Conserved Protein Domain Family
Hydrolase

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pfam00702: Hydrolase 
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haloacid dehalogenase-like hydrolase
This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Pseudomonas sp. (S)-2-haloacid dehalogenase 1. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.
Statistics
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PSSM-Id: 250068
View PSSM: pfam00702
Aligned: 239 rows
Threshold Bit Score: 32.2565
Threshold Setting Gi: 46396279
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00702 is classified as a model that may span more than one domain.
pfam00702 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RF6_B        16 KIAFAFAIDGVLFRGKKPIagasdalkllnrnkipyillTNGGGFSERARTEfisskldvDVSPLQIIQSHTPYkslv-n 94
gi 74956022    4 ISSVLIDLSGTI---------------------------HIEEFAIPGAQTA--------LELLRQHAKVKFVT------ 42
gi 74956239    7 VNGFLLDITGVL------Yn-------------------SIYKSDGVAVPKS--------AEAVNFLYQHSKVKfl---- 49
gi 544271    493 ERVFVWDLDETL------Ii-------------------FHTLLSGSYANRY--------TKDHSSLMTIAFRM------ 533
gi 239938901 303 ERVFLWDLDETI------Ii-------------------FHSLLTGSYAQKY--------GKDPTVVIGSGLTM------ 343
3HB1_C         4 ERVFVWDLDETI------Ii-------------------FHSLLTGTFASRY--------GKDTTTSVRIGLMM------ 44
gi 3183005   322 ERVFIWDLDETI------Iv-------------------FHSLLTGSYANRY--------GRDPPTSVSLGLRM------ 362
gi 81554811   16 YDVFLFDLWGVIIEGNHTYp-------------------GVVQNINKIIAQK--------KVYFVTNAPRNIFSlhktik 68
gi 81625921   15 YDVISFDIFDTL-------------------------------LLRPFIKPT--------DLFLYIETKYNIKG------ 49
gi 81555852    3 LEVVLWDFDGVIFDSMHLK----------------------NEGFRALFQKH--------GNKNQESLKQFEVY------ 46
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RF6_B        95 kysRilavgtpsvrgvaegygfqdvvhqtDIVRYNRDIAPFS--GLSDEQVMEYSRDIPDLTTKKfdavlvf-------- 164
gi 74956022   43 -----------------------------NTTKESKRLLHQR--LINCGFKVEKEEIFTSLTAARd-------------- 77
gi 74956239   50 -snA-------------------------KGNSNRNVARRLQ--RLGINVREEDVITPAPVVAQ---------------- 85
gi 544271    534 ---Eemvfnmadthf---ffneieecdqvHIDDVSSDDNGQD--LSAYNFATDGFHTNTPPGAPPnlclptgvrggvdwm 605
gi 239938901 344 ---Eemifevadthl---ffndleecdqvHVEDVASDDNGQD--LSNYSFSTDGFSGSGGSGSHGssvgvqggvdwm--- 412
3HB1_C        45 ---Eemifnladthl---ffndledcdqiHVDDVSSDDNGQD--LSTYNFSADGFHSSAPAANLClgsgvhggvdwm--- 113
gi 3183005   363 ---Eemifnladthl---ffndleecdqvHIDDVSSDDNGQD--LSTYNFGTDGFPAAATSANLClatgvrggvdwm--- 431
gi 81554811   69 swgInalpemiissgeiavqmileskkrfDITNPIIYHLGHL--ENDIINLMQCYTTDDINKANIs-------------- 132
gi 81625921   50 ---F-------------------------HQARILAEMQSRKlsKRQDITLDEIYHQIPKEFHSYk-------------- 87
