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pfam01794: Ferric_reduct 
Ferric reductase like transmembrane component
This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.
Statistics
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PSSM-Id: 250871
View PSSM: pfam01794
Aligned: 209 rows
Threshold Bit Score: 30.7264
Threshold Setting Gi: 122402821
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:

pfam01794 is a member of the superfamily cl01043.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582999  114 LGYLSCGLFFVSYFf---sLKN---NPFClm--lFSSHEK----MNY-LHRWLSVYAVLISVLHGILFMIFS-------- 172
gi 20178258   47 TGQLALIVLTLSLActp---------------arVWLGWT----WAArIRKALGLLAAFYAVLHFGIYL-RGqdf----- 101
gi 81653408   37 TGLGALALLFGTLAltp---------------lsRYSS-P----KLIsYRRFLGLFSFFYATLHFGAYLILDlsl----- 91
gi 20178162   44 LGFSALTILLIMFIlgk---------------vfYLLKQP----QLQvLRRALGLWAWFYVVLHVYAYLALElgy----- 99
gi 82186825  246 FPIVSLILLALVYLpgi------iaAVLQlyrgtKYSRFPdwldTWMlCRKQLGLVALAYAFLHAIYTLVMPiryyvrww 319
gi 152979494  43 LGFTAISILLAVFLlrs---------------liILWQQP----SLAiLHRPLGSWAIFYALLHLLSYLLLElgg----- 98
gi 149186961  42 SGDWAAWLLMVTLAvtp---------------vrLLFRKQrwaqWLMrHRRDLGVASFAYAAIHTGAYLWKKg------- 99
gi 156742598  58 TGYAAIILLVVSLVctp---------------lsVVSGWK----RILtLRRPFGLYGFFYAALHMLIFTALDfgl----- 113
gi 152995360   1 MGQYFPDPGKLLMRlsgiwASVfvvAVMSmtlvgKIKPLK----VINrYRRFIGLTAFFYGLLHFVIYLVLFagl----- 71
gi 222824075  39 SGIFGLIFFGLSLFfs----------------llKYKHTKd-------YPKFLGFYAFFWALIHFFNYFAFGknl----- 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582999  173 ----------------AQSYKPLLYDKISIYGYFITVVLFLMTVASLPSVR-RKFFEWFFVLHHT-CSV----------- 223
gi 20178258  102 --------------slGRIWEDVTERPFITSGFAALLLLLPLVLTSGKGSVrRLGFARWTLLHRL-VYL----------- 155
gi 81653408   92 --------------ewSALWNQAVQKPFVLLGFFGWMILAGLALTSIPKLW-----KRFQRGHIV-IYL----------- 140
gi 20178162  100 --------------dfSLFVQELVNRGYLIIGAIAFLILTLMALSSWSYLKlKMG-KWWFYLHQL-GYY----------- 152
gi 82186825  320 snnyiitqiktnntyeFLNYYAWLSDSYVALGILGFFFYVLLGITSLPSVSnAVNWREFRFVQSKlGYLtlvlctahtlv 399
gi 152979494  99 --------------dlPLFFHEISRRTYLILGLLSLLILCIVPISLIPFIHrILG-KNWLTMHKL-VYF----------- 151
gi 149186961 100 ---------------aLAWSGGELGQDFILAGWLAFALFVPLAVTSNDKSMrTLK-RSWKALHRL-VYP----------- 151
gi 156742598 114 --------------niPLIAQEIAEKRYILVGAMALLLLAPLALTSTKEWQrWLG-RSWKRLHRL-VYL----------- 166
gi 152995360  72 --------------swTWISSDLVEKPYIYVGVAALSIMAVLAITSTKRMMcALG-KKWKPLHRL-MYL----------- 124
gi 222824075  91 --------------dlILFFKDTFSKNLEFSGFVSFFILTFMFISSFKLFKkISK------IRKL-GYF----------- 138
                        170       180
                 ....*....|....*....|....
gi 74582999  224 ------------------LIIFLI 229
gi 20178258  156 ------------------AAALGA 161
gi 81653408  141 ------------------ALWLGA 146
gi 20178162  153 ------------------ALLLGA 158
gi 82186825  400 yggdrfiygpfykwylppAFVIAL 423
gi 152979494 152 ------------------SLIFAV 157
gi 149186961 152 ------------------AAVLTF 157
gi 156742598 167 ------------------AVPLAI 172
gi 152995360 125 ------------------AAIGVI 130
gi 222824075 139 ------------------CFLLAT 144
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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