Conserved Protein Domain Family
TGFb_propeptide

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pfam00688: TGFb_propeptide 
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TGF-beta propeptide
This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.
Statistics
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PSSM-Id: 279078
View PSSM: pfam00688
Aligned: 70 rows
Threshold Bit Score: 104.639
Threshold Setting Gi: 575773383
Created: 20-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00688 is a member of the superfamily cl02928.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RJR_A         2 PLSTSKTIDMELVKRKRIEAIRGQILSKLRLASPPsqgdvppGPLPEAVLALYNSTRD------RVAGESVEPEPEPEAD 75
gi 556961780  31 rkfTESGRSSPQQSEEILNEFELRLLNMFGLKRRPnpg--ksAVIPQYMRDLYRLYSRsgedslDQHGSSLN-PQLERSA 107
gi 18858367   30 egkkkASALHLAQSHELLRDFEATLLHMFGLQRRPrps--hsAVVPQYLLDLYRLQSGeleeagAQHVSF---DYPERST 104
gi 345329089  31 rrfTESGRSTPQRSEDILSEFELRLLNMFGLKRRPnps--kgAVIPPYMLDLYRLHSGqleepaMDYRL-------ERAA 101
gi 554558488  37 eiqSHAGGRRSGQSHELLRDFEATLLQMFGLRRRPqps--ksAVIPEYMRDLYRLQSGeeeeeeQIHSIAL--EYPERPA 112
gi 556946788  37 eiqgQAGGRRSGQSHELLREFEASLLQMFGLQRRPqps--ksVVVPRYMLDLYRFQSGden------vkdINFKYPERST 108
gi 38195048   21 AESSSQRAKHEVRNSADFQMMEQRFLDTMGMRSRPrpk--rgTRIPQYMLDLYNSHKAhpdwisTQFR-------FGDKW 91
gi 167859050  38 serssQNEGDQNRKAQVIEAFESTLLGMFGLKERPrpq--gkLRVPQYMMDLYRSHTEaed------giNMLFDFKHVST 109
gi 597747400  24 GSSHSDGNLLTSLDPSLAQTIQNLLLTRLGLQSHPnpr--pgALVPQYLLDLYRFHTEqyhlieDPD-----FSYPTKHV 96
gi 47225032   74 pssllsppaaPSLKPSLAETIQSLLLSRLGLQSQPdpr--pgVPVPRYLLDLYRFHQQqyhlveDPSFSF-----PRQHI 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RJR_A        76 YYAKEVTRVLMveSGNQIYDKFK--G---TPHs--LYMLFNTSElreaVPEPVLLSR-------AELRLLRLKL------ 135
gi 556961780 108 SRANTIRSFHH----EESLEELPetG---TKTa--RHFFFNLSS----IPGEEMPASael--riFREEVQPTLA------ 166
gi 18858367  105 SRANTVRGFHH----EEHLEELQ--SdgsQETp--LRFVFNLSS----IPEDELISTael--rvYRQQIDDAFSdpdqtg 170
gi 345329089 102 SRANTVRSFHH----EESLEELP--E---ASGttaRRFFFNLTS----VPNEEFITSael--qvFREQVREALD------ 160
gi 554558488 113 SRANTVRSFHH----EEHLENIP--Gt-sENSa--FRFLFNLSS----IPENEVISSael--rlFREQVDQGPD------ 171
gi 556946788 109 SRANTVRSFHH--EERLEKDSAN--S---DDSl--SHFIFNISS----LPENEVFSSael--rlYREQIEQGPS------ 167
gi 38195048   92 IGANTIRAFHH--TDNDGIDAS---E---NSNl--TRIIFDLST----LPMYETVTSaelrlstRSGDLKQPSN------ 151
gi 167859050 110 GTANTIRSYHH--QDAGQV--VS--T---EHHr--HKVIFNVST----MPEEEVMTTael--rlFRKDLDEHHI------ 166
gi 597747400  97 QGANTVRSFHH--AASPDLPSHG--D---KKGr--IHMAFNLSS----IPSSENVVSael--rfLRGGL--GHS------ 153
gi 47225032  147 QQANTVRSFHH--NELSDDNSLP--D---NPQr--VHISFNISS----IPEDERVLSael--rlLRS-SRAFWG------ 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RJR_A       136 -KVE---Q---------------HVELYQKYsqDs--------WRYLSNR------LLaPSD---SPEWLSFDVTGVVRQ 179