gi 81555852   47 -----------------------------HYQSGGISRNEKI--QYFYNEILKTPIAQEEVDALAle------------- 82
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RF6_B       165 ------ndphdwAADIQIISDAINSENGMLNTLRN------------EKsgkpSIPIYFsNQDLLWANPYKLNRfgq--- 223
gi 74956022   78 ------------LIVKNQYRPFFIVDDRAMEDFEGistddpnavvigLApekfNDTTLThAFRLIKEKKASLIAinkgry 145
gi 74956239   86 ------------YCRENKLRPHLFVRDDVLEYFDGidtsspncvvmgEVeegfSFDRINrAFRILIDMPKPLLItmgngk 153
gi 544271    606 rklafryrkikdIYNSYRGNVGTLLGPGKREAWLQirseievatdnwATlalkCLSMISqRENCVNVLVTSTQLa----- 680
gi 239938901 413 rklafryrkvreIYDKHKSNVGGLLSPQRKEALQRlraeievltdswLGtalkSLLLIQsRKNCVNVLITTTQLv----- 487
3HB1_C       114 rklafryrrvkeMYNTYKNNVGGLIGTPKRETWLQlraelealtdlwLThslkALNLINsRPNCVNVLVTTTQLi----- 188
gi 3183005   432 rklafryrrvkeIYNTYKNNVGGLLGPAKREAWLQlraeiealtdswLTlalkALSLIHsRTNCVNILVTTTQLi----- 506
gi 81554811  133 ------------LITIYRDENEKLDLNEFDELFKIivqr-----kiiNIcanpDLGINQhGIYRYCSGYYAEKIkq---- 191
gi 81625921   88 ------------GVEIATEKEVLVPNLEMLELYRFak---------enNk---RVIIVS-------DMYLPLEVl----- 131
gi 81555852   83 ----------fgTIIEQKLFDREHLNSEVMAFIDKhy--------knHV-----FHIASaALHSELQVLCEFLGi----- 134
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RF6_B       224 ------gaFRLLVRRLYLElngeplqdYTLGKp-TKLtYDfahHVLIDWekrLSGkigqsvkqklpllgtKPStSpfhaV 296
gi 74956022  146 h-qtnaglCLGPGTYVAGLeysagveaTIVGKp-NKL-FF---ESALQS---LNEn-------------vDFS-S----A 198
gi 74956239  154 ffqrvdgpCIDVGAFAAALkfstncevLNIGKp-SRF-YF---EQGMNA---LGM---------------KPE-E----I 205
gi 544271    681 --------PALAKVLLFGLggifnienIYSAHkiGHEtCY---ERIVTR---FGR---------------KST------Y 725
gi 239938901 488 --------PALAKVLLYGLgeifpienIYSATkiGKEsCF---ERIVSR---FGK---------------KVT------Y 532
3HB1_C       189 --------PALAKVLLYGLgsvfpienIYSATktGKEsCF---ERIMQR---FGR---------------KAV------Y 233
gi 3183005   507 --------PALAKVLLYGLgivfpienIYSATkiGKEsCF---ERIIQR---FGR---------------KVV------Y 551
gi 81554811  192 ------lgGKVIYSGK------------------PYEeIY---HKILKEcsnI-----------------PKN-R----M 222
gi 81625921  132 -------eDILISKGFDGYtnfylsnhIMLTKh-SKD-LF---KHVLKQeniTNT-------------------Q----I 176
gi 81555852  135 -------iKYFKSVEG--------------SPp-NKPkII---ANIIQK---YAY---------------NPG-R----M 166
                        330
                 ....*....|....*...
3RF6_B       297 FMVGDNPaSDIIGAQNYG 314
gi 74956022  199 VMIGDDVnDDALGAIKIG 216
gi 74956239  206 VMVGDDLmSDVGGAQACG 223
gi 544271    726 VVIGDGN-EEETAAKAMN 742
gi 239938901 533 VVIGDGR-DEEIAAKQHN 549
3HB1_C       234 VVIGDGV-EEEQGAKKHN 250
gi 3183005   552 VVIGDGV-EEEQGAKKHA 568
gi 81554811  223 LMIGDTFyTDILAANRLG 240
gi 81625921  177 LHIGDNSwADDAMPKSLG 194
gi 81555852  167 LMIGDSV-NDYESAQANE 183
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