSPILSEGAA 114
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