gi 556961780 167 -NNSsghH---------------RINIYEIImpAsstl-rdpiTRLLDTR------LV-HQS---QSKWESFDVTSAVMR 219
gi 18858367  171 dHGL---H---------------RINIYEVLkaPreg---qliTQLLDTR------LV-RHN---TSKWESFDVSPAVLR 219
gi 345329089 161 -NNSgyhH---------------RINIYEIIkpAtais-kdpvTRLLDTR------LV-NHN---ASKWESFDVTPAVTR 213
gi 554558488 172 -WEQg-fH---------------RINIYEVMkpPaelvsghliTRLLDTR------LV-HHN---VTRWETFDVSPAVLR 224
gi 556946788 168 -WEE---Hf-------------hRINIYEVMrpPsrng--qliTRLLDTR------LV-HQN---ATQWESFDVSPAVVR 218
gi 38195048  152 -STQ---L---------------WIRVYQVLlpGmgdt--palRRLLDSR------EV-DAR---VAGWESFNVELAIQH 200
gi 167859050 167 -VKR---HalhdreslkpihymqRINVYHILkpVarnr--dtiKRLIDTR------LV-DVR---NASWESFDVRPAMRA 230
gi 597747400 154 -SKP---H---------------TISLYQf---Ggnt---dsnSRLLYSR------QL-TTDptaRKSWEVFPLDGELFQ 201
gi 47225032  205 -PGV---H---------------RLNIYLVEshg------dpePTLLETRlfttanNT-HES---SSLWEAFPLSSDILL 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RJR_A       180 WLTRREAIEGFRLSA--------------------HC-----Sc----dS----K----------DNtLHVEIN-G---- 211
gi 556961780 220 WLMYQEPNHGFVVEV--------------------VH-----VdkeesaS----K----------RH-VRISRS-L---- 254
gi 18858367  220 WTQEKRSNHGLAVEV--------------------VQ-----Mk----rNpvqkG----------RH-VRVSRSvH---- 255
gi 345329089 214 WIAQGQPNHGFVVEV--------------------VH-----LedergvS----E----------RH-VRISRS-L---- 248
gi 554558488 225 WTQEKQPNYGLAIEV--------------------TH-----LhqtrthQ----G----------QH-VRISRS-L---- 259
gi 556946788 219 WIRDKQPYRGFAVEV--------------------IH-----LnqtkthQ----G----------KH-VRISRS-L---- 253
gi 38195048  201 WVKNPEQNYGLDIQV--------------------TT-----Ke----gHs--iK----------DA-VRTREH-H---- 233
gi 167859050 231 WLDEPEKNHGLEIEL--------------------ID-----SrgrpspN----H----------HH-VRVTRE-Adpsk 269
gi 597747400 202 KLPDWSGSMSFILEV--------------------TTnsensSh----hP----VeedavdveaeEH-LRVRRS-A---- 247
gi 47225032  256 EVLGGTGTLGFLLEVrpenrtssgvqqnvyaaagkED-----Ae----kE----G-----------H-LRVRRS------ 304
                        330       340       350
                 ....*....|....*....|....*....|
3RJR_A       212 -----FnSGRR--GDlatihGMNRPFLLLM 234
gi 556961780 255 -----H-EDEE--SW-----PQMRPLLVTF 271
gi 18858367  256 -----P-LPDE--EW-----DQLRPLLVTF 272
gi 345329089 249 -----H-QDEQ--SW-----PQIRPLLVTF 265
gi 554558488 260 -----P-QGSG--DW-----AQLRPLLVTF 276
gi 556946788 254 -----P-QGDT--DW-----SQLRPLLVTF 270
gi 38195048  234 --------AEE--DW-----HEERPLIVTY 248
gi 167859050 270 veeleN-EEED--RW-----FQTRPQIVTY 291
gi 597747400 248 -----G-QDER--SW-----TRQRPLLVTY 264
gi 47225032  305 -------VGQDeySW-----TQERPLLVTY 322
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