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pfam00654: Voltage_CLC 
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Voltage gated chloride channel
This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains.
Statistics
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PSSM-Id: 250034
View PSSM: pfam00654
Aligned: 139 rows
Threshold Bit Score: 47.1585
Threshold Setting Gi: 81567735
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:

pfam00654 is a member of the superfamily cl02915.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ND0_B        84 GMVALSFWLMKRFapdtsgSGIPQIEGHLegklplvwq---rvlpiklvGGFLSLGAGMLAGFEGPTIQMGGSIGQMTG- 159
gi 81557108   84 GGGLVIGLFGVMVaqi-mpRSPVDPIEANalhggrmsv---rdslvivcQTVLSNGVGGSIGLEAGFTQIAAAFGSRIG- 158
gi 123098321  96 AGAVILALIAIFYagr-fkGQLADAIEANalyggrvsm---rgsllisiQTLLSNGFGASVGLEAGYTQICAAFSSQIG- 170
gi 123722730  77 LGGLVLAAFNWAAgv--rrRALVDAVEANalhggrmsa---mdsavvagQTVISNGFGASVGLEAAYAQVGGLFGSLGA- 150
gi 123725997  78 AGGLLVGLYYAKVmpggkpQGVAQVIGAVartggrmra---gdgvlaacGSALSLGCGASVGREGPAVHLGAALAAGLA- 153
gi 122498279  74 GGGLVVGAILHKFtpdgrvRSVADVIEGAalnegrveg---raglasalASLITLGSGGSTGREGPVVHLAAVISSKIS- 149
gi 122681518  83 GGILI----VRRLfgikrwHGPADAIHAAhrsdneldv---ksgfgstlAAFISASGGASVGQYGPLVHFGATMGSFLR- 154
gi 122463387  73 VVFLKTSLGISRW------AGPADSMYAAhqvnepldi---ktgmastlAAFASASGGGSVGQYGPIVHFGATMGIWV-- 141
gi 424871075  87 viggallglllFVlakrrkKPMVDPIEANalhggrlsl---tdsiivavQNLISNGFGASVGLEAGYTQLAAGLASKFG- 162
gi 423520068  61 IGGILVGFTQKYF------GTYPRLMPEVmveykktgrieyrfvhkatlTAIIVLIFGASLGPEAALVGIIGGLCTWVGd 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ND0_B       160 -----GWfk--aTQeNQRiLIAVGAGAGLATAFNAPLAGVALIGEEMHprfrsQT-------LAYHSLLFGCVMATIILR 225
gi 81557108  159 -----RSfrvrrED-LRV-LVGAGAGAAIGAAFDAPVAGAFYAFELVIgs--ySL-------GSLSPVAVAALAGVGVTR 222
gi 123098321 171 -----QRlaarrAD-LRL-LVACGAAGAISAAFSAPLAGAFFAFEVVLga--yTS-------AALVPVIASAVAAWLVTR 234
gi 123722730 151 -----RLlslrrPD-ARI-LVGAGAGSAIAAAFGAPLAGAFYAFEIVIga--yTP-------SAIAPVVAAALAGAQVAR 214
gi 123725997 154 -----GRlrlgpGL-ART-VLGCGVAAAVAASFNAPIAGALFAGEVVIgh--yAL-------SAFAPIVVSSVVATVLSR 217
gi 122498279 150 -----RWinadgIT-GRD-LLGCAVAAAVSASFNAPIAGAIFALEVVLrh--fAV-------HAFAPIVIASAAGTVINR 213
gi 122681518 155 -----QRtqgvlST--DI-FIGCGVAGAIAAGFNAPIAGIVFAHEAILrh--fSM-------KAIVPIAIASVSSVWFSD 217
gi 122463387 142 -----KRfissrLS-HEI-YLGCGVAAAISAGFNAPIAGVVFAHEAVLrh--fSV-------RAIAPITVASISASALGN 205
gi 424871075 163 -----LKlqlrrSD-LRT-LVGCGAAGAIAAAFNAPLTGAFYAFELIIgt--yTI-------VSLTPVVVSALVSTLIAR 226
gi 423520068 135 rfnfaLKg---mNE-----LTEVGIGATLSVIFNAPLFGYLAPNEne-----gEQinefskgKKAIVYLATTFAGFSVYL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ND0_B       226 MI--------RGQSAIislteFKr----VPLDSLWMFIILGILFGVMGYTFNRGLFKVLDWFDRLppl--atKWK-GFLL 290
gi 81557108  223 SL--------GSVPPGi---vIPsp-gtLSWEGTAGAVIISVLTALTAIGLMFCVTQTEALFRRMpg----pVWLrPAVG 286
