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pfam00688: TGFb_propeptide 
TGF-beta propeptide
This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.
Statistics
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PSSM-Id: 250057
View PSSM: pfam00688
Aligned: 81 rows
Threshold Bit Score: 89.4273
Threshold Setting Gi: 2501179
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:

pfam00688 is a member of the superfamily cl02928.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82267416   42 LLllmvlllpqvssgrqggdasqtdhgrvppvpssllsPPAAPSLKPSLAETIQSLLLSRLGLQSQPDP----RPGVPVP 117
gi 74767619   22 ALfltvh--------------------------sencsDVCLEKMAQIRLEDIKSRLLSSMGMEEPPKV-----DHIDIP 70
gi 341940737  12 FL--------------------------------------LLTLPWGQTSEFQDSDLLQFLGLEKAPSP----HRFQPVP 49
gi 82111386   17 WA--------------------------------------LLTVALGMDLSLQESLLLKSLGLSAKPSP----KIPIPVP 54
gi 137969      9 FL------------------------------------HILAIVTLDPELKRREELFLRSLGFSSKPNP----VSPPPVP 48
gi 82097648    9 FL------------------------------------VLLVPADTDTKLWHMEEFSIKLIHP-ANPVP----VSPPPVP 47
gi 544196     12 TL--------------------------------------SLCSPAEDDGLVQEKLFLSSMGLWSRPKP----SHHAAVP 49
gi 74767620    4 ALlvvcvsvv---------------------ltlstppVSASLALSPHELGMLQKGFLRRFGFPRVPNLs---GPALPIP 59
gi 157823831   1 ---------------------------mqpsqrlltlgfllltlaRGQTSEFQDYDFLQFLGLKKAPSPh----RFQPVP 49
gi 154104626  23 vnstrerlsgssvdtavpttaygeeatgppgetskcgaARTRGQEREMRVETLKRHILDKLGLKRSPTIprnrTLPRAPP 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82267416  118 RY-L-LDLY----RFH-Qq-QYHLVEDPSfsfpr------------------qhiqqANTVRSFHHNELSDDnsl----p 167
gi 74767619   71 PS-AiEQMI----EGM-E--EQDDKLDEDaa-------------------------eKTFIMAVDPSDGFDR-------- 109
gi 341940737  50 RV-L-RKII----RAR-Ea-AAASGASQDlcyvk------------------elgvrGNLLQLLPDQGFFLNtqkpf-qd 102
gi 82111386   55 SV-L-WRIF----QKR-RspPATNRDPVDgcrve------------------efnvpGNIIRVFADQGRFIHstqp--hp 107
gi 137969     49 SI-L-WRIF----NQR-Mg-SSIQKKKPDlcfve------------------efnvpGSVIRVFPDQGRFIIpysddihp 102
gi 82097648   48 SV-L-WKIY----NQR-Mg-SKAPKKNQElcfmk------------------elnvpGNIIRVFPDQGEFAPwspeq-ps 100
gi 544196     50 SQ-M-WKIF----K------QASKQTVNDpcvvs------------------eygvrGNIVRFMQDQGSLISapav--hs 97
gi 74767620   60 DH-V-WDIY----E----------EASEDg--------------------------eMDWIRHYYPKELFEL-------- 89
gi 157823831  50 RI-L-RKII----RAReT--AAASGASQDlcyvk------------------elgvrGNLLRLLPDQGFFLNtqkps-qd 102
gi 154104626 103 MQsL-LDQYgfypDRS-G--NIVSAEDITqafqgdspasynyhlvdterrhyedsaeTETVITVATPPPVAp-------- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82267416  168 dnPQRVHISFNISSI---PEDERVLSAE-LRLLRSSRA---FWGPGVHRLNIYLVES-------HGDPEPTLLETRLf-t 232
