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pfam00780: CNH 
CNH domain
Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.
Statistics
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PSSM-Id: 250127
View PSSM: pfam00780
Aligned: 62 rows
Threshold Bit Score: 158.18
Threshold Setting Gi: 341941195
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:
pfam00780 is a member of the superfamily cl02434.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74920668   782 IHPETRDQHLLIG-A-EEGIFNLNLn--------ELH-------DAAIEQLYPr--rTVWLYVIK--DILMSL----SGk 836
gi 81864762    50 DCLAAWEEWLLVGtK-QGHLLLYRIrkdvgcnrfEVT-------LEKSNKNFSk--kIQQIHVVSqfKILVSL----LE- 114
gi 341941195 1142 YCGSLWGVNLLLG-T-QSHLYLMDR----------SG-------KAEIVKLIKrr-pFRQIQVVEqlNLLITI----SGk 1197
gi 123899077  230 LCAALWGVNLLVG-T-ENGLMLLDR----------SG-------QGKVYNLINrr-rFQQMDVLEglNVLVTIs--gKK- 286
gi 67477462   782 LCAALWGVNLLIG-T-DSGLMLLDR----------SG-------QGKVYPLISrr-rFDQMTVLEgqNILATIs--gRK- 838
gi 162416278  493 VCADPWGQALLVS-T-DAGVLLVDDd-------lPSV-------PVFDRTL-P----VKQMHVLEtlDLLVLR----ADk 547
gi 82081855   487 VCADSWGQSLLVS-T-DAGILLIDD-------------------GQTTVQVFDktlqIKQMHVLEalDYLIARtdkgkD- 544
gi 162416109  502 VCGDSWGQSLLVAtD-SAGVMLLED----------SP-------TLPPVQVFDktltVKQMHVLEpqDLLIARadkgkD- 562
gi 156371022  405 LCGDSWGDSVLLG-T-EEGIYLV------------QE-------GKSMRQLFDrsviCQQLYVLEayGLLLFR----VE- 458
gi 156364589   19 eCIATYADCLLVG-TrQGHLLLYSIk-------dGSGairfkvdLRSSNKLFSkk-pILQLTVVEelSILISL----SD- 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74920668   837 --tA-------QLYRHDLLALHSKQTHrfsmhmkkipeklvprkfalttKVPDTKGCMQCCv---tRNPYNGYKYLCGSM 904
gi 81864762   115 ---N-------NIYVHDLLTFQQIT------------------------TVSKAKGASLFTcdlqhTETGEEVLRMCVAV 160
gi 341941195 1198 --kN-------RLRVYHLSWLRNKILNndpkskkrqk--amrkkeeackAIDKLIGCEHFS-----VLQHEETTYIAVAV 1261
gi 123899077  287 ---N-------KLRVYYLSWLRNRILHndpeve----------kkqgwiTVGDLEGCVHYK-----VVKYERIKFLVIAL 341
gi 67477462   839 ---R-------RIRVYYLSWLRQKILRtegagsant-----tekrngwvNVGDLQGAIHFK-----IVRYERIKFLVVGL 898
gi 162416278  548 gkdA-------RLFVFRLSALQKGLEGkqagksr---------sdcrenKLEKTKGCHLYAi----NTHHSRELRIVVAI 607
gi 82081855   545 ---S-------RLLVFRLSSVQKDIETkqvirsk---------ydcrenKLERTKGCHLYAi----NTHHSSELRIVVAI 601
gi 162416109  563 ---A-------RLYVYRLSTLKQGIEErqlvrtk---------cdsrenKLEKTKGCHLYSi----NTHHGVELRIVAAI 619
gi 156371022  459 ---KskefhnpRVCVFKLSDLEEDEDVvftre------------dckkhKLDRTKGCHLFA-----ALRSSQPLFLAVAC 518
gi 156364589   85 ---N-------VISVHNLETFALLST------------------------LSKSKGATFFA--------VDLTLKLCVAV 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74920668   905 ATGIFLMQWYDplNKF------------------MLLKQ--CEWPsgniqyyganSNVFEMIITpe---leYPI---VCV 958
gi 81864762   161 RKKLQLYFWKDreFH-------------------ELQGD--FSVP----------DVPKSMAWC-------ENS---ICV 199
gi 341941195 1262 KSSIHLFAWAP--KSFden------------taiKVFPT--RDLK----------PLTVDLAVGse----kTLK---IFF 1308