gi 123098321 235 HL--------AHQQFLm---vPGvp-tpVSVEMIGQVMAVGILCAFFSILVMLAVAFAERTLQRVtw---lrGGLrFVIG 299
gi 123722730 215 RL--------GVVPYVv---sAEpg-paIHTAGYIAYGGLGAVCALLGIVLMRAVALVETGSRKai-----pGPWrPAIG 277
gi 123725997 218 GW--------FGDFPAf---iLPhltlaSAW-EFPAFVVLGGLCGLVAVAFMRGVFLAGGLASALrl----pVVLrPMVA 281
gi 122498279 214 LE--------FGDVTEf---aLSgdgmlRFYVELPAFLILGILCGFVAVLFMRGTFWAEDLGTSLqnriklpRYLrPAVA 282
gi 122681518 218 RL--------FGSNHLf---dLAgvsidLGE-MLPPALIAGPFFGILAVLFMQAIRHSARFAATSgw----sPVKlLLTA 281
gi 122463387 206 QW--------FPHTTTf---dISatlppLAE-VVPVLVMLAPAFALVAICFMAALRYSAQTAAKMnt----sPLLlPFIA 269
gi 424871075 227 LL--------AGSDFTi---dIGsf-gsVVPADYIPALLLGAFCAGVGILIMQGVAFVEELARKSsi----sPPFrPALG 290
gi 423520068 202 LLskldnrgsFIVDfgegslaLNe---------WVAFLPLASIGAIVGFFYFKLEFALE-KLIHPfrey---kvslGIIG 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ND0_B       291 GSIIGILSLF-PlP--LTDGGDNAVLWAF---NSqshfstLIL---VFCGRFLLTLICYGSGAIGGIFAPMLGIASIVSV 361
gi 81557108  287 GLIVGGLATLhP-S--VLSAGHEAMRAVF---AGnv---tAQMavvLLFLKALTSCLCIGSGFRGGLFFASLYLGSLAGT 357
gi 123098321 300 AAMLGCLGLLtP-T--VLGSGHGAMQILL---VSnp---tWLMlatTILLKTAASAISLGAGFRGGLFFASLMLGSMIGQ 370
gi 123722730 278 GLLLIPLAMLtP-Q--ALSAGHSALHLDM---TEtl---sLAFvamILLVKSASSIVSLGFGFRGGLFFASLFLGTLVGH 348
gi 123725997 282 GALVGLLALVlP-E--VLGVGYEATDQVL---KGay---hLDLllpLILAKLAASVICLGFGFGGGVFSPSLTLGALVGG 352
gi 122498279 283 GVLLGSLAIFfP-H--IIGVGYETTSAAL---TGel---lLWEaiiFAILKAVATAITVAGRMGGGVFSPSLMIGAITGL 353
gi 122681518 282 ATGTGVVGMFiP-E--VLGLGTAPLAHML---DGgf---ePGYlivLLVFKLVLTALCIGFGMFGGVFSPALFVGAAAGA 352
gi 122463387 270 ATICGLVGVWiP-Q--ILGLGISSINEMI---AGef---aLSLlltVLVAKLLMTALCIGFGLFGGVFSPSLFIGVAAGA 340
gi 424871075 291 GIIVGLLAMIsP-Q--VLSAGHGALHLNL---SHev---aIPTligLFLLKSFASAISIGSGFRGGLFFASLFMGALLGK 361
gi 423520068 269 GILLGVTGTFlP-YtlFSGEHQ--LKDLVvewSHl----sFWVlllSGVLKLCITAVCLNTGWRGGHIFPIIFAGSSIGY 341
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
3ND0_B       362 AMARHFHLLfpsq--ipepAVMAIAGMGALVAATVRAPLTAILLTIEMTDnYFVILPLLVTCLVASVVAEA 430
gi 81557108  358 IYG--TLLEplgva-pdsaTACALVGMSAMAVAVIGSPMTMICLMLELTGsVSMSGATLVAAVLSLLTVRR 425
gi 123098321 371 LYS--TVLSgpfpelalqpGTAAVAGMVALGTGVLGAPFSMVCLALELTGdFSITAGAVVAASISAMIVRE 439
gi 123722730 349 LYA--GLLAlglghpvlniGNASLVGMAALAVAVVGAPFTMAMLVLEATGnFSLTGAVLAASLVSSTLVRE 417
gi 123725997 353 AFGLAIALVapvs---asgA-YALIGMGALSAAVLGAPISTTLIVFELTGdYALSVGTMVAAVVAGALSRQ 419
gi 122498279 354 AFGLVATGIfpdv--sgseTLYALAGMGAVAAAVLGAPISTTLIVFELTGdWQTGLAVMVAVSMSTAISSK 422
gi 122681518 353 VAGQLMVGLtgfg---smtA-LAICGMAAVASAVIGAPVAGVLIILELTMnYDFALVAMVSIVASIMVTNF 419
gi 122463387 341 VAGELLI-Lfgfg---diaSIISVAGMAAVSSAVIGAPVSAVLIILELTQsYEYAVAAMIAVMVCNLLTNR 407
gi 424871075 362 LFAY-CGPYfada--tltpVIYAVVGMSSLAVAVIGGPLTMTFLALEITGdFPITALVLAAVITSSLVVRs 429
gi 423520068 342 AIASILPIDp---------ISSVAIVTTAISSYALRKPIAITLLLLMFFP-LNLLLPMLGAAAIGNAFPLP 402
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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