gi 74767619  110 ---ETLVARFPVSMT---TMLRKVAKAY-LHVYLYVEEa--LPEPETVEVVVHERR--------LNGEVGEAVATKT--- 169
gi 341940737 103 gsCLQKVLYFNLSAI---KEKAKLTMAQ-LTLDLGPRSy--YNLRPELVVALSVVQDrgv-wgrSHPKVGRLLFLRS--- 172
gi 82111386  108 llCLQKRLYFNLSVL---EEDERLTMAQ-LEIKFSHNSyhsPGRGGGFELRLYRSCPvplrgtpSLERGRKLLLEQSfa- 182
gi 137969    103 tqCLEKRLFFNISAI---EKEERVTMGSgIEVQPE------HLLRKGIDLRLYRTLQitlkgmgRSKTSRKLLVAQTfr- 172
gi 82097648  101 nlCLQKIIFFNLQVM---EKEEQLTMGQ-LELRFNQN----SYYGGTFDLQLYMLRIlspqdirRKMSSKKLLAAQTfr- 171
gi 544196     98 fnCVRKHLFFNMSVL---EEVEQLSLAQ-LEMKFKQDLl--LLGPHVFSVDLYRVLKttl-kgvTHESSRKLLQSQT--- 167
gi 74767620   90 --NSGLLVSYNLSASvrnAAEEEVVRAN-LKIKL-------HQTKRPTRVSVYEVEQ-------QHPEIRRLLDSKT--- 149
gi 157823831 103 gsCLQKVLSFNLSAV---KEKGKLTMAQ-LILHLGPRSy--HYLQLELVVAVSVVQDrgv-wgrSHPKLGRLLVQKS--- 172
gi 154104626 171 -fNESGCCYFKFGRH---VSRTKVNKAF-LWLYVRAAe---DMQSTSIPLKIYRIAQas---sfYTEPYKVLISSHKitd 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82267416  233 TANNThessSLWEAFPLSSD-ILLEVLGGTGtLG-FLLEVRPENR-T-SSGVQQNVYAAAGKEdaekeghlrvrrsvgqd 308
gi 74767619  170 VTLQR----STKVVVPLKSSdVERWWRSDPI-LGlYVVAMLNGQN-I-AVHPQEDRHA---------------------- 220
gi 341940737 173 VPGP-----QGQLQFNLQGA-LKDWSSNRLKnLD-LHLEILVKEDrY-SRVTVQPENPCDRLL----------------- 227
gi 82111386  183 -------rlHKSLLFNLSDV-AKDWTTHSRN-LG-LVLEIAVSGD-G-ASAPGSTGPQSPCAGi---------------- 234
gi 137969    173 -------llHKSLFFNLTEI-CQSWQDPLKN-LG-LVLEIFPKKE-S-SWMSTANDECKDIQ------------------ 222
gi 82097648  172 -------llHKTLYFNLTNV-CRIWRDRTKN-LG-LLLEIFTRRE-D-TLAECRGIQTF--------------------- 218
gi 544196    168 LSPGA----HASVLVNLTNL-AQSWRKPEKN-FG-MQLELQVMHL-N-NMLHDHAYVQIPD------------------- 219
gi 74767620  150 IDVSDtsrpTQWVDLDVAPA-LRASRNDHDTv--tLFIDHPDTAI-Y-SSEPHSMSTLPLTR------------------ 206
gi 157823831 173 V-LGP----QGSLQFNLQGV-VKDWNRHQLKnLD-LYLEILVKED-RySRVNAQLDNPCNQLM----------------- 227
gi 154104626 240 VKPNE----GLWVSYPIRDQ-VRRWFHNPAEnLG-IVIE-TSEAG-K-DLIVLDPKPGEEP------------------- 291
                        330
                 ....*....|....
gi 82267416  309 eysWTQERPLLVTY 322
gi 74767619  221 -----RHTMFMSIT 229
gi 341940737 228 ---RSLHASLLVVT 238
gi 82111386  235 --dSFMDTSLLVVT 246
gi 137969    223 ---TFLYTSLLTVT 233
gi 82097648  219 -----LSSSLMTVT 227
gi 544196    220 -----IHATLVVVS 228
gi 74767620  207 ----HQSLPLVVYS 216
gi 157823831 228 ---HSLHASLLVVT 238
gi 154104626 292 ------LQPFLVMH 299
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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