gi 123899077  342 KNAVEIYAWAP--KPYhkf------------mafKSFTD--LQHK----------PLLVDLTVEeg----qRLK---VIY 388
gi 67477462   899 ESSIEIYAWAP--KPYhkf------------msfKSFGS--LSHV----------PLIVDLTVEdn----aRLK---VLY 945
gi 162416278  608 RNKLLLITRKHnkPSGvtstsllsplsespveefQYIRE--ICLS----------DSPMVMTLVdgpaeesDNL---ICV 672
gi 82081855   602 RNKLLLITKKYnpCNSltgsslsl--sespveefQYIREicLSDPpv------vmTLVDGPTGDs------DNM---ICV 664
gi 162416109  620 RNKLLLITRKQsrLECvssiatvtgstdspveefQYIREicLCDSpv------vmALVDGPTGEn------DHM---ICV 684
gi 156371022  519 GRKVALLKWKHplVWSswavgnv----rdmtegfELIREvtFSEP----------AILLTILLT-------ESQeplLCA 577
gi 156364589  123 KKKIQLYIWRNe--SFq-----------------ELPPE--LGLP----------DVVRAVAWA-------GDS---LCV 161
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74920668   959 NVrkgpndTLKLDLINTN--STPTwFNtTVEEMDgmATVinrrdTLRPIKVHQIEKD---AILVCYDRFVQIVDI---QG 1030
gi 81864762   200 GF------KRDYYLIRVDgkGSIKeLF-PTGKQL-------------EPLVAPLADG---KVAVGQDDLTVVLNE---EG 253
gi 341941195 1309 SS------ANGYHIIDAEs-EVMSeVT-LPNN-----------------NVVILPDClglGVMLSLNAEAASEEA---NE 1360
gi 123899077  389 GS------SVGFHVIDVDs-GNPYdIY-IPSHG-----------SVTPHAIVVLPKTdgmEMLLCYEDEGVYVNT---YG 446
gi 67477462   946 GS------TGGFHAIDLDs-AAVYdIY-TPAQSg---------qTTTPHCIVVLPNSngmQLLLCYDNEGVYVNT---YG 1005
gi 162416278  673 AY------RHQFDVVNESt-GEAFrLH-HVEANR--VNF---------VAAIDVYEDgeaGLLLCYNYSCIYKKVcpfNG 733
gi 82081855   665 AY------RHQFDLVNESt-GESYrLH-HIEANKvn-----------fVAAIDVYEDgeaGLLLCYNYVCQYRKVypfNG 725
gi 162416109  685 AY------RHQFDLINESt-GDAYrLH-HVDSNRvn-----------fVAAIDVYEDgeaGLLLCYNNICVYKKVcpfNG 745
gi 156371022  578 GY------KNNFDLVQ-Rt-GEIKrVH-SVDTQK--TTL---------VSAIDVYEDhepELLLTFNRKCLFKRL---NG 634
gi 156364589  162 GF------KRDYSLIKVNt-GAATeLF-STGKHL-------------EPTIATLPNS---GLILCRDDMSIITDS---EG 214
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74920668  1031 Fp-----KQSrklISRVEFSFVIESIVC-LTDSVLAFHKYGMQGRSLRNGEI---TQEITDTSRIYELIGS 1092
gi 81864762   254 I------CTQ---KCALNWTDIPVAMEH-QPPYIVAVLPRYVEIRTLEPRLL---VQSIELQRPRFITSGG 311
gi 341941195 1361 Q------LLK---KILDVWKDIPSSVAFeCTKRITGWDQKAIEVRSLQSTILeneLKRRSIKKLRFLCARG 1422
gi 123899077  447 R------ITK---DVVLQWGEMPTSVAYiHSNQIMGWGEKAIEIRSVETGHLdgvFMHKRAQRLKFLSERN 508
gi 67477462  1006 R------MTK---NVVLQWGEMPSSVAYiSTGQIMGWGNKAIEIRSVDTGHLdgvFMHKKAQKLKFLCERN 1067
gi 162416278  734 GsflvqpSAS---DFQFCWNQAPYAIVC-AFPYLLAFTTDSMEIRLVVNGNL---VHTAVVPQLQLV-ASR 796
gi 82081855   726 GspliqpSAY---DFHFSWNQVPYAVVC-AFPYILAFTTDSIEIRLVVNGNL---VHTAVVPELQLVASRS 789
gi 162416109  746 AtpmiqpNTS---DFHFSWNQMPNATVC-AFPYILAFTTDSIEIRLVVNGNL---VYTAVVPELQLTASRS 809
gi 156371022  635 K------NSS---NFYLNWNSAPQFVVC-AFPYLLAFTTNTIEIRLVVNGNL---VHTLVLPNLRVITSkv 692
gi 156364589  215 K------HTQ---KQSLTWSDTPMALEY-VEPYVIGVLPRYIEMRTISPRAL---IQSIELQKPRFIAKGk 272